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1. Full Text Proximal Tubule–Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice
by Li, Xiao C and Soleimani, Manoocher and Zhu, Dongmin and Rubera, Isabelle and Tauc, Michel and Zheng, Xiaowen and Zhang, Jianfeng and Chen, Xu and Zhuo, Jia L
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 12/2018, Volume 72, Issue 6, pp. 1328 - 1336
blood pressure | kidney | natriuresis | hypertension | mice | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Natriuresis - physiology | Kidney - metabolism | Animals | Sodium-Hydrogen Exchanger 3 - genetics | Kidney Tubules, Proximal - metabolism | Blood Pressure - physiology | Mice | Sodium-Hydrogen Exchanger 3 - metabolism | Sodium Chloride, Dietary | Mice, Knockout | Hypertension | Control | Rats as laboratory animals | Kidneys | Research | Natriuresis | Health aspects | Membrane proteins | Index Medicus | Life Sciences
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2. Full Text Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice
by Li, Xiao C and Zhu, Dongmin and Chen, Xu and Zheng, Xiaowen and Zhao, Chunling and Zhang, Jianfeng and Soleimani, Manoocher and Rubera, Isabelle and Tauc, Michel and Zhou, Xinchun and Zhuo, Jia L
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 09/2019, Volume 74, Issue 3, pp. 526 - 535
Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Angiotensin II - pharmacology | Kidney Tubules, Proximal - pathology | Sodium-Hydrogen Exchanger 3 - genetics | Injections, Intraperitoneal | Hypertension - drug therapy | Male | Reference Values | Treatment Outcome | Random Allocation | Hypertension - physiopathology | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Animals | Hypertension - chemically induced | Receptor, Angiotensin, Type 1 - metabolism | Kidney Tubules, Proximal - metabolism | Female | Mice | Losartan - administration & dosage | Disease Models, Animal | Index Medicus | Life Sciences
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3. Full Text Inhibition of Na+/H+ exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator‐deficient and F508del mutant mice
by Tan, Qinghai and Stefano, Gabriella and Tan, Xinjie and Renjie, Xiu and Römermann, Dorothee and Talbot, Steven R and Seidler, Ursula E
British journal of pharmacology, ISSN 0007-1188, 03/2021, Volume 178, Issue 5, pp. 1018 - 1036
intestinal fluid absorption | sodium hydrogen exchange | anion secretion | DIOS | fluid secretion | mucoviscidosis | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Digestive system | Na+/H+-exchanging ATPase | Cystic fibrosis | Guanylate cyclase | Mutants | Jejunum | Fluidity | Intestine | Irritable bowel syndrome | Titration | Conductance | Alkalinity | Colon | Constipation | Digestive tract | Index Medicus
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4. Full Text Antihypertensive and Laxative Effects by Pharmacological Inhibition of Sodium-Proton-Exchanger Subtype 3–Mediated Sodium Absorption in the Gut
by Linz, Dominik and Wirth, Klaus and Linz, Wolfgang and Heuer, Hubert O O and Frick, Wendelin and Hofmeister, Armin and Heinelt, Uwe and Arndt, Petra and Schwahn, Uwe and Böhm, Michael and Ruetten, Hartmut
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 12/2012, Volume 60, Issue 6, pp. 1560 - 1567
intestinal sodium absorption | obese spontaneously hypertensive rats | sodium-proton-exchanger subtype 3 inhibition | spontaneously hypertensive rats | constipation blood pressure | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiovascular system | Cardiology. Vascular system | Arterial hypertension. Arterial hypotension | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Blood and lymphatic vessels | Antihypertensive agents | Rats, Inbred SHR | Up-Regulation | Antihypertensive Agents - pharmacology | Rats | Gastrointestinal Tract - drug effects | Hypertension - drug therapy | Antihypertensive Agents - therapeutic use | Gastrointestinal Tract - metabolism | Quinolines - pharmacology | Hypertension - metabolism | Sodium-Hydrogen Exchangers - metabolism | Animals | Sodium-Hydrogen Exchangers - genetics | Blood Pressure - drug effects | Blood Pressure - physiology | Quinolines - therapeutic use | Ramipril - pharmacology | Hypertension - genetics | Ramipril - therapeutic use | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Sodium-Hydrogen Exchanger 3 | Index Medicus
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5. Full Text Discovery and Optimization of 1‑Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)
by Rackelmann, Nils and Matter, Hans and Englert, Heinrich and Follmann, Markus and Maier, Thomas and Weston, John and Arndt, Petra and Heyse, Winfried and Mertsch, Katharina and Wirth, Klaus and Bialy, Laurent
Journal of medicinal chemistry, ISSN 0022-2623, 10/2016, Volume 59, Issue 19, pp. 8812 - 8829
Caco-2 Cells | Indans - chemistry | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Administration, Oral | Humans | Models, Molecular | Crystallography, X-Ray | Drug Discovery | Rats, Sprague-Dawley | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Sodium-Hydrogen Exchangers - metabolism | Sodium-Hydrogen Exchangers - chemistry | Animals | Swine | Drug Design | Cytochrome P-450 CYP2D6 - metabolism | Indans - administration & dosage | Cytochrome P-450 CYP2D6 Inhibitors - pharmacology | Indans - pharmacokinetics | Quantitative Structure-Activity Relationship | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Indans - pharmacology | Sodium-Hydrogen Exchanger 3 | Index Medicus
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6. Full Text Genetic and genomic evidence for an important role of the Na + /H + exchanger 3 in blood pressure regulation and angiotensin II-induced hypertension
by Li, Xiao C and Zheng, Xiaowen and Chen, Xu and Zhao, Chunling and Zhu, Dongmin and Zhang, Jianfeng and Zhuo, Jia L
Physiological genomics, ISSN 1094-8341, 04/2019, Volume 51, Issue 4, pp. 97 - 108
kidney | intestines | NHE3 | proximal tubule | hypertension | angiotensin II | Physiology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Angiotensin II - pharmacology | Animals | Sodium-Hydrogen Exchanger 3 - genetics | Blood Pressure - genetics | Humans | Hypertension - chemically induced | Blood Pressure - drug effects | Hypertension - genetics | Kidney Tubules, Proximal - drug effects | Hypertension | Adenosine | Animal models | Kidneys | Hydrogen | Na+/H+-exchanging ATPase | Homeostasis | Proximal tubules | Na+/K+-exchanging ATPase | Triphosphatase | Sodium | Angiotensin | Blood pressure | Angiotensin II | Adenosine triphosphatase | Index Medicus | Review
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7. Full Text Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) null mice: cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule
by Murtazina, Rakhilya and Kovbasnjuk, Olga and Zachos, Nicholas C and Li, Xuhang and Chen, Yueping and Hubbard, Ann and Hogema, Boris M and Steplock, Deborah and Seidler, Ursula and Hoque, Kazi M and Chung, Ming Tse and De Jonge, Hugo R and Weinman, Edward J and Donowitz, M
The Journal of biological chemistry, ISSN 0021-9258, 08/2007, Volume 282, Issue 34, pp. 25141 - 25151
Guanine Nucleotide Exchange Factors - physiology | Sodium-Hydrogen Exchangers - physiology | Mice, Inbred C57BL | Ileum - metabolism | Male | Mice, Transgenic | Phosphoproteins - genetics | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | Tissue Distribution | Animals | Protein Isoforms | Sodium-Hydrogen Exchangers - genetics | Mice | Phosphoproteins - physiology | Kidney Tubules - metabolism | Cyclic AMP - metabolism | Microscopy, Fluorescence | Sodium-Hydrogen Exchanger 3 | Index Medicus
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8. Full Text Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability
by King, Andrew J and Siegel, Matthew and He, Ying and Nie, Baoming and Wang, Ji and Koo-McCoy, Samantha and Minassian, Natali A and Jafri, Qumber and Pan, Deng and Kohler, Jill and Kumaraswamy, Padmapriya and Kozuka, Kenji and Lewis, Jason G and Dragoli, Dean and Rosenbaum, David P and O'Neill, Debbie and Plain, Allein and Greasley, Peter J and Jönsson-Rylander, Ann-Cathrine and Karlsson, Daniel and Behrendt, Margareta and Strömstedt, Maria and Ryden-Bergsten, Tina and Knöpfel, Thomas and Pastor Arroyo, Eva M and Hernando, Nati and Marks, Joanne and Donowitz, Mark and Wagner, Carsten A and Todd Alexander, R and Caldwell, Jeremy S
Science translational medicine, ISSN 1946-6234, 08/2018, Volume 10, Issue 456, p. eaam6474
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Potassium - metabolism | Protons | Humans | Middle Aged | Intestinal Absorption - drug effects | Male | Sodium - metabolism | Healthy Volunteers | Young Adult | Isoquinolines - pharmacology | Base Sequence | Adult | Female | Tight Junction Proteins - metabolism | Epithelium - metabolism | Ions - urine | Cells, Cultured | Sodium-Hydrogen Exchanger 3 - antagonists & inhibitors | Rats | Sodium-Hydrogen Exchanger 3 - metabolism | Electric Impedance | Sulfonamides - pharmacology | Gastrointestinal Tract - metabolism | Phosphates - metabolism | Animals | Cell Membrane Permeability - drug effects | Aged | Mice | Hydrogen-Ion Concentration | Phenotypes | Tight junctions | Na+/H+-exchanging ATPase | Phosphate transporter | Phosphorus | Gastrointestinal tract | Permeability | Sodium | Intestine | Electrical resistivity | Phosphate | Stem cells | Hyperphosphatemia | Kidney diseases | Index Medicus
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9. Full Text Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice
by Charoenphandhu, Narattaphol and Charoenphandhu, Narattaphol and Kraidith, Kamonshanok and Kraidith, Kamonshanok and Lertsuwan, Kornkamon and Lertsuwan, Kornkamon and Sripong, Chanakarn and Sripong, Chanakarn and Suntornsaratoon, Panan and Suntornsaratoon, Panan and Svasti, Saovaros and Svasti, Saovaros and Krishnamra, Nateetip and Krishnamra, Nateetip and Wongdee, Kannikar and Wongdee, Kannikar
Molecular and cellular biochemistry, ISSN 0300-8177, 3/2017, Volume 427, Issue 1, pp. 201 - 208
Life Sciences | Biochemistry, general | Medical Biochemistry | Oncology | Beta-thalassemia | Ussing chamber | Tenapanor | Cardiology | Hepcidin | Calcium absorption | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Plasma Membrane Calcium-Transporting ATPases - genetics | Calcium - metabolism | Hepcidins - pharmacology | Sodium-Calcium Exchanger - genetics | Plasma Membrane Calcium-Transporting ATPases - metabolism | Sodium-Hydrogen Exchangers - metabolism | Isoquinolines - pharmacology | Sodium-Calcium Exchanger - metabolism | Duodenum - metabolism | Thalassemia - metabolism | Female | Ion Transport - drug effects | Sodium-Hydrogen Exchangers - genetics | Thalassemia - genetics | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Thalassemia - pathology | Sulfonamides - pharmacology | beta-Globins - genetics | Mice, Knockout | Animals | beta-Globins - metabolism | Duodenum - pathology | Mice | Ion Transport - genetics | Sodium-Hydrogen Exchanger 3 | Index Medicus
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10. Full Text Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea
by Janecke, Andreas R and Heinz-Erian, Peter and Yin, Jianyi and Petersen, Britt-Sabina and Franke, Andre and Lechner, Silvia and Fuchs, Irene and Melancon, Serge and Uhlig, Holm H and Travis, Simon and Marinier, Evelyne and Perisic, Vojislav and Ristic, Nina and Gerner, Patrick and Booth, Ian W and Wedenoja, Satu and Baumgartner, Nadja and Vodopiutz, Julia and Frechette-Duval, Marie-Christine and De Lafollie, Jan and Persad, Rabindranath and Warner, Neil and Tse, C Ming and Sud, Karan and Zachos, Nicholas C and Sarker, Rafiquel and Zhu, Xinjun and Muise, Aleixo M and Zimmer, Klaus-Peter and Witt, Heiko and Zoller, Heinz and Donowitz, Mark and Müller, Thomas
Human molecular genetics, ISSN 0964-6906, 12/2015, Volume 24, Issue 23, pp. 6614 - 6623
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Abnormalities, Multiple - metabolism | Oligonucleotide Array Sequence Analysis | Diarrhea - physiopathology | Humans | Child, Preschool | Infant | Inflammatory Bowel Diseases - physiopathology | Male | Intestines - metabolism | Inflammatory Bowel Diseases - metabolism | Young Adult | DNA Mutational Analysis | Inflammatory Bowel Diseases - genetics | Adult | Female | Sodium-Hydrogen Exchangers - genetics | Child | Abnormalities, Multiple - genetics | Infant, Newborn | Diarrhea - congenital | Metabolism, Inborn Errors - metabolism | Genes, Recessive | Metabolism, Inborn Errors - genetics | Abnormalities, Multiple - physiopathology | Microvilli - metabolism | Diarrhea - genetics | Adolescent | Diarrhea - metabolism | Intestines - physiopathology | Mutation | Metabolism, Inborn Errors - physiopathology | Sodium-Hydrogen Exchanger 3 | Index Medicus
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