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1. Full Text Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD
by Labonté, Eric D and Carreras, Christopher W and Leadbetter, Michael R and Kozuka, Kenji and Kohler, Jill and Koo-McCoy, Samantha and He, Limin and Dy, Edward and Black, Deborah and Zhong, Ziyang and Langsetmo, Ingrid and Spencer, Andrew G and Bell, Noah and Deshpande, Desiree and Navre, Marc and Lewis, Jason G and Jacobs, Jeffrey W and Charmot, Dominique
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2015, Volume 26, Issue 5, pp. 1138 - 1149
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease,... 
MORTALITY | SEVELAMER | CALCIUM | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | PARATHYROID-HORMONE | UREMIC RATS | PHOSPHATE BINDERS | EXTRAOSSEOUS CALCIFICATIONS | CHRONIC KIDNEY-DISEASE | FGF23 | Gastrointestinal Tract - drug effects | Male | Random Allocation | Renal Insufficiency, Chronic - complications | Sodium - metabolism | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Gastrointestinal Tract - metabolism | Renal Insufficiency, Chronic - drug therapy | Sodium-Hydrogen Exchangers - metabolism | Renal Insufficiency, Chronic - metabolism | Phosphorus - urine | Animals | Isoquinolines - pharmacology | Calcinosis - etiology | Sulfonamides - therapeutic use | Isoquinolines - therapeutic use | Calcinosis - prevention & control | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Disease Models, Animal | Sodium-Hydrogen Exchanger 3 | Index Medicus | coronary calcification | epithelial sodium | intestine | phosphate uptake | hyperphosphatemia | hypertrophy | transport | Basic Research
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2. Full Text Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans
by Spencer, Andrew G and Labonte, Eric D and Rosenbaum, David P and Plato, Craig F and Carreras, Christopher W and Leadbetter, Michael R and Kozuka, Kenji and Kohler, Jill and Koo-Mccoy, Samantha and He, Limin and Bell, Noah and Tabora, Jocelyn and Joly, Kristin M and Navre, Marc and Jacobs, Jeffrey W and Charmot, Dominique
Science Translational Medicine, ISSN 1946-6234, 03/2014, Volume 6, Issue 227, pp. 227ra36 - 227ra36
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an... 
MEDICINE, RESEARCH & EXPERIMENTAL | DIETARY-SODIUM RESTRICTION | PULSE-WAVE VELOCITY | RISK-FACTORS | HEART-FAILURE | NEPHRECTOMIZED RATS | EXTRACELLULAR FLUID VOLUME | CHRONIC KIDNEY-DISEASE | STAGE RENAL-DISEASE | BLOOD-PRESSURE | HYPERTENSIVE PATIENTS | CELL BIOLOGY | Intestines - drug effects | Albuminuria - complications | Intestinal Mucosa - metabolism | Isoquinolines - pharmacokinetics | Kidney - pathology | Sodium Chloride, Dietary - pharmacology | Humans | Sodium Chloride, Dietary - administration & dosage | Male | Renal Insufficiency, Chronic - complications | Sodium - metabolism | Healthy Volunteers | Enalapril - therapeutic use | Renal Insufficiency, Chronic - drug therapy | Sodium-Hydrogen Exchangers - metabolism | Dose-Response Relationship, Drug | Albuminuria - physiopathology | Kidney - metabolism | Isoquinolines - pharmacology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Nephrectomy | Myocardium - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Feces | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Disease Models, Animal | Kidney - drug effects | Rats | Myocardium - pathology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - physiopathology | Sulfonamides - pharmacokinetics | Animals | Enalapril - pharmacology | Electrolytes - urine | Sulfonamides - therapeutic use | Albuminuria - drug therapy | Dogs | Isoquinolines - therapeutic use | Isoquinolines - administration & dosage | Sulfonamides - administration & dosage | Hypertrophy | Sodium-Hydrogen Exchanger 3 | Index Medicus
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3. Full Text Renal Proximal Tubular Reabsorption Is Reduced In Adult Spontaneously Hypertensive Rats: Roles of Superoxide and Na+/H+ Exchanger 3
by Panico, Carolina and Luo, Zaiming and Damiano, Sara and Artigiano, Francesca and Gill, Pritmohinder and Welch, William J
Hypertension, ISSN 0194-911X, 12/2009, Volume 54, Issue 6, pp. 1291 - 1297
Proximal tubule reabsorption is regulated by systemic and intrinsic mechanisms, including locally produced autocoids. Superoxide, produced by NADPH oxidase... 
Hypertension | Tempol | Superoxide | Proximal reabsorption | Apocynin | FLUID REABSORPTION | NITRIC-OXIDE SYNTHASE | TUBULOGLOMERULAR FEEDBACK | MACULA DENSA | INHIBITION | proximal reabsorption | MESSENGER-RNA | H+ EXCHANGE | NHERF ISOFORMS | PERIPHERAL VASCULAR DISEASE | superoxide | apocynin | KIDNEY | hypertension | EXPRESSION | Age Factors | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Rats, Inbred WKY | Hypertension, Renal - metabolism | Spin Labels | Sodium-Hydrogen Exchangers - metabolism | Cyclic N-Oxides - pharmacology | Acetophenones - pharmacology | Superoxides - metabolism | NADPH Oxidases - genetics | Blood Pressure - physiology | Sodium Chloride - metabolism | Rats, Inbred SHR | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Antioxidants - pharmacology | Animals | Homeostasis - physiology | Kidney Tubules, Proximal - metabolism | RNA, Small Interfering | Oxidative Stress - drug effects | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3 | Index Medicus
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4. Full Text Na+/H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine
by Chan, Leo K. Y and Wang, Yi and Ng, Enders K. W and Leung, Po Sing
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2018, Volume 20, Issue 3, pp. 709 - 717
AimTo elucidate the role of Na+/H+ exchanger 3 (NHE3) in sodium-glucose co-transporter 1 (SGLT1)-mediated small intestinal brush border membrane (BBM) glucose... 
glucose intolerance | NHE3 inhibitor | postprandial hyperglycaemia | diabetes | TRANSPORTER SGLT1 | ACTIVATION | ENTEROCYTES | KINASE | HYPOGLYCEMIC AGENT | RECEPTOR | NHE3 | GROWTH | ENDOCRINOLOGY & METABOLISM | Intestinal Mucosa - metabolism | Humans | Amiloride - analogs & derivatives | Male | Diabetes Mellitus, Type 2 - metabolism | Glucose Transporter Type 2 - metabolism | Gene Knockdown Techniques | Dose-Response Relationship, Drug | Immediate-Early Proteins - metabolism | Postprandial Period | Epithelial Sodium Channel Blockers - pharmacology | Sodium-Glucose Transporter 1 - metabolism | Hyperglycemia - physiopathology | Glucose Intolerance - physiopathology | Protein-Serine-Threonine Kinases - metabolism | Intestinal Absorption - physiology | Caco-2 Cells | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Mice, Inbred C57BL | Sodium-Hydrogen Exchanger 3 - antagonists & inhibitors | Down-Regulation - physiology | Animals | Glucose - pharmacokinetics | Amiloride - pharmacology | Intestine, Small - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Blood sugar monitoring | RNA | Analysis | Insulin resistance | Glucose | Glucose tolerance tests | Insulin | Dextrose | Glucose transporter | Glucocorticoids | Hydrogen | Na+/H+-exchanging ATPase | Diabetes mellitus | mRNA | siRNA | Gastrectomy | Small intestine | Glucose tolerance | Intolerance | Hyperglycemia | Jejunum | Sodium | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus
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5. Full Text Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA(5) and NHERF2
by Lin, SB and Yeruva, S and He, PJ and Singh, AK and Zhang, HC and Chen, MM and Lamprecht, G and de Jonge, HR and Tse, M and Donowitz, M and Hogema, BM and Chun, J and Seidler, U and Yun, CC
GASTROENTEROLOGY, ISSN 0016-5085, 02/2010, Volume 138, Issue 2, pp. 649 - 658
BACKGROUND & AIMS: Diarrhea results from reduced net fluid and salt absorption caused by an imbalance in intestinal absorption and secretion. The bulk of... 
NHE3 ACTIVITY | ACTIVATION | DIARRHEA | EMERGING ROLE | ION-TRANSPORT | REGULATORY PROTEIN | RECEPTOR | GROWTH-FACTOR | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | CANCER | Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Mice, Inbred C57BL | Water - metabolism | Receptors, Lysophosphatidic Acid - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Colon - metabolism | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Animals | Microvilli - metabolism | Diarrhea - metabolism | Signal Transduction - physiology | Sodium-Hydrogen Exchangers - genetics | Mice | Disease Models, Animal | Intestinal Absorption - physiology | Sodium-Hydrogen Exchanger 3 | Index Medicus | Abridged Index Medicus
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6. Full Text The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II
by He, Peijian and Zhao, Luqing and No, Yi Ran and Karvar, Serhan and Yun, C. Chris
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 08/2016, Volume 311, Issue 2, pp. F343 - F351
Na+/H+ exchanger (NHE) 3, a major Na+ transporter in the luminal membrane of the proximal tubule, is subject to ANG II regulation in renal Na+/fluid absorption... 
5-trisphosphate receptor-binding protein released with inositol 1 | Inositol 1 | 5-trisphosphate | exchanger regulatory factor 1 | Angiotensin II | exchanger 3 | SIGNALING PATHWAYS | PHYSIOLOGY | inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5 trisphosphate | Na+/H+ exchanger 3 | ANGIOTENSIN-II | BLOOD-PRESSURE | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | BRUSH-BORDER | IP3 RECEPTOR | angiotensin II | Na+/H+ exchanger regulatory factor 1 | UROLOGY & NEPHROLOGY | ACTIN CYTOSKELETON | PROXIMAL TUBULE | APICAL MEMBRANE | inositol 1,4,5-trisphosphate | RECEPTOR-BINDING PROTEIN | Cell Line | Angiotensin II - pharmacology | Biotinylation | Adenosylhomocysteinase - metabolism | Sodium-Hydrogen Exchangers - agonists | Sodium - metabolism | Phosphoproteins - metabolism | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Receptor, Angiotensin, Type 1 - genetics | Animals | Microvilli - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Plasmids - genetics | Mice | Receptor, Angiotensin, Type 1 - drug effects | Hydrogen-Ion Concentration | Sodium-Hydrogen Exchanger 3 | Protein expression | Membranes | Phosphorylation | Blood pressure | Kidneys | Binding sites | Index Medicus | Na+ | H+ exchanger 3 | Research | H+ exchanger regulatory factor 1 | inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate
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7. Full Text The adrenergic regulation of proximal tubular Na+/H+ exchanger 3 in the rat
by Healy, V and Thompson, C and Johns, E. J
Acta Physiologica, ISSN 1748-1708, 03/2014, Volume 210, Issue 3, pp. 678 - 689
AimThis study in the anaesthetized rat investigated how renal sympathetic nerve activity and catecholamine release influenced NHE3 abundance and activity in... 
sodium reabsorption | kidney | NHE | NHE3 | Sodium reabsorption | Kidney | PHYSIOLOGY | TRANSPORT | BRUSH-BORDER | INHIBITION | EPITHELIAL-CELLS | HYPERTENSION | RECEPTORS | REABSORPTION | THICK ASCENDING LIMB | ANESTHETIZED RATS | Adrenergic Neurons - metabolism | Rats, Wistar | Sympathectomy | Rats | Male | Sodium - metabolism | Sympathetic Nervous System - metabolism | Blotting, Western | Kidney Function Tests | Sodium-Hydrogen Exchangers - metabolism | Animals | Microvilli - metabolism | Kidney Tubules, Proximal - metabolism | Sodium-Hydrogen Exchanger 3 | Laws, regulations and rules | Noradrenaline | Membranes | Rodents | Mucous membrane | Index Medicus
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8. Full Text Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension
by Li, Xiao C and Shull, Gary E and Miguel-Qin, Elisa and Zhuo, Jia L
Physiological Genomics, ISSN 1094-8341, 10/2015, Volume 47, Issue 10, pp. 479 - 487
The renal mechanisms responsible for angiotensin II (ANG II)-induced hypertension remain incompletely understood. The present study tested the hypothesis that... 
Hypertension | Intestines | Angiotensin II | NHE3 | Kidney | PHYSIOLOGY | RESISTANT HYPERTENSION | MAMMALIAN KIDNEY | AMERICAN-HEART-ASSOCIATION | NEPHRON FUNCTION | BLOOD-PRESSURE | CELL BIOLOGY | kidney | NHE-3 EXPRESSION | NHE3-DEFICIENT MICE | PROXIMAL TUBULE CELLS | H+ EXCHANGE | angiotensin II | GENETICS & HEREDITY | intestines | hypertension | GENOME-WIDE ASSOCIATION | Blood Pressure | Kidney Tubules - physiopathology | Phosphorylation | Intestines - pathology | Kidney - pathology | Signal Transduction | Aldosterone - blood | Angiotensin II - blood | Male | Systole | Hypertension - physiopathology | Hypertension - metabolism | Sodium-Hydrogen Exchangers - metabolism | Hypertension - blood | Phenotype | Animals | Electrolytes - urine | Sodium - urine | Hypertension - chemically induced | Potassium - urine | Anesthesia | Mice | Kidney Tubules - metabolism | Index Medicus | Molecular Genetics of Complex Traits
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9. Full Text Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice
by Charoenphandhu, Narattaphol and Kraidith, Kamonshanok and Lertsuwan, Kornkamon and Sripong, Chanakarn and Suntornsaratoon, Panan and Svasti, Saovaros and Krishnamra, Nateetip and Wongdee, Kannikar
Molecular and Cellular Biochemistry, ISSN 0300-8177, 3/2017, Volume 427, Issue 1, pp. 201 - 208
Recent investigation has shown that the liver-derived iron-regulating hormone, hepcidin, can potentiate intestinal calcium absorption in hemizygous β-globin... 
Biochemistry, general | Life Sciences | Medical Biochemistry | Beta-thalassemia | Ussing chamber | Oncology | Tenapanor | Cardiology | Hepcidin | Calcium absorption | CELLS | PROTEIN | MODEL | NHE3 | INTESTINAL IRON-ABSORPTION | CELL BIOLOGY | FEMALE RATS | MUTATION | VILLUS | BINDING | Plasma Membrane Calcium-Transporting ATPases - genetics | Calcium - metabolism | Hepcidins - pharmacology | Sodium-Calcium Exchanger - genetics | Plasma Membrane Calcium-Transporting ATPases - metabolism | Sodium-Hydrogen Exchangers - metabolism | Isoquinolines - pharmacology | Sodium-Calcium Exchanger - metabolism | Duodenum - metabolism | Thalassemia - metabolism | Female | Ion Transport - drug effects | Sodium-Hydrogen Exchangers - genetics | Thalassemia - genetics | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Thalassemia - pathology | Sulfonamides - pharmacology | beta-Globins - genetics | Mice, Knockout | Animals | beta-Globins - metabolism | Duodenum - pathology | Mice | Ion Transport - genetics | Sodium-Hydrogen Exchanger 3 | Index Medicus
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10. Full Text Lysophosphatidic acid 5 receptor induces activation of Na +/H + exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells
by Yoo, Byong Kwon and He, Peijian and Lee, Sei-Jung and Chris Yun, C
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 11/2011, Volume 301, Issue 5, pp. C1008 - C1016
Yoo BK, He P, Lee SJ, Yun CC. Lysophosphatidic acid 5 receptor induces activation of Na+/H+ exchanger 3 via apical epidermal growth factor receptor in... 
Extracellular signal-regulated kinase | Proline-rich tyrosine kinase 2 | NHE3 ACTIVITY | LOCALIZATION | extracellular signal-regulated kinase | PHYSIOLOGY | STIMULATION | PHOSPHORYLATION | SRC | PROTEIN-KINASE | CELL BIOLOGY | proline-rich tyrosine kinase 2 | PYK2 | TRANSACTIVATION | TGF-ALPHA | ABSORPTION | Caco-2 Cells | Intestines - drug effects | Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Butadienes - pharmacology | Nitriles - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Morpholines - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | rho-Associated Kinases - antagonists & inhibitors | Sodium-Hydrogen Exchangers - metabolism | Receptor, Epidermal Growth Factor - metabolism | Phospholipase C beta - antagonists & inhibitors | Focal Adhesion Kinase 2 - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Flavonoids - pharmacology | Chromones - pharmacology | Intestines - enzymology | Sodium-Hydrogen Exchanger 3 | Cell growth | Membranes | T cell receptors | Kinases | Digestive system | Rodents | Index Medicus | Membrane Transporters, Ion Channels and Pumps
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11. Full Text Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea
by Yang, Jun and Zhao, Xiaofeng and Patel, Archana and Potru, Rachana and Azizi-Ghannad, Sadra and Dolinger, Michael and Cao, James and Bartholomew, Catherine and Mazurkiewicz, Joseph and Conti, David and Jones, David and Huang, Yunfei and Zhu, Xinjun Cindy
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 1, pp. 151 - 162
Background & Aims The immunosuppressant rapamycin frequently causes noninfectious diarrhea in organ transplant recipients. We investigated the mechanisms of... 
Gastroenterology and Hepatology | Sodium Transport | mTOR | Immunosuppression | Transplantation | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Rats | Male | Phosphoproteins - metabolism | Ubiquitin-Activating Enzymes - metabolism | Rats, Sprague-Dawley | Sirolimus - pharmacology | Case-Control Studies | Sodium-Hydrogen Exchangers - metabolism | Autophagy-Related Protein 7 | Animals | Biopsy | Adult | Diarrhea - metabolism | Female | Anti-Bacterial Agents - pharmacology | Diarrhea - drug therapy | Mice | Sodium-Hydrogen Exchanger 3 | Diarrhea | Organ transplant recipients | Medical colleges | Neurosciences | Rapamycin | Index Medicus | Abridged Index Medicus | sodium transport | immunosuppression | transplantation
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12. Full Text Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum
by Thammayon, Nithipak and Wongdee, Kannikar and Lertsuwan, Kornkamon and Suntornsaratoon, Panan and Thongbunchoo, Jirawan and Krishnamra, Nateetip and Charoenphandhu, Narattaphol
Amino Acids, ISSN 0939-4451, 4/2017, Volume 49, Issue 4, pp. 725 - 734
Na+/H+ exchanger (NHE)-3 is important for intestinal absorption of nutrients and minerals, including calcium. The previous investigations have shown that the... 
Biochemistry, general | Life Sciences | Analytical Chemistry | Duodenum | Life Sciences, general | Neurobiology | Proteomics | Biochemical Engineering | Aliphatic amino acid | Ussing chamber | Tenapanor | Calcium transport | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLACTIN | SODIUM RECIRCULATION | CA(V)1.3 | INTESTINAL EPITHELIUM | TIGHT JUNCTIONS | FEMALE RATS | GENE FAMILY | ABSORPTION | EXPRESSION | Epithelium - metabolism | Calcium - metabolism | Sodium-Hydrogen Exchanger 3 - antagonists & inhibitors | Rats | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Amino Acids - metabolism | Animals | Isoquinolines - pharmacology | Duodenum - metabolism | Glucose - metabolism | Female | Ion Transport | Duodenum - drug effects | Index Medicus
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13. Full Text Parathyroid hormone inhibition of Na+/H+ exchanger 3 transcription: Intracellular signaling pathways and transcription factor expression
by Neri, Elida Adalgisa and Bezerra, Camila Nogueira Alves and Queiroz-Leite, Gabriella Duarte and Polidoro, Juliano Zequini and Rebouças, Nancy Amaral
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2015, Volume 461, Issue 4, pp. 582 - 588
The main transport mechanism of reabsorption of sodium bicarbonate and fluid in the renal proximal tubules involves Na /H exchanger 3 (NHE3), which is acutely... 
Proximal tubule | OKP cells | Sodium hydrogen exchanger | Transcriptional regulation | RAT NHE3 GENE | CELLS | ACTIVATION | STIMULATION | SP-FAMILY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | BIOPHYSICS | SP3 | PROMOTER | BINDING | Kidney - physiology | Cell Line | Transcriptional Activation - genetics | Kidney - drug effects | Gene Expression Regulation - genetics | Opossums | Transcriptional Activation - drug effects | Parathyroid Hormone - pharmacology | Kidney - cytology | Promoter Regions, Genetic - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Sodium-Hydrogen Exchangers - genetics | Sodium-Hydrogen Exchanger 3 | Index Medicus | ANTIBODIES | FLUIDS | TRANSCRIPTION FACTORS | SODIUM | ACID CARBONATES | MOBILITY | HYDROGEN IONS 1 PLUS | GENE MUTATIONS | TRANSCRIPTION | SIGNALS | 60 APPLIED LIFE SCIENCES | INHIBITION | ELECTROPHORESIS | MESSENGER-RNA | PROMOTERS | GENES | MARSUPIALS | SODIUM IONS | HORMONES
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14. Full Text Defective jejunal and colonic salt absorption and alteredNa +/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice
by Broere, Nellie and Chen, Min and Cinar, Ayhan and Singh, Arbind and Hillesheim, Jutta and Riederer, Beat Michel and Lunnemann, M and Rottinghaus, Ingrid and Krabbenhöft, Anja and Engelhardt, Regina and Rausch, B and Weinman, Edward and Donowitz, Mark and Hubbard, A and Kocher, Olivier and Jonge, Hugo and Hogema, Boris and Seidler, Ursula
Pfluegers Archiv: European journal of physiology, ISSN 0031-6768, 03/2009, Volume 457, Issue 5, pp. 1079 - 1091
textabstractWe investigated the role of the Na+/H+ exchanger regulatory factor 1 (NHERF1) on intestinal salt and water absorption, brush border membrane (BBM)... 
Intestinal electrolyte transport | Knockout mice | Biomedicine | NHERF1 | Human Physiology | PDZ domain proteins | PDZK1 | EPAC | CAMP-MEDIATED INHIBITION | SODIUM | PHYSIOLOGY | INTESTINAL ION-TRANSPORT | COMPLEXES | PROXIMAL TUBULAR CELLS | TRANSMEMBRANE CONDUCTANCE REGULATOR | TARGETED DISRUPTION | NULL MICE | NA+/H+ EXCHANGER | UP-REGULATION | Immunohistochemistry | Intestinal Mucosa - metabolism | Animals | Microvilli - ultrastructure | Phosphoproteins - deficiency | Mice | Sodium Chloride - metabolism | Colon - metabolism | Intestinal Absorption - physiology | Jejunum - metabolism | Sodium-Hydrogen Exchanger 3 | Sodium-Hydrogen Exchangers - metabolism | Proteins | Rodents | Index Medicus
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