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Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2015, Volume 26, Issue 5, pp. 1138 - 1149
Journal Article
Science Translational Medicine, ISSN 1946-6234, 03/2014, Volume 6, Issue 227, pp. 227ra36 - 227ra36
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an... 
MEDICINE, RESEARCH & EXPERIMENTAL | DIETARY-SODIUM RESTRICTION | PULSE-WAVE VELOCITY | RISK-FACTORS | HEART-FAILURE | NEPHRECTOMIZED RATS | EXTRACELLULAR FLUID VOLUME | CHRONIC KIDNEY-DISEASE | STAGE RENAL-DISEASE | BLOOD-PRESSURE | HYPERTENSIVE PATIENTS | CELL BIOLOGY | Intestines - drug effects | Albuminuria - complications | Intestinal Mucosa - metabolism | Isoquinolines - pharmacokinetics | Kidney - pathology | Sodium Chloride, Dietary - pharmacology | Humans | Sodium Chloride, Dietary - administration & dosage | Male | Renal Insufficiency, Chronic - complications | Sodium - metabolism | Healthy Volunteers | Enalapril - therapeutic use | Renal Insufficiency, Chronic - drug therapy | Sodium-Hydrogen Exchangers - metabolism | Dose-Response Relationship, Drug | Albuminuria - physiopathology | Kidney - metabolism | Isoquinolines - pharmacology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Nephrectomy | Myocardium - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Feces | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Disease Models, Animal | Kidney - drug effects | Rats | Myocardium - pathology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - physiopathology | Sulfonamides - pharmacokinetics | Animals | Enalapril - pharmacology | Electrolytes - urine | Sulfonamides - therapeutic use | Albuminuria - drug therapy | Dogs | Isoquinolines - therapeutic use | Isoquinolines - administration & dosage | Sulfonamides - administration & dosage | Hypertrophy | Sodium-Hydrogen Exchanger 3 | Index Medicus
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2018, Volume 20, Issue 3, pp. 709 - 717
AimTo elucidate the role of Na+/H+ exchanger 3 (NHE3) in sodium-glucose co-transporter 1 (SGLT1)-mediated small intestinal brush border membrane (BBM) glucose... 
glucose intolerance | NHE3 inhibitor | postprandial hyperglycaemia | diabetes | TRANSPORTER SGLT1 | ACTIVATION | ENTEROCYTES | KINASE | HYPOGLYCEMIC AGENT | RECEPTOR | NHE3 | GROWTH | ENDOCRINOLOGY & METABOLISM | Intestinal Mucosa - metabolism | Humans | Amiloride - analogs & derivatives | Male | Diabetes Mellitus, Type 2 - metabolism | Glucose Transporter Type 2 - metabolism | Gene Knockdown Techniques | Dose-Response Relationship, Drug | Immediate-Early Proteins - metabolism | Postprandial Period | Epithelial Sodium Channel Blockers - pharmacology | Sodium-Glucose Transporter 1 - metabolism | Hyperglycemia - physiopathology | Glucose Intolerance - physiopathology | Protein-Serine-Threonine Kinases - metabolism | Intestinal Absorption - physiology | Caco-2 Cells | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Mice, Inbred C57BL | Sodium-Hydrogen Exchanger 3 - antagonists & inhibitors | Down-Regulation - physiology | Animals | Glucose - pharmacokinetics | Amiloride - pharmacology | Intestine, Small - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Blood sugar monitoring | RNA | Analysis | Insulin resistance | Glucose | Glucose tolerance tests | Insulin | Dextrose | Glucose transporter | Glucocorticoids | Hydrogen | Na+/H+-exchanging ATPase | Diabetes mellitus | mRNA | siRNA | Gastrectomy | Small intestine | Glucose tolerance | Intolerance | Hyperglycemia | Jejunum | Sodium | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 08/2016, Volume 311, Issue 2, pp. F343 - F351
Na+/H+ exchanger (NHE) 3, a major Na+ transporter in the luminal membrane of the proximal tubule, is subject to ANG II regulation in renal Na+/fluid absorption... 
5-trisphosphate receptor-binding protein released with inositol 1 | Inositol 1 | 5-trisphosphate | exchanger regulatory factor 1 | Angiotensin II | exchanger 3 | SIGNALING PATHWAYS | PHYSIOLOGY | inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5 trisphosphate | Na+/H+ exchanger 3 | ANGIOTENSIN-II | BLOOD-PRESSURE | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | BRUSH-BORDER | IP3 RECEPTOR | angiotensin II | Na+/H+ exchanger regulatory factor 1 | UROLOGY & NEPHROLOGY | ACTIN CYTOSKELETON | PROXIMAL TUBULE | APICAL MEMBRANE | inositol 1,4,5-trisphosphate | RECEPTOR-BINDING PROTEIN | Cell Line | Angiotensin II - pharmacology | Biotinylation | Adenosylhomocysteinase - metabolism | Sodium-Hydrogen Exchangers - agonists | Sodium - metabolism | Phosphoproteins - metabolism | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Receptor, Angiotensin, Type 1 - genetics | Animals | Microvilli - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Plasmids - genetics | Mice | Receptor, Angiotensin, Type 1 - drug effects | Hydrogen-Ion Concentration | Sodium-Hydrogen Exchanger 3 | Protein expression | Membranes | Phosphorylation | Blood pressure | Kidneys | Binding sites | Index Medicus | Na+ | H+ exchanger 3 | Research | H+ exchanger regulatory factor 1 | inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 3/2017, Volume 427, Issue 1, pp. 201 - 208
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 11/2011, Volume 301, Issue 5, pp. C1008 - C1016
Journal Article
Journal Article
Journal Article