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Development, ISSN 0950-1991, 01/2010, Volume 137, Issue 2, pp. 203 - 212
The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification in multipotent pancreatic progenitor cells in the mouse embryo.... 
Mouse | Rfx | Endocrine | Zebrafish | Cell differentiation | Pancreas | Transcription factor | Neurogenin 3 | PROGENITOR CELLS | NEUROGENIN3 | BETA-CELLS | DEVELOPMENTAL BIOLOGY | HORMONE-EXPRESSING CELLS | PROTEIN ISL-1 | ENDOCRINE PANCREAS | GENE | EMBRYONIC STEM-CELLS | DIFFERENTIATION | Immunohistochemistry | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Pancreas - cytology | Winged-Helix Transcription Factors - metabolism | Embryo, Nonmammalian - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Embryo, Mammalian - metabolism | Endocrine Cells - metabolism | In Situ Hybridization | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Somatostatin - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Zebrafish Proteins - metabolism | Winged-Helix Transcription Factors - genetics | Cells, Cultured | Pancreas - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Pancreas - embryology | Homeodomain Proteins - genetics | Endoderm - metabolism | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Blotting, Northern | Animals | Endocrine Cells - cytology | Glucagon - metabolism | Mice | Zebrafish Proteins - genetics | In Vitro Techniques | Paired Box Transcription Factors - metabolism | Index Medicus | Development and Stem Cells
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 2052 - 2062
Background & Aims The winged helix transcription factors Foxa1 and Foxa2 are expressed in all epithelia of the gastrointestinal tract from its embryonic origin... 
Gastroenterology and Hepatology | RESPONSE ELEMENT | GLUCOSE-HOMEOSTASIS | GLUCAGON-LIKE PEPTIDE-1 | PROGLUCAGON GENE-TRANSCRIPTION | IN-VIVO | INSULIN-SECRETION | PANCREATIC BETA-CELLS | GASTROENTEROLOGY & HEPATOLOGY | ISLET CELLS | EXPRESSION | ENDOCRINE-CELLS | Immunohistochemistry | Hepatocyte Nuclear Factor 3-beta - genetics | Intestine, Small - pathology | Peptide YY - metabolism | Homeodomain Proteins - metabolism | Male | RNA, Messenger - metabolism | Cell Differentiation | Enteroendocrine Cells - metabolism | Proglucagon - metabolism | Somatostatin - metabolism | Repressor Proteins - metabolism | Hepatocyte Nuclear Factor 3-beta - metabolism | Mucin-2 - metabolism | Enteroendocrine Cells - pathology | Somatostatin-Secreting Cells - pathology | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 2 - metabolism | Hepatocyte Nuclear Factor 3-alpha - deficiency | Hepatocyte Nuclear Factor 3-alpha - genetics | PAX6 Transcription Factor | Goblet Cells - metabolism | Hepatocyte Nuclear Factor 3-alpha - metabolism | Mice, Knockout | Mucin-5B - metabolism | Animals | Eye Proteins - metabolism | Mucin 5AC - metabolism | LIM-Homeodomain Proteins | Mice | Transcription Factors | Goblet Cells - pathology | Intestine, Small - metabolism | Somatostatin-Secreting Cells - metabolism | Hepatocyte Nuclear Factor 3-beta - deficiency | Paired Box Transcription Factors - metabolism | Chromatin | Messenger RNA | DNA binding proteins | Cholecystokinin | Peptides | Mucins | Index Medicus | Abridged Index Medicus
Journal Article
American journal of physiology. Gastrointestinal and liver physiology, ISSN 0193-1857, 11/2014, Volume 307, Issue 10, pp. G979 - G991
Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of... 
Islet1 | incretins | enteroendocrine | glucose regulation | PHYSIOLOGY | ENDOCRINE CELL-DEVELOPMENT | GASTROINTESTINAL-TRACT | FATE SPECIFICATION | ENTEROINSULAR AXIS | CONGENITAL MALABSORPTIVE DIARRHEA | CHROMOGRANIN-A | INCRETIN HORMONES | HOMEOBOX GENE ISL-1 | GLUCAGON-LIKE PEPTIDE-1 | RECEPTOR KNOCKOUT MICE | GASTROENTEROLOGY & HEPATOLOGY | Dietary Fats - metabolism | Intestinal Mucosa - metabolism | Gastric Inhibitory Polypeptide - metabolism | Age Factors | Intestine, Small - pathology | Transcription Factors - deficiency | Male | Malabsorption Syndromes - metabolism | Intestinal Absorption | Cholecystokinin - metabolism | LIM-Homeodomain Proteins - deficiency | Glucose Metabolism Disorders - metabolism | Female | Chromogranin A - metabolism | Enteroendocrine Cells - metabolism | Weight Gain | Microfilament Proteins - genetics | Somatostatin - metabolism | Animals, Newborn | Enteroendocrine Cells - pathology | Glucose Tolerance Test | Glucagon-Like Peptide 1 - metabolism | Mice, Inbred C57BL | Genotype | Biomarkers - blood | Transcription Factors - genetics | Gastrins - metabolism | Malabsorption Syndromes - genetics | Mice, Knockout | Ghrelin - metabolism | LIM-Homeodomain Proteins - genetics | Phenotype | Animals | Diarrhea - genetics | Glucose Metabolism Disorders - genetics | Serotonin - metabolism | Glucose Metabolism Disorders - blood | Diarrhea - metabolism | Intestine, Small - metabolism | Blood Glucose - metabolism | Integrases - genetics | Intestinal Mucosa - pathology | Glucose metabolism | Pancreatic beta cells | Cell research | Gene mutations | Homeostasis | Genetic research | Genetic aspects | Research | Health aspects | Glucose | Hormones | Endocrine system | Rodents | Cells | Index Medicus | Hormones and Signaling
Journal Article
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 05/2014, Volume 522, Issue 7, pp. 1506 - 1526
Dynorphins, leumorphin, and neoendorphins are preprodynorphin (PPD)‐derived peptides and ligands for κ‐opioid receptors. Using an antibody to PPD C‐terminal,... 
GABAergic neuron | double immunofluorescence labeling | opioid peptide | combined labeling of immunofluorescence and fluorescent mRNA signals | somatostatin | Double immunofluorescence labeling | Somatostatin | Combined labeling of immunofluorescence and fluorescent mRNA signals | Opioid peptide | IMMUNOHISTOCHEMICAL LOCALIZATION | ULTRASTRUCTURAL-LOCALIZATION | RECEPTOR MESSENGER-RNA | IN-SITU HYBRIDIZATION | KAPPA-OPIOID RECEPTOR | NEUROSCIENCES | CEREBRAL-CORTEX | ZOOLOGY | RAT CNS | VASOACTIVE INTESTINAL POLYPEPTIDE | CENTRAL-NERVOUS-SYSTEM | CHOLINE-ACETYLTRANSFERASE | Cell Count | Male | Neurons - cytology | RNA, Messenger - metabolism | Immunoenzyme Techniques | Neuropeptide Y - metabolism | Neocortex - metabolism | GABAergic Neurons - cytology | Somatosensory Cortex - cytology | Cell Adhesion Molecules, Neuronal - metabolism | Interneurons - cytology | Neurons - metabolism | GABAergic Neurons - metabolism | Dynorphins - metabolism | Somatostatin - metabolism | Extracellular Matrix Proteins - metabolism | Calbindin 2 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Vesicular Glutamate Transport Proteins - metabolism | Protein Precursors - metabolism | Nerve Tissue Proteins - metabolism | Animals | Interneurons - metabolism | Fluorescent Antibody Technique | Glutamate Decarboxylase - metabolism | Neocortex - cytology | Mice | Nitric Oxide Synthase - metabolism | Serine Endopeptidases - metabolism | Somatosensory Cortex - metabolism | Neuropeptide Y | GABA | Glutamate | Neurons | Index Medicus
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3909 - 3923
In the stomach, somatostatin (SST) acts as a general paracrine negative regulator of exocrine secretion of gastric acid and pepsinogen and endocrine secretion... 
PERFUSED RAT STOMACH | CALCIUM-SENSING RECEPTOR | GLUCAGON-LIKE PEPTIDE-1 | GROWTH-HORMONE | GHRELIN SECRETION | ENTEROENDOCRINE CELLS | ACID-SECRETION | ENDOCRINOLOGY & METABOLISM | ISLET AMYLOID POLYPEPTIDE | RELEASE-INHIBITING HORMONE | ENDOCRINE-CELLS | Peptide YY - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Transcriptome | Male | Receptors, Muscarinic - metabolism | Receptors, Neuropeptide - metabolism | Islet Amyloid Polypeptide - genetics | Stomach - metabolism | Gastric Mucosa - metabolism | Receptors, Somatostatin - genetics | Glucagon-Like Peptide-1 Receptor - genetics | Glucagon-Like Peptide-1 Receptor - metabolism | In Situ Hybridization | Receptors, Adrenergic - genetics | Receptors, Somatostatin - metabolism | Peptide YY - genetics | Somatostatin - metabolism | Receptors, Muscarinic - genetics | Somatostatin - secretion | Somatostatin - genetics | Receptors, Adrenergic - metabolism | Cells, Cultured | Islet Amyloid Polypeptide - metabolism | Receptors, Neuropeptide - genetics | Mice, Transgenic | Gastric Mucosa - cytology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microscopy, Confocal | Animals | Stomach - cytology | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Somatostatin-Secreting Cells - metabolism | Luminescent Proteins - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2861 - 2871
OBJECTIVE-Class Ha histone deacetylases (HDACs) belong to a large family of enzymes involved in protein deacetylation and play a role in regulating gene... 
PLAY | PROGENITORS | RESPONSIVENESS | CONTROLS CHONDROCYTE HYPERTROPHY | SMALL-MOLECULE | GROWTH | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MEF2 TRANSCRIPTION FACTOR | DIFFERENTIATION | INHIBITORS | Embryo, Mammalian - drug effects | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Repressor Proteins - antagonists & inhibitors | Insulin-Secreting Cells - metabolism | Isoenzymes - metabolism | Mice, Mutant Strains | Somatostatin-Secreting Cells - drug effects | Insulin-Secreting Cells - cytology | Somatostatin - metabolism | Repressor Proteins - metabolism | Animals, Newborn | Histone Deacetylases - genetics | Isoenzymes - genetics | Tissue Culture Techniques | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Histone Deacetylases - chemistry | Organ Size | Pancreas - drug effects | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Pancreas - metabolism | Organ Specificity | Insulin - metabolism | Algorithms | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Mice | Pancreas - growth & development | Somatostatin-Secreting Cells - metabolism | Isoenzymes - antagonists & inhibitors | Paired Box Transcription Factors - metabolism | Beta cells | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 7, pp. 2631 - 2646
Somatostatin secreted by pancreatic delta cells mediates important paracrine interactions in Langerhans islets, including maintenance of glucose metabolism... 
ISLET FUNCTION | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | LINKED MENTAL-RETARDATION | CALCIUM-CHANNELS | UBIQUITIN LIGASE | BETA-CELLS | INSULIN-SECRETION | SOMATOSTATIN RECEPTOR | EXPRESSION | CUL4B | Calcium - metabolism | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | Multienzyme Complexes - metabolism | Cullin Proteins - metabolism | Insulin - genetics | Cyclic AMP - metabolism | Insulin Secretion | Somatostatin - metabolism | Somatostatin - genetics | Paracrine Communication | Multienzyme Complexes - genetics | Adenylyl Cyclases - metabolism | Transcription Factors - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Cullin Proteins - genetics | Transcription Factors - metabolism | Insulin - metabolism | Animals | Calcium Channels, L-Type - genetics | Mice | Calcium Channels, L-Type - metabolism | Adenylyl Cyclases - genetics | Somatostatin-Secreting Cells - metabolism | Histone-lysine N-methyltransferase | Glucagon | Methyltransferase | Homeostasis | Paracrine signalling | Bipolar disorder | Glucose | Cullin | Homeobox | Proteins | Glucose metabolism | Adenylate cyclase | Transgenic animals | Rodents | N-Methyltransferase | Somatostatin | Pancreas | Ubiquitin-protein ligase | Obesity | Calcium (intracellular) | Secretion | Diabetes mellitus | Calcium channels (voltage-gated) | Cyclic AMP | Insulin | Studies | Glucose tolerance | Polycomb group proteins | Urocortin | Lysine | Epigenetics | Diabetes | Mutation | Index Medicus | Abridged Index Medicus
Journal Article