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Diabetologia, ISSN 0012-186X, 10/2016, Volume 59, Issue 10, pp. 2156 - 2165
Aims/hypothesis Intra-islet and gut-islet crosstalk are critical in orchestrating basal and postprandial metabolism. The aim of this study was to identify... 
Beta cells | RNA sequencing | Delta cells | Glucagon | Ghrelin | Somatostatin | Alpha cells | Insulin | ACTIVATION | INSULIN-SECRETION | HUMANS | SENSITIVITY | RECEPTOR | RELEASE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | MICE | Proteins | Physiological aspects | Glucose metabolism | RNA | Cells | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 01/2018, Volume 596, Issue 2, pp. 197 - 215
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 2052 - 2062
Background & Aims The winged helix transcription factors Foxa1 and Foxa2 are expressed in all epithelia of the gastrointestinal tract from its embryonic origin... 
Gastroenterology and Hepatology | RESPONSE ELEMENT | GLUCOSE-HOMEOSTASIS | GLUCAGON-LIKE PEPTIDE-1 | PROGLUCAGON GENE-TRANSCRIPTION | IN-VIVO | INSULIN-SECRETION | PANCREATIC BETA-CELLS | GASTROENTEROLOGY & HEPATOLOGY | ISLET CELLS | EXPRESSION | ENDOCRINE-CELLS | Immunohistochemistry | Hepatocyte Nuclear Factor 3-beta - genetics | Intestine, Small - pathology | Peptide YY - metabolism | Homeodomain Proteins - metabolism | Male | RNA, Messenger - metabolism | Cell Differentiation | Enteroendocrine Cells - metabolism | Proglucagon - metabolism | Somatostatin - metabolism | Repressor Proteins - metabolism | Hepatocyte Nuclear Factor 3-beta - metabolism | Mucin-2 - metabolism | Enteroendocrine Cells - pathology | Somatostatin-Secreting Cells - pathology | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 2 - metabolism | Hepatocyte Nuclear Factor 3-alpha - deficiency | Hepatocyte Nuclear Factor 3-alpha - genetics | PAX6 Transcription Factor | Goblet Cells - metabolism | Hepatocyte Nuclear Factor 3-alpha - metabolism | Mice, Knockout | Mucin-5B - metabolism | Animals | Eye Proteins - metabolism | Mucin 5AC - metabolism | LIM-Homeodomain Proteins | Mice | Transcription Factors | Goblet Cells - pathology | Intestine, Small - metabolism | Somatostatin-Secreting Cells - metabolism | Hepatocyte Nuclear Factor 3-beta - deficiency | Paired Box Transcription Factors - metabolism | Chromatin | Messenger RNA | DNA binding proteins | Cholecystokinin | Peptides | Mucins | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0144597 - e0144597
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural... 
IDENTITY | ALPHA-CELLS | MOUSE PANCREAS | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | INSULIN-SECRETION | 7B2 | MICE | ENZYMATIC-ACTIVITY | DIFFERENTIATION | EXPRESSION | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | Male | Cell Lineage - drug effects | Pancreatic Polypeptide-Secreting Cells - metabolism | Pancreatic Polypeptide-Secreting Cells - cytology | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | Somatostatin-Secreting Cells - drug effects | Female | Integrases - metabolism | Cell Differentiation | Insulin-Secreting Cells - cytology | Eye Proteins - genetics | Insulin - genetics | Cell Lineage - genetics | Genes, Reporter | Repressor Proteins - metabolism | Glucagon-Secreting Cells - cytology | Signal Transduction | Bacterial Proteins - genetics | Ghrelin - genetics | Repressor Proteins - genetics | PAX6 Transcription Factor | Pancreatic Polypeptide-Secreting Cells - drug effects | Homeodomain Proteins - genetics | Mice, Knockout | Ghrelin - metabolism | Insulin - metabolism | Animals | Eye Proteins - metabolism | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Integrases - genetics | Somatostatin-Secreting Cells - metabolism | Paired Box Transcription Factors - metabolism | Crosses, Genetic | Luminescent Proteins - metabolism | Care and treatment | Research | Glucagon | Pancreas | Ghrelin | Risk factors | Spinal cord | Cerebral cortex | Transcription factors | Deactivation | Maturation | Developmental biology | Genes | Cortex | Organs | Glucose | Kinases | Cell differentiation | Inactivation | Insulin | Proteins | Pax6 protein | Rodents | Diabetes | Alzheimers disease | Index Medicus | Life Sciences | Development Biology
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2861 - 2871
OBJECTIVE-Class Ha histone deacetylases (HDACs) belong to a large family of enzymes involved in protein deacetylation and play a role in regulating gene... 
PLAY | PROGENITORS | RESPONSIVENESS | CONTROLS CHONDROCYTE HYPERTROPHY | SMALL-MOLECULE | GROWTH | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MEF2 TRANSCRIPTION FACTOR | DIFFERENTIATION | INHIBITORS | Embryo, Mammalian - drug effects | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Repressor Proteins - antagonists & inhibitors | Insulin-Secreting Cells - metabolism | Isoenzymes - metabolism | Mice, Mutant Strains | Somatostatin-Secreting Cells - drug effects | Insulin-Secreting Cells - cytology | Somatostatin - metabolism | Repressor Proteins - metabolism | Animals, Newborn | Histone Deacetylases - genetics | Isoenzymes - genetics | Tissue Culture Techniques | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Histone Deacetylases - chemistry | Organ Size | Pancreas - drug effects | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Pancreas - metabolism | Organ Specificity | Insulin - metabolism | Algorithms | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Mice | Pancreas - growth & development | Somatostatin-Secreting Cells - metabolism | Isoenzymes - antagonists & inhibitors | Paired Box Transcription Factors - metabolism | Beta cells | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3909 - 3923
In the stomach, somatostatin (SST) acts as a general paracrine negative regulator of exocrine secretion of gastric acid and pepsinogen and endocrine secretion... 
PERFUSED RAT STOMACH | CALCIUM-SENSING RECEPTOR | GLUCAGON-LIKE PEPTIDE-1 | GROWTH-HORMONE | GHRELIN SECRETION | ENTEROENDOCRINE CELLS | ACID-SECRETION | ENDOCRINOLOGY & METABOLISM | ISLET AMYLOID POLYPEPTIDE | RELEASE-INHIBITING HORMONE | ENDOCRINE-CELLS | Peptide YY - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Transcriptome | Male | Receptors, Muscarinic - metabolism | Receptors, Neuropeptide - metabolism | Islet Amyloid Polypeptide - genetics | Stomach - metabolism | Gastric Mucosa - metabolism | Receptors, Somatostatin - genetics | Glucagon-Like Peptide-1 Receptor - genetics | Glucagon-Like Peptide-1 Receptor - metabolism | In Situ Hybridization | Receptors, Adrenergic - genetics | Receptors, Somatostatin - metabolism | Peptide YY - genetics | Somatostatin - metabolism | Receptors, Muscarinic - genetics | Somatostatin - secretion | Somatostatin - genetics | Receptors, Adrenergic - metabolism | Cells, Cultured | Islet Amyloid Polypeptide - metabolism | Receptors, Neuropeptide - genetics | Mice, Transgenic | Gastric Mucosa - cytology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microscopy, Confocal | Animals | Stomach - cytology | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Somatostatin-Secreting Cells - metabolism | Luminescent Proteins - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
eLife, ISSN 2050-084X, 04/2014, Volume 2014, Issue 3, pp. e01846 - e01846
Direct lineage conversion of adult cells is a promising approach for regenerative medicine. A major challenge of lineage conversion is to generate specific... 
PLURIPOTENT STEM-CELLS | PROGENITORS | DEFINED FACTORS | MAFB | BETA-CELLS | TRANSCRIPTION | BIOLOGY | DIRECT CONVERSION | NEURONS | HUMAN FIBROBLASTS | GENERATION | Acinar cells | Transcription factors | Glucagon | Insulin | Studies | Polymerase chain reaction | Regeneration | Rodents | Stem cells | DNA methylation | Fibroblasts | Somatostatin | Islets of Langerhans | Pancreas | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3924 - 3936
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 09/2015, Volume 64, Issue 9, pp. 3182 - 3188
Journal Article