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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17296 - 17301
Journal Article
Neurobiology of aging, ISSN 0197-4580, 11/2018, Volume 71, pp. 266.e11 - 266.e24
SORL1 encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of... 
Alzheimer’s disease risk gene | Exon 30B | SORL1 | Alternative transcription | SorLA
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2018, Volume 61, Issue 4, pp. 1275 - 1281
The SORL1 gene encodes a protein involved in the amyloidogenic process, and its variants have been associated with Alzheimer's disease (AD) physiopathology. We... 
SORLA protein | familial | SORL1 gene | Alzheimer's disease | neurogenetics | SORLA/LR11 | AMYLOID PRECURSOR PROTEIN | MUTATIONS | ASSOCIATION | NEUROSCIENCES | RECEPTOR LR11
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2010, Volume 30, Issue 39, pp. 13110 - 13115
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17296 - 17301
Endocytic sorting of amyloid precursor protein (APP) governed by the vacuolar protein sorting (Vps10) family of receptors plays a decisive role in controlling... 
adrenergic receptor | Biological Sciences | processing | amyloid | SorLA | sorting
Journal Article
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 10/2014, Volume 19, Issue 10, pp. 1125 - 1132
Journal Article
Journal Article
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 04/2015, Volume 9
The intracellular transport and localization of amyloid precursor protein (APP) are critical determinants of APP processing and beta-amyloid peptide... 
TYR682 | DOMAIN | PHOSPHORYLATION | DISEASE CEREBROSPINAL-FLUID | ALZHEIMERS-DISEASE | AUTOPHAGY | NEUROSCIENCES | SorLA | endosome | Abeta | RECEPTOR SORLA/LR11 | TYROSINE | APP,YG mutation | MOUSE MODEL | ADAPTER | neuronal trafficking | lysosomes | Alzheimer's disease
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2016, Volume 36, Issue 9, pp. 1972 - 1979
OBJECTIVE—We aimed to determine whether LR11 (low-density lipoprotein receptor with 11 binding repeats) is a potential key regulator of smooth muscle cell... 
Biomarkers | Vascular smooth muscle | Pulmonary hypertension | Atherosclerosis | Disease progression | LR11/SorLA | atherosclerosis | MIGRATION | vascular smooth muscle | BRAIN NATRIURETIC PEPTIDE | LR11 | biomarkers | pulmonary hypertension | disease progression | PATHOLOGY | SorLA | REGULATOR | INFLAMMATION | CIRCULATING SOLUBLE LR11 | LYMPHOMA | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HEMATOLOGY | EXPRESSION | RECEPTOR FAMILY-MEMBER | LDL-Receptor Related Proteins - metabolism | Vascular Remodeling | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Humans | Muscle, Smooth, Vascular - physiopathology | Hypertension, Pulmonary - prevention & control | Hypoxia - metabolism | Membrane Transport Proteins - deficiency | Pulmonary Artery - metabolism | Arterial Pressure | Neointima | Transfection | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Membrane Transport Proteins - genetics | Receptors, LDL - deficiency | Membrane Transport Proteins - metabolism | Hypertrophy, Right Ventricular - metabolism | Myocytes, Smooth Muscle - metabolism | Ventricular Dysfunction, Right - metabolism | Receptors, LDL - genetics | Vascular Resistance | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Genotype | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Hypoxia - complications | Pulmonary Artery - physiopathology | Mice, Knockout | Ventricular Dysfunction, Right - prevention & control | Hypoxia - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Hypertrophy, Right Ventricular - prevention & control | Ventricular Pressure | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 03/2019, Volume 490, pp. 69 - 76
The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated... 
Smooth muscle cell | Soluble LR11 | Carotid artery stenosis | Ultrasound | ELEMENTS | PROTEIN | MARKER | DISEASE | MEDICAL LABORATORY TECHNOLOGY | LR11/SORLA | EXPRESSION | RECEPTOR FAMILY-MEMBER
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 03/2013, Volume 54, Issue 3, pp. 649 - 661
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 04/2006, Volume 395, pp. 285 - 293
Several transmembrane molecules are cleaved at juxtamembrane extracellular sites leading to shedding of ectodomains. We allalysed shedding of members of the... 
ACTIVATION | DOMAIN | ectodomain shedding | sorLA | P75 NEUROTROPHIN RECEPTOR | INTRAMEMBRANE PROTEOLYSIS | PROPEPTIDE CLEAVAGE | SORLA/LR11 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SORTING PROTEIN | Vps10p-domain receptor | AMYLOID PRECURSOR PROTEIN | sortilin | GROWTH-FACTOR | LIGAND | tumour necrosis factor alpha-converting enzyme | Chinese hamster ovary (CHO) cell
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 05/2019, Volume 77, pp. 144 - 153
There is in vitro evidence that sorting nexin family member 27 (SNX27), a member of the retromer complex, changes the distribution of the amyloid-beta (Aβ)... 
APP | Endocytosis | Hippocampal degeneration | SNX27 | Cholinergic basal forebrain | APP/PS1 | Spatial navigation | Alzheimer's disease | Retromer | SorLA | FOREBRAIN CHOLINERGIC NEURONS | DEPENDENT TRAFFICKING | ATROPHY | AMYLOID PRECURSOR PROTEIN | SPATIAL MEMORY DEFICITS | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | DYSFUNCTION | MUTATIONS | MODULATION | BASAL
Journal Article
Journal Article
by Tan, JG and Evin, G
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 03/2012, Volume 120, Issue 6, pp. 869 - 880
beta-Site APP-cleaving enzyme (BACE1) cleaves the amyloid precursor protein (APP) at the beta-secretase site to initiate the production of A beta peptides.... 
cellular trafficking | OXIDATIVE STRESS | HUMAN BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | proteolytic processing | ss-secretase | GGA adaptor protein | NEUROSCIENCES | amyloid precursor protein | RECEPTOR SORLA/LR11 | LIPID RAFTS | BETA-SECRETASE BACE1 | A-BETA | GGA PROTEINS | GAMMA-SECRETASE | TRANSGENIC MICE
Journal Article
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