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1. Full Text A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport
by Steinberg, Florian and Gallon, Matthew and Winfield, Mark and Thomas, Elaine C and Bell, Amanda J and Heesom, Kate J and Tavaré, Jeremy M and Cullen, Peter J
Nature Cell Biology, ISSN 1465-7392, 05/2013, Volume 15, Issue 5, pp. 461 - 471
The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized transmembrane proteins from endosomes to the plasma membrane by linking... 
RECRUITMENT | GLUT1 | RETROMER | COMPLEX | PROTEIN | INTEGRINS | TAIL | TRAFFICKING | DEGRADATION | BINDING | CELL BIOLOGY | RNA, Small Interfering - genetics | Sorting Nexins - genetics | Copper-transporting ATPases | Vesicular Transport Proteins - metabolism | Humans | Glucose Transporter Type 1 - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Culture Media - metabolism | Multiprotein Complexes - metabolism | Lysosomes - metabolism | Cation Transport Proteins - metabolism | Proteolysis | Cation Transport Proteins - genetics | Ion Transport | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Proteomics - methods | Sorting Nexins - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Computational Biology - methods | Vesicular Transport Proteins - genetics | Adenosine Triphosphatases - metabolism | Sorting Nexins - analysis | Blotting, Western | Protein Folding | Protein Interaction Mapping | Protein Transport | Isotope Labeling - methods | Glucose Transporter Type 1 - genetics | Glucose - metabolism | PDZ Domains | Adenosine Triphosphatases - genetics | HeLa Cells | RNA, Small Interfering - metabolism | Cellular control mechanisms | Ion transport | Research | Properties | Observations | Membrane proteins | Testing
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2. Full Text MicroRNA-95 promotes cell proliferation and targets sorting nexin 1 in human colorectal carcinoma
by Huang, Zhaohui and Huang, Shenglin and Wang, Qifeng and Liang, Linhui and Ni, Shujuan and Wang, Lisha and Sheng, Weiqi and He, Xianghuo and Du, Xiang
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2582 - 2589
MicroRNAs (miRNAs) are strongly implicated in cancer but their specific roles and functions in the major cancers have yet to be fully elucidated. In this... 
LUNG-CANCER | SUPPRESSOR | METASTASIS | CANCER CELLS | ONCOLOGY | PANCREATIC-CANCER | DOWN-REGULATION | TUMORIGENICITY | IDENTIFICATION | EXPRESSION | FAMILY | Sorting Nexins - genetics | Up-Regulation | Sorting Nexins - biosynthesis | Colorectal Neoplasms - genetics | HCT116 Cells | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - biosynthesis | Gene Expression Profiling | Animals | HEK293 Cells | Cell Line, Tumor | Female | Mice | MicroRNAs - genetics | Sorting Nexins - antagonists & inhibitors | 3' Untranslated Regions | Cell Growth Processes - genetics | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism
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3. Full Text Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: Structures, functions and roles in disease
by Teasdale, Rohan D and Collins, Brett M
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 39 - 59
The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain, responsible for membrane attachment to organelles of the secretory and... 
Phox-homology domain (PX domain) | Phosphoinositide | Sorting nexin (SNX) | Alzheimer's disease | Endosome | Retromer | CLATHRIN-MEDIATED ENDOCYTOSIS | SALMONELLA-CONTAINING VACUOLE | CHRONIC GRANULOMATOUS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | ALDRICH-SYNDROME PROTEIN | phosphoinositide | sorting nexin (SNX) | phox-homology domain (PX domain) | BREAST-CANCER CELLS | HUMAN COLORECTAL-CARCINOMA | GROWTH-FACTOR RECEPTOR | endosome | retromer | PHOSPHOLIPASE-D ACTIVITY | MEMBRANE-BINDING ANALYSIS | Sorting Nexins - genetics | Multigene Family | Animals | Humans | Gene Expression Regulation - physiology | Phosphatidylinositols - metabolism | Sorting Nexins - metabolism | Mammals | Lipid Metabolism - physiology
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4. Full Text Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth
by Chan, Audrey S. M and Clairfeuille, Thomas and Landao-Bassonga, Euphemie and Kinna, Genevieve and Ng, Pei Ying and Loo, Li Shen and Cheng, Tak Sum and Zheng, Minghao and Hong, Wanjin and Teasdale, Rohan D and Collins, Brett M and Pavlos, Nathan J
Molecular Biology of the Cell, ISSN 1059-1524, 04/2016, Volume 27, Issue 8, pp. 1367 - 1382
The parathyroid hormone 1 receptor (PTHR) is central to the process of bone formation and remodeling. PTHR signaling requires receptor internalization into... 
Calcification, Physiologic - genetics | Sorting Nexins - genetics | Receptor, Parathyroid Hormone, Type 1 - metabolism | Signal Transduction | Bone Development - physiology | Humans | Osteoblasts - drug effects | Calcification, Physiologic - physiology | Parathyroid Hormone - pharmacology | Bone Remodeling - physiology | Endosomes - metabolism | Mice, Knockout | Protein Transport | Multiprotein Complexes - metabolism | Animals | PDZ Domains | Receptor, Parathyroid Hormone, Type 1 - genetics | Bone Development - genetics | Sorting Nexins - metabolism | Osteoblasts - metabolism | HEK293 Cells - metabolism
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5. Full Text Actin-sorting nexin 27 (SNX27)-retromer complex mediates rapid parathyroid hormone receptor recycling
by McGarvey, Jennifer C and Xiao, Kunhong and Bowman, Shanna L and Mamonova, Tatyana and Zhan, Qiangmin and Bisello, Alessandro and Bruce Sneddon, W and Ardura, Juan A and Jean-Alphonse, Frederic and Vilardaga, Jean-Pierre and Puthenveedu, Manojkumar A and Friedman, Peter A
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 21, pp. 10986 - 11002
The G protein-coupled parathyroid hormone receptor (PTHR) regulates mineral-ion homeostasis and bone remodeling. Upon parathyroid hormone (PTH) stimulation,... 
parathyroid hormone | PDZ-DOMAIN | MOLECULAR-DYNAMICS | PTH | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | RETROMER COMPLEX | receptor recycling | sorting nexin (SNX) | ETHYLMALEIMIDE-SENSITIVE FACTOR | endosome | INTERNALIZATION | PROTEIN-COUPLED RECEPTOR | G protein-coupled receptor (GPCR) | BINDING | N-Ethylmaleimide-Sensitive Proteins - metabolism | Protein Subunits | Receptor, Parathyroid Hormone, Type 1 - chemistry | Sorting Nexins - genetics | Cricetulus | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Actins - metabolism | Multiprotein Complexes - genetics | Endosomes - metabolism | Multiprotein Complexes - metabolism | Proteolysis | HEK293 Cells | Actins - chemistry | Sorting Nexins - metabolism | CHO Cells | Recombinant Proteins - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Protein Transport | Multiprotein Complexes - chemistry | Sorting Nexins - chemistry | Animals | Metabolic Networks and Pathways | PDZ Domains | Protein Binding | Receptor, Parathyroid Hormone, Type 1 - genetics | Cell Biology
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6. Full Text Measuring Interactions of FERM Domain-Containing Sorting Nexin Proteins with Endosomal Lipids and Cargo Molecules
by Ghai, Rajesh and Mobli, Mehdi and Collins, Brett M
2014, Methods in Enzymology, ISBN 0123979269, Volume 534, 19
Endosomal recycling pathways regulate cellular homeostasis via the transport of internalized material back to the plasma membrane. Phox homology (PX) and band... 
Band 4.1/ezrin/radixin/moesin domain | Phosphoinositide | Sorting nexin | Phosphotyrosine-binding domain | Phox homology domain | Endosome | Proteins | Lipids | NMR | RECONSTRUCTION | INFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | TRAFFICKING | DEGRADATION | CRYSTALLOGRAPHY | RECEPTORS | MULTIPLE SEQUENCE ALIGNMENT | FAMILY | TOOL | Sorting Nexins - genetics | Humans | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Endosomes - metabolism | Cell Membrane - chemistry | Escherichia coli - metabolism | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Sorting Nexins - metabolism | Binding Sites | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Magnetic Resonance Spectroscopy | Signal Transduction | Phosphatidylinositols - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Amino Acid Motifs | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Sorting Nexins - chemistry | Animals | Escherichia coli - genetics | Endosomes - chemistry | Protein Binding | Calorimetry | Mice
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7. Full Text A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer
by Matthew Gallon and Thomas Clairfeuille and Florian Steinberg and Caroline Mas and Rajesh Ghai and Richard B. Sessions and Rohan D. Teasdale and Brett M. Collins and Peter J. Cullen
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 35, pp. E3604 - E3613
The sorting nexin 27 (SNX27)-retromer complex is a major regulator of endosome-to-plasma membrane recycling of transmembrane cargos that contain a PSD95, Dlg1,... 
Parkinson disease | Down syndrome | Endosomal recycling | Alzheimer's disease | endosomal recycling | RECRUITMENT | PROTEIN | RECOGNITION | POTASSIUM CHANNELS | CRYSTAL-STRUCTURE | RECONSTRUCTION | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | RETROMER | WASH COMPLEX | VPS35 | Brain Diseases - metabolism | RNA, Small Interfering - genetics | Sorting Nexins - genetics | Vesicular Transport Proteins - metabolism | Humans | Brain Diseases - genetics | Molecular Sequence Data | Crystallography, X-Ray | Endosomes - metabolism | Nerve Tissue Proteins - chemistry | HEK293 Cells | Sorting Nexins - metabolism | Arrestin - chemistry | Arrestin - genetics | Amino Acid Sequence | Vesicular Transport Proteins - genetics | Rats | Vesicular Transport Proteins - chemistry | Nerve Tissue Proteins - genetics | Protein Folding | Endocytosis - physiology | Nerve Tissue Proteins - metabolism | Sequence Homology, Amino Acid | Sorting Nexins - chemistry | Animals | Brain Diseases - pathology | PDZ Domains - genetics | Mutagenesis | Protein Sorting Signals - genetics | Mice | Biological Sciences | PNAS Plus
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8. Full Text Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction
by Elwell, Cherilyn A and Czudnochowski, Nadine and von Dollen, John and Johnson, Jeffrey R and Nakagawa, Rachel and Mirrashidi, Kathleen and Krogan, Nevan J and Engel, Joanne N and Rosenberg, Oren S
eLife, ISSN 2050-084X, 03/2017, Volume 6
is an obligate intracellular pathogen that resides in a membrane-bound compartment, the inclusion. The bacteria secrete a unique class of proteins, Incs, which... 
Sorting Nexins - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Chlamydia trachomatis - immunology | Crystallography, X-Ray | Receptor, IGF Type 2 - chemistry | Receptor, IGF Type 2 - metabolism | Protein Interaction Mapping | Host-Pathogen Interactions | Receptor, IGF Type 2 - genetics | Sorting Nexins - chemistry | Animals | Immune Evasion | DNA Mutational Analysis | Bacterial Proteins - metabolism | Protein Conformation | Mice | Sorting Nexins - metabolism | Chlamydia trachomatis - physiology | Proteins | Chlamydia infections | Phosphates | Chlamydia | Crystals | Structure | Cells | Sugars | Monosaccharides | Pathogens | Immunoglobulins | Pathogenesis | Cell division | Amino acids | Infections | Mannose | Hydrophobicity | Mutagenesis | Nexin | Binding sites | Crystal structure | Index Medicus
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9. Full Text A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
by Harterink, M and Port, F and Lorenowicz, M.J and McGough, I.J and Silhankova, M and Betist, M.C and van Weering, J.R and van Heesbeen, R.G and Middelkoop, T.C and Basler, K and Cullen, P.J and Korswagen, H.C
Nature Cell Biology, ISSN 1465-7392, 2011, Volume 13, Issue 8, pp. 914 - 923
Wnt proteins are lipid-modified glycoproteins that play a central role in development, adult tissue homeostasis and disease. Secretion of Wnt proteins is... 
CAENORHABDITIS-ELEGANS | GOLGI NETWORK | HOX GENE-EXPRESSION | C-ELEGANS | GRADIENT FORMATION | TO-TGN TRANSPORT | MANNOSE 6-PHOSPHATE RECEPTOR | MEMBRANE-PROTEINS | SACCHAROMYCES-CEREVISIAE | TRANSMEMBRANE PROTEIN | CELL BIOLOGY | Sorting Nexins - genetics | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Signal Transduction | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - metabolism | Endosomes - metabolism | Biological Transport, Active | trans-Golgi Network - metabolism | Animals | RNA Interference | Models, Biological | Drosophila - growth & development | Sorting Nexins - antagonists & inhibitors | Drosophila - metabolism | HeLa Cells | Sorting Nexins - metabolism | Drosophila - genetics | Physiological aspects | Research | Gene expression | Wnt proteins | Binding proteins
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10. Full Text Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR
by Simonetti, Boris and Danson, Chris M and Heesom, Kate J and Cullen, Peter J
Journal of Cell Biology, ISSN 0021-9525, 11/2017, Volume 216, Issue 11, pp. 3695 - 3712
Endosomal recycling of transmembrane proteins requires sequence-dependent recognition of motifs present within their intracellular cytosolic domains. In this... 
SORTING NEXIN | GOLGI RETROGRADE TRANSPORT | WASH COMPLEX | MAMMALIAN RETROMER | ENDOSOME | TRAFFICKING | RECEPTOR | IDENTIFICATION | PROTEINS | BINDING | CELL BIOLOGY | Retinal Pigment Epithelium - metabolism | Sorting Nexins - genetics | Humans | Nerve Tissue Proteins - genetics | Endosomes - metabolism | Receptor, IGF Type 2 - chemistry | Receptor, IGF Type 2 - metabolism | Protein Transport | Nerve Tissue Proteins - metabolism | Receptor, IGF Type 2 - genetics | Sorting Nexins - chemistry | trans-Golgi Network - metabolism | Transfection | RNA Interference | Time Factors | CRISPR-Cas Systems | Protein Binding | Protein Interaction Domains and Motifs | HeLa Cells | Sorting Nexins - metabolism
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11. Full Text A novel PDZ domain interaction mediates the binding between human papillomavirus 16 L2 and sorting nexin 27 and modulates virion trafficking
by Pim, David and Broniarczyk, Justyna and Bergant, Martina and Playford, Martin P and Banks, Lawrence
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 20, pp. 10145 - 10155
Previous studies have demonstrated an interaction between sorting nexin 17 and the L2 capsid proteins from a variety of papillomavirus types. This interaction... 
RETROMER | ENTRY | VIROLOGY | SNX27 | WASH COMPLEX | ENDOSOME | INFECTION | TYPE-16 | SNX27-RETROMER | IDENTIFICATION | REVEALS | RNA, Small Interfering - genetics | Sorting Nexins - genetics | Capsid - chemistry | Oncogene Proteins, Viral - chemistry | Virus Replication - genetics | Humans | Molecular Sequence Data | Endosomes - metabolism | Cell Nucleus - metabolism | Biological Transport | Capsid Proteins - chemistry | Cell Nucleus - virology | HEK293 Cells | Oncogene Proteins, Viral - genetics | Cell Membrane - metabolism | Sorting Nexins - metabolism | Capsid - metabolism | Binding Sites | Oncogene Proteins, Viral - metabolism | Endosomes - virology | Amino Acid Sequence | Cell Line | Gene Expression | Signal Transduction | Capsid Proteins - metabolism | Keratinocytes | DNA - metabolism | Human papillomavirus 16 - metabolism | DNA - genetics | Host-Pathogen Interactions | PDZ Domains - genetics | Protein Binding | Cell Membrane - virology | Sorting Nexins - antagonists & inhibitors | Human papillomavirus 16 - genetics | Capsid Proteins - genetics | RNA, Small Interfering - metabolism
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12. Full Text Sorting nexin (MoVps17) is required for fungal development and plant infection by regulating endosome dynamics in the rice blast fungus
by Zheng, Huawei and Guo, Zhongkun and Xi, Yang and Yuan, Mingyue and Lin, Yahong and Wu, Congxian and Abubakar, Yakubu Saddeeq and Dou, Xianying and Li, Guangpu and Wang, Zonghua and Zheng, Wenhui and Zhou, Jie
Environmental Microbiology, ISSN 1462-2912, 10/2017, Volume 19, Issue 10, pp. 4301 - 4317
Summary Vps17 is a sorting nexin (SNX) and a component of the retromer, a protein complex mediating retrograde vesicle transport between endosomes and the... 
RECRUITMENT | COMPLEX | PATHOGENICITY | GOLGI RETROGRADE TRANSPORT | MEMBRANE CURVATURE | TRAFFICKING | MICROBIOLOGY | RETROMER-SUBCOMPLEX | MAGNAPORTHE-GRISEA | ENDOCYTOSIS | DOMAINS | Sorting Nexins - genetics | Vesicular Transport Proteins - metabolism | Vesicular Transport Proteins - genetics | Plant Diseases - microbiology | Fungal Proteins - genetics | Phosphatidylinositol 3-Kinases | Endosomes - metabolism | Two-Hybrid System Techniques | trans-Golgi Network - metabolism | Magnaporthe - metabolism | Oryza - microbiology | Magnaporthe - pathogenicity | Biological Transport - genetics | Biological Transport - physiology | Endocytosis - genetics | Magnaporthe - growth & development | Sorting Nexins - metabolism | Magnaporthe - genetics | Phosphatidylinositol 3-Kinase - metabolism | Fungal Proteins - metabolism | Fungi | Health aspects | Analysis | Pathogens | Yeasts | Mutations | Yeast | Rice blast | Imaging techniques | Infections | Kinases | Golgi apparatus | 1-Phosphatidylinositol 3-kinase | Defects | Pathogenicity | Proteins | Endocytosis | Immunology | Dynamics | Genetic analysis | Nexin | Localization | Budding | Endosomes
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13. Full Text The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)–IGF1 receptor pathway
by Bareja, Akshay and Hodgkinson, Conrad P and Soderblom, Erik and Waitt, Greg and Dzau, Victor J
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 17, pp. 6449 - 6459
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from... 
BIOTINYLATION | INSULIN-LIKE-GROWTH-FACTOR-1 | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | AFFINITY PURIFICATION | TRAFFICKING | Akt PKB | IGF1R | INTERACTOME | growth factor | extracellular-signal-regulated kinase (ERK) | BioID | QUANTITATIVE PHOSPHOPROTEOMICS | retromer | insulin-like growth factor (IGF) | cell signaling | PROTEIN-PROTEIN INTERACTIONS | SNX6 | LIVING CELLS | Sorting Nexins - genetics | Humans | Insulin-Like Growth Factor I - genetics | Insulin Receptor Substrate Proteins - metabolism | Carbon-Nitrogen Ligases - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | MAP Kinase Signaling System | Phosphorylation - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Sorting Nexins - metabolism | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Repressor Proteins - metabolism | Carbon-Nitrogen Ligases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Repressor Proteins - genetics | Escherichia coli Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Receptors, Somatomedin - metabolism | Staining and Labeling | Escherichia coli Proteins - genetics | Insulin-Like Growth Factor I - metabolism | Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Methods and Resources
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