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PLoS biology, ISSN 1545-7885, 2006, Volume 4, Issue 6, pp. e187 - 1009
The genes encoding members of the wingless-related MMTV integration site ( WNT) and fibroblast growth factor ( FGF) families coordinate growth, morphogenesis,... 
DETERMINING REGION | NUCLEAR IMPORT | SERTOLI-CELL DIFFERENTIATION | TESTIS DIFFERENTIATION | FACTOR SOX9 | DEVELOPING GONAD | GERM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | BIOLOGY | EXPRESSION | CHONDROCYTE DIFFERENTIATION | Gonads - embryology | Sex-Determining Region Y Protein - genetics | Fibroblast Growth Factor 9 - physiology | Male | Wnt Proteins - metabolism | Fibroblast Growth Factor 9 - genetics | Gonads - cytology | Sex Determination Processes | Wnt Proteins - genetics | Gene Expression Regulation, Developmental | Female | Proto-Oncogene Proteins - metabolism | High Mobility Group Proteins - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Fibroblast Growth Factor 9 - metabolism | Transcription Factors - metabolism | Gonads - metabolism | Animals | Proto-Oncogene Proteins - physiology | Sex-Determining Region Y Protein - metabolism | Mice | Wnt Proteins - physiology | Mutation | SOX9 Transcription Factor | Wnt4 Protein | High Mobility Group Proteins - genetics | Cell culture | Experiments | Insulin | Embryos | Rodents | Genes | High Mobility Group Proteins | Sex-Determining Region Y Protein | Biochemistry, Molecular Biology | Wnt Proteins | Life Sciences | Transcription Factors | Proto-Oncogene Proteins | Gonads | Fibroblast Growth Factor 9 | Development | Mus (Mouse) | Vertebrates | Mammals | Cell Biology
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e21679
.... However, the precise mechanisms involved in this process still remain to be defined. MicroRNAs (miRNAs) regulate various biological processes by binding target mRNA to attenuate protein synthesis... 
ACTIVATION | SMAD3 | PROTEIN | MECHANISM | MESSENGER-RNA EXPRESSION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | SIGNALS | NUCLEAR EXPORT | DICER | SOX9 Transcription Factor - metabolism | Transforming Growth Factor beta3 - pharmacology | Cell Line | Mesenchymal Stromal Cells - drug effects | Chondrogenesis - drug effects | Chondrogenesis - genetics | 3' Untranslated Regions - genetics | Mesenchymal Stromal Cells - metabolism | Genes, Reporter - genetics | MicroRNAs - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Luciferases - genetics | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Animals | Cell Differentiation - drug effects | Base Sequence | Mice | MicroRNAs - genetics | SOX9 Transcription Factor - genetics | MicroRNA | Genes | Luciferase | Stem cells | Bone morphogenetic proteins | Protein biosynthesis | DNA binding proteins | Genetic transcription | Transforming growth factors | Protein binding | Transcription factors | Mesenchyme | Laboratories | Collagen (type II) | Sox9 protein | Homeostasis | Stem cell transplantation | Smooth muscle | Kinases | Cartilage oligomeric matrix protein | Proteins | Cartilage | Genotype & phenotype | Allografts | Reporter gene | Collagen (type IX) | Cascades | Bone marrow | miRNA | Matrix protein | Chondrogenesis | Growth factors | Transforming growth factor-b1 | Gene expression | Ribonucleic acid--RNA | Biological activity | Studies | Biomechanics | Signaling | High mobility group proteins | Overexpression | 3' Untranslated regions | Protein synthesis | MicroRNAs | Protein expression | Aggrecan | Differentiation | Binding sites | Apoptosis | RNA | Ribonucleic acid
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11481 - 18
.... Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the target genes that are directly activated by Notch in the respective tissues... 
PROGENITOR CELLS | SKELETAL-MUSCLE | STEM-CELLS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | HES | DOWN-REGULATION | MODEL | FATE | EXPRESSION | BINDING | Paired Box Transcription Factors - genetics | Cell Cycle - genetics | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Myogenic Regulatory Factor 5 - genetics | Homeodomain Proteins - metabolism | Apoptosis - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Myogenic Regulatory Factor 5 - metabolism | Eye Proteins - genetics | Cell Differentiation - physiology | Repressor Proteins - metabolism | SOX9 Transcription Factor - metabolism | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Repressor Proteins - genetics | PAX6 Transcription Factor | Receptor, Notch1 - metabolism | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Animals | Eye Proteins - metabolism | Cell Cycle - physiology | Mice | Apoptosis - physiology | Receptor, Notch1 - genetics | Core Binding Factor Alpha 2 Subunit - genetics | SOX9 Transcription Factor - genetics | Paired Box Transcription Factors - metabolism | Analysis | Genes | Genetic research | Protein biosynthesis | Genetic transcription | DNA binding proteins | Tamoxifen | Cell differentiation | Embryonic stem cells | Protein binding | Transcription factors | Ontology | Sox9 protein | Genomics | Differentiation (biology) | Embryo cells | Decisions | Stem cell transplantation | Smooth muscle | Genomes | Biology | Biochemistry | Tissues | Proteins | Consortia | Allografts | Cell fate | Repressors | Cell cycle | Bioinformatics | Deoxyribonucleic acid--DNA | Biomedical engineering | Data analysis | Dendritic cells | Runx1 protein | Mammals | Gene expression | Signalling | Studies | Pax6 protein | Musculoskeletal system | Protein synthesis | Collaboration | Stem cells | Ligands | Notch protein | Binding sites | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 5, pp. 1875 - 1880
.... A tissue-specific inactivation of the Notch transcriptional effector recombination signal binding protein for Ig kappa J (RBPjκ... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | skeletal development | BONE-DEVELOPMENT | LIGANDS | ARTICULAR-CARTILAGE | PATHWAY | GROWTH | cartilage degradation | DIFFERENTIATION | RECEPTORS | EXPRESSION | REVEALS | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 51, pp. 35670 - 35680
.... Little is known of the mechanisms by which SRY regulates its target genes. Recently a KRAB domain protein (KRAB-O... 
COMPLEX | COREPRESSOR | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | DNA-BINDING SITE | TRANSCRIPTIONAL REPRESSION | SEX DETERMINATION | A DOMAIN | BOX | DOMAIN PROTEIN | Sex-Determining Region Y Protein - genetics | Chromatin - metabolism | Thrombospondins - genetics | Humans | Protein Methyltransferases - genetics | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Tripartite Motif-Containing Protein 28 | Protein Methyltransferases - metabolism | Female | Nuclear Proteins - genetics | Repressor Proteins - metabolism | SOX9 Transcription Factor - metabolism | Cell Line | Histone-Lysine N-Methyltransferase | Gene Silencing | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Carrier Proteins - genetics | Transcription, Genetic - physiology | Animals | Carrier Proteins - metabolism | Promoter Regions, Genetic - physiology | Sex-Determining Region Y Protein - metabolism | Mice | Chromatin - genetics | SOX9 Transcription Factor - genetics | Thrombospondins - metabolism | Chromatin | Transcription factors | Sox9 protein | adaptor proteins | Promoters | epigenetics | Gene silencing | Embryogenesis | Mutagenesis | Sex determination | Tumorigenesis | Zinc finger proteins | Differentiation | Testes | Cancer | Index Medicus | Transcription, Chromatin, and Epigenetics
Journal Article
Circulation research, ISSN 1524-4571, 2009, Volume 104, Issue 6, pp. 733 - 741
.... We found that smooth muscle cells (SMCs) gave rise to osteochondrogenic precursor- and chondrocyte-like cells in calcified blood vessels of matrix Gla protein deficient (MGP) mice... 
Vascular calcification | Smooth muscle cells | Genetic fate mapping | Lineage reprogramming | Runx2/Cbfa1 | WALL | CARDIAC & CARDIOVASCULAR SYSTEMS | vascular calcification | ATHEROSCLEROSIS | lineage reprogramming | genetic fate mapping | CARTILAGE | smooth muscle cells | IN-VITRO | DEFICIENT | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | MATRIX-GLA-PROTEIN | HEMATOLOGY | EXPRESSION | Calcinosis - genetics | Vascular Diseases - pathology | Homeodomain Proteins - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Arteries - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Mice, Mutant Strains | Bone Morphogenetic Protein 2 - metabolism | Calcinosis - metabolism | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | SOX9 Transcription Factor - metabolism | Bone Morphogenetic Protein 2 - genetics | Chondrocytes - pathology | RNA, Messenger - genetics | Vascular Diseases - genetics | Arteries - pathology | Transcription Factors - genetics | Down-Regulation - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Proteins - genetics | Transcription Factors - metabolism | Animals | Proteins - metabolism | Sp7 Transcription Factor | Stem Cells - pathology | Wnt3 Protein | Mice | Calcinosis - pathology | Vascular Diseases - metabolism | Wnt3A Protein | Cell Dedifferentiation - genetics | SOX9 Transcription Factor - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Cbfa1 | Runx2
Journal Article
PloS one, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145235
Journal Article
The EMBO journal, ISSN 0261-4189, 10/2016, Volume 35, Issue 20, pp. 2192 - 2212
.... However, its potential oncogenic activity and regulatory mechanisms that control SOX9 protein stability are poorly understood... 
SOX9 | cisplatin | FBW7 | medulloblastoma | metastasis | TRANSCRIPTION FACTOR SOX9 | PROTEIN | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | DOWN-REGULATION | BRAIN-TUMORS | CELL BIOLOGY | TUMOR-SUPPRESSOR | CELL-DIFFERENTIATION | EXPRESSION | HUMAN CANCER | F-Box-WD Repeat-Containing Protein 7 | Phosphoinositide-3 Kinase Inhibitors | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Ubiquitination | HEK293 Cells | Cell Cycle Proteins - genetics | Chromones - pharmacology | Medulloblastoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | SOX9 Transcription Factor - metabolism | Aniline Compounds - pharmacology | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Morpholines - pharmacology | Medulloblastoma - metabolism | Cisplatin - pharmacology | Pyrimidines - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Pyrroles - pharmacology | Animals | Mice, Nude | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Benzamides | Medulloblastoma - drug therapy | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | SOX9 Transcription Factor - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cell Movement | Enzymes | Transcription factors | Chemotherapy | Brain cancer | Stem cells | Cell adhesion & migration | Post-translational Modifications, Proteolysis & Proteomics | Cancer
Journal Article
PloS one, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e98063
MicroRNAs (miRs) play a pivotal role in a variety of biological processes including stem cell differentiation and function. Human foetal femur derived skeletal... 
OSTEOBLAST | SKELETOGENESIS | RNA | MULTIDISCIPLINARY SCIENCES | TISSUE | LEVEL | EXPRESSION | CHONDROGENESIS | CARTILAGE | Protein Biosynthesis | Chondrogenesis - genetics | Humans | Epiphyses - cytology | 3' Untranslated Regions - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Gene Expression Profiling | Smad3 Protein - metabolism | Stem Cells - cytology | Cell Shape - genetics | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Stem Cells - metabolism | Cell Differentiation - genetics | Smad3 Protein - genetics | Base Sequence | Smad2 Protein - genetics | Muscle, Skeletal - embryology | Binding Sites | Chondrocytes - metabolism | Osteogenesis - genetics | Chondrocytes - pathology | Cell Separation | RNA, Messenger - genetics | Smad2 Protein - metabolism | Femur - embryology | Down-Regulation - genetics | Fetus - cytology | Feedback, Physiological | MicroRNAs - genetics | Transforming Growth Factor beta - metabolism | Diaphyses - cytology | Hypertrophy | Bone morphogenetic proteins | MicroRNA | Transforming growth factors | Cell differentiation | Gene expression | Stem cells | Cell proliferation | Regulations | Femur | Transcription factors | Genes | Sox9 protein | Differentiation (biology) | Smad3 protein | Kinases | Proteins | Signal transduction | Biomedical materials | Smad2 protein | Cell cycle | Biocompatibility | miRNA | Chondrogenesis | Growth factors | Cbfa-1 protein | Antigens | Transducers | Cytokines | Tissue engineering | Ribonucleic acid--RNA | Biological activity | Skeletogenesis | MicroRNAs | Medical prognosis | Epigenetics | Genetic engineering | Activin | Osteogenesis | Ribonucleic acid
Journal Article
The FASEB journal, ISSN 0892-6638, 08/2017, Volume 31, Issue 8, pp. 3512 - 3526
ABSTRACT Shp‐1 (Src homology region 2 domain‐containing protein tyrosine phosphatase... 
intestinal epithelial cells | Shp‐1 | PI3K | β‐catenin | secretory cell fate | Secretory cell fate | B-catenin | Shp-1 | Intestinal epithelial cells | beta-catenin | PANETH | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOTH-EATEN | RECEPTOR | CELL BIOLOGY | WNT/BETA-CATENIN | BIOLOGY | GENE-EXPRESSION | PROTEIN-TYROSINE-PHOSPHATASE | T-CELLS | Humans | Intestines - growth & development | Gene Expression Regulation - physiology | Mice, Transgenic | Intestines - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Wnt Proteins - metabolism | Catenins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Colonic Neoplasms - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Catenins - metabolism | Epithelial Cells - physiology | Animals | Wnt Proteins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Mice | Intestines - cytology | TOR protein | Cell proliferation | Wnt protein | SHP-1 protein | Epithelial cells | Sox9 protein | Differentiation (biology) | Homology | AKT protein | Villus | Phosphatase | Small intestine | β-catenin | Perturbation methods | Intestine | Rodents | Tumorigenesis | Tyrosine | Rapamycin | Paneth cells | Cell differentiation | Src protein | Epithelium | 1-Phosphatidylinositol 3-kinase | Hemopoiesis | Signaling | Mucin | Stem cells | Tumor suppressor genes | Cell size | Tumors | Protein-tyrosine-phosphatase
Journal Article