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Oncogene, ISSN 0950-9232, 08/2012, Volume 31, Issue 35, pp. 3973 - 3988
Journal Article
Journal Article
by Jin, M and Ande, A and Kumar, A and Kumar, S
Cell Death and Disease, ISSN 2041-4889, 03/2013, Volume 4, Issue 3, pp. e554 - e554
CYP2E1 metabolizes ethanol leading to production of reactive oxygen species (ROS) and acetaldehyde, which are known to cause not only liver damage but also... 
Oxidative stress | Monocytes | CYP2E1 | Ethanol | Astrocytes | PKC/JNK/SP1 | monocytes | PROTEIN-KINASE-C | C/EBP-BETA | INDUCTION | KNOCKOUT MICE | CELL-LINES | ethanol | CELL BIOLOGY | LIVER-INJURY | MESSENGER-RNA | ALCOHOL | astrocytes | oxidative stress | BRAIN | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Astrocytes - pathology | Monocytes - metabolism | Sp1 Transcription Factor - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Reactive Oxygen Species - agonists | Sp1 Transcription Factor - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | Protein Kinase C - metabolism | Monocytes - pathology | MAP Kinase Kinase 4 - antagonists & inhibitors | Sulfides - pharmacology | Astrocytes - drug effects | Cytochrome P-450 CYP2E1 Inhibitors | Protein Kinase C - antagonists & inhibitors | Allyl Compounds - pharmacology | Plicamycin - pharmacology | Anthracenes - pharmacology | Plicamycin - analogs & derivatives | Gene Expression Regulation - drug effects | Monocytes - drug effects | Ethanol - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Signal Transduction - drug effects | Sp1 Transcription Factor - genetics | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Oxidative Stress - drug effects | Staurosporine - pharmacology | Astrocytes - metabolism | Index Medicus | SP1 | JNK | PKC | Original
Journal Article
Oncogene, ISSN 0950-9232, 06/2013, Volume 32, Issue 26, pp. 3119 - 3129
Tumor stem cells, postulated to be the source cells for malignancies, have been identified in several cancers using cell-surface expression of markers... 
glioma Stem Cell | promoter methylation | Sp1 | epigenetic regulation | Myc | CD133 | DNA METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CPG BINDING-PROTEIN | TUMOR-INITIATING CELLS | CELL BIOLOGY | CHROMOSOMAL-PROTEIN | EPITHELIAL-CELLS | ONCOLOGY | GENETICS & HEREDITY | FUNCTIONAL-ANALYSIS | GENE-EXPRESSION | TRANSCRIPTION FACTOR | HEMATOPOIETIC STEM | Nucleic Acid Synthesis Inhibitors - pharmacology | Epigenesis, Genetic | Humans | Glycoproteins - metabolism | Methyl-CpG-Binding Protein 2 - metabolism | Peptides - genetics | Sp1 Transcription Factor - metabolism | Sp1 Transcription Factor - immunology | Antigens, CD - genetics | Methyl-CpG-Binding Protein 2 - genetics | Antigens, CD - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | Sp1 Transcription Factor - antagonists & inhibitors | DNA Methylation | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Base Sequence | Transcription, Genetic | Cell Differentiation | Glycoproteins - genetics | Promoter Regions, Genetic | Oncogene Protein p55(v-myc) - metabolism | DNA-Binding Proteins - genetics | Plicamycin - pharmacology | AC133 Antigen | Sequence Analysis, DNA | Transcription Factors - metabolism | Sp1 Transcription Factor - genetics | Cell Line, Tumor | CpG Islands - genetics | Oncogene Protein p55(v-myc) - immunology | Care and treatment | Gliomas | Stem cells | Genetic aspects | Research | Methylation | Health aspects | Risk factors | Epigenetics | DNA methylation | Gene expression | Index Medicus | Chromatin
Journal Article
Scientific reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, pp. 7162 - 7162
Journal Article
Oncology Reports, ISSN 1021-335X, 10/2013, Volume 30, Issue 4, pp. 1782 - 1792
The transcription factor specificity protein 1 (Sp1) plays a role in the development and progression of various types of human cancers, while cancer stem cells... 
Sp1 | colon cancer | CD44 | CD166 | CSCs | Colon cancer | DRUG | C-KIT | SELF-RENEWAL | BREAST-CANCER | MELANOMA | ADHESION MOLECULE | ONCOLOGY | COLORECTAL-CANCER | EXPRESSION | CARCINOMA | PROGRESSION | Neoplasm Transplantation | Up-Regulation | Peptides | Antigens, CD - biosynthesis | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Apoptosis - genetics | Sp1 Transcription Factor - metabolism | Sp1 Transcription Factor - biosynthesis | Sp1 Transcription Factor - antagonists & inhibitors | Heterografts | Neoplastic Stem Cells - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | Activated-Leukocyte Cell Adhesion Molecule - biosynthesis | Colorectal Neoplasms - metabolism | Down-Regulation | HCT116 Cells | Spheroids, Cellular - metabolism | Hyaluronan Receptors - biosynthesis | Plicamycin - pharmacology | AC133 Antigen | Plicamycin - analogs & derivatives | Glycoproteins - biosynthesis | HT29 Cells | Animals | Sp1 Transcription Factor - genetics | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Biomarkers, Tumor - biosynthesis | Cell culture | Immunoglobulins | Transcription factors | Dehydrogenases | Colorectal cancer | Metastasis | Gene expression | Drug resistance | Polymerase chain reaction | Proteins | Cell growth | Medical prognosis | Stem cells | Tumorigenesis | Growth factors | Apoptosis | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 08/2019, Volume 412, pp. 207 - 215
High voltage-activated (HVA) Ca (Ca ) channels are oligomeric complexes formed by an ion-conducting main subunit (Cavα ) and at least two auxiliary subunits... 
Sp1 | neuropathic pain | calcium channels
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2016, Volume 22, Issue 5, pp. 1197 - 1210
Journal Article
The Journal of Pathology, ISSN 0022-3417, 01/2013, Volume 229, Issue 1, pp. 12 - 24
Although recent studies indicate that DNA methylation contributes to the down‐regulation of microRNAs (miRNAs) in colorectal cancer (CRC), this field remains... 
overall survival | epigenetic silencing | promoter methylation | Sp1 | CRC | miR‐149 | miR-149 | SURVIVAL | DNA METHYLATION | TRANSCRIPTION FACTOR SP1 | GENETIC-VARIANTS | PATHOLOGY | MICRORNA EXPRESSION PROFILES | HUMAN GASTRIC-CANCER | COLON-CANCER | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | Multivariate Analysis | Cell Proliferation | Prognosis | Oligonucleotide Array Sequence Analysis | CpG Islands - drug effects | DNA Modification Methylases - antagonists & inhibitors | Colorectal Neoplasms - genetics | Humans | Middle Aged | Molecular Sequence Data | Male | MicroRNAs - metabolism | Sp1 Transcription Factor - metabolism | Gene Knockdown Techniques | Transfection | Time Factors | Base Sequence | Polymerase Chain Reaction | Female | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | DNA Modification Methylases - metabolism | Risk Assessment | Signal Transduction | Neoplasm Invasiveness | Down-Regulation | HCT116 Cells | Risk Factors | Enzyme Inhibitors - pharmacology | Gene Silencing | Kaplan-Meier Estimate | Proportional Hazards Models | Azacitidine - analogs & derivatives | Gene Expression Profiling - methods | Chi-Square Distribution | HT29 Cells | Azacitidine - pharmacology | DNA Modification Methylases - genetics | Sp1 Transcription Factor - genetics | Colorectal Neoplasms - pathology | DNA Methylation - drug effects | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 6, pp. 1286 - 1296
Multidrug resistance (MDR) remains a major obstacle to effective chemotherapy treatment in ovarian cancer. In our study, paclitaxel‐resistant ovarian cancer... 
pRb | miR‐145 | Cdk6 | Sp1 | P‐gp | P-gp | miR-145 | ACTIVATION | DOWN-REGULATION | GENE PROMOTER | INHIBITION | ONCOLOGY | RESISTANCE | TRANSCRIPTION FACTOR INTERACTIONS | AGENTS | TUMOR-SUPPRESSOR MIR-145 | EXPRESSION | MICRORNA SIGNATURES | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Cyclin-Dependent Kinase 6 - biosynthesis | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Drug Resistance, Neoplasm | MicroRNAs - metabolism | Sp1 Transcription Factor - metabolism | Paclitaxel - pharmacokinetics | Sp1 Transcription Factor - biosynthesis | Ovarian Neoplasms - genetics | Retinoblastoma Protein - biosynthesis | Transfection | MCF-7 Cells | Cell Cycle Checkpoints - genetics | Female | Ovarian Neoplasms - metabolism | Antineoplastic Agents, Phytogenic - pharmacokinetics | Ovarian Neoplasms - drug therapy | MicroRNAs - administration & dosage | Retinoblastoma Protein - metabolism | Cyclin-Dependent Kinase 6 - genetics | Cyclin-Dependent Kinase 6 - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Xenograft Model Antitumor Assays | Animals | Sp1 Transcription Factor - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Cycle Checkpoints - drug effects | Retinoblastoma Protein - genetics | Cell Line, Tumor | Ovarian Neoplasms - therapy | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Antineoplastic Agents, Phytogenic - pharmacology | RNA, Small Interfering - administration & dosage | Antimitotic agents | Yuan (China) | Chemotherapy | Cancer cells | Drug resistance | Antineoplastic agents | Cancer | Ovarian cancer | Medical research | Cancer therapies | Index Medicus
Journal Article