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Cancer Research, ISSN 0008-5472, 03/2007, Volume 67, Issue 6, pp. 2816 - 2823
Betulinic acid is a pentacyclic triterpene natural product initially identified as a melanoma-specific cytotoxic agent that exhibits low toxicity in animal... 
PROXIMAL PROMOTER | NITRIC-OXIDE PRODUCTION | ONCOLOGY | NATURAL-PRODUCTS | PANCREATIC-CANCER | DRUG DISCOVERY | HUMAN-MELANOMA CELLS | DOWN-REGULATION | FACTOR EXPRESSION | 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID | SYNTHETIC OLEANANE | Prostatic Neoplasms - metabolism | Sp3 Transcription Factor - antagonists & inhibitors | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Male | Sp1 Transcription Factor - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Promoter Regions, Genetic - drug effects | Sp1 Transcription Factor - antagonists & inhibitors | Liver - drug effects | Neoplasm Proteins - genetics | Prostatic Neoplasms - drug therapy | Sp3 Transcription Factor - metabolism | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Inhibitor of Apoptosis Proteins | Cell Growth Processes - drug effects | Liver - metabolism | Sp3 Transcription Factor - genetics | Sp Transcription Factors - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Sp Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Sp4 Transcription Factor - metabolism | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Sp4 Transcription Factor - antagonists & inhibitors | Sp4 Transcription Factor - genetics | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2015, Volume 34, Issue 45, pp. 5648 - 5661
The long noncoding RNA TINCR shows aberrant expression in human squamous carcinomas. However, its expression and function in gastric cancer remain unclear. We... 
SURVIVAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR SP1 | CELL BIOLOGY | NCRNAS | REPRESSION | ONCOLOGY | POOR-PROGNOSIS | GENETICS & HEREDITY | CARCINOMAS | KRUPPEL-LIKE FACTOR-2 | INHIBITORS | HALLMARKS | DECREASED EXPRESSION | RNA-Binding Proteins - genetics | Cell Proliferation | Cytoskeletal Proteins - genetics | Humans | Stomach Neoplasms - metabolism | Sp1 Transcription Factor - metabolism | Stomach Neoplasms - pathology | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | RNA, Long Noncoding - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cytoskeletal Proteins - metabolism | Stomach Neoplasms - genetics | Kruppel-Like Transcription Factors - biosynthesis | RNA, Messenger - genetics | RNA, Long Noncoding - genetics | RNA Stability | Sp1 Transcription Factor - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Kruppel-Like Transcription Factors - genetics | RNA-Binding Proteins - metabolism | Apoptosis | Cell proliferation | Complications and side effects | Care and treatment | Analysis | Development and progression | Stomach cancer | Proteins | Ribonucleic acid--RNA | Kinases | Gene expression | Cancer therapies | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e48208 - e48208
Acetylsalicylic acid (aspirin) is highly effective for treating colon cancer patients postdiagnosis; however, the mechanisms of action of aspirin in colon... 
SURVIVAL | ANGIOGENESIS | INDUCED APOPTOSIS | ACETYL SALICYLIC-ACID | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | IN-VIVO | FACTOR EXPRESSION | DEGRADATION | NF-KAPPA-B | ANTIINFLAMMATORY DRUGS | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Sp3 Transcription Factor - genetics | Sp Transcription Factors - metabolism | Sp1 Transcription Factor - metabolism | Colonic Neoplasms - metabolism | Xenograft Model Antitumor Assays | Sp4 Transcription Factor - metabolism | Animals | Sp1 Transcription Factor - genetics | Mice, Nude | Female | Aspirin - therapeutic use | Cell Proliferation - drug effects | Mice | Sp Transcription Factors - genetics | Aspirin - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Sp3 Transcription Factor - metabolism | Sp4 Transcription Factor - genetics | Care and treatment | Aspirin | RNA | Growth | B cells | DNA binding proteins | Prevention | Colon cancer | Genetic research | Salicylates | Vascular endothelial growth factor | Apoptosis | Cancer | Tumors | Salts | Transcription factors | Bcl-2 protein | Genes | Colorectal cancer | Acetylsalicylic acid | Cyclin D1 | Anticancer properties | Proteins | β-catenin | Cell growth | Xenografts | Physiology | Inhibition | Colon | Salicylic acid | Immunoglobulins | RNA-mediated interference | Caspase | Pharmacology | Survivin | Gene expression | Metabolism | Sp1 protein | Zinc | Studies | Sodium salicylate | Acids | Ribonucleic acids | Sodium | Phenols | Antitumor activity | Sulfate | Zinc sulfate | Index Medicus
Journal Article
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 02/2015, Volume 21, Issue 2, pp. 150 - 158
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2013, Volume 25, Issue 4, pp. 931 - 938
The interleukin-6 (IL-6)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway mediates cell proliferation and migration.... 
Cytoskeleton | p27 | Gastric cancer | Migration | Invasion | Signal transducer and activator of transcription 3 | P27 | ACTIVATION | E-CADHERIN | BETA-CATENIN | INTERLEUKIN-6 | IL-6 | CELL BIOLOGY | OVEREXPRESSION | SIGNALING PATHWAY | SKP2 | CARCINOMA | CYCLE | Up-Regulation | Cell Proliferation | Cadherins - metabolism | Humans | Stomach Neoplasms - metabolism | Sp1 Transcription Factor - metabolism | Stomach Neoplasms - pathology | rhoA GTP-Binding Protein - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Matrix Metalloproteinase 9 - metabolism | Microtubules - metabolism | RNA Interference | Janus Kinase 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Focal Adhesion Kinase 1 - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Down-Regulation | S-Phase Kinase-Associated Proteins - metabolism | Cell Adhesion | GPI-Linked Proteins - metabolism | Cell Line, Tumor | STAT3 Transcription Factor - antagonists & inhibitors | Stathmin - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | RNA, Small Interfering - metabolism | Phosphates | Enzymes | Cysteine | Analysis | Fluorescein | Cancer cells | Tubulins | Stomach cancer | Enzyme-linked immunosorbent assay | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33927 - 33938
Pancreatic cancer, the fourth most prevalent cancer-related cause of death in the United States, is a disease with a dismal survival rate of 5% 5 years after... 
PATHWAYS | APOPTOSIS | ACTIVATION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Pancreatic Cancer | KAPPA-B | O-GlcNAc | N-ACETYLGLUCOSAMINE TRANSFERASE | Heat Shock Protein | Minnelide | IN-VITRO | INHIBITION | Sp1 | Triptolide | Pancreas | TUMOR-GROWTH | EXPRESSION | Pancreatic Neoplasms - metabolism | Humans | Cell Survival - genetics | N-Acetylglucosaminyltransferases - genetics | Antineoplastic Agents, Alkylating - pharmacology | NF-kappa B - metabolism | Sp1 Transcription Factor - metabolism | Glycosylation - drug effects | Neoplasm Proteins - metabolism | Acetylglucosamine - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Cell Nucleus - metabolism | Epoxy Compounds - pharmacology | Cell Death - genetics | Cell Nucleus - pathology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Active Transport, Cell Nucleus - genetics | Gene Expression Regulation, Neoplastic - genetics | HSP70 Heat-Shock Proteins - biosynthesis | Diterpenes - pharmacology | Cell Survival - drug effects | Pancreatic Neoplasms - pathology | HSP70 Heat-Shock Proteins - genetics | Pancreatic Neoplasms - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Acetylglucosamine - genetics | DNA-Binding Proteins - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | N-Acetylglucosaminyltransferases - metabolism | Transcription Factors - metabolism | Phenanthrenes - pharmacology | Cell Nucleus - genetics | NF-kappa B - genetics | Signal Transduction - drug effects | Sp1 Transcription Factor - genetics | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Index Medicus | Molecular Bases of Disease
Journal Article