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1. Paraplegia
International Medical Society of Paraplegia
Paraplegia, ISSN 0031-1758, 1963
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2. My body politic
: a memoir
by Linton, Simi, 1947
2006, ISBN 0472115391, 246
Traffic accident victims | Linton, Simi, 1947 | Paraplegics | Women with disabilities | Paraplegics - United States
Book
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3. Genetics of Hereditary Spastic Paraplegia
by Tucci, Arianna
2014, The genetic basis of neurological disorders
Spastic Paraplegia, Hereditary | Genetic disorders | genetics | pathology | therapy | Nervous system | Genetic aspects | Nervous System Diseases | Diseases
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4. Full Text SPG11 spastic paraplegia
: A new cause of juvenile parkinsonism
by Anheim, Mathieu and Lagier-Tourenne, Clotilde and Stevanin, Giovanni and Fleury, Marie and Durr, Alexandra and Namer, Izzie Jacques and Denora, Paola and Brice, Alexis and Mandel, Jean Louis and Koenig, Michel and Tranchant, Christine
Journal of Neurology, ISSN 0340-5354, 1/2009, Volume 256, Issue 1, pp. 104 - 108
Autosomal recessive hereditary spastic paraplegia (AR HSP) with thin corpus callosum (TCC) is a rare neurodegenerative disorder often caused by mutations in... 
spastic paraplegia | Neurology | Neurosciences | Medicine & Public Health | parkinsonism | SPG11 | Neuroradiology | thin corpus callosum | Parkinsonism | Thin corpus callosum | Spastic paraplegia | Paraplegia - pathology | Parkinsonian Disorders - complications | Humans | Parkinsonian Disorders - diagnosis | Paraplegia - genetics | Male | Proteins - genetics | Magnetic Resonance Imaging | Parkinsonian Disorders - pathology | DNA Mutational Analysis | Adolescent | Polymerase Chain Reaction | Brain - pathology | Adult | Female | Parkinsonian Disorders - genetics | Gene mutations | Paralysis, Spastic | Causes of | Genetic aspects | Research | Diagnosis | Health aspects | Risk factors | Index Medicus
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5. Full Text Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia
by Allison, Rachel and Edgar, James R and Pearson, Guy and Rizo, Tania and Newton, Timothy and Günther, Sven and Berner, Fiamma and Hague, Jennifer and Connell, James W and Winkler, Jürgen and Lippincott-Schwartz, Jennifer and Beetz, Christian and Winner, Beate and Reid, Evan
Journal of Cell Biology, ISSN 0021-9525, 05/2017, Volume 216, Issue 5, pp. 1337 - 1355
Contacts between endosomes and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of tubule fission... 
PROTEIN | STRUCTURAL BASIS | SITES | TRAFFICKING | RETROMER COMPLEX | ACCUMULATION | MUTATIONS | PATHOLOGY | ENDOLYSOSOMES | INHERITANCE | CELL BIOLOGY | Humans | Middle Aged | Cells, Cultured | Endoplasmic Reticulum - metabolism | Male | Spastic Paraplegia, Hereditary - metabolism | Endosomes - metabolism | Animals | Lysosomes - metabolism | Adult | Female | Mice | HeLa Cells | Paralysis, Spastic | Physiological aspects | Tubulins | Health aspects | Endoplasmic reticulum | Protein-protein interactions | Phosphates | Animal models | Neurons | Trafficking | Abnormalities | Cytology | Heat shock proteins | Mannose | Fission | Defects | Proteins | Hereditary spastic paraplegia | Paraplegia | Neurodegeneration | Rodents | Stem cells | Degeneration | Mutation | Spastic paraplegia | Endosomes | Index Medicus
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6. Full Text A Kinesin Heavy Chain ( KIF5A) Mutation in Hereditary Spastic Paraplegia (SPG10)
by Reid, Evan and Kloos, Mark and Ashley-Koch, Allison and Hughes, Lori and Bevan, Simon and Svenson, Ingrid K and Graham, Felicia Lennon and Gaskell, Perry C and Dearlove, Andrew and Pericak-Vance, Margaret A and Rubinsztein, David C and Marchuk, Douglas A
The American Journal of Human Genetics, ISSN 0002-9297, 2002, Volume 71, Issue 5, pp. 1189 - 1194
We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene in a family with hereditary spastic paraplegia. The... 
MECHANISM | ELEGANS | ATPASE | DISEASE | GENETICS & HEREDITY | NEURONS | GENETIC-HETEROGENEITY | NUCLEOTIDE-BINDING | AXONAL-TRANSPORT | PROTEINS | DROSOPHILA | Spastic Paraplegia, Hereditary - genetics | Amino Acid Sequence | Sequence Alignment | Animals | Pedigree | Humans | Axons - metabolism | Kinesin - genetics | Molecular Sequence Data | Female | Male | Mutation | Genetic disorders | Gene mutations | Neurons | Paralysis, Spastic | Physiological aspects | Genetic aspects | Kinesin | Index Medicus | Report
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7. Full Text A new case of infantile‐onset hereditary spastic paraplegia with complicated phenotype (SPG61) in a consanguineous Russian family
by Chukhrova, A. L and Akimova, I. A and Shchagina, O. A and Kadnikova, V. A and Ryzhkova, O. P and Polyakov, A. V
European Journal of Neurology, ISSN 1351-5101, 05/2019, Volume 26, Issue 5, pp. e61 - e62
ARL | SPG | hereditary spastic paraplegia | whole‐exome sequencing | consanguineous | homozygosity | SPG61 | ARL6IP1 | whole-exome sequencing | NEUROSCIENCES | CLINICAL NEUROLOGY | Paralysis, Spastic | Genetic aspects | Hereditary spastic paraplegia | Paraplegia | Phenotypes | Spastic paraplegia
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8. Full Text SPG11 spastic paraplegia
by Anheim, M and Lagier-Tourenne, C and Stevanin, G and Fleury, M and Durr, A and Namer, IJ and Denora, P and Brice, A and Mandel, J and Koenig, M and Tranchant, C
JOURNAL OF NEUROLOGY, ISSN 0340-5354, 01/2009, Volume 256, Issue 1, pp. 104 - 108
Autosomal recessive hereditary spastic paraplegia (AR HSP) with thin corpus callosum (TCC) is a rare neurodegenerative disorder often caused by mutations in... 
parkinsonism | MENTAL IMPAIRMENT | SPATACSIN | LOCUS | thin corpus callosum | PARAPARESIS | CLINICAL NEUROLOGY | spastic paraplegia | FAMILIES | GENETIC-HETEROGENEITY | MUTATIONS | SPG11 | THIN CORPUS-CALLOSUM | PROGRESSION
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9. Full Text Considering Spastic Paraplegia Type 7 and Adult-Onset Alexander Disease—Reply
by Remster, Eric and Dubey, Divyanshu
JAMA Neurology, ISSN 2168-6149, 07/2017, Volume 74, Issue 7, pp. 869 - 869
CLINICAL NEUROLOGY | Alexander Disease | Adult | Paraplegia | Spastic Paraplegia, Hereditary | Humans | Index Medicus | Abridged Index Medicus
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10. Full Text Genetic and phenotypic characterization of complex hereditary spastic paraplegia
by Kara, Eleanna and Tucci, Arianna and Manzoni, Claudia and Lynch, David S and Elpidorou, Marilena and Bettencourt, Conceicao and Chelban, Viorica and Manole, Andreea and Hamed, Sherifa A and Haridy, Nourelhoda A and Federoff, Monica and Preza, Elisavet and Hughes, Deborah and Pittman, Alan and Jaunmuktane, Zane and Brandner, Sebastian and Xiromerisiou, Georgia and Wiethoff, Sarah and Schottlaender, Lucia and Proukakis, Christos and Morris, Huw and Warner, Tom and Bhatia, Kailash P and Korlipara, L.V. Prasad and Singleton, Andrew B and Hardy, John and Wood, Nicholas W and Lewis, Patrick A and Houlden, Henry
Brain, ISSN 0006-8950, 07/2016, Volume 139, Issue 7, pp. 1904 - 1918
High-throughput next-generation sequencing can identify disease-causing mutations in extremely heterogeneous disorders. Kara et al. investigate a series of 97... 
mutation | Parkinson's disease | hereditary spastic paraplegia | gene | SPG11 | SPG11 MUTATIONS | MASA SYNDROME | SPATACSIN | NEUROSCIENCES | CLINICAL NEUROLOGY | DOPA-RESPONSIVE PARKINSONISM | DISEASE | AUTOSOMAL-DOMINANT | LYSOSOMAL PROTEIN | ATP13A2 | SPECTRUM | THIN CORPUS-CALLOSUM | Spastic Paraplegia, Hereditary - genetics | Cell Line | Humans | Child, Preschool | Male | United Kingdom | Proteins - genetics | Spastic Paraplegia, Hereditary - diagnostic imaging | Young Adult | Phenotype | Pedigree | Adolescent | Fibroblasts | Adult | Female | Mutation | Child | Spastic Paraplegia, Hereditary - physiopathology | Cohort Studies | Index Medicus | Abridged Index Medicus | Editor's Choice | Original | Parkinson’s disease
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11. Full Text Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients
by Schüle, Rebecca and Wiethoff, Sarah and Martus, Peter and Karle, Kathrin N and Otto, Susanne and Klebe, Stephan and Klimpe, Sven and Gallenmüller, Constanze and Kurzwelly, Delia and Henkel, Dorothea and Rimmele, Florian and Stolze, Henning and Kohl, Zacharias and Kassubek, Jan and Klockgether, Thomas and Vielhaber, Stefan and Kamm, Christoph and Klopstock, Thomas and Bauer, Peter and Züchner, Stephan and Liepelt‐Scarfone, Inga and Schöls, Ludger
Annals of Neurology, ISSN 0364-5134, 04/2016, Volume 79, Issue 4, pp. 646 - 658
ObjectiveHereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. To investigate the... 
SPINAL MUSCULAR-ATROPHY | FRIEDREICHS-ATAXIA | FREQUENT CAUSE | SPG4 MUTATIONS | DIGENIC INHERITANCE | PHENOTYPE | CLINICAL-FEATURES | SPECTRUM | NEUROSCIENCES | ONSET | CLINICAL NEUROLOGY | DISEASE PROGRESSION | Severity of Illness Index | Spastic Paraplegia, Hereditary - genetics | Cross-Sectional Studies | Humans | Middle Aged | Male | Germany - epidemiology | Pedigree | Adult | Female | Aged | Spastic Paraplegia, Hereditary - epidemiology | Spastic Paraplegia, Hereditary - physiopathology | Studies | Paralysis | Index Medicus
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12. Full Text Autosomal recessive hereditary spastic paraplegia—clinical and genetic characteristics of a well-defined cohort
by Yoon, G and Baskin, B and Tarnopolsky, M and Boycott, K M and Geraghty, M T and Sell, E and Goobie, S and Meschino, W and Banwell, B and Ray, P N and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik and Uppsala universitet
neurogenetics, ISSN 1364-6745, 11/2013, Volume 14, Issue 3, pp. 181 - 188
We describe the clinical and genetic features of a well-characterized cohort of patients with autosomal recessive hereditary spastic paraplegia (ARHSP) in the... 
Human Genetics | Neurosciences | Biomedicine | Ataxia | Genetics | Molecular Medicine | Spastic paraplegia | FREQUENT | SPG11 MUTATIONS | SPATACSIN | CYP7B1 | CLINICAL NEUROLOGY | KJELLIN-SYNDROME | DEGENERATION | GENETICS & HEREDITY | SPECTRUM | THIN CORPUS-CALLOSUM | Spastic Paraplegia, Hereditary - genetics | Genome-Wide Association Study | Spastic Paraplegia, Hereditary - diagnosis | Humans | Middle Aged | Male | Young Adult | Adolescent | Adult | Female | Aged | Spastic Paraplegia, Hereditary - pathology | Mutation | Child | Pyramidal Tracts - pathology | Cohort Studies | Genotype & phenotype | Genetic disorders | Paralysis | Index Medicus | Genetik | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
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13. Full Text New hypothesis for the etiology of SPAST‐based hereditary spastic paraplegia
by Qiang, Liang and Piermarini, Emanuela and Baas, Peter W
Cytoskeleton, ISSN 1949-3584, 04/2019, Volume 76, Issue 4, pp. 289 - 297
Mutations of the SPAST gene are the chief cause of hereditary spastic paraplegia. Controversy exists in the medical community as to whether the etiology of the... 
microtubule | gain‐of‐function | spastin | haploinsufficiency | HSP‐SPG4 | SPAST | hereditary spastic paraplegia | DEFECTS | MECHANISM | AXONAL-TRANSPORT | PHENOTYPES | MODEL | HSP-SPG4 | SPG4 | CELL BIOLOGY | RESCUE | gain-of-function | GENE DOSAGE | MUTATIONS | EXPRESSION | Hereditary spastic paraplegia | Proteins | Paraplegia | Animal models | Etiology | Paralysis | Pyramidal tracts | Mutation | Spastic paraplegia | Haploinsufficiency
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14. Full Text PMCA4 (ATP2B4) mutation in familial spastic paraplegia
by Li, Miaoxin and Ho, Philip Wing-Lok and Pang, Shirley Yin-Yu and Tse, Zero Ho-Man and Kung, Michelle Hiu-Wai and Sham, Pak-Chung and Ho, Shu-Leong
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e104790 - e104790
Familial spastic paraplegia (FSP) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness. More than 50... 
FRAMEWORK | DISEASES | MULTIDISCIPLINARY SCIENCES | LIPID RAFTS | CALCIUM | Spastic Paraplegia, Hereditary - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Asian Continental Ancestry Group - genetics | Molecular Sequence Data | Sequence Analysis, DNA | Mutation, Missense - genetics | Protein Folding | Exome - genetics | Phenotype | Pedigree | Base Sequence | Models, Genetic | Genes, Dominant - genetics | Genetic aspects | Nucleotide sequencing | Paralysis, Spastic | DNA sequencing | Plasma | Calcium | Computational neuroscience | Pathogenesis | Genes | Homeostasis | Genomes | Ca2+-transporting ATPase | Gene sequencing | Proteins | Signal transduction | Paraplegia | Databases | Missense mutation | Protein folding | Ataxia | Paralysis | Spastic paraplegia | Bioinformatics | Deoxyribonucleic acid--DNA | Calcium homeostasis | Phenotypes | Spasticity | Heredity | Stability analysis | Free energy | Medicine | Studies | Neurology | Neural networks | Computer applications | Predictions | Mutation | Protein interaction | Psychiatry | Protein structure | Index Medicus | Deoxyribonucleic acid | DNA
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15. Full Text Tensor‐based morphometry using scalar and directional information of diffusion tensor MRI data (DTBM): Application to hereditary spastic paraplegia
by Sadeghi, Neda and Arrigoni, Filippo and D'Angelo, Maria Grazia and Thomas, Cibu and Irfanoglu, M. Okan and Hutchinson, Elizabeth B and Nayak, Amritha and Modi, Pooja and Bassi, Maria Teresa and Pierpaoli, Carlo
Human Brain Mapping, ISSN 1065-9471, 12/2018, Volume 39, Issue 12, pp. 4643 - 4651
Tensor‐based morphometry (TBM) performed using T1‐weighted images (T1WIs) is a well‐established method for analyzing local morphological changes occurring in... 
diffusion | deformation‐based morphometry | diffusion tensor MRI | hereditary spastic paraplegia | spastic paraplegia of type 11 | diffusion tensor imaging | DTBM | tensor‐based morphometry | tensor-based morphometry | deformation-based morphometry | WHITE | HUMAN BRAIN | SPG11 MUTATIONS | NEUROSCIENCES | NEUROIMAGING | PARAPARESIS | FEATURES | DIFFEOMORPHIC REGISTRATION | ROBUST ESTIMATION | THIN CORPUS-CALLOSUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | IMAGE REGISTRATION | Medicine, Experimental | Medical research | Magnetic resonance imaging | Anisotropy | Paralysis, Spastic | Attention deficit disorder | Brain | Deformation | Change detection | Information dissemination | Atrophy | Paraplegia | Maps | Pathways | Mathematical analysis | Aging | Paralysis | Spastic paraplegia | Localization | Diffusion | Abnormalities | Data processing | Substantia alba | Patients | Hereditary spastic paraplegia | Tensors | Morphology | Morphometry | Index Medicus
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16. Full Text Hereditary spastic paraplegia‐linked REEP1 modulates endoplasmic reticulum/mitochondria contacts
by Lim, Youngshin and Cho, Il‐Taeg and Schoel, Leah J and Cho, Ginam and Golden, Jeffrey A
Annals of Neurology, ISSN 0364-5134, 11/2015, Volume 78, Issue 5, pp. 679 - 696
ObjectiveMutations in receptor expression enhancing protein 1 (REEP1) are associated with hereditary spastic paraplegias (HSPs). Although axonal degeneration... 
PROTEIN | AXON DEGENERATION | MOUSE MODEL | MITOCHONDRIA | MEMBRANES | RETICULUM | MUTATIONS | SPECTRUM | EXPRESSION | NEUROSCIENCES | CLINICAL NEUROLOGY | Spastic Paraplegia, Hereditary - genetics | Neurites | Endoplasmic Reticulum - genetics | Humans | Nervous System - metabolism | Nerve Degeneration - genetics | Axons - physiology | Mutation - genetics | Cerebral Cortex - cytology | Gene Knockdown Techniques | DNA - genetics | Animals | Mitochondria - genetics | Nervous System - growth & development | Membrane Transport Proteins - genetics | Brain - pathology | Mice | Cerebral Cortex - drug effects | HeLa Cells | Localization | Endoplasmic reticulum | Mitochondria | Index Medicus
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