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2011, Methods in molecular biology, ISBN 1617790346, Volume 720.
Web Resource
Journal Article
Annals of Botany, ISSN 0305-7364, 05/2018, Volume 121, Issue 6, pp. 1243 - 1256
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 21, pp. 9683 - 9692
RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human... 
DRUG | EFLORNITHINE | REPLICATION | VIROLOGY | ALPHA-DIFLUOROMETHYLORNITHINE | DEPLETION | INFECTION | TRANSLATION | MAMMALIAN-CELLS | RESPIRATORY SYNDROME CORONAVIRUS | SPERMIDINE | Zika Virus Infection - drug therapy | Acetyltransferases - metabolism | Ebolavirus - metabolism | Chikungunya virus - metabolism | Humans | Eflornithine - pharmacology | Ebolavirus - drug effects | Zika Virus Infection - virology | Disease Outbreaks | RNA Viruses - drug effects | Hemorrhagic Fever, Ebola - virology | Hemorrhagic Fever, Ebola - drug therapy | Spermine - analogs & derivatives | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Chikungunya Fever - drug therapy | Zika Virus - drug effects | Chikungunya Fever - virology | Polyamines - metabolism | Chikungunya virus - drug effects | Animals | Spermine - pharmacology | Mice | Index Medicus | Spermine/analogs & derivatives | Virus Replication/drug effects | Hemorrhagic Fever, Ebola/virology | Life Sciences | Zika Virus/drug effects | Immunology | Chikungunya virus/metabolism | Chikungunya Fever/drug therapy | Zika Virus Infection/drug therapy | Ebolavirus/drug effects | Acetyltransferases/metabolism | Chikungunya virus/drug effects | Eflornithine/pharmacology | Spermine/pharmacology | Polyamines/metabolism | Chikungunya Fever/virology | Hemorrhagic Fever, Ebola/drug therapy | Virology | Microbiology and Parasitology | Zika Virus Infection/virology | Ebolavirus/metabolism | Antiviral Agents/pharmacology | RNA Viruses/drug effects
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0175917 - e0175917
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert... 
BREAST-CANCER | ANTIZYME INHIBITOR | METABOLISM | OXIDASE | MULTIDISCIPLINARY SCIENCES | SPERMINE | LUNG-CANCER-CELLS | ANALOG PG-11047 | DRUG RESPONSE | SPERMIDINE/SPERMINE N-1-ACETYLTRANSFERASE | DELIVERY | Acetyltransferases - metabolism | Ornithine Decarboxylase - metabolism | Respiratory Mucosa - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Polyamines - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Acetyltransferases - genetics | Prodrugs - metabolism | Drug Carriers | Respiratory Mucosa - pathology | Biotransformation | Antineoplastic Agents - pharmacology | Spermine - analogs & derivatives | Ornithine Decarboxylase - genetics | Cell Survival - drug effects | Spermine - chemical synthesis | Oxidoreductases Acting on CH-NH Group Donors - genetics | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Hydrogen Peroxide - metabolism | Polyamines - metabolism | Spermine - pharmacology | Tumor Burden - drug effects | Spermine - metabolism | Cell Line, Tumor | Nanostructures - chemistry | Prodrugs - chemical synthesis | Cell Proliferation - drug effects | Respiratory Mucosa - metabolism | Prodrugs - pharmacology | Enzyme inhibitors | Research | Polyamines | Health aspects | Lung cancer | Cell lines | Drugs | Enzymes | Clinical trials | Amino acids | Biosynthesis | Gene expression | Metabolism | Anticancer properties | Proteins | Cell growth | Lymphomas | Pharmaceutical sciences | Oncogenes | Cancer | Pharmaceuticals | Tumors | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 7, pp. 558 - 566
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop... 
LAPATINIB | OVEREXPRESSION | TYROSINE-PHOSPHATASE 1B | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BINDING-SITE | MECHANISMS | INDUCTION | HUMAN BREAST-CANCER | CONTRIBUTES | TUMORS | Receptor, ErbB-2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - enzymology | Protein Binding - drug effects | Mammary Neoplasms, Experimental - pathology | Female | Antineoplastic Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Mammary Neoplasms, Experimental - enzymology | Spermine - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Signal Transduction | Allosteric Site - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Spermine - chemistry | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Breast Neoplasms - genetics | Spermine - pharmacology | Breast Neoplasms - pathology | Cholestanes - chemistry | Cholestanes - pharmacology | Mice | Kinetics | Breast cancer | Tumorigenesis | Diabetes | Drug therapy | Index Medicus | Cholestanes | Allosteric Regulation | Breast Neoplasms | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Antineoplastic Agents | Spermine | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Mammary Neoplasms, Experimental | Allosteric Site | Protein Binding | Receptor, ErbB-2
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1257 - 15
Polyamines are tightly regulated polycations that are essential for life. Loss-of-function mutations in spermine synthase (SMS), a polyamine biosynthesis... 
STORAGE | MENTAL-RETARDATION | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | MISSENSE MUTATION | ALDEHYDE LOAD | POLYAMINE CATABOLISM | AUTOPHAGY | CEREBRAL-ISCHEMIA | MOUSE MODELS | BRAIN | Reactive Oxygen Species - metabolism | Humans | Spermidine - metabolism | Electron Transport Complex IV - metabolism | Brain - metabolism | Retinal Neurons - ultrastructure | Mental Retardation, X-Linked - genetics | Spermine Synthase - metabolism | Lysosomes - metabolism | Brain - ultrastructure | Spermine Synthase - deficiency | Autophagy - genetics | Retinal Neurons - drug effects | Disease Models, Animal | Electroretinography | Microscopy, Electron, Transmission | Synapses - drug effects | Animals, Genetically Modified | Oxidative Stress - genetics | Survival Rate | Synapses - ultrastructure | Antioxidants - pharmacology | Polyamines - metabolism | Brain - drug effects | Animals | Spermine Synthase - genetics | Drosophila Proteins - genetics | Drosophila melanogaster | Mental Retardation, X-Linked - metabolism | Neuropathogenesis | Oxidative stress | Intellectual disabilities | Drosophila | Nervous system | Pharmacology | Biosynthesis | Metabolism | Polyamines | Defects | Neurological diseases | Antioxidants | Mitochondria | Spermine | Metabolites | Insects | Polycations | Spermidine | Spermine synthase | Degeneration | Catabolism | Mutation | Phagocytosis | Therapeutic applications | Autophagy | Index Medicus
Journal Article
Journal Article