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PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10431
... their relevance for pre-clinical drug discovery, disease modeling and basic research. Primary and non-transformed prostate epithelial cells, but also several PrCa lines, formed well... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GENE-EXPRESSION SIGNATURE | STEM-CELLS | MAMMARY EPITHELIA | METASTASIS | BIOLOGY | TUMOR-CELL INVASION | DIFFERENTIATION | CULTURE MODEL | LINES | Laminin - pharmacology | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Spheroids, Cellular - pathology | Male | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - enzymology | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Prostate - pathology | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Prostate - drug effects | Antineoplastic Agents - pharmacology | Collagen - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Principal Component Analysis | Prostatic Neoplasms - drug therapy | Epithelium - drug effects | Prostatic Neoplasms - pathology | Epithelium - pathology | Neoplasm Invasiveness | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Epithelial Cells - pathology | Cell Shape - drug effects | Phenotype | Proteoglycans - pharmacology | Signal Transduction - drug effects | Models, Biological | Prostatic Neoplasms - enzymology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Cell Transformation, Neoplastic - pathology | Mesoderm - pathology | Drug Combinations | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Epigenetic inheritance | Growth | Oncology, Experimental | Genes | Research | Gene expression | Ionizing radiation | Stem cells | Physiological aspects | Models | Drug discovery | Drug therapy | Prostate cancer | Integrins | Cancer | Cell culture | Biotechnology | Transformation | Motility | Leukocyte migration | Mesenchyme | Epithelial cells | Homeostasis | AKT protein | Metastasis | Drug resistance | Tissues | Ovarian cancer | Cell adhesion & migration | Metastases | Rodents | Fibroblasts | Extracellular matrix | Basal lamina | Lipid metabolism | Medical research | Invasiveness | Phenotypic plasticity | Tumor cell lines | Metabolism | Spheroids | 1-Phosphatidylinositol 3-kinase | Signaling | Interferon | Three dimensional models | Prostate | Cell migration
Journal Article
Cell death & disease, ISSN 2041-4889, 2013, Volume 4, Issue 10, pp. e875 - e875
Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this study, we investigated the role and association of... 
BEZ235 | RADIATION SENSITIVITY | IDENTIFICATION | EMT | PI3K/Akt/mTOR | CELL BIOLOGY | CSC | IN-VITRO | radiation therapy | PROTEASOME | RESISTANCE | INHIBITOR | Prostate cancer | radioresistance | Prostatic Neoplasms - radiotherapy | Epithelial-Mesenchymal Transition - radiation effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - radiation effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Radiation Tolerance - radiation effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | Imidazoles - therapeutic use | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasm Invasiveness | Imidazoles - pharmacology | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Radiation Tolerance - drug effects | Phenotype | Animals | Cell Cycle Checkpoints - radiation effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Quinolines - therapeutic use | Neoplastic Stem Cells - enzymology | PI3K | mTOR | Akt | Original
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e24099
...]. The ability of miRNAs to regulate multiple genes conform them to play important roles in biological processes that effect tumor progression including migration, invasion... 
BIOMARKERS | NERVOUS-SYSTEM | APOPTOSIS | TRAIL | SIGNALING PATHWAY | P53 PROTEIN | MULTIDISCIPLINARY SCIENCES | NOTCH | TUMOR-SUPPRESSOR | MICRORNAS | EXPRESSION | Cell Cycle - genetics | Chromatin - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Apoptosis - genetics | Epithelial-Mesenchymal Transition - drug effects | MicroRNAs - metabolism | Epithelial-Mesenchymal Transition - genetics | Pancreatic Neoplasms - drug therapy | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Epigenesis, Genetic - drug effects | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Hydroxamic Acids - pharmacology | Tumor Stem Cell Assay | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Spheroids, Cellular - metabolism | Pancreatic Neoplasms - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Azacitidine - pharmacology | Cell Movement - drug effects | Cell Line, Tumor | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | MicroRNAs - genetics | Cell Cycle - drug effects | Azacitidine - therapeutic use | Prevention | Epigenetic inheritance | Care and treatment | Chemotherapy | Chromatin | Pancreatic cancer | Stem cells | Development and progression | Tumor proteins | Cancer | Apoptosis | Bcl-2 protein | p53 Protein | Metastasis | Caspase-3 | Cancer therapies | Toxicology | Scholarships & fellowships | Cell growth | N-Cadherin | Restoration | Physiology | Tumorigenesis | Inhibition | Gene expression | SIRT1 protein | Pathology | Biomarkers | Notch protein | Mutation | Cell proliferation | Azacytidine | Histone deacetylase | Transcription | Mesenchyme | Laboratories | Leukemia | Gene regulation | Multiple myeloma | E-cadherin | Modulators | Cell cycle | miRNA | Inducers | Departments | Caspase | Pharmacology | Breast cancer | Tumor cell lines | Ribonucleic acid--RNA | Medicine | Cyclin-dependent kinase inhibitor p21 | Medical prognosis | Reagents | Epigenetics | Cyclin-dependent kinase inhibitor p27 | Prostate cancer | RNA | Ribonucleic acid
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 36, pp. 9685 - 9695
... with spatial-temporally defined features and properties to control cellular activities, such as spreading, migration, and differentiation [5–7]. PEG diacrylate (PEGDA... 
Advanced Basic Science | Dentistry | Degradation | Hydrogel | Photopolymerization | Type 1 diabetes | CHYMOTRYPSIN | MATERIALS SCIENCE, BIOMATERIALS | ISLETS | ENGINEERING, BIOMEDICAL | PROTEIN-KINASE | NETWORK STRUCTURE | TRANSPLANTATION | IN-VITRO | HMSC VIABILITY | POLY(ETHYLENE GLYCOL) HYDROGELS | PANCREATIC BETA-CELLS | Cells, Immobilized - radiation effects | Chymotrypsin - metabolism | Cell Count | Cross-Linking Reagents - pharmacology | Biophysical Phenomena - drug effects | Elastic Modulus - drug effects | Polyethylene Glycols - chemistry | Hydrogels - chemical synthesis | Spheroids, Cellular - radiation effects | Spheroids, Cellular - cytology | Cells, Immobilized - drug effects | Polymerization - drug effects | Light | Sulfhydryl Compounds - chemistry | Insulin-Secreting Cells - cytology | Spheroids, Cellular - drug effects | Cell Survival - drug effects | Polymerization - radiation effects | Click Chemistry - methods | Sulfhydryl Compounds - chemical synthesis | Cell Survival - radiation effects | Cells, Immobilized - cytology | Biophysical Phenomena - radiation effects | Elastic Modulus - radiation effects | Animals | Insulin-Secreting Cells - drug effects | Cell Proliferation - drug effects | Mice | Hydrogels - pharmacology | Hydrogels - chemistry | Cell Proliferation - radiation effects | Insulin-Secreting Cells - radiation effects | Enzymes | Ethylene glycol | Pancreatic beta cells | Biological products | Polymerization | Permeability | Glucose | Dextrose | Beta cells | photopolymerization | type 1 diabetes | degradation
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18784
Background: The aggressiveness of melanoma tumors is likely to rely on their well-recognized heterogeneity and plasticity. Melanoma comprises... 
INITIATING CELLS | IN-VITRO | ACTIVATION | METASTASIS | MULTIDISCIPLINARY SCIENCES | B-16 MELANOMA | PHENOTYPE | LIGAND | EXPRESSION | CANCER STEM-CELLS | MHC CLASS-II | Embryonic Stem Cells - metabolism | Immunomodulation - drug effects | Transcription, Genetic - drug effects | Neoplastic Stem Cells - drug effects | Genes, Neoplasm | Humans | Neural Crest - pathology | Spheroids, Cellular - pathology | Gene Expression Profiling | Cell Lineage - drug effects | Neural Crest - metabolism | Neoplastic Stem Cells - metabolism | Melanoma - genetics | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Neoplasm Invasiveness | Spheroids, Cellular - metabolism | Melanoma - pathology | Neural Crest - drug effects | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Movement - drug effects | Phenotype | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Melanoma - immunology | Pluripotent Stem Cells - drug effects | Culture Media - pharmacology | Cell Proliferation - drug effects | Metastasis | T cells | Gene expression | Analysis | Stem cells | Cancer | Cell proliferation | Transcription factors | Mesenchyme | Oct-4 protein | Lymphocytes T | Activation | Assaying | Immunity | Metastases | Skin cancer | Heterogeneity | Genotype & phenotype | Cell activation | KLF4 protein | Lymphocytes | Mathematical models | Immune system | Subpopulations | Antigens | Aggressive behavior | Cytokines | Immunomodulation | Tumor cells | Invasiveness | Melanoma | Tumorigenicity | Neural crest | Embryos | Spheroids | Studies | Ligands | Prostate cancer | Cell migration | Chemokines | Tumors | Apoptosis | Cell Proliferation | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells | Cellular Biology | Neural Crest | Life Sciences | Cell Lineage | Pluripotent Stem Cells | Culture Media | Transcription, Genetic | Cell Differentiation | Transcription Factors | Embryonic Stem Cells | Spheroids, Cellular | Cell Movement
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 3390 - 18
...). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs... 
ASSEMBLED GOLD NANOPARTICLES | HSP47 SIRNA | IN-VITRO | RETINOIC ACID | COLLAGEN-SPECIFIC CHAPERONE | DUCTAL ADENOCARCINOMA | A-COUPLED LIPOSOMES | MULTIDISCIPLINARY SCIENCES | EXTRACELLULAR-MATRIX | SIRNA DELIVERY | CANCER MODEL | Gene Silencing - drug effects | Stromal Cells - pathology | Humans | Pancreatic Stellate Cells - drug effects | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Homeostasis | Polyethylene Glycols - chemistry | Polyethyleneimine - chemistry | Stromal Cells - drug effects | Female | Spheroids, Cellular - drug effects | Tretinoin - pharmacokinetics | Pancreatic Stellate Cells - pathology | Metal Nanoparticles - ultrastructure | Tretinoin - pharmacology | Gold - chemistry | Tumor Microenvironment - drug effects | Tissue Distribution - drug effects | Endocytosis - drug effects | Extracellular Matrix - drug effects | Metal Nanoparticles - chemistry | Pancreatic Neoplasms - pathology | Spheroids, Cellular - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Mice, Inbred BALB C | Cell Cycle - drug effects | Hydrogen-Ion Concentration | Pancreatic Stellate Cells - metabolism | RNA, Small Interfering - metabolism | Adenocarcinoma | Polyethyleneimine | Gold | Stellate cells | Drug delivery systems | Hyperplasia | Heat shock proteins | Recovery of function | siRNA | Drug delivery | Cobalt | Anticancer properties | Nanoparticles | Proteins | Chemotherapy | Stromal cells | Collagen | Extracellular matrix | Pancreas | Retinoic acid | Tumors | Heat shock
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2018, Volume 215, Issue 7, pp. 1891 - 1912
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2012, Volume 181, Issue 6, pp. 2188 - 2201
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 8, p. e43726
... with other cellular features of tumor aggressiveness would be invaluable for developing newer targeted therapy for solid tumors... 
BREAST-CANCER | LUNG-CANCER | STEM-CELLS | PROGNOSTIC-FACTOR | TUMOR HYPOXIA | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | ANALOG CDF | DRUG-RESISTANCE | MICRORNAS | INTERLEUKIN-6 | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A - biosynthesis | Curcumin - analogs & derivatives | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | 3' Untranslated Regions - genetics | Male | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - metabolism | Epithelial Cell Adhesion Molecule | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hyaluronan Receptors - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Interleukin-6 - metabolism | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Rabbits | Cell Hypoxia - drug effects | Cell Dedifferentiation - drug effects | Neoplasm Invasiveness | Spheroids, Cellular - metabolism | Curcumin - pharmacology | Antineoplastic Agents - chemistry | Cell Adhesion Molecules - metabolism | Cell Movement - drug effects | Animals | Endothelial Cells - cytology | Cell Line, Tumor | Interleukin-6 - biosynthesis | Endothelial Cells - drug effects | Complications and side effects | MicroRNA | Physiological aspects | Development and progression | Hypoxia | Genetic aspects | Research | Vascular endothelial growth factor | Prostate cancer | Cell culture | Deregulation | Mesenchyme | Oct-4 protein | Lung cancer | Radiation | Carbon dioxide | Metastasis | Drug resistance | Cancer therapies | Anticancer properties | Interleukin 6 | Angiogenesis | Antitumor agents | Pathways | miRNA | Curcumin | Cytokines | Breast cancer | Radiation therapy | Gene expression | Studies | Pathology | Signaling | Chemotherapy | MicroRNAs | Medical prognosis | Pancreatic cancer | Stem cells | Radiation tolerance | Solid tumors | Prostate | Cell migration | Tumors | Cancer | Apoptosis
Journal Article