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P L o S Genetics (Print), ISSN 1553-7390, 10/2009, Volume 5, Issue 10, pp. e1000672 - e1000672
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 08/2017, Volume 77, Issue 2, pp. 268 - 273.e6
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2016, Volume 12, Issue 7, pp. e1006160 - e1006160
While most yeast enzymes for the biosynthesis of glycerophospholipids, sphingolipids and ergosterol are known, genes for several postulated transporters... 
CELL-WALL | HEDGEHOG ACYLTRANSFERASE | CHAIN FATTY-ACIDS | GENETIC INTERACTION MAP | GENETICS & HEREDITY | BOUND O-ACYLTRANSFERASES | ENDOPLASMIC-RETICULUM | GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE | PLASMA-MEMBRANE | RAFT ASSOCIATION | GPI-ANCHORED PROTEINS | Ergosterol - genetics | Ergosterol - metabolism | Saccharomyces cerevisiae - genetics | Glycosylphosphatidylinositols - genetics | Saccharomyces cerevisiae - metabolism | Fatty Acids - genetics | Membrane Transport Proteins - genetics | Lipid Metabolism - genetics | Membrane Transport Proteins - metabolism | Phosphatidylinositols - metabolism | Fatty Acids - metabolism | Chromosome Deletion | Phosphatidylinositols - genetics | Amino Acid Sequence | Ceramides - metabolism | Membrane Proteins - genetics | Mutant Proteins - genetics | Cell Wall - genetics | Sphingolipids - metabolism | Saccharomyces cerevisiae Proteins - genetics | Ceramides - genetics | Sphingolipids - genetics | Glycosylphosphatidylinositols - metabolism | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Crosses, Genetic | Physiological aspects | Genetic aspects | Lipid metabolism | Brewer's yeast | Gene expression | Observations | Mitogen-activated protein kinases | Proteins | Enzymes | Membranes | Maps | Biomedical research | Sterols | Genes | Glycerol | Lipids | Biosynthesis | Mutation | Metabolism | Index Medicus
Journal Article
Journal Article
Annual Review of Genomics and Human Genetics, ISSN 1527-8204, 8/2014, Volume 15, Issue 1, pp. 173 - 194
Cholesterol plays a key role in many cellular processes, and is generated by cells through de novo biosynthesis or acquired from exogenous sources through the... 
Tangier disease | cholesterol | Smith-Lemli-Opitz syndrome | Niemann-Pick disease type C | sphingolipids | CELLULAR CHOLESTEROL | LEMLI-OPITZ-SYNDROME | LOW-DENSITY-LIPOPROTEIN | LYSOSOMAL STORAGE | SUBSTRATE REDUCTION THERAPY | N-BUTYLDEOXYNOJIRIMYCIN | TANGIER-DISEASE | MOUSE MODEL | GENETICS & HEREDITY | ABCA1-DEPENDENT LIPID EFFLUX | CENTRAL-NERVOUS-SYSTEM | Abnormalities, Multiple - pathology | Limb Deformities, Congenital - genetics | Osteochondrodysplasias - pathology | Lipid Metabolism, Inborn Errors - genetics | Humans | Ichthyosiform Erythroderma, Congenital - pathology | Homeostasis | Steroid Metabolism, Inborn Errors - pathology | Lipoproteins, LDL - genetics | Cholesterol - genetics | Oxidoreductases Acting on CH-CH Group Donors - deficiency | Osteochondrodysplasias - genetics | Lipid Metabolism, Inborn Errors - pathology | Genetic Diseases, X-Linked - genetics | Oxidoreductases Acting on CH-CH Group Donors - genetics | Lipoproteins, LDL - metabolism | Abnormalities, Multiple - genetics | Steroid Metabolism, Inborn Errors - genetics | Antley-Bixler Syndrome Phenotype - genetics | Chondrodysplasia Punctata - genetics | Cholesterol - metabolism | Chondrodysplasia Punctata - pathology | Antley-Bixler Syndrome Phenotype - pathology | Genetic Diseases, X-Linked - pathology | Cholesterol - biosynthesis | Ichthyosiform Erythroderma, Congenital - genetics | Limb Deformities, Congenital - pathology | Genetic research | Metabolic diseases | Genetic aspects | Research | Gene expression | Cholesterol metabolism | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 6/2013, Volume 162, Issue 2, pp. 567 - 580
Very-long-chain fatty acids (VLCFAs) with chain lengths from 20 to 34 carbons are involved in diverse biological functions such as membrane constituents, a... 
Epicuticular wax | Plant roots | Lipids | Sphingolipids | Biosynthesis | Complementation | Plants | Waxes | BIOCHEMISTRY AND METABOLISM | Fatty acids | Plant cells | SECONDARY ALCOHOLS | ABC TRANSPORTER | COA REDUCTASE | PLANT TRANSFORMATION | BRASSICA-NAPUS | ALKANE BIOSYNTHESIS | GENE FAMILY | CONDENSING ENZYME | ACYL-COENZYME | SACCHAROMYCES-CEREVISIAE | PLANT SCIENCES | Sphingolipids - biosynthesis | Acetyltransferases - metabolism | Arabidopsis - enzymology | Endoplasmic Reticulum - metabolism | Plant Roots - genetics | Lipids - biosynthesis | Phylogeny | Acetyltransferases - genetics | Genetic Complementation Test | Plant Stems - genetics | Arabidopsis Proteins - metabolism | Plants, Genetically Modified | Gene Expression Regulation, Plant | Phospholipids - metabolism | Plant Leaves - enzymology | Acyl Coenzyme A - metabolism | Fatty Acids - metabolism | 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - genetics | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Seeds - metabolism | Endoplasmic Reticulum - genetics | Seeds - genetics | Bacterial Proteins - genetics | Waxes - metabolism | Gene Knockout Techniques | Phospholipids - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Sequence Homology, Amino Acid | Plant Leaves - genetics | Plant Stems - metabolism | Membrane Lipids - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mutation | 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - metabolism | Luminescent Proteins - metabolism | Arabidopsis thaliana | Physiological aspects | Eicosanoic acid | Research | Lipid metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, pp. e0200739 - e0200739
Sphingolipids are bioactive molecules associated with oxidative stress, inflammation, and neurodegenerative diseases, but poorly studied in the context of... 
CHOLESTEROL-METABOLISM | COMPLEMENT FACTOR-H | OXIDATIVE STRESS | PLASMA CERAMIDES | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | DENSITY-LIPOPROTEIN | STRESS-INDUCED APOPTOSIS | CARDIOVASCULAR-DISEASE | TANDEM MASS-SPECTROMETRY | GENOME-WIDE ASSOCIATION | Cell Line | Choroidal Neovascularization - diagnosis | Ceramides - metabolism | Membrane Proteins - genetics | Down-Regulation | Humans | Middle Aged | Risk Factors | Complement C3b Inactivator Proteins - genetics | Ceramides - blood | Macular Degeneration - diagnosis | Genetic Variation | Macular Degeneration - genetics | Sphingosine N-Acyltransferase - genetics | Tumor Suppressor Proteins - genetics | Sphingomyelins - blood | Aged, 80 and over | Aged | Polymorphism, Single Nucleotide | Complement Factor H - genetics | Choroidal Neovascularization - genetics | Glucosyltransferases - genetics | Protein Isoforms - genetics | Macular degeneration | Medical research | Nervous system diseases | Physiological aspects | Medicine, Experimental | Lipids | Neovascularization | Gene expression | Risk factors | Diabetic retinopathy | Disease | Cognitive ability | Retina | Protein turnover | Vascularization | Proteins | Neurodegeneration | Ceramide | Aging | Genetics | Sensitivity analysis | Splicing | Neurodegenerative diseases | Metabolism | Risk analysis | Patients | Fatty acids | Malondialdehyde | Neurological diseases | Serum levels | Genetic variance | FHL-1 protein | Oxidative stress | Plasma | Alternative splicing | Genes | Biology | Sphingolipids | Infections | Autophagy | Acetaldehyde | Ceramide glucosyltransferase | Atrophy | Complement factor H | Genetic analysis | Oxidation | Degeneration | Age | Glucosyltransferase | Adducts | Triglycerides | Inflammation | Cholesterol | Lipoproteins | Natural products | Diabetes | Apoptosis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19399 - 19409
Sphingolipid metabolites, such as ceramide (Cer), sphingosine (SPH), and sphingosine 1-phosphate (S1P), contribute to multiple aspects of carcinogenesis... 
SPHINGOLIPID METABOLISM | SIGNALING PATHWAYS | PROTEIN-COUPLED RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | IN-VIVO | SOY PHYTOESTROGEN GENISTEIN | SPHINGOSINE KINASE | UP-REGULATION | TUMOR-GROWTH | ESTROGEN-RECEPTOR | Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Receptors, G-Protein-Coupled - metabolism | src-Family Kinases | Protein-Tyrosine Kinases - metabolism | Humans | Acid Ceramidase - biosynthesis | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Protein-Tyrosine Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Anticarcinogenic Agents - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins - metabolism | Acid Ceramidase - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Receptors, Estrogen | Proto-Oncogene Proteins - genetics | Sphingolipids - metabolism | Signal Transduction - genetics | Acetylation - drug effects | Breast Neoplasms - genetics | Histones - genetics | Sphingolipids - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Gene Expression Regulation, Enzymologic - genetics | Genistein - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Receptors, G-Protein-Coupled - genetics | Histones - metabolism | Transcription, Genetic - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Gene Regulation | Signal Transduction | GPR-30 | Estrogen Receptor | Genistein | Sphingolipid | Steroid Hormone Receptor | Acid Ceramidase | Breast Cancer
Journal Article