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1. Full Text Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages
by Traini, Mathew and Quinn, Carmel M and Sandoval, Cecilia and Johansson, Erik and Schroder, Kate and Kockx, Maaike and Meikle, Peter J and Jessup, Wendy and Kritharides, Leonard
The Journal of biological chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 47, pp. 32895 - 32913
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Sphingomyelin Phosphodiesterase - genetics | Cricetulus | Oligonucleotide Array Sequence Analysis | Humans | Orphan Nuclear Receptors - metabolism | Foam Cells - drug effects | RNA Interference | Liver X Receptors | Sphingomyelin Phosphodiesterase - metabolism | HEK293 Cells | Nucleotides - pharmacology | Foam Cells - metabolism | CHO Cells | Cricetinae | Phosphoric Diester Hydrolases - metabolism | Cells, Cultured | Phosphoric Diester Hydrolases - genetics | Transcriptome - drug effects | Transcriptome - genetics | Cholesterol - metabolism | Nucleotides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cyclic AMP - pharmacology | Microscopy, Confocal | Macrophages - metabolism | Animals | Cell Line, Tumor | Cholesterol - pharmacology | Golgi Apparatus - metabolism | Macrophages - drug effects | Sphingomyelin Phosphodiesterase - blood | Index Medicus | Enzymology | Metalloenzyme | Phosphodiesterases | Cholesterol | Atherosclerosis | Macrophage
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2. Full Text Sphingomyelinase‐like phosphodiesterase 3b mediates radiation‐induced damage of renal podocytes
by Ahmad, Anis and Mitrofanova, Alla and Bielawski, Jacek and Yang, Yidong and Marples, Brian and Fornoni, Alessia and Zeidan, Youssef H
The FASEB journal, ISSN 0892-6638, 02/2017, Volume 31, Issue 2, pp. 771 - 780
lipids | ceramide | radioprotection | cancer | Ceramide | Lipids | Radioprotection | Cancer | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sphingomyelin Phosphodiesterase - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Ceramides - metabolism | Podocytes - metabolism | Down-Regulation | Humans | Mice, Inbred C57BL | Immunologic Factors - administration & dosage | Gene Expression Regulation, Enzymologic | Rituximab - administration & dosage | Rituximab - pharmacology | Animals | Podocytes - radiation effects | Sphingomyelin Phosphodiesterase - metabolism | Mice | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Immunologic Factors - pharmacology | Phosphates | Change detection | Pathogenesis | Radiation | Sphingolipids | Remodeling | Caspase-3 | Cytosol | Sphingosine 1-phosphate | Actin | Radiation injuries | Pretreatment | Phosphodiesterase | Radiation effects | Kidneys | Ezrin | Rituximab | Caspase | Pseudopodia | Radiation dosage | Sphingomyelin phosphodiesterase | Molecular modelling | Nephropathy | CD20 antigen | Irradiation | Cytoskeleton | Radiation damage | Proteinuria | Index Medicus | Research
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3. Full Text The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a – an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity
by Lim, Sing Mei and Yeung, Kit and Trésaugues, Lionel and Ling, Teo Hsiang and Nordlund, Pär
The FEBS journal, ISSN 1742-464X, 03/2016, Volume 283, Issue 6, pp. 1107 - 1123
calcineurin‐like phosphodiesterase | binuclear metallophosphodiesterase | acid sphingomyelinase like | Niemann–Pick disease | nucleotide hydrolase | Niemann-Pick disease | Nucleotide hydrolase | Binuclear metallophosphodiesterase | Acid sphingomyelinase like | Calcineurin-like phosphodiesterase | calcineurin-like phosphodiesterase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytidine Monophosphate - metabolism | Sphingomyelin Phosphodiesterase - genetics | Zinc - metabolism | Humans | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Phylogeny | Disulfides - chemistry | Sphingomyelin Phosphodiesterase - metabolism | Niemann-Pick Diseases - enzymology | Conserved Sequence | Niemann-Pick Diseases - genetics | Amino Acid Sequence | Catalytic Domain | Sphingomyelin Phosphodiesterase - chemistry | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Glycosylation | Static Electricity | Sequence Homology, Amino Acid | Point Mutation | Mutant Proteins - chemistry | Protein Conformation | Enzymes | Hydrolases | Phospholipids | Nucleotides | Analysis | Lipids | Genetic disorders | Molecular biology | Index Medicus
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4. Full Text Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis)
by Han, Lei and Ding, Guiling and Liu, Yanjie and Huang, Jiaxing and Wu, Jie
Journal of insect science (Tucson, Ariz.), ISSN 1536-2442, 09/2018, Volume 18, Issue 5
Life Sciences & Biomedicine | Entomology | Science & Technology | Amino Acid Sequence | Sphingomyelin Phosphodiesterase - genetics | Sphingomyelin Phosphodiesterase - chemistry | Molecular Conformation | Insect Proteins - genetics | Gene Expression Profiling | Phylogeny | Bees | Reproduction | Animals | Gene Expression Regulation, Developmental | Insect Proteins - chemistry | Sphingomyelin Phosphodiesterase - metabolism | Insect Proteins - metabolism | Physiological aspects | Enzymes | Bumblebees | Gene expression | Genetic regulation | Analysis | Index Medicus
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5. Full Text Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid‐like 3B
by Liu, Binggang and Xiao, Juan and Dong, Mingjun and Qiu, Zhidong and Jin, Junfei
Cancer science, ISSN 1347-9032, 07/2020, Volume 111, Issue 7, pp. 2259 - 2274
migration | invasion | proliferation | alkaline ceramidase 2 | sphingomyelin phosphodiesterase acid‐like 3B | hepatocellular carcinoma | Life Sciences & Biomedicine | Oncology | Science & Technology | Medical research | Enzymes | Membranes | Cell survival | Statistical analysis | Therapeutic applications | Antibodies | Hepatocellular carcinoma | Metastasis | Metabolism | Gene expression | Ceramidase | Experiments | Sphingomyelin phosphodiesterase | Cell adhesion & migration | Hydrolysis | Proteins | Liver cancer | Cell growth | Plasmids | Ceramide | Cell migration | Phosphodiesterase | Tumors | Index Medicus | Original
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6. Full Text Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin
by Shi, Yu and Lin, Peng and Wang, Xiaoning and Zou, Guangmei and Li, Kefeng
Biochemical and biophysical research communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 2, pp. 637 - 643
Myocardial infarction | Cardiac fibrosis | Lipidomics | Astaxanthin | SMPD1 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Mice, Inbred C57BL | Male | Myocardium - pathology | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Xanthophylls - therapeutic use | Cardiotonic Agents - therapeutic use | Animals | Myocardial Infarction - drug therapy | Signal Transduction - drug effects | Fibrinolytic Agents - therapeutic use | Myocardial Infarction - pathology | Myocardium - metabolism | Sphingomyelin Phosphodiesterase - metabolism | Fibrosis | Heart - drug effects | Xanthophylls - pharmacology | Molecular Docking Simulation | Medical colleges | Enzymes | Phospholipids | Transforming growth factors | Heart attack | Antioxidants | Collagen | Analysis | Physiological aspects | Ceramides | Bone morphogenetic proteins | Cardiology | Index Medicus
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7. Full Text A deletion in the gene encoding sphingomyelin phosphodiesterase 3 ( Smpd3 ) results in osteogenesis and dentinogenesis imperfecta in the mouse
by Goldberg, Michel and Poirier, Christophe and Auge, Nathalie and Guénet, Jean-Louis and Opsahl, Sibylle and Aubin, Isabelle and Negre-Salvayre, Anne and Adams, Carolyn P and Bishop, Colin E and Septier, Dominique and Salvayre, Robert
Nature genetics, ISSN 1061-4036, 08/2005, Volume 37, Issue 8, pp. 803 - 805
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Animals | Sphingomyelin Phosphodiesterase | Mice, Mutant Strains | Gene Deletion | Osteogenesis Imperfecta - genetics | Dentinogenesis Imperfecta - enzymology | Mice | Mutation | Osteogenesis Imperfecta - enzymology | Dentinogenesis Imperfecta - genetics | Complications and side effects | Gene mutations | Osteogenesis imperfecta | Physiological aspects | Genetic aspects | Diagnosis | Research | Phosphodiesterases | Risk factors | Index Medicus
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8. Full Text Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells
by Miyauchi, S and Kitagaki, J and Masumoto, R and Imai, A and Kobayashi, K and Nakaya, A and Kawai, S and Fujihara, C and Asano, Y and Yamashita, M and Yanagita, M and Yamada, S and Kitamura, M and Murakami, S
Journal of dental research, ISSN 0022-0345, 3/2017, Volume 96, Issue 3, pp. 339 - 346
molecular biology | aggressive periodontitis | cell biology | calcification | single nucleotide polymorphism | genome-wide association study | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Aggressive Periodontitis - enzymology | Cell Line | Sphingomyelin Phosphodiesterase - genetics | Gene Expression | Genome-Wide Association Study | Collagen Type I - metabolism | Osteocalcin - metabolism | Humans | Japan | Alkaline Phosphatase - metabolism | Cells, Cultured | Immunoblotting | Male | Osteopontin - metabolism | Aggressive Periodontitis - genetics | Periodontal Ligament - cytology | Phenotype | Calcification, Physiologic | Adult | Female | Cell Differentiation | Polymorphism, Single Nucleotide | Sphingomyelin Phosphodiesterase - physiology | Real-Time Polymerase Chain Reaction | Alkaline phosphatase | Collagen (type I) | Homeostasis | Genomes | Single-nucleotide polymorphism | Gene polymorphism | Dwarfism | Periodontal ligament | Odontoblasts | Transgenic animals | Mineralization | Population | Bones | Phosphodiesterase | Cbfa-1 protein | Data analysis | Osteocalcin | Teeth | Alveolar bone | Osteopontin | Gene expression | Sphingomyelin phosphodiesterase | Genetic variance | Periodontitis | Calcification | Index Medicus | Dentistry
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9. Full Text Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis
by Kumazoe, Motofumi and Kim, Yoonhee and Bae, Jaehoon and Takai, Mika and Murata, Motoki and Suemasu, Yumi and Sugihara, Kaori and Yamashita, Shuya and Tsukamoto, Shuntaro and Huang, Yuhui and Nakahara, Kanami and Yamada, Koji and Tachibana, Hirofumi
FEBS letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 18, pp. 3052 - 3057
Laminin receptor | cGMP | Epigallocatechin-3-O-gallate | Acute myeloid leukemia | Acid sphingomyelinase | Apoptosis | AML | acid sphingomyelinase | EGCG | (−)-epigallocatechin-3-O-gallate | PDE | acute myeloid leukemia | 67-kDa laminin receptor | ASM | phosphodiesterase | 67LR | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptors, Laminin - metabolism | Sphingomyelin Phosphodiesterase - genetics | Receptors, Laminin - agonists | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Receptors, Laminin - genetics | Sphingomyelin Phosphodiesterase - metabolism | Oncogene Protein v-akt - genetics | Leukemia, Myeloid, Acute - drug therapy | Nitric Oxide Synthase Type III - metabolism | Catechin - pharmacology | Oncogene Protein v-akt - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Gene Expression Regulation, Leukemic - drug effects | Enzyme Activation - drug effects | Nitric Oxide Synthase Type III - genetics | Drug Synergism | Cyclic GMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | HL-60 Cells | Catechin - analogs & derivatives | Primary Cell Culture | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Catechin | Laminin | Antineoplastic agents | Index Medicus
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10. Full Text Biochemical and Molecular Characterization of a Novel Choline-specific Glycerophosphodiester Phosphodiesterase Belonging to the Nucleotide Pyrophosphatase/Phosphodiesterase Family
by Hideki Sakagami and Junken Aoki and Yumiko Natori and Kiyotaka Nishikawa and Yoshiyuki Kakehi and Yasuhiro Natori and Hiroyuki Arai
The Journal of biological chemistry, ISSN 0021-9258, 06/2005, Volume 280, Issue 24, pp. 23084 - 23093
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Immunohistochemistry | Models, Chemical | Humans | Kidney - enzymology | Brain - enzymology | Phosphorylcholine - analogs & derivatives | Phylogeny | RNA, Messenger - metabolism | Tissue Distribution | Glycerylphosphorylcholine - chemistry | Time Factors | Swine | Base Sequence | Cell Membrane - metabolism | Antibodies, Monoclonal - chemistry | Amino Acid Sequence | Fatty Acids - chemistry | Sphingomyelin Phosphodiesterase - chemistry | Recombinant Proteins - chemistry | Type C Phospholipases - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Blotting, Western | Pyrophosphatases - metabolism | Sphingosine - analogs & derivatives | Models, Biological | Phosphorylcholine - chemistry | Mice | HeLa Cells | Kinetics | Nephrons - metabolism | Sphingosine - chemistry | Cell Movement | Species Specificity | Molecular Sequence Data | Transfection | Sphingomyelin Phosphodiesterase - metabolism | Phospholipids - metabolism | Sphingomyelin Phosphodiesterase - physiology | Protein Structure, Tertiary | Lysophosphatidylcholines - metabolism | Pyrophosphatases - chemistry | Hydrolysis | Sequence Homology, Amino Acid | Phosphoric Diester Hydrolases | Blotting, Northern | Myocardium - enzymology | Animals | Protein Binding | Cations | Lysophosphatidylcholines - chemistry | Microscopy, Fluorescence | Index Medicus
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