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British journal of pharmacology, ISSN 0007-1188, 11/2009, Volume 158, Issue 5, pp. 1173 - 1182
FTY720 (fingolimod) is a first-in-class sphingosine 1-phosphate (S1P) receptor modulator that was highly effective in Phase II clinical trials for Multiple... 
Multiple Sclerosis | infection | FTY720 (fingolimod) | S1P (sphingosine 1-phosphate) | autoimmunity | immunotherapy | central nervous system | S1P (sphingosine 1‐phosphate) | Autoimmunity | Infection | Multiple sclerosis | Immunotherapy | Central nervous system | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | T-Lymphocytes - physiology | Phosphorylation | Receptors, Lysosphingolipid - antagonists & inhibitors | Lymph Nodes - pathology | Humans | Astrocytes - pathology | Encephalomyelitis, Autoimmune, Experimental - immunology | Astrocytes - immunology | Propylene Glycols - therapeutic use | Receptors, Lysosphingolipid - genetics | Propylene Glycols - pharmacology | Sphingosine - physiology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Fingolimod Hydrochloride | Phosphotransferases (Alcohol Group Acceptor) - genetics | Receptors, Lysosphingolipid - physiology | Inflammation - immunology | Lymph Nodes - immunology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Brain - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Gap Junctions - physiology | Immune System - drug effects | Multiple Sclerosis - immunology | Sphingosine - therapeutic use | Lysophospholipids - physiology | Multiple Sclerosis - drug therapy | Index Medicus | Review
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2484 - 2492
Journal Article
International journal of cancer, ISSN 0020-7136, 02/2013, Volume 132, Issue 3, pp. 605 - 616
Sphingosine kinase is an enzyme that catalyses the phosphorylation of sphingosine to form sphingosine 1‐phosphate. Sphingosine 1‐phosphate is a bioactive... 
c‐SRC | SRC family kinases | sphingosine kinase | disease‐specific survival and recurrence | nuclear factor kappa B | sphingosine 1‐phosphate | extracelluar signal regulated kinase | AKT | c‐RAF‐1 | sphingosine 1‐phosphate receptor | c-SRC | c-RAF-1 | disease-specific survival and recurrence | sphingosine 1-phosphate receptor | sphingosine 1-phosphate | Life Sciences & Biomedicine | Oncology | Science & Technology | Lysophospholipids - metabolism | Phosphorylation | Receptors, Estrogen - metabolism | Prognosis | Humans | Middle Aged | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Biomarkers, Tumor | Breast Neoplasms - metabolism | Cell Nucleus - metabolism | Lysophospholipids - biosynthesis | src-Family Kinases - metabolism | Female | Cell Membrane - metabolism | Sphingosine - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Lysosphingolipid - metabolism | Signal Transduction | Breast Neoplasms - drug therapy | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Breast Neoplasms - radiotherapy | Sphingosine - analogs & derivatives | Sphingosine - biosynthesis | Tamoxifen - therapeutic use | Aged | Care and treatment | Analysis | Estrogen | Sphingosine | Phenols | Development and progression | Breast cancer | Phosphotransferases | Cells | Cancer | Proteins | Biomarkers | Kinases | Tumors | Index Medicus
Journal Article
Journal Article
Seminars in immunopathology, ISSN 1863-2297, 1/2012, Volume 34, Issue 1, pp. 73 - 91
Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin by the sequential enzymatic actions of sphingomyelinase, ceramidase, and... 
Biomedicine | Immunology | Vascular barrier integrity | G-protein-coupled receptor | Coagulation | Immune cell trafficking | Internal Medicine | Inflammation | Sphingosine 1-phosphate | Pathology | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Receptors, Lysosphingolipid - antagonists & inhibitors | Lymph Nodes - pathology | Multiple Sclerosis - blood | Humans | Immunosuppressive Agents - therapeutic use | Tumor Necrosis Factor-alpha - blood | Inflammation - blood | Lysophospholipids - immunology | Neovascularization, Pathologic - blood | Neovascularization, Pathologic - pathology | Signal Transduction - immunology | Neoplasm Metastasis | Lymphocytes - immunology | Neoplasms - blood | Blood Coagulation - immunology | Inflammation - drug therapy | Propylene Glycols - therapeutic use | Tumor Necrosis Factor-alpha - immunology | Neovascularization, Pathologic - immunology | Receptors, Lysosphingolipid - metabolism | Lymphocytes - metabolism | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Fingolimod Hydrochloride | Lymph Nodes - metabolism | Sphingosine - immunology | Inflammation - immunology | Lysophospholipids - blood | Lymph Nodes - immunology | Neoplasms - drug therapy | Atherosclerosis - blood | Receptors, Lysosphingolipid - immunology | Lymphocytes - pathology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Neoplasms - immunology | Neovascularization, Pathologic - drug therapy | Multiple Sclerosis - immunology | Sphingosine - blood | Sphingosine - therapeutic use | Neoplasms - pathology | Multiple Sclerosis - drug therapy | Enzymes | Multiple sclerosis | Lymphocytes | Sphingosine | Atherosclerosis | Metastasis | Index Medicus | G protein-coupled receptors | sphingosine kinase | Central nervous system | Lipids | Cell surface | Ceramidase | Blood | Lymph nodes | Metastases | Sphingomyelin phosphodiesterase | Angiogenesis | Tumor necrosis factor | Arteriosclerosis | FTY720 | sphingomyelin | Lymph
Journal Article