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Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18633 - 18640
Journal Article
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2007, Volume 115, Issue 4, pp. 501 - 508
.... Methods and Results - Low- density lipoprotein receptor - deficient mice on a cholesterol- rich diet were given FTY720, a synthetic S1P analogue, at low ( 0.04 mg/ kg per day) or high ( 0.4 mg/ kg per day) doses for 16 weeks... 
FTY 720 | Lipoproteins | Inflammation | Atherosclerosis | Sphingosine 1-phosphate | atherosclerosis | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PLAQUES | LYMPHOCYTE EGRESS | G-PROTEIN | ISCHEMIA-REPERFUSION INJURY | THYMUS | S1P | inflammation | IMMUNOMODULATOR | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate | lipoproteins | Lysophospholipids - metabolism | Signal Transduction - immunology | Lymphocytes - immunology | Cell Division - immunology | Mice, Mutant Strains | Female | Sphingosine - metabolism | Immunosuppressive Agents - pharmacology | Macrophages - immunology | Cytokines - blood | Disease Models, Animal | Propylene Glycols - pharmacology | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Macrophages - pathology | Mice, Inbred C57BL | Fingolimod Hydrochloride | Cell Division - drug effects | Sphingosine - pharmacology | Lymphocytes - pathology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Lymphocytes - drug effects | Triglycerides - blood | Cholesterol, HDL - blood | Lymphocyte Count | Macrophages - drug effects | Mice | Proteolipids | Usage | Animal models in research | Sphingosine | Physiological aspects | Development and progression | Research | Blood lipoproteins
Journal Article
EMBO molecular medicine, ISSN 1757-4684, 2012, Volume 5, Issue 1, pp. 105 - 121
...‐directed mutagenesis. Because I2PP2A/SET was found overexpressed, whereas ceramide was downregulated in lung tumours, a sphingolipid analogue drug, FTY720, was identified to mimick ceramide for binding and targeting... 
sphingosine kinase 2 | ceramide | sphingolipids | sphingosine | FTY720 | Ceramide | Sphingolipids | Sphingosine kinase 2 | Sphingosine | MEDICINE, RESEARCH & EXPERIMENTAL | NETWORK | KINASE | ESSENTIAL REQUIREMENT | PROTEIN PHOSPHATASE 2A | CANCER | MASS-SPECTROMETRY | CERAMIDE SYNTHASES | CELL-DEATH PATHWAY | INHIBITION | LEUKEMIA | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Lung Neoplasms - drug therapy | Phosphorylation | Transcription Factors - chemistry | Histone Chaperones - genetics | Humans | Lung Neoplasms - metabolism | Histone Chaperones - metabolism | Lung Neoplasms - pathology | Histone Chaperones - chemistry | Gene Knockdown Techniques | Necrosis | Antineoplastic Agents - pharmacology | Sphingosine - metabolism | Propylene Glycols - pharmacology | Propylene Glycols - metabolism | Fingolimod Hydrochloride | Models, Molecular | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, SCID | Histone Chaperones - antagonists & inhibitors | Sphingosine - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Sphingosine - analogs & derivatives | Animals | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Medical colleges | Phosphatases | Cell death | Lung cancer | Oncology, Experimental | Medical genetics | Research | Plant lipids | Cancer | Tumors | Enzymes | Statistical analysis | Phosphoprotein phosphatase | Phosphatase | Kinases | Experiments | Proteins | Molecular modelling | Simulation | Mutagenesis | Protein phosphatase | Mutation | Localization | Apoptosis | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 5, p. e64050
Sphingosine-1-phosphate (S1P) is a pluripotent lipophilic mediator working as a ligand for G-protein coupled S1P receptors (S1PR), which is currently... 
PRESENILIN | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | PROTEIN | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SPHINGOSINE-1-PHOSPHATE | A-BETA | GAMMA-SECRETASE ACTIVITY | T-CELLS | IMMUNOMODULATORY DRUG FTY720 | Propylene Glycols - pharmacology | Sulfhydryl Compounds - pharmacology | Amyloid beta-Peptides - biosynthesis | Humans | Fingolimod Hydrochloride | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Brain - drug effects | Brain - metabolism | Sphingosine - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Propylene Glycols - chemistry | Brain - pathology | Sulfhydryl Compounds - chemistry | Mice | Mice, Inbred BALB C | Neurons - metabolism | Neurons - drug effects | Sphingosine - chemistry | Disease Models, Animal | Phosphates | Regulators | Neurosciences | Multiple sclerosis | Laboratories | Neuropathology | Antagonists | Kinases | Neuromodulation | Modulators | Sphingosine 1-phosphate | Proteins | Lipophilic | Signal transduction | Receptors | Metabolites | Alzheimer's disease | Pharmaceutical sciences | Enzymes | Sphingosine kinase | Immunoglobulins | Neurodegenerative diseases | Transgenic mice | Pharmacology | Medicine | Signaling | Brain research | FTY720 | β-Amyloid | Autoimmune diseases | Alzheimers disease | Pluripotency
Journal Article
Archives of Medical Research, ISSN 0188-4409, 2016, Volume 47, Issue 4, pp. 262 - 270
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 07/2018, Volume 24, Issue 38, pp. 9667 - 9674
Journal Article
The FASEB Journal, ISSN 0892-6638, 10/2011, Volume 25, Issue 10, pp. 3388 - 3400
Journal Article