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The Journal of immunology (1950), ISSN 1550-6606, 12/2008, Volume 181, Issue 11, pp. 8010 - 8017
Sphingosine kinase (SphK) is a key enzyme in the sphingolipid metabolic pathway responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P).... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Inflammation - pathology | Lysophospholipids - metabolism | Phosphotransferases (Alcohol Group Acceptor) - immunology | Humans | Matrix Metalloproteinase 9 - immunology | Lysophospholipids - immunology | Cyclooxygenase 2 - biosynthesis | Signal Transduction - immunology | RNA, Small Interfering - immunology | U937 Cells | Leukocytes, Mononuclear - immunology | Mice, Inbred DBA | Sphingosine - metabolism | Collagen Type II - pharmacology | Cytokines - blood | Cytokines - immunology | Disease Models, Animal | Inflammation Mediators - immunology | Matrix Metalloproteinase 9 - biosynthesis | Collagen Type II - immunology | Gene Expression Regulation - immunology | Jurkat Cells | Enzyme Inhibitors - pharmacology | Inflammation Mediators - blood | Arthritis, Rheumatoid - enzymology | Sphingosine - immunology | Inflammation - immunology | Synovial Fluid - enzymology | Neovascularization, Physiologic - immunology | Arthritis, Rheumatoid - pathology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Synovial Fluid - immunology | Leukocytes, Mononuclear - pathology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Receptors, Lysosphingolipid - immunology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Mice | Arthritis, Rheumatoid - immunology | Inflammation - enzymology | Receptors, Lysosphingolipid - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 08/2010, Volume 207, Issue 8, pp. 1791 - 1804
Studies of T cell responses to tumors have focused on the draining lymph node (LN) as the site of activation. We examined the tumor mass as a potential site of... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | CD8-Positive T-Lymphocytes - cytology | Cell Proliferation | Ovalbumin - immunology | Carcinoma, Lewis Lung - immunology | Interferon-gamma - metabolism | Cell Movement - immunology | Lymphocyte Activation - immunology | Peptide Fragments - immunology | Hyaluronan Receptors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Antigen, T-Cell - immunology | CD11a Antigen - metabolism | Propylene Glycols - pharmacology | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - immunology | Antigen Presentation - immunology | Lymph Nodes - cytology | Mice, Knockout | Sphingosine - pharmacology | Cell Differentiation - immunology | Cell Movement - drug effects | Sphingosine - analogs & derivatives | Neoplasms - immunology | Carcinoma, Lewis Lung - pathology | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | beta 2-Microglobulin - genetics | T-Lymphocyte Subsets - immunology | Lymph Nodes - pathology | T-Lymphocyte Subsets - cytology | Granzymes - metabolism | Adoptive Transfer | Melanoma, Experimental - immunology | Neoplasms - genetics | Immunosuppressive Agents - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Mice, Inbred C57BL | Fingolimod Hydrochloride | DNA-Binding Proteins - genetics | Antigen-Presenting Cells - immunology | Animals | Carcinoma, Lewis Lung - genetics | Integrin alpha4 - metabolism | Monophenol Monooxygenase - immunology | T-Lymphocyte Subsets - metabolism | Neoplasms - pathology | Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 01/2010, Volume 207, Issue 1, pp. 17 - 27
Lymphocyte egress from lymph nodes (LNs) is dependent on sphingosine-1-phosphate (S1P), but the cellular source of this S1P is not defined. We generated mice... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Lysophospholipids - metabolism | Intercellular Junctions - enzymology | Phosphotransferases (Alcohol Group Acceptor) - immunology | Peyer's Patches - metabolism | Glycoproteins - metabolism | Intercellular Junctions - immunology | Cell Movement - genetics | Lysophospholipids - immunology | Cell Movement - immunology | GTP-Binding Protein alpha Subunits, Gi-Go - immunology | Lymph Nodes - enzymology | Signal Transduction - immunology | Lymphocytes - immunology | Sphingosine - metabolism | Pertussis Toxin - pharmacology | Glycoproteins - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Sphingosine - immunology | Signal Transduction - genetics | Lymph Nodes - immunology | Intercellular Junctions - genetics | Lymph Nodes - cytology | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Endothelial Cells - immunology | Cell Movement - drug effects | Glycoproteins - immunology | Lysophospholipids - genetics | Peyer's Patches - cytology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Lymphocytes - enzymology | Sphingosine - genetics | Mice | Peyer's Patches - immunology | Endothelial Cells - enzymology | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Index Medicus | Brief Definitive Report
Journal Article
Seminars in immunopathology, ISSN 1863-2297, 1/2012, Volume 34, Issue 1, pp. 73 - 91
Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin by the sequential enzymatic actions of sphingomyelinase, ceramidase, and... 
Biomedicine | Immunology | Vascular barrier integrity | G-protein-coupled receptor | Coagulation | Immune cell trafficking | Internal Medicine | Inflammation | Sphingosine 1-phosphate | Pathology | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Receptors, Lysosphingolipid - antagonists & inhibitors | Lymph Nodes - pathology | Multiple Sclerosis - blood | Humans | Immunosuppressive Agents - therapeutic use | Tumor Necrosis Factor-alpha - blood | Inflammation - blood | Lysophospholipids - immunology | Neovascularization, Pathologic - blood | Neovascularization, Pathologic - pathology | Signal Transduction - immunology | Neoplasm Metastasis | Lymphocytes - immunology | Neoplasms - blood | Blood Coagulation - immunology | Inflammation - drug therapy | Propylene Glycols - therapeutic use | Tumor Necrosis Factor-alpha - immunology | Neovascularization, Pathologic - immunology | Receptors, Lysosphingolipid - metabolism | Lymphocytes - metabolism | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Fingolimod Hydrochloride | Lymph Nodes - metabolism | Sphingosine - immunology | Inflammation - immunology | Lysophospholipids - blood | Lymph Nodes - immunology | Neoplasms - drug therapy | Atherosclerosis - blood | Receptors, Lysosphingolipid - immunology | Lymphocytes - pathology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Neoplasms - immunology | Neovascularization, Pathologic - drug therapy | Multiple Sclerosis - immunology | Sphingosine - blood | Sphingosine - therapeutic use | Neoplasms - pathology | Multiple Sclerosis - drug therapy | Enzymes | Multiple sclerosis | Lymphocytes | Sphingosine | Atherosclerosis | Metastasis | Index Medicus | G protein-coupled receptors | sphingosine kinase | Central nervous system | Lipids | Cell surface | Ceramidase | Blood | Lymph nodes | Metastases | Sphingomyelin phosphodiesterase | Angiogenesis | Tumor necrosis factor | Arteriosclerosis | FTY720 | sphingomyelin | Lymph
Journal Article
Journal of leukocyte biology, ISSN 0741-5400, 12/2006, Volume 80, Issue 6, pp. 1298 - 1307
Journal Article
Nature communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6956 - 6956
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 7882 - 7890
IgE-mediated mast cell degranulation and release of vasoactive mediators induced by allergens elicits allergic responses. Although G protein-coupled receptor... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-8 - genetics | RGS Proteins - genetics | RNA, Small Interfering - genetics | Humans | Calcium - immunology | Receptors, G-Protein-Coupled - agonists | Lysophospholipids - immunology | Proto-Oncogene Proteins c-akt - genetics | Receptors, G-Protein-Coupled - immunology | Phosphorylation - genetics | Cell Degranulation - genetics | Immunoglobulin E - immunology | Allergens - immunology | Lysophospholipids - pharmacology | Anaphylaxis - immunology | Phosphorylation - immunology | RGS Proteins - antagonists & inhibitors | Chemotaxis - immunology | Phosphorylation - drug effects | Chemokine CXCL12 - immunology | Cell Line | Mast Cells - immunology | Adenosine - immunology | Immunoglobulin E - pharmacology | Sphingosine - immunology | Allergens - genetics | Adenosine - pharmacology | Chemotaxis - drug effects | Cell Degranulation - immunology | Chemotaxis - genetics | Anaphylaxis - genetics | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Complement C5a - pharmacology | Proto-Oncogene Proteins c-akt - immunology | Chemokine CXCL12 - pharmacology | Antigens - immunology | Ligands | Allergens - pharmacology | Mice | Receptors, G-Protein-Coupled - genetics | Complement C5a - immunology | Interleukin-8 - immunology | RGS Proteins - immunology | Antigens - pharmacology | Antigens - genetics | Cell Degranulation - drug effects | Index Medicus | Abridged Index Medicus | Signal transduction | Mast cells | basophils | Chemokines
Journal Article