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Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 501 - 511.e1
Background Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated... 
Allergy and Immunology | airway hyperresponsiveness | asthma | nuclear factor κB | mast cells | sphingosine kinase | Sphingosine-1-phosphate | IMMUNITY | FC-EPSILON-RI | nuclear factor kappa B | FACTOR-KAPPA-B | IMMUNOLOGY | MULTIPLE FEATURES | REGULATES MUCIN PRODUCTION | RESPONSES | CYTOKINE PRODUCTION | ALLERGY | GENE-EXPRESSION | MICE | Tumor Necrosis Factor-alpha - metabolism | Lysophospholipids - metabolism | Asthma - metabolism | Bronchial Hyperreactivity - drug therapy | Humans | Goblet Cells - drug effects | NF-kappa B - metabolism | Amino Alcohols - pharmacology | Interferon-gamma - metabolism | Interleukins - metabolism | Inflammation - metabolism | Inflammation - drug therapy | Methacholine Chloride - pharmacology | Mast Cells - metabolism | Bronchial Hyperreactivity - metabolism | Female | Chemokine CCL2 - metabolism | Hyperplasia - drug therapy | Lung - metabolism | Sphingosine - metabolism | Hyperplasia - metabolism | Asthma - enzymology | Immunoglobulin E - metabolism | Mice, Inbred C57BL | Cells, Cultured | Ovalbumin - pharmacology | Asthma - drug therapy | Goblet Cells - metabolism | Mast Cells - drug effects | Asthma - chemically induced | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Bronchial Hyperreactivity - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Bronchial Hyperreactivity - pathology | Sphingosine - analogs & derivatives | Animals | Lung - drug effects | Mice | Bronchoalveolar Lavage Fluid - chemistry | Phosphates | Medical colleges | Isoenzymes | Analysis | Sphingosine | Inflammation | Asthma | Studies | Cytokines | Lungs | Rodents | Kinases | Laboratory animals | Allergies
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 6, pp. 724 - 734
ABSTRACT—Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is now recognized as a potent modulator of cell regulation. In... 
Sphingolipid mediators | Sphingosine kinase | Sphingosine 1-phosphate lyase | Sphingosine 1-phosphate receptors | Sphingosine 1-phosphate phosphatase | NOVO CERAMIDE SYNTHESIS | sphingosine 1-phosphate lyase | CARDIAC & CARDIOVASCULAR SYSTEMS | sphingosine kinase | LIPID PHOSPHATE PHOSPHATASES | LOW-DENSITY-LIPOPROTEIN | SACCHAROMYCES-CEREVISIAE | sphingosine 1-phosphate receptors | HUMAN ENDOTHELIAL-CELLS | LONG-CHAIN BASES | SPHINGOLIPID METABOLISM | SPHINGOSINE-1-PHOSPHATE LYASE | sphingolipid mediators | PROTEIN-COUPLED RECEPTOR | sphingosine 1-phosphate phosphatase | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Lysophospholipids - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Receptors, G-Protein-Coupled - metabolism | Species Specificity | Humans | Invertebrates - metabolism | Receptors, Lysophospholipid | Fungi - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Sphingosine - analogs & derivatives | Animals | Cardiovascular System - metabolism | Endothelium, Vascular - metabolism | Myocardium - metabolism | Aldehyde-Lyases - metabolism | Second Messenger Systems - physiology | Membrane Proteins - metabolism | Sphingosine - metabolism | Phosphoric Monoester Hydrolases - metabolism | Receptors, G-Protein-Coupled - drug effects | Vertebrates - metabolism | Receptors, G-Protein-Coupled - physiology
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 10/2009, Volume 105, Issue 9, pp. 897 - 905
RATIONALE:Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior,... 
Insulin-like growth factor binding protein-3 | Vascular repair | Nitric oxide | Hematopoietic stem cells | nitric oxide | STEM-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | RAT RETINA | LOW-DENSITY-LIPOPROTEIN | RECEPTOR | ENDOTHELIAL-CELL APOPTOSIS | FACTOR-I | CHOROIDAL NEOVASCULARIZATION | vascular repair | SPHINGOSINE 1-PHOSPHATE | RETINOPATHY | PERIPHERAL VASCULAR DISEASE | hematopoietic stem cells | HEMATOLOGY | insulin-like growth factor binding protein-3 | Cell Proliferation | Mesenteric Arteries - physiopathology | Humans | Male | Green Fluorescent Proteins - genetics | Retinal Neovascularization - metabolism | Retinopathy of Prematurity - physiopathology | Vasodilation | Retinal Vessels - pathology | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Infant, Newborn | Cytoprotection | Disease Models, Animal | Animals, Newborn | Gene Transfer Techniques | Sphingomyelins - metabolism | Retinal Vessels - metabolism | Signal Transduction | Endothelial Cells - metabolism | Rats | Mice, Transgenic | Mesenteric Arteries - metabolism | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Cerebral Arteries - metabolism | Stem Cells - pathology | Mice | Retinopathy of Prematurity - metabolism | Endothelial Cells - pathology | Retinal Neovascularization - physiopathology | Retinal Neovascularization - pathology | Astrocytes - metabolism | Cell Movement | Insulin-Like Growth Factor Binding Protein 3 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - metabolism | Stem Cells - metabolism | Cell Death | Female | Microfilament Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Ceramides - metabolism | Mice, Inbred C57BL | Cells, Cultured | Cerebral Arteries - physiopathology | Pregnancy | Animals | Retinal Vessels - physiopathology | Scavenger Receptors, Class B - metabolism | Nitric Oxide - metabolism | Retinopathy of Prematurity - pathology | Vascular Repair | Hematopoietic Stem Cells
Journal Article