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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 2, pp. 751 - 756
Sphingosine 1-phosphate (S1P), a lysophospholipid, has gained relevance to multiple sclerosis through the discovery of FTY720 (fingolimod), recently approved... 
Receptors | Multiple sclerosis | Spinal cord | Astrocytes | Neurons | Lymphocytes | Central nervous system | Cell lines | Null condition | Mice | G protein-coupled receptor | Lysophospholipid | Neuroprotection | Knockout | knockout | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | ORAL FINGOLIMOD | WHITE-MATTER | MULTIDISCIPLINARY SCIENCES | LYMPHOCYTE EGRESS | AGONISTS | neuroprotection | FIBRILLARY ACIDIC PROTEIN | SPHINGOSINE-1-PHOSPHATE | IMMUNOSUPPRESSANT FTY720 | CENTRAL-NERVOUS-SYSTEM | lysophospholipid | Astrocytes - cytology | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Gene Expression Regulation | Fingolimod Hydrochloride | Mice, Knockout | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Female | Receptors, Lysosphingolipid - metabolism | Immunosuppressive Agents - pharmacology | Disease Models, Animal | Multiple Sclerosis - drug therapy | Physiological aspects | Care and treatment | Studies | Prescription drugs | Phosphorylation | Immunology | Metabolites | Rodents | Lipids | Models | Gene expression | Index Medicus | Animal models | Cell lineage | Data processing | Neuromodulation | Experimental allergic encephalomyelitis | sphingosine 1-phosphate receptors | Sphingosine 1-phosphate | Signal transduction | Gliosis | Demyelination | FTY720 | Glia | Protein transport | Biological Sciences
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1505 - 1512
OBJECTIVE—Sphingosine 1-phosphate (S1P) partly accounts for antiatherogenic properties of high-density lipoproteins. We previously demonstrated that FTY720, a... 
Inflammation | High-density lipoproteins | T cells | Macrophage | Murine models of disease | Sphingosine 1-phosphate | CELLS | ACTIVATION | APOLIPOPROTEIN M | SPHINGOSINE-1-PHOSPHATE ANALOG | macrophage | high-density lipoproteins | DEFICIENT MICE | HYPERLIPIDEMIC MICE | murine models of disease | HIGH-DENSITY-LIPOPROTEIN | REDUCES ATHEROSCLEROSIS | inflammation | IMMUNE-RESPONSES | FTY720 | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate | HEMATOLOGY | Inflammation - pathology | Sulfhydryl Compounds - pharmacology | Atherosclerosis - genetics | Dendritic Cells - immunology | Humans | Aorta - metabolism | Aortic Diseases - metabolism | CD4-Positive T-Lymphocytes - immunology | Inflammation - metabolism | U937 Cells | Lipids - blood | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Dendritic Cells - drug effects | Receptors, Lysosphingolipid - metabolism | Macrophages - immunology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Aortic Diseases - immunology | Aorta - drug effects | Aorta - immunology | Inflammation - immunology | Biomarkers - blood | Atherosclerosis - metabolism | Cardiovascular Agents - pharmacology | Mice, Knockout | Aorta - pathology | Endothelial Cells - immunology | Aortic Diseases - genetics | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Inflammation - genetics | Receptors, Lysosphingolipid - agonists | Macrophages - drug effects | Inflammation - prevention & control | Lymphopenia - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Macrophage Activation - drug effects | Atherosclerosis - prevention & control | CD4-Positive T-Lymphocytes - drug effects | Endothelial Cells - drug effects | Index Medicus
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2015, Volume 21, Issue 6, pp. 354 - 363
Highlights • S1P is a pleiotropic signaling molecule that regulates BBB permeability. • Fingolimod targets S1P receptors and may have therapeutic potential in... 
Pathology | blood–brain barrier | sphingosine 1-phosphate | neuroinflammation | astrocyte | fingolimod | multiple sclerosis | Neuroinflammation | Multiple sclerosis | Astrocyte | Blood-brain barrier | Fingolimod | Sphingosine 1-phosphate | blood-brain barrier | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | RELAPSING MULTIPLE-SCLEROSIS | ORAL FINGOLIMOD | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASTROCYTE-ENDOTHELIAL INTERACTIONS | PROTEIN-COUPLED RECEPTORS | FINGOLIMOD FTY720 | CELL BIOLOGY | VE-CADHERIN | CENTRAL-NERVOUS-SYSTEM | PLACEBO-CONTROLLED TRIAL | SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 | Fingolimod Hydrochloride - pharmacology | Lysophospholipids - metabolism | Humans | Astrocytes - pathology | Capillary Permeability - drug effects | Lysophospholipids - immunology | Astrocytes - immunology | Sphingosine - metabolism | Receptors, Lysosphingolipid - metabolism | Astrocytes - drug effects | Blood-Brain Barrier - immunology | Endothelial Cells - metabolism | Sphingosine - immunology | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Endothelial Cells - immunology | Blood-Brain Barrier - pathology | Receptors, Lysosphingolipid - immunology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Endothelial Cells - pathology | Immunologic Factors - pharmacology | Astrocytes - metabolism | Endothelial Cells - drug effects | Multiple Sclerosis - drug therapy | Phosphates | Sphingosine | Permeability | Index Medicus
Journal Article
Journal Article
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 2006, Volume 1758, Issue 12, pp. 2016 - 2026
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 3/2018, Volume 55, Issue 3, pp. 2320 - 2332
Journal Article
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2017
Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is... 
HDL | Atherosclerosis | Apolipoprotein M | Sphingosine 1-phosphate
Journal Article
Circulation Research, ISSN 0009-7330, 03/2008, Volume 102, Issue 6, pp. 669 - 676
Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors. In this report, we... 
Plasma S1P gradient | Shear stress | S1P lyase (Sgpl) | Sphingosine 1-phosphate (S1P) | Sphingosine kinase (Sphk) | CELLS | sphingosine kinase (Sphk) | CARDIAC & CARDIOVASCULAR SYSTEMS | EXTRACELLULAR EXPORT | LIPID PHOSPHATE PHOSPHATASES | MECHANISMS | SPHINGOLIPIDS | plasma S1P gradient | KINASE-1 | SPHINGOSINE-1-PHOSPHATE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate (S1P) | MICE | HEMATOLOGY | BLOOD | Lysophospholipids - metabolism | Whole-Body Irradiation | Liver - enzymology | Anemia - blood | Bone Marrow Cells - enzymology | Humans | Half-Life | Stress, Mechanical | Endothelium, Vascular - enzymology | Leukopenia - blood | RNA Interference | Time Factors | Bone Marrow Transplantation | Adenoviridae - genetics | Membrane Proteins - metabolism | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Disease Models, Animal | Cell Line | Transduction, Genetic | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Phosphotransferases (Alcohol Group Acceptor) - deficiency | Thrombocytopenia - immunology | Cells, Cultured | Anemia - chemically induced | Phosphotransferases (Alcohol Group Acceptor) - genetics | Lysophospholipids - blood | Antibodies, Monoclonal | Bone Marrow Cells - radiation effects | Phenylhydrazines | Thrombocytopenia - blood | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - analogs & derivatives | Animals | Endothelium, Vascular - metabolism | Aldehyde-Lyases - metabolism | Cell Line, Tumor | Sphingosine - blood | Mice | Genetic Vectors | Phosphoric Monoester Hydrolases - metabolism | Endothelial Cells - enzymology | Bone Marrow Cells - metabolism | Platelet Glycoprotein GPIb-IX Complex - immunology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN 0167-4889, 02/2012, Volume 1823, Issue 2, pp. 439 - 450
Journal Article
Journal Article