X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
sphingosine 1-phosphate (20) 20
index medicus (15) 15
humans (14) 14
sphingosine-1-phosphate (14) 14
sphingosine (12) 12
sphingosine - analogs & derivatives (12) 12
animals (9) 9
biochemistry & molecular biology (9) 9
fty720 (9) 9
sphingosine - pharmacology (8) 8
multiple-sclerosis (7) 7
phosphates (7) 7
propylene glycols - pharmacology (7) 7
receptors, lysosphingolipid - metabolism (7) 7
fingolimod hydrochloride (6) 6
lymphocyte egress (6) 6
protein-coupled receptor (6) 6
biophysics (5) 5
endothelial-cells (5) 5
immunology (5) 5
pharmacology & pharmacy (5) 5
protein-coupled receptors (5) 5
sphingosine 1-phosphate receptor (5) 5
analysis (4) 4
article (4) 4
cell biology (4) 4
lymphocytes (4) 4
lysophospholipids - metabolism (4) 4
mice (4) 4
multiple sclerosis (4) 4
sphingosine - metabolism (4) 4
acute lung injury (3) 3
apoptosis (3) 3
cell line (3) 3
central-nervous-system (3) 3
cytology (3) 3
dendritic cells (3) 3
dendritic cells - drug effects (3) 3
discovery (3) 3
expression (3) 3
fingolimod (3) 3
growth (3) 3
immunosuppression (3) 3
inhibition (3) 3
kinase (3) 3
lysophosphatidic acid (3) 3
multiple sclerosis - drug therapy (3) 3
receptors (3) 3
receptors, lysosphingolipid - agonists (3) 3
review (3) 3
smooth-muscle-cells (3) 3
sphingosine 1-phosphate receptors (3) 3
t-lymphocytes - drug effects (3) 3
t-lymphocytes - immunology (3) 3
acids (2) 2
activation (2) 2
cancer (2) 2
capillary permeability - physiology (2) 2
cell line, tumor (2) 2
cell migration (2) 2
cells, cultured (2) 2
ceramide (2) 2
chemistry, multidisciplinary (2) 2
chemistry, organic (2) 2
chemotherapy (2) 2
communicable diseases (2) 2
cutting edge (2) 2
cytotoxicity (2) 2
dendritic cells - immunology (2) 2
dendritic cells - metabolism (2) 2
disease (2) 2
disease models, animal (2) 2
down-regulation (2) 2
endothelial cells - drug effects (2) 2
endothelial cells - metabolism (2) 2
fingolimod hydrochloride - analogs & derivatives (2) 2
fingolimod hydrochloride - pharmacology (2) 2
g proteins (2) 2
heart cells (2) 2
hemic and lymphatic diseases (2) 2
immunosuppressant (2) 2
immunosuppressive agents - pharmacology (2) 2
infectious diseases (2) 2
lung diseases (2) 2
lymphocytes - drug effects (2) 2
lymphocytes t (2) 2
lysophospholipids - pharmacology (2) 2
lysophospholipids - physiology (2) 2
macrophages (2) 2
macrophages - drug effects (2) 2
macrophages - immunology (2) 2
male (2) 2
multiple sclerosis - immunology (2) 2
natural killer cells (2) 2
neurosciences (2) 2
oncology (2) 2
phosphorylation (2) 2
pulmonary artery - drug effects (2) 2
rats (2) 2
receptors, lysosphingolipid - genetics (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 08/2007, Volume 19, Issue 8, pp. 1754 - 1764
Novel therapeutic strategies are needed to reverse the loss of endothelial cell (EC) barrier integrity that occurs during inflammatory disease states such as... 
cytoskeleton | PHOSPHORYLATION | PROTEIN-COUPLED RECEPTORS | G-coupled receptors | LYMPHOCYTE EGRESS | AGONISTS | CELL BIOLOGY | rac | FTY720 | SPHINGOSINE-1-PHOSPHATE | CYTOSKELETAL REARRANGEMENT | IMMUNOSUPPRESSANT FTY720 | VASCULAR MATURATION | HEART-RATE | sphingosine 1-phosphate | vascular permeability
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 05/2006, Volume 343, Issue 4, pp. 1038 - 1044
Sphingosine-1-phosphate regulates diverse biological processes through five receptor types, SIP1-5. Two or more SIP receptors are usually co-expressed on... 
RNA INTERFERENCE | smooth muscle contraction | PLC-beta | Rho kinase | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | siRNA | lentiviral vector | SPHINGOSINE 1-PHOSPHATE RECEPTOR | S1P | BIOPHYSICS | CONTRACTION | PROTEIN-COUPLED RECEPTOR | ENDOTHELIAL-CELLS | sphingosine-1-phosphate | MICE | S1P receptors | VECTORS | EXPRESSION
Journal Article
Journal Article
DRUG NEWS & PERSPECTIVES, ISSN 0214-0934, 07/2004, Volume 17, Issue 6, pp. 365 - 382
The sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G-protein-coupled receptors, termed S1P(1) (formerly endothelial differentiation gene-1... 
SPHINGOSINE 1-PHOSPHATE RECEPTOR | STIMULATES TYROSINE PHOSPHORYLATION | NITRIC-OXIDE PRODUCTION | PROTEIN-COUPLED RECEPTOR | FACTOR-INDUCED ACTIVATION | GROWTH-FACTOR RECEPTORS | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | MULTIPLE SIGNALING PATHWAYS | FOCAL ADHESION KINASE | HUMAN ENDOTHELIAL-CELLS
Journal Article
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 06/2006, Volume 344, Issue 3, pp. 852 - 858
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 06/2016, Volume 116, pp. 222 - 238
In a previous communication we reported on the discovery of alkylamino pyridine derivatives (e.g. 1) as a new class of potent, selective and efficacious SIP1... 
NONSPECIFIC-BINDING | FTY720 FINGOLIMOD | CHEMISTRY, MEDICINAL | Aminomethyl benzene | Aminomethyl thiophene | S1P receptor agonist | LYMPHOCYTE EGRESS | DISCOVERY | SPHINGOSINE 1-PHOSPHATE | PREDICTION | Immunomodulator | MULTIPLE-SCLEROSIS | Lymphocyte count | SPHINGOSINE-1-PHOSPHATE | Phototoxicity | SINGLET OXYGEN | CENTRAL-NERVOUS-SYSTEM | Aminomethyl pyridine
Journal Article
Journal Article
Journal Article
JOURNAL OF NEUROIMMUNOLOGY, ISSN 0165-5728, 11/2009, Volume 216, Issue 1-2, pp. 59 - 65
Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model... 
ENCEPHALOMYELITIS | IMMUNOSUPPRESSANT | IMMUNOLOGY | Macrophages | Inflammatory demyelinating polyradiculoneuropathy | NEUROSCIENCES | RAT MODEL | SPHINGOSINE 1-PHOSPHATE | AUY954 | MATRIX METALLOPROTEINASES | Experimental autoimmune neuritis | MULTIPLE-SCLEROSIS | Lymphocytes | CELL-MIGRATION | FTY720 | SPHINGOSINE-1-PHOSPHATE | CENTRAL-NERVOUS-SYSTEM | Sphingosine-1-phosphate receptor 1 | Paraparesis - prevention & control | Thiophenes - therapeutic use | Paraparesis - immunology | Paraparesis - drug therapy | Rats, Inbred Lew | Male | Sciatic Nerve - immunology | Matrix Metalloproteinase 9 - metabolism | Sciatic Nerve - metabolism | Chemotaxis, Leukocyte - drug effects | T-Lymphocytes - drug effects | beta-Alanine - pharmacology | Neuritis, Autoimmune, Experimental - immunology | Sciatic Nerve - drug effects | Receptors, Lysosphingolipid - metabolism | beta-Alanine - analogs & derivatives | Macrophages - immunology | Disease Models, Animal | Guillain-Barre Syndrome - metabolism | Guillain-Barre Syndrome - drug therapy | beta-Alanine - therapeutic use | Rats | Thiophenes - pharmacology | Treatment Outcome | Receptors, Lysosphingolipid - drug effects | B-Lymphocytes - drug effects | Interleukin-17 - metabolism | Animals | B-Lymphocytes - immunology | Guillain-Barre Syndrome - immunology | Neuritis, Autoimmune, Experimental - metabolism | Macrophages - drug effects | T-Lymphocytes - immunology | Chemotaxis, Leukocyte - immunology | Neuritis, Autoimmune, Experimental - drug therapy | Immunologic Factors - pharmacology | Immunologic Factors - therapeutic use
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 07/2009, Volume 50, Issue 28, pp. 4081 - 4083
A scalable and enantioselective synthesis of a potent SIP1 agonist containing two stereogenic centers oil a cyclopentane ring is described. Control of the... 
ASYMMETRIC-SYNTHESIS | MULTIPLE-SCLEROSIS | ACIDS | FTY720 | ENANTIOSELECTIVE HYDROGENATION | SPHINGOSINE-1-PHOSPHATE | PHASE-TRANSFER CATALYSIS | CHEMISTRY, ORGANIC | RECEPTORS | DRUG TARGETS | SPHINGOSINE 1-PHOSPHATE
Journal Article
Journal Article
CANCER LETTERS, ISSN 0304-3835, 07/2002, Volume 181, Issue 2, pp. 195 - 204
The regulation of glioma cell proliferation by sphingosine-1-phosphate (S1P) was studied using the human glioblastoma cell line U-373 MG. U-373 MG cells... 
ACTIVATION | POSSIBLE INVOLVEMENT | LYSOPHOSPHATIDIC-ACID | SURFACE RECEPTORS | mitogenesis | DIFFERENTIATION GENE FAMILY | SPHINGOSINE 1-PHOSPHATE RECEPTORS | ONCOLOGY | PROTEIN-COUPLED RECEPTOR | ENDOTHELIAL-CELLS | glioma | MOLECULAR-CLONING | sphingosine-1-phosphate (S1P) | SIGNAL-REGULATED KINASE | endothelial differentiation gene | G protein
Journal Article
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 2006, Volume 17, Issue 19, pp. 2781 - 2792
We herein report an asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives , key intermediates of a novel immunomodulator, using enzymatic... 
ENANTIOSELECTIVE SYNTHESIS | ACIDS | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | ENZYMATIC DESYMMETRISATION | IMMUNOSUPPRESSANT | SPHINGOSINE 1-PHOSPHATE | CHEMISTRY, INORGANIC & NUCLEAR | CHIRAL BUILDING-BLOCKS | FTY720 | LIPASE | STEREOSELECTIVE-SYNTHESIS | BIS-LACTIM ETHERS
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 03/2018, Volume 24, Issue 3, pp. 193 - 201
Journal Article