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Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106725
Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports demonstrated that S1P... 
MIGRATION | APOPTOSIS | CANCER CELLS | PROTEIN-COUPLED RECEPTOR | EARLY HUMAN-PREGNANCY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | HUMAN DECIDUA | EXPRESSION | SPHINGOSINE 1-PHOSPHATE | RHO/RHO-KINASE | RNA, Small Interfering - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen - chemistry | Proteoglycans - chemistry | MAP Kinase Kinase 1 - genetics | Trophoblasts - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Biological Assay | Trophoblasts - cytology | Receptors, Lysosphingolipid - metabolism | MAP Kinase Kinase 2 - genetics | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Trophoblasts - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Sphingosine - analogs & derivatives | Diffusion Chambers, Culture | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Receptors, Lysosphingolipid - agonists | Laminin - chemistry | Protein Kinase Inhibitors - pharmacology | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Phosphates | Enzymes | RNA | Sphingosine | Enzyme activity | Extracellular signal-regulated kinase | Activation | mRNA | siRNA | Kinases | Gene expression | Tissues | Sphingosine 1-phosphate | Cell adhesion & migration | Gelatinase A | Pregnancy | Proteins | Signaling | Receptors | Molecular modelling | Pathways | Enzymatic activity | Gelatin | Pharmacy | Receptor mechanisms | Cell migration | Cancer
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2006, Volume 24, Issue 11, pp. 2557 - 2565
The ease of isolation and ex vivo culture of marrow‐derived stromal cells (MSCs) from adult bone marrow renders them a very promising source of adult stem... 
Matrix metalloproteinases | Rho GTPases | Marrow‐derived stromal cells | ROCK MEK1/ERK | Actin cytoskeleton | Cell migration | Sphingosine‐1‐phosphate | MEK1/ERK | ROCK | Marrow-derived stromal cells | Sphingosine-1-phosphate | GLIOMA-CELLS | PAXILLIN | marrow-derived stromal cells | BONE-MARROW | CANCER | MESENCHYMAL STEM-CELLS | SPHINGOSINE 1-PHOSPHATE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | actin cytoskeleton | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | cell migration | sphingosine-1-phosphate | FOCAL ADHESION KINASE | GROWTH-FACTOR | RHO-GTPASES | HEMATOLOGY | matrix metalloproteinases | MOTILITY | Paxillin - metabolism | Phosphorylation | Bone Marrow Cells - enzymology | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Dose-Response Relationship, Drug | Stromal Cells - enzymology | Actin Cytoskeleton - drug effects | rho-Associated Kinases | Lysophospholipids - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bone Marrow Cells - drug effects | Female | Indoles - pharmacology | Flavonoids - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | MAP Kinase Kinase 1 - antagonists & inhibitors | Actin Cytoskeleton - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | Chemotaxis - drug effects | Hydroxamic Acids | Cell Shape - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | MAP Kinase Signaling System - drug effects | Matrix Metalloproteinase Inhibitors | Mice | Pyridines - pharmacology | Matrix Metalloproteinases - metabolism | Bone Marrow Cells - metabolism
Journal Article
Journal Article
Journal Article
Circulation Research: Journal of The American Heart Association, ISSN 0009-7330, 07/2002, Volume 91, Issue 2, pp. 112 - 119
Although recent investigations have suggested that a Rho-kinase–mediated Ca sensitization of vascular smooth muscle contraction plays a critical role in the... 
Rho-kinase | Sphingolipid | Membrane permeabilization | Vasospasm | Protein kinase C | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | SKINNED MUSCLE | sphingolipid | PERMEABILIZED SMOOTH-MUSCLE | PHOSPHORYLATION | vasospasm | membrane permeabilization | ARACHIDONIC-ACID | ENDOTHELIAL-CELLS | SUBARACHNOID HEMORRHAGE | PERIPHERAL VASCULAR DISEASE | CHRONIC VASOSPASM | HEMATOLOGY | MYOSIN LIGHT-CHAIN | protein kinase C | CALCIUM SENSITIZATION | Protein-Serine-Threonine Kinases - analysis | Culture Techniques | Phorbol 12,13-Dibutyrate - pharmacology | Phosphorylcholine - analogs & derivatives | Cerebral Arteries - drug effects | Cattle | Phosphorylcholine - pharmacology | rho-Associated Kinases | Escin - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Calcium Signaling | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | GTP-Binding Proteins - physiology | Protein Kinase C - physiology | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Protein Kinase C - antagonists & inhibitors | Cerebral Arteries - physiology | Sphingosine - pharmacology | Cell Membrane - enzymology | Sphingosine - analogs & derivatives | Animals | Cerebral Arteries - enzymology | Cerebral Arteries - metabolism | Muscle Contraction - drug effects | Cell Membrane Permeability - drug effects | Kinetics
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2004, Volume 91, Issue 5, pp. 1231 - 1243
The sphingomyelin‐derived messenger ceramides provoke neuronal apoptosis through caspase‐3 activation, while the neuropeptide pituitary adenylate... 
Bax | Bcl‐2 | pituitary adenylate cyclase‐activating polypeptide | mitochondrial apoptotic pathway | JNK | ERK | Bcl-2 | Pituitary adenylate cyclase-activating polypeptide | Mitochondrial apoptotic pathway | NEURONAL APOPTOSIS | CYCLASE-ACTIVATING POLYPEPTIDE | SIGNALING PATHWAYS | pituitary adenylate cyclase-activating polypeptide | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | CERAMIDE LEVELS | NEUROSCIENCES | CYTOCHROME-C | CASPASE-3 ACTIVATION | PITUITARY | ADENYLATE-CYCLASE | CEREBRAL-ISCHEMIA | Intracellular Signaling Peptides and Proteins - pharmacology | Benzimidazoles | Caspase 9 | Rats, Wistar | Cytosol - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Carbocyanines | Dose-Response Relationship, Drug | Nerve Growth Factors - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA, Messenger - biosynthesis | Caspases - metabolism | Drug Interactions | MAP Kinase Kinase 4 | Time Factors | Neuropeptides - pharmacology | Neurotransmitter Agents - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Caspase 3 | Neurons - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide | Animals, Newborn | Membrane Potentials - drug effects | Blotting, Western - methods | Cytochromes c - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mitochondria - drug effects | bcl-2-Associated X Protein | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Cerebellum - cytology | Mice | Models, Neurological | Mitochondria - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Cerebellum | Enzyme Inhibitors | Cytochromes c | Neuropeptides | Cytosol | Life Sciences | Mitochondria | Toxicology | Mitogen-Activated Protein Kinase Kinases | Sphingosine | JNK Mitogen-Activated Protein Kinases | Mitogen-Activated Protein Kinases | Signal Transduction | Neurons | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Neurotransmitter Agents | Membrane Potentials | Nerve Growth Factors | Fluorescent Antibody Technique | Proto-Oncogene Proteins c-bcl-2 | Caspases | RNA, Messenger
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18633 - 18640
Journal Article
Journal Article