Nature Reviews Immunology, ISSN 1474-1733, 03/2015, Volume 15, Issue 3, pp. 160 - 171
The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts...
GERMINAL CENTER B | UNFOLDED PROTEIN RESPONSE | SPI-B | TRANSCRIPTION FACTOR BLIMP-1 | BONE-MARROW | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | ADAPTIVE IMMUNE-RESPONSES | MARROW STROMAL CELLS | T-CELLS | MEMORY B | Cell Differentiation - immunology | Antibody Formation - immunology | B-Lymphocytes - immunology | Humans | Antibodies - immunology | Plasma Cells - secretion | Plasma Cells - immunology | Immune response | Genetic research | Genetic aspects | B cells | Research | Properties | Cell differentiation
GERMINAL CENTER B | UNFOLDED PROTEIN RESPONSE | SPI-B | TRANSCRIPTION FACTOR BLIMP-1 | BONE-MARROW | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | ADAPTIVE IMMUNE-RESPONSES | MARROW STROMAL CELLS | T-CELLS | MEMORY B | Cell Differentiation - immunology | Antibody Formation - immunology | B-Lymphocytes - immunology | Humans | Antibodies - immunology | Plasma Cells - secretion | Plasma Cells - immunology | Immune response | Genetic research | Genetic aspects | B cells | Research | Properties | Cell differentiation
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 08/2015, Volume 15, Issue 8, pp. 471 - 485
Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune...
SYSTEMIC-LUPUS-ERYTHEMATOSUS | COLONY-STIMULATING FACTOR | IIFN-PRODUCING CELLS | PERSISTENT LCMV INFECTION | TOLL-LIKE RECEPTORS | IMMUNOLOGY | I INTERFERON-PRODUCTION | IFN-ALPHA PRODUCTION | DEPENDENT VIRAL RECOGNITION | TRANSCRIPTION FACTOR E2-2 | FACTOR SPI-B | Adaptive Immunity | Autoimmunity | Virus Diseases - immunology | Signal Transduction | Dendritic Cells - immunology | Humans | Autoimmune Diseases - immunology | Gene Expression Regulation | Dendritic Cells - pathology | Virus Diseases - virology | Immunity, Innate | Interferon Type I - immunology | Animals | Antigen Presentation | Virus Diseases - pathology | Interferon Type I - genetics | Mice | Dendritic Cells - virology | Autoimmune Diseases - pathology | Cytokines - genetics | Cytokines - immunology | Immune response | Dendritic cells | Cellular control mechanisms | Interferon | Genetic aspects | Disease susceptibility | Properties | transcription factor | autoimmunity | plasmacytoid dendritic cell | cancer | interferon | virus | human | mucosal immunity
SYSTEMIC-LUPUS-ERYTHEMATOSUS | COLONY-STIMULATING FACTOR | IIFN-PRODUCING CELLS | PERSISTENT LCMV INFECTION | TOLL-LIKE RECEPTORS | IMMUNOLOGY | I INTERFERON-PRODUCTION | IFN-ALPHA PRODUCTION | DEPENDENT VIRAL RECOGNITION | TRANSCRIPTION FACTOR E2-2 | FACTOR SPI-B | Adaptive Immunity | Autoimmunity | Virus Diseases - immunology | Signal Transduction | Dendritic Cells - immunology | Humans | Autoimmune Diseases - immunology | Gene Expression Regulation | Dendritic Cells - pathology | Virus Diseases - virology | Immunity, Innate | Interferon Type I - immunology | Animals | Antigen Presentation | Virus Diseases - pathology | Interferon Type I - genetics | Mice | Dendritic Cells - virology | Autoimmune Diseases - pathology | Cytokines - genetics | Cytokines - immunology | Immune response | Dendritic cells | Cellular control mechanisms | Interferon | Genetic aspects | Disease susceptibility | Properties | transcription factor | autoimmunity | plasmacytoid dendritic cell | cancer | interferon | virus | human | mucosal immunity
Journal Article
CELL REPORTS, ISSN 2211-1247, 08/2016, Volume 16, Issue 5, pp. 1253 - 1258
The prevailing paradigmis that tuberculosis infection is initiated when patrolling alveolar macrophages and dendritic cells within the terminal alveolus ingest...
RESPONSES | PROTEIN | ENTRY | BOVIS | LYMPHOID-TISSUE | SPI-B | ANTIGEN | CELL BIOLOGY
RESPONSES | PROTEIN | ENTRY | BOVIS | LYMPHOID-TISSUE | SPI-B | ANTIGEN | CELL BIOLOGY
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2019, Volume 216, Issue 4, pp. 831 - 846
Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate...
MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | RANKL | INTESTINAL M CELLS | PEYERS-PATCHES | PATCH DENDRITIC CELLS | DIFFERENTIATION | MUCOSAL | IMMUNOLOGY | TRANSCRIPTION FACTOR | FOLLICLE-ASSOCIATED EPITHELIUM | FACTOR SPI-B | 319
MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | RANKL | INTESTINAL M CELLS | PEYERS-PATCHES | PATCH DENDRITIC CELLS | DIFFERENTIATION | MUCOSAL | IMMUNOLOGY | TRANSCRIPTION FACTOR | FOLLICLE-ASSOCIATED EPITHELIUM | FACTOR SPI-B | 319
Journal Article
Mucosal Immunology, ISSN 1933-0219, 07/2013, Volume 6, Issue 4, pp. 666 - 677
The transcytosis of antigens across the gut epithelium by microfold cells ( M cells) is important for the induction of efficient immune responses to some...
PEYERS PATCH | ISOLATED LYMPHOID FOLLICLES | IMMUNOGLOBULIN-A | PATCH M-CELLS | IMMUNE-RESPONSES | TUNNELING NANOTUBES | ORAL TOLERANCE | CD103(+) DENDRITIC CELLS | IMMUNOLOGY | FOLLICLE-ASSOCIATED EPITHELIUM | FACTOR SPI-B | Cell Communication - immunology | Intestinal Mucosa - metabolism | RANK Ligand - metabolism | Age Factors | Receptors, G-Protein-Coupled - metabolism | Peyer's Patches - metabolism | Humans | Monitoring, Immunologic | Antigens - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Host-Pathogen Interactions - immunology | Intestinal Mucosa - cytology | Transcription Factors - metabolism | Peyer's Patches - cytology | Animals | Intestinal Mucosa - immunology | Antigens, Surface - metabolism | Antigens - immunology | Cell Differentiation | Peyer's Patches - immunology | Antigens, Surface - immunology
PEYERS PATCH | ISOLATED LYMPHOID FOLLICLES | IMMUNOGLOBULIN-A | PATCH M-CELLS | IMMUNE-RESPONSES | TUNNELING NANOTUBES | ORAL TOLERANCE | CD103(+) DENDRITIC CELLS | IMMUNOLOGY | FOLLICLE-ASSOCIATED EPITHELIUM | FACTOR SPI-B | Cell Communication - immunology | Intestinal Mucosa - metabolism | RANK Ligand - metabolism | Age Factors | Receptors, G-Protein-Coupled - metabolism | Peyer's Patches - metabolism | Humans | Monitoring, Immunologic | Antigens - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Host-Pathogen Interactions - immunology | Intestinal Mucosa - cytology | Transcription Factors - metabolism | Peyer's Patches - cytology | Animals | Intestinal Mucosa - immunology | Antigens, Surface - metabolism | Antigens - immunology | Cell Differentiation | Peyer's Patches - immunology | Antigens, Surface - immunology
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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Nature Genetics, ISSN 1061-4036, 08/2010, Volume 42, Issue 8, pp. 658 - 660
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated...
SYSTEMIC-LUPUS-ERYTHEMATOSUS | VARIANTS | SPI-B | TRANSCRIPTION | GENETICS & HEREDITY | RISK | ASTHMA | CELL | EXPRESSION | Canada | Interferon Regulatory Factors | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | Humans | Alleles | Liver Cirrhosis, Biliary | Genome | Odds Ratio | Autoimmunity | Chromosome mapping | Autoantibodies | Genomics | Development and progression | Genetic aspects | Biliary cirrhosis | Research | Properties | Methods | Celiac disease | Medical research | Disease | Autoimmune diseases
SYSTEMIC-LUPUS-ERYTHEMATOSUS | VARIANTS | SPI-B | TRANSCRIPTION | GENETICS & HEREDITY | RISK | ASTHMA | CELL | EXPRESSION | Canada | Interferon Regulatory Factors | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | Humans | Alleles | Liver Cirrhosis, Biliary | Genome | Odds Ratio | Autoimmunity | Chromosome mapping | Autoantibodies | Genomics | Development and progression | Genetic aspects | Biliary cirrhosis | Research | Properties | Methods | Celiac disease | Medical research | Disease | Autoimmune diseases
Journal Article
Nature immunology, ISSN 1529-2908, 2009, Volume 10, Issue 1, pp. 66 - 74
The human body contains over 500 individual lymph nodes, yet the biology of their formation is poorly understood. Here we identify human lymphoid...
ORGAN DEVELOPMENT | COLONY-STIMULATING FACTOR | B-CELL | PEYERS-PATCHES | SPI-B | GENE-EXPRESSION | NK-CELLS | GAMMA-T | T-CELL | IMMUNOLOGY | AUTOIMMUNE-DISEASE | Spleen - embryology | Spleen - immunology | Humans | Interleukin-7 Receptor alpha Subunit - immunology | Lymphoid Tissue - embryology | Lymphotoxin-alpha - immunology | Palatine Tonsil - immunology | Lymphoid Tissue - immunology | Palatine Tonsil - cytology | Mesentery - immunology | Mesentery - embryology | Receptors, Retinoic Acid - immunology | Cell Differentiation | Interleukins - biosynthesis | Receptors, Thyroid Hormone - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 | CD56 Antigen - metabolism | Cells, Cultured | Lymph Nodes - embryology | Interleukin-17 - biosynthesis | Lymph Nodes - immunology | Immunity, Innate | Lymph Nodes - cytology | Organogenesis | Animals | Mice | Precursor Cells, T-Lymphoid - immunology | Immunity, Cellular | Interferon-gamma - biosynthesis | Natural Killer T-Cells - immunology
ORGAN DEVELOPMENT | COLONY-STIMULATING FACTOR | B-CELL | PEYERS-PATCHES | SPI-B | GENE-EXPRESSION | NK-CELLS | GAMMA-T | T-CELL | IMMUNOLOGY | AUTOIMMUNE-DISEASE | Spleen - embryology | Spleen - immunology | Humans | Interleukin-7 Receptor alpha Subunit - immunology | Lymphoid Tissue - embryology | Lymphotoxin-alpha - immunology | Palatine Tonsil - immunology | Lymphoid Tissue - immunology | Palatine Tonsil - cytology | Mesentery - immunology | Mesentery - embryology | Receptors, Retinoic Acid - immunology | Cell Differentiation | Interleukins - biosynthesis | Receptors, Thyroid Hormone - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 | CD56 Antigen - metabolism | Cells, Cultured | Lymph Nodes - embryology | Interleukin-17 - biosynthesis | Lymph Nodes - immunology | Immunity, Innate | Lymph Nodes - cytology | Organogenesis | Animals | Mice | Precursor Cells, T-Lymphoid - immunology | Immunity, Cellular | Interferon-gamma - biosynthesis | Natural Killer T-Cells - immunology
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 02/2012, Volume 12, Issue 2, pp. 101 - 113
Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and adaptive immune responses. The genetic programme that coordinates...
LINEAGE COMMITMENT | REGULATORY FACTOR-4 | COLONY-STIMULATING FACTOR | SUBSET DEVELOPMENT | ANTIGEN PRESENTATION | T-CELL | IMMUNOLOGY | FACTOR SPI-B | CUTTING EDGE | CROSS-PRESENTATION | LANGERHANS CELLS | Gene Regulatory Networks - genetics | Dendritic Cells - immunology | Humans | Gene Expression Regulation | Signal Transduction - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Cell Differentiation - genetics | Cell Differentiation - immunology | Signal Transduction - immunology | Models, Immunological | Transcription, Genetic | Gene Regulatory Networks - immunology | Transcription Factors - immunology | Dendritic Cells - metabolism | Physiological aspects | Genetic aspects | Immune response | DNA binding proteins | Research | Dendritic cells | Bone marrow | Transcription factors | Cytokines | Differentiation
LINEAGE COMMITMENT | REGULATORY FACTOR-4 | COLONY-STIMULATING FACTOR | SUBSET DEVELOPMENT | ANTIGEN PRESENTATION | T-CELL | IMMUNOLOGY | FACTOR SPI-B | CUTTING EDGE | CROSS-PRESENTATION | LANGERHANS CELLS | Gene Regulatory Networks - genetics | Dendritic Cells - immunology | Humans | Gene Expression Regulation | Signal Transduction - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Cell Differentiation - genetics | Cell Differentiation - immunology | Signal Transduction - immunology | Models, Immunological | Transcription, Genetic | Gene Regulatory Networks - immunology | Transcription Factors - immunology | Dendritic Cells - metabolism | Physiological aspects | Genetic aspects | Immune response | DNA binding proteins | Research | Dendritic cells | Bone marrow | Transcription factors | Cytokines | Differentiation
Journal Article
Nature Methods, ISSN 1548-7091, 04/2013, Volume 10, Issue 6, pp. 577 - 583
The distinct cell types of multicellular organisms arise owing to constraints imposed by gene regulatory networks on the collective change of gene expression...
METHYLATION | COMMITMENT | CONVERSION | REGULATORY NETWORKS | SPI-B | DNA | EMBRYONIC STEM-CELLS | BIOCHEMICAL RESEARCH METHODS | DYNAMICS | DIFFERENTIATION | SPECIFICATION | Cell Lineage | Cell Differentiation | Gene Regulatory Networks | Humans | Transcriptome | Stem cell research | Genetic transcription | Research | Cellular biology | Gene expression | Genomics
METHYLATION | COMMITMENT | CONVERSION | REGULATORY NETWORKS | SPI-B | DNA | EMBRYONIC STEM-CELLS | BIOCHEMICAL RESEARCH METHODS | DYNAMICS | DIFFERENTIATION | SPECIFICATION | Cell Lineage | Cell Differentiation | Gene Regulatory Networks | Humans | Transcriptome | Stem cell research | Genetic transcription | Research | Cellular biology | Gene expression | Genomics
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 5/2019, Volume 244, Issue 7, pp. 554 - 564
M cells are an epithelial cell population found in the follicle-associated epithelium overlying gut-associated lymphoid tissues. They are specialized in the...
MEDICINE, RESEARCH & EXPERIMENTAL | M cells | PEYERS-PATCHES | follicle-associated epithelium | enteroid | MUCOSAL | MODEL | organoid | Gp-2 | FACTOR SPI-B | TRANSPORT | LECTIN | PATCH M-CELLS | LYMPHOID-TISSUE | UEA-1 | ANTIGEN
MEDICINE, RESEARCH & EXPERIMENTAL | M cells | PEYERS-PATCHES | follicle-associated epithelium | enteroid | MUCOSAL | MODEL | organoid | Gp-2 | FACTOR SPI-B | TRANSPORT | LECTIN | PATCH M-CELLS | LYMPHOID-TISSUE | UEA-1 | ANTIGEN
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