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Lancet Neurology, The, ISSN 1474-4422, 2015, Volume 14, Issue 4, pp. 348 - 349
... spinal cord pathology and might also be relevant for patients with primary progressive multiple sclerosis. The data also show that the assessment of focal spinal... 
Neurology | CLINICAL NEUROLOGY | Magnetic Resonance Imaging | Multiple Sclerosis - diagnosis | Magnetic Resonance Spectroscopy | Spinal Cord - pathology | Humans | Diffusion Tensor Imaging | Multiple sclerosis | Clinical trials | Pathology | Nervous system | Spinal cord | Neuropathology
Journal Article
Journal Article
Brain, ISSN 0006-8950, 03/2019, Volume 142, Issue 3, pp. 760 - 770
A common presentation of the P102L prion protein mutation is Gerstmann-Straussler-Scheinker syndrome. Rudge et al. show that serial measurement of lower limb... 
spinal cord | GSS | P102L | sensory symptoms | NEUROSCIENCES | CLINICAL NEUROLOGY
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2017, Volume 18, Issue 8, p. 1666
...International Journal of Molecular Sciences Article Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology... 
Animal model | ALS | Neuroinflammation | Innate immune system | SOD1 mice | TAK-242 | TLR4 | GLIAL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | DEATH | ASTROCYTES | CHEMISTRY, MULTIDISCIPLINARY | FAMILIAL ALS | SPORADIC ALS | innate immune system | neuroinflammation | DISEASE | NEURON DEGENERATION | MICE | animal model | BRAIN | Microglia - metabolism | Spinal Cord - drug effects | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Astrocytes - pathology | Motor Activity - drug effects | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neurons - pathology | Interleukin-1beta - blood | Spinal Cord - pathology | Superoxide Dismutase-1 - metabolism | Microglia - pathology | Behavior, Animal - drug effects | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Spleen - pathology | Motor Neurons - drug effects | Disease Models, Animal | Astrocytes - drug effects | Microglia - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Amyotrophic Lateral Sclerosis - blood | Sulfonamides - pharmacology | Toll-Like Receptor 4 - metabolism | Disease Progression | Motor Neurons - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Amyotrophic Lateral Sclerosis - pathology | Animals | Sulfonamides - therapeutic use | Lipopolysaccharides - pharmacology | Cell Proliferation - drug effects | Spinal Cord - physiopathology | Astrocytes - metabolism | Spinal cord | Animal models | Body weight | Fuel consumption | Activation | mRNA | Body weight loss | Lipopolysaccharides | Proteins | Splenocytes | Rodents | Toll-like receptors | Attenuation | Inhibition | Immune system | Motor neurons | Astrocytes | Transgenic mice | Amyotrophic lateral sclerosis | Inflammation | TLR4 protein | IL-1β | Survival | Pathology | Gliosis | Inhibitors | Tumor necrosis factor | In vivo methods and tests | In vitro methods and tests
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2014, Volume 53, Issue C, pp. 67 - 77
Abstract Spinal cord pathology with inflammatory, demyelinating lesions spanning three or more vertebral segments is a characteristic feature of neuromyelitis optica (NMO... 
Allergy and Immunology | NMO | Aquaporin-4 | Astrocyte | Demyelination | Complement-dependent cytotoxicity | OPTICA-IMMUNOGLOBULIN-G | AQUAPORIN 4 | MECHANISMS | IMMUNOLOGY | DEFICIENCY | IN-VITRO | MEMBRANE ATTACK COMPLEX | NEUROMYELITIS-OPTICA | PROTEIN CD59 | REGULATORS | TARGETED FORM | Hemoglobinuria - genetics | CD59 Antigens - immunology | Humans | Astrocytes - pathology | Immunoglobulin G - toxicity | Neuromyelitis Optica - genetics | Anemia, Hemolytic - genetics | Complement Membrane Attack Complex - immunology | Hemoglobinuria - pathology | Neuromyelitis Optica - immunology | Neuromyelitis Optica - chemically induced | Complement Membrane Attack Complex - genetics | Glial Fibrillary Acidic Protein | Astrocytes - immunology | Immunoglobulin G - immunology | Spinal Cord - pathology | Aquaporin 4 - genetics | Disease Models, Animal | Aquaporin 4 - immunology | Anemia, Hemolytic - immunology | Nerve Tissue Proteins - immunology | Anemia, Hemolytic - pathology | Cells, Cultured | CD59 Antigens - genetics | Neuromyelitis Optica - pathology | Hemoglobinuria - immunology | Nerve Tissue Proteins - genetics | Mice, Knockout | Spinal Cord - immunology | Animals | Mice | Autoimmunity | Monoclonal antibodies | Autoantibodies | Aquaporins | Analysis | Immunoglobulin G | aquaporin-4 | astrocyte | demyelination | complement-dependent cytotoxicity
Journal Article
FRONTIERS IN NEUROLOGY, ISSN 1664-2295, 08/2019, Volume 10, p. 820
Introduction: Spinal cord (SC) pathology is strongly associated with disability in multiple sclerosis (MS). We aimed to evaluate the association between focal... 
CERVICAL CORD | magnetic resonance imaging | ATROPHY | ABNORMALITIES | MRI PARAMETERS | spinal cord reserve | NEUROSCIENCES | LESIONS | DAMAGE | CLINICAL NEUROLOGY | focal lesions | AREA | DISEASE | spinal cord | diffuse abnormalities | BRAIN | Medicine, Experimental | Medical research | Multiple sclerosis
Journal Article
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article