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1. Full Text Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
by Firestone, Ari J and Weinger, Joshua S and Maldonado, Maria and Barlan, Kari and Langston, Lance D and O'Donnell, Michael and Gelfand, Vladimir I and Kapoor, Tarun M and Chen, James K
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 125 - 129
The conversion of chemical energy into mechanical force by AAA+ (ATPases associated with diverse cellular activities) ATPases is integral to cellular... 
NIH 3T3 Cells | Molecular Weight | Hedgehog Proteins - metabolism | Protein Transport - drug effects | Cytoplasmic Dyneins - antagonists & inhibitors | Peroxisomes - drug effects | Microtubules - metabolism | Spindle Apparatus - metabolism | Cattle | Kruppel-Like Transcription Factors - metabolism | Microtubules - drug effects | Enzyme Inhibitors - chemistry | Cilia - drug effects | Melanosomes - drug effects | Quinazolinones - pharmacology | Cytoplasmic Dyneins - metabolism | Cytoplasm - enzymology | Movement - drug effects | Cilia - pathology | Kinetochores - metabolism | Peroxisomes - physiology | Enzyme Inhibitors - pharmacology | Spindle Apparatus - pathology | Cilia - metabolism | Animals | Signal Transduction - drug effects | Kinetochores - drug effects | Mice | Quinazolinones - chemistry | Spindle Apparatus - drug effects | Melanosomes - metabolism | Physiological aspects | Research | Adenosine triphosphatase | Cellular control mechanisms
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2. Full Text Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles
by Zasadil, Lauren M and Andersen, Kristen A and Yeum, Dabin and Rocque, Gabrielle B and Wilke, Lee G and Tevaarwerk, Amye J and Raines, Ronald T and Burkard, Mark E and Weaver, Beth A
Science Translational Medicine, ISSN 1946-6234, 03/2014, Volume 6, Issue 229, pp. 229ra43 - 229ra43
The blockbuster chemotherapy drug paclitaxel is widely presumed to cause cell death in tumors as a consequence of mitotic arrest, as it does at concentrations... 
MEDICINE, RESEARCH & EXPERIMENTAL | ASSEMBLY CHECKPOINT | SOLID TUMORS | TAXOL | IN-VIVO | ANTIMITOTIC DRUGS | TUMOR-SUPPRESSOR | MITOTIC CHECKPOINT | FLAWED RATIONALE | GREAT DRUGS | CELL-DEATH | CELL BIOLOGY | Humans | Middle Aged | Spindle Apparatus - pathology | Chromosome Segregation - drug effects | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Dose-Response Relationship, Drug | Mitosis - drug effects | Paclitaxel - toxicity | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Adult | Female | Aged | Spindle Apparatus - drug effects | Cell Death - drug effects | Tumor Cells, Cultured | Interphase - drug effects | Index Medicus
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3. Full Text Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs
by Gascoigne, Karen E and Taylor, Stephen S
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 2, pp. 111 - 122
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is... 
CELLBIO | CELLCYCLE | Chromosomes, Human - genetics | Humans | Neoplasms - enzymology | Chromosomal Instability - drug effects | Cell Lineage - drug effects | Caspases - metabolism | Mitosis - drug effects | Spindle Apparatus - metabolism | Microscopy | Time Factors | Models, Biological | Cell Line, Tumor | Antimitotic Agents - pharmacology | Spindle Apparatus - drug effects | Cell Death - drug effects | Neoplasms - pathology | Antimitotic agents | Care and treatment | Antineoplastic agents | Cancer
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4. Full Text Synthetic lethal screen identification of chemosensitizer loci in cancer cells
by Whitehurst, Angelique W and Bodemann, Brian O and Cardenas, Jessica and Ferguson, Deborah and Girard, Luc and Peyton, Michael and Minna, John D and Michnoff, Carolyn and Hao, Weihua and Roth, Michael G and Xie, Xian-Jin and White, Michael A
Nature, ISSN 0028-0836, 04/2007, Volume 446, Issue 7137, pp. 815 - 819
Abundant evidence suggests that a unifying principle governing the molecular pathology of cancer is the co-dependent aberrant regulation of core machinery... 
V-ATPASE | MITOSIS | MULTIDISCIPLINARY SCIENCES | SALICYLIHALAMIDE-A | COMPLEXES | DRUGS | CHECKPOINT | DISCOVERY | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Survival - drug effects | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Lung - pathology | Paclitaxel - pharmacology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Spindle Apparatus - pathology | Lung Neoplasms - pathology | Dose-Response Relationship, Drug | Microtubules - metabolism | Mitosis - drug effects | Spindle Apparatus - metabolism | DNA Mutational Analysis | Microtubules - drug effects | Genes, Lethal - genetics | Lung - drug effects | Cell Line, Tumor | Lung - metabolism | Spindle Apparatus - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | RNA, Small Interfering - metabolism | Proteins | Cellular biology | Ribonucleic acid | Genomics | Ribonucleic acid--RNA | Cancer | Apoptosis
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5. Full Text The Small Molecule Hesperadin Reveals a Role for Aurora B in Correcting Kinetochore-Microtubule Attachment and in Maintaining the Spindle Assembly Checkpoint
by Silke Hauf and Richard W. Cole and Sabrina LaTerra and Christine Zimmer and Gisela Schnapp and Rainer Walter and Armin Heckel and Jacques van Meel and Conly L. Rieder and Jan-Michael Peters
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | Molecules | Genes | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
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6. Full Text Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage
by Zeng, Xing and Sigoillot, Frederic and Gaur, Shantanu and Choi, Sungwoon and Pfaff, Kathleen L and Oh, Dong-Chan and Hathaway, Nathaniel and Dimova, Nevena and Cuny, Gregory D and King, Randall W
Cancer Cell, ISSN 1535-6108, 2010, Volume 18, Issue 4, pp. 382 - 395
Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the... 
CDC20 | APC/C | ASSEMBLY CHECKPOINT | ACTIVATOR | ONCOLOGY | CYCLIN-A | KINASE | DESTRUCTION BOX | ANTIMITOTIC DRUGS | DEGRADATION | AURORA-B | Xenopus | Anaphase-Promoting Complex-Cyclosome | Tosylarginine Methyl Ester - pharmacology | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Spindle Apparatus - pathology | Mutant Proteins - metabolism | Metaphase - drug effects | Enzyme Activation - drug effects | Microtubules - metabolism | Animals | Mitosis - drug effects | Ubiquitin-Protein Ligase Complexes - metabolism | Microtubules - drug effects | Protein Binding - drug effects | Protein Biosynthesis - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Prodrugs - pharmacology | Ubiquitin | Care and treatment | Proteolysis | Ligases | Cancer
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7. Full Text Microtubules as a target for anticancer drugs
by Jordan, Mary Ann and Wilson, Leslie
Nature Reviews Cancer, ISSN 1474-175X, 04/2004, Volume 4, Issue 4, pp. 253 - 265
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including paclitaxel and... 
IN-VITRO | TRIPEPTIDE HEMIASTERLIN | STABILIZING AGENTS | ONCOLOGY | MITOTIC BLOCK | HOMOHALICHONDRIN-B | ESTRAMUSTINE PHOSPHATE | CELL-PROLIFERATION | PACLITAXEL TAXOL | COMBRETASTATIN A-4-PHOSPHATE | DEPOLYMERIZING ACTIVITY | Colchicine - pharmacology | Paclitaxel - pharmacology | Humans | Microtubules - physiology | Angiogenesis Inhibitors - pharmacology | Drug Resistance, Neoplasm | Neoplasms - drug therapy | Drug Synergism | Microtubules - drug effects | Vinca Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Spindle Apparatus - drug effects | Neoplasms - physiopathology | Cell Cycle - drug effects | Spindle Apparatus - physiology | Antimitotic agents | Control | Microtubules | Cell division | Physiological aspects | Dosage and administration | Research | Antineoplastic agents
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8. Full Text Characterization of alisertib (MLN8237), an investigational small-molecule inhibitor of Aurora A kinase using novel in vivo pharmacodynamic assays
by Manfredi, Mark G and Ecsedy, Jeffrey A and Chakravarty, Arijit and Silverman, Lee and Zhang, Mengkun and Hoar, Kara M and Stroud, Stephen G and Chen, Wei and Shinde, Vaishali and Huck, Jessica J and Wysong, Deborah R and Janowick, David A and Hyer, Marc L and LeRoy, Patrick J and Gershman, Rachel E and Silva, Matthew D and Germanos, Melissa S and Bolen, Joseph B and Claiborne, Christopher F and Sells, Todd B
Clinical Cancer Research, ISSN 1078-0432, 12/2011, Volume 17, Issue 24, pp. 7614 - 7624
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology... 
APOPTOSIS | RESPONSES | MLN8054 | DISCODERMOLIDE | ONCOLOGY | PHOSPHORYLATION | MITOTIC ARREST | A KINASE | CHECKPOINT | CANCER | PACLITAXEL | Neoplasms - metabolism | Humans | Positron-Emission Tomography | Pyrimidines - chemistry | Aurora Kinase A | Lymphoma - metabolism | Lymphoma - drug therapy | Spindle Apparatus - metabolism | Azepines - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Lymphoma - pathology | Molecular Structure | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | HCT116 Cells | Aurora Kinases | Pyrimidines - pharmacology | Mice, SCID | Neoplasms - drug therapy | Azepines - pharmacology | Dideoxynucleosides - pharmacokinetics | Xenograft Model Antitumor Assays | Mitotic Index | Animals | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Spindle Apparatus - drug effects | Fluorine Radioisotopes | HeLa Cells | Neoplasms - pathology
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9. Full Text Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes
by Sun, Shao-Chen and Wang, Zhen-Bo and Xu, Yong-Nan and Lee, Seung-Eun and Cui, Xiang-Shun and Kim, Nam-Hyung
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18392
Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly... 
CDC42 | F-ACTIN | NUCLEATOR | ACTIVATION | CORTACTIN | BIOLOGY | POLAR BODY FORMATION | ACTIN-BASED MOTILITY | N-WASP | MEIOTIC SPINDLE | POLYMERIZATION | Cytochalasin B - pharmacology | RNA Interference - drug effects | Oocytes - metabolism | Cytoplasmic Granules - drug effects | Actins - metabolism | Protein Transport - drug effects | Oocytes - cytology | Actin-Related Protein 2-3 Complex - metabolism | Meiosis - drug effects | Animals | Spindle Apparatus - metabolism | Cell Differentiation - drug effects | Models, Biological | Cytoplasmic Granules - metabolism | Oocytes - drug effects | Indoles - pharmacology | Cell Polarity - drug effects | Mice | Spindle Apparatus - drug effects | Cytokinesis - drug effects | Muscle proteins | Actin | Polarization | Maturation | RNA-mediated interference | Cortex | Animal sciences | Polymerization | Meiosis | Cytokinesis | Oocytes | Cell adhesion & migration | Proteins | Studies | Locomotion | Asymmetry | Fibroblasts | Polarity | Ligands | Disruption | Localization | Cell migration | Phagocytosis
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10. Full Text Aurora B Couples Chromosome Alignment with Anaphase by Targeting BubR1, Mad2, and Cenp-E to Kinetochores
by Claire Ditchfield and Victoria L. Johnson and Anthony Tighe and Rebecca Ellston and Carolyn Haworth and Trevor Johnson and Andrew Mortlock and Nicholas Keen and Stephen S. Taylor
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | Proteins | Genes | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
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