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1. Full Text Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
by Firestone, Ari J and Weinger, Joshua S and Maldonado, Maria and Barlan, Kari and Langston, Lance D and O'Donnell, Michael and Gelfand, Vladimir I and Kapoor, Tarun M and Chen, James K
Nature (London), ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 125 - 129
Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cytoskeleton, cytoplasm. Intracellular movements | Molecular and cellular biology | Cell structures and functions | NIH 3T3 Cells | Molecular Weight | Hedgehog Proteins - metabolism | Protein Transport - drug effects | Cytoplasmic Dyneins - antagonists & inhibitors | Peroxisomes - drug effects | Microtubules - metabolism | Spindle Apparatus - metabolism | Cattle | Kruppel-Like Transcription Factors - metabolism | Microtubules - drug effects | Enzyme Inhibitors - chemistry | Cilia - drug effects | Melanosomes - drug effects | Quinazolinones - pharmacology | Cytoplasmic Dyneins - metabolism | Cytoplasm - enzymology | Movement - drug effects | Cilia - pathology | Kinetochores - metabolism | Peroxisomes - physiology | Enzyme Inhibitors - pharmacology | Spindle Apparatus - pathology | Cilia - metabolism | Animals | Signal Transduction - drug effects | Kinetochores - drug effects | Mice | Quinazolinones - chemistry | Spindle Apparatus - drug effects | Melanosomes - metabolism | Physiological aspects | Research | Adenosine triphosphatase | Cellular control mechanisms | Index Medicus
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2. Full Text The Small Molecule Hesperadin Reveals a Role for Aurora B in Correcting Kinetochore-Microtubule Attachment and in Maintaining the Spindle Assembly Checkpoint
by Silke Hauf and Richard W. Cole and Sabrina LaTerra and Christine Zimmer and Gisela Schnapp and Rainer Walter and Armin Heckel and Jacques van Meel and Conly L. Rieder and Jan-Michael Peters
The Journal of cell biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | Molecules | Genes | Index Medicus | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
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3. Full Text Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles
by Zasadil, Lauren M and Andersen, Kristen A and Yeum, Dabin and Rocque, Gabrielle B and Wilke, Lee G and Tevaarwerk, Amye J and Raines, Ronald T and Burkard, Mark E and Weaver, Beth A
Science translational medicine, ISSN 1946-6234, 03/2014, Volume 6, Issue 229, pp. 229ra43 - 229ra43
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Humans | Middle Aged | Spindle Apparatus - pathology | Chromosome Segregation - drug effects | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Dose-Response Relationship, Drug | Mitosis - drug effects | Paclitaxel - toxicity | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Adult | Female | Aged | Spindle Apparatus - drug effects | Cell Death - drug effects | Tumor Cells, Cultured | Interphase - drug effects | Index Medicus
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4. Full Text HDAC3 inhibition disrupts the assembly of meiotic apparatus during porcine oocyte maturation
by Gu, Ling and Li, Xiaoyan and Liu, Xiaohui and Gao, Min and He, Yongfu and Xiong, Bo and Liu, Honglin
Journal of cellular physiology, ISSN 0021-9541, 07/2019, Volume 234, Issue 7, pp. 10178 - 10183
oocyte | meiosis | HDAC | pig | reproduction | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Meiosis - physiology | Oogenesis - physiology | Histone Deacetylases - metabolism | Meiosis - drug effects | Oocytes - enzymology | Animals | Microtubules - drug effects | Swine | Microtubules - enzymology | Oocytes - drug effects | Female | Histone Deacetylase Inhibitors - pharmacology | Oogenesis - drug effects | Spindle Apparatus - drug effects | Spindle Apparatus - enzymology | Tubulin | Maturation | Microscopy | Deacetylation | Metaphase | Confocal microscopy | Meiosis | Control stability | Inhibition | Assembly | Oocytes | Biological activity | Index Medicus
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5. Full Text Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality
by Jeelani, Roohi and Khan, Sana N and Shaeib, Faten and Kohan-Ghadr, Hamid-Reza and Aldhaheri, Sarah R and Najafi, Tohid and Thakur, Mili and Morris, Robert and Abu-Soud, Husam M
Free radical biology & medicine, ISSN 0891-5849, 09/2017, Volume 110, pp. 11 - 18
Acrolein | Oxidative stress | Cyclophosphamide | Chemotherapy | Infertility | Follicle dysfunction | Chromosome alignment | Meiotic spindle | Oocyte quality | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Oocytes - ultrastructure | Reactive Oxygen Species - metabolism | Oocytes - pathology | Acrolein - metabolism | Reactive Oxygen Species - agonists | Dose-Response Relationship, Drug | Cumulus Cells - ultrastructure | Microtubules - metabolism | Cumulus Cells - drug effects | Spindle Apparatus - metabolism | Cumulus Cells - metabolism | Microtubules - drug effects | Biotransformation | Metaphase | Acrolein - toxicity | Microtubules - ultrastructure | Oocytes - drug effects | Female | Spindle Apparatus - ultrastructure | Cumulus Cells - pathology | Oocytes - metabolism | Cyclophosphamide - metabolism | Injections, Intraperitoneal | Spindle Apparatus - pathology | Microtubules - pathology | Animals | Antineoplastic Agents, Alkylating - toxicity | Cyclophosphamide - toxicity | Mice | Spindle Apparatus - drug effects | Oxidative Stress - drug effects | Primary Cell Culture | Antineoplastic Agents, Alkylating - metabolism | Antioxidants | Medical colleges | Metabolites | Chromosomes | Cancer | Quality management | Index Medicus
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6. Full Text Aurora B Couples Chromosome Alignment with Anaphase by Targeting BubR1, Mad2, and Cenp-E to Kinetochores
by Claire Ditchfield and Victoria L. Johnson and Anthony Tighe and Rebecca Ellston and Carolyn Haworth and Trevor Johnson and Andrew Mortlock and Nicholas Keen and Stephen S. Taylor
The Journal of cell biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | Proteins | Genes | Index Medicus | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
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7. Full Text 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1
by Yu, Hang and Li, Zihuan and Yang, Zongying and Song, Meiqi and Liu, Yungang
Chemico-biological interactions, ISSN 0009-2797, 12/2020, Volume 332, pp. 109283 - 109283
Centromere protein B | Metabolic activation | Centrioles | 1-Methylpyrene | Mitotic spindle | Micronuclei | Cell Line | Cell Survival - drug effects | Cricetinae | Humans | Micronucleus, Germline - drug effects | Cytochrome P-450 CYP1A2 - metabolism | Cell Shape - drug effects | Mitotic Index | Animals | Micronucleus, Germline - metabolism | Mitosis - drug effects | Spindle Apparatus - metabolism | Centromere Protein B - metabolism | Spindle Apparatus - drug effects | Chromosomes, Mammalian - metabolism | Arylsulfotransferase - metabolism | Pyrenes - pharmacology | Medical research | Cytochrome P-450 | Genetic research | Physiological aspects | Medicine, Experimental | Tubulins | Chromosomes | Hamsters | Cells | Index Medicus
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8. Full Text Synthetic lethal screen identification of chemosensitizer loci in cancer cells
by Peyton, Michael and Bodemann, Brian O and Minna, John D and Hao, Weihua and Ferguson, Deborah and White, Michael A and Xie, Xian-Jin and Cardenas, Jessica and Roth, Michael G and Girard, Luc and Michnoff, Carolyn and Whitehurst, Angelique W
Nature (London), ISSN 0028-0836, 04/2007, Volume 446, Issue 7137, pp. 815 - 819
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Survival - drug effects | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Lung - pathology | Paclitaxel - pharmacology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Spindle Apparatus - pathology | Lung Neoplasms - pathology | Dose-Response Relationship, Drug | Microtubules - metabolism | Mitosis - drug effects | Spindle Apparatus - metabolism | DNA Mutational Analysis | Microtubules - drug effects | Genes, Lethal - genetics | Lung - drug effects | Cell Line, Tumor | Lung - metabolism | Spindle Apparatus - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | RNA, Small Interfering - metabolism | Proteins | Cellular biology | Ribonucleic acid | Genomics | Ribonucleic acid--RNA | Cancer | Apoptosis | Index Medicus
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9. Full Text Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells
by Wen, Chuangyu and Chen, Junxiong and Zhang, Di and Wang, Huihui and Che, Jia and Qin, Qiyuan and He, Lu and Cai, Zerong and Lin, Mengmeng and Lou, Qiong and Huang, Lanlan and Chen, Daici and Iwamoto, Aikichi and Ren, Donglin and Wang, Lei and Lan, Ping and Wang, Jianping and Liu, Huanliang and Yang, Xiangling
Cancer letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 295 - 308
Hematology, Oncology and Palliative Medicine | 5-FU resistance | Spindle | Mitotic arrest | Pseudolaric acid B | Colorectal cancer | Apoptosis | Life Sciences & Biomedicine | Oncology | Science & Technology | CDC2 Protein Kinase | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Dose-Response Relationship, Drug | Caspases - metabolism | Spindle Apparatus - metabolism | Time Factors | Colorectal Neoplasms - drug therapy | Antimetabolites, Antineoplastic - pharmacology | Colorectal Neoplasms - metabolism | Diterpenes - pharmacology | M Phase Cell Cycle Checkpoints - drug effects | HCT116 Cells | Spindle Apparatus - pathology | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Mitosis - drug effects | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | Spindle Apparatus - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Colorectal Neoplasms - pathology | Medicinal plants | Chemotherapy | Communicable diseases | Medicine, Botanic | Medicine, Herbal | Research institutes | Cancer | Fluorouracil | Index Medicus
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10. Full Text MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
by Abdelfattah, Nourhan and Rajamanickam, Subapriya and Panneerdoss, Subbarayalu and Timilsina, Santosh and Yadav, Pooja and Onyeagucha, Benjamin C and Garcia, Michael and Vadlamudi, Ratna and Chen, Yidong and Brenner, Andrew and Houghton, Peter and Rao, Manjeet K
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4541 - 19
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Vincristine - pharmacology | Spindle Apparatus - radiation effects | Eukaryotic Initiation Factor-4E - metabolism | MicroRNAs - metabolism | Cerebellar Neoplasms - genetics | Proto-Oncogene Proteins c-myc - metabolism | Microtubules - metabolism | Animals | Spindle Apparatus - metabolism | Signal Transduction - drug effects | Mice, Nude | Microtubules - drug effects | Medulloblastoma - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | MicroRNAs - genetics | Spindle Apparatus - drug effects | Cerebellar Neoplasms - pathology | DNA Damage | Gene Expression Regulation, Neoplastic - drug effects | Cell Cycle - drug effects | Medulloblastoma - genetics | Histone Deacetylase 1 - metabolism | Radiation, Ionizing | Cell culture | Animal models | DNA damage | Radiation | DNA repair | Defects | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Sensitizing | Radiation effects | Cell survival | Survival | Patients | Vincristine | Screens | Quality of life | Side effects | Chemotherapy | Medulloblastoma | Stem cells | Neural stem cells | Tumor suppressor genes | Radiation damage | Tumors | Index Medicus
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