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1. Full Text Katanin Controls Mitotic and Meiotic Spindle Length
by Karen McNally and Anjon Audhya and Karen Oegema and Francis J. McNally
The Journal of Cell Biology, ISSN 0021-9525, 12/2006, Volume 175, Issue 6, pp. 881 - 891
Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation... 
Depolymerization | Microtubules | Metaphase | Fluorescence | Embryos | Rotation | Chromosomes | Anaphase | Oocytes | Mitotic spindle apparatus | KINESIN | MICROTUBULE-SEVERING ACTIVITY | MEIOSIS | ANAPHASE-B | C-ELEGANS | CAENORHABDITIS-ELEGANS EMBRYO | SACCHAROMYCES-CEREVISIAE | CROSS-LINKS | GAMMA-TUBULIN | OOCYTE CORTEX | CELL BIOLOGY | Meiosis - physiology | Embryo, Nonmammalian - cytology | Fibroblasts - enzymology | Nocodazole - pharmacology | Caenorhabditis elegans Proteins - metabolism | Caenorhabditis elegans - embryology | Tubulin - metabolism | Animals | Caenorhabditis elegans - cytology | Embryo, Nonmammalian - enzymology | Microtubules - drug effects | Fibroblasts - drug effects | Microtubules - enzymology | Female | Katanin | Fibroblasts - cytology | Spindle Apparatus - ultrastructure | Adenosine Triphosphatases - physiology | Caenorhabditis elegans - enzymology | Spindle Apparatus - enzymology | Cell division | Physiological aspects
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2. Full Text The Small Molecule Hesperadin Reveals a Role for Aurora B in Correcting Kinetochore-Microtubule Attachment and in Maintaining the Spindle Assembly Checkpoint
by Silke Hauf and Richard W. Cole and Sabrina LaTerra and Christine Zimmer and Gisela Schnapp and Rainer Walter and Armin Heckel and Jacques van Meel and Conly L. Rieder and Jan-Michael Peters
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
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3. Full Text Moesin and Its Activating Kinase Slik Are Required for Cortical Stability and Microtubule Organization in Mitotic Cells
by Sébastien Carreno and Ilektra Kouranti and Edith Szafer Glusman and Margaret T. Fuller and Arnaud Echard and François Payre
The Journal of Cell Biology, ISSN 0021-9525, 2/2008, Volume 180, Issue 4, pp. 739 - 746
Cell division requires cell shape changes involving the localized reorganization of cortical actin, which must be tightly linked with chromosome segregation... 
Phosphorylation | Double stranded RNA | Mitosis | Report | Metaphase | Microtubules | Drosophila | Cell division | Actins | Cytokinesis | Mitotic spindle apparatus | EPITHELIAL INTEGRITY | MORPHOGENESIS | CYTOKINESIS | RNAI | ERM PROTEINS | ACTIN | OOGENESIS | CYCLE PROGRESSION | CONTRIBUTES | DIVISION | CELL BIOLOGY | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Prometaphase - physiology | Cytoskeleton - enzymology | Cytokinesis - physiology | Microtubules - ultrastructure | Membrane Proteins - metabolism | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Cytoskeleton - pathology | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Cell Membrane - ultrastructure | Cytoskeleton - ultrastructure | Drosophila melanogaster - ultrastructure | Microtubules - pathology | Mutation - genetics | Actomyosin - metabolism | Down-Regulation - genetics | Cell Membrane - enzymology | Animals | Membrane Proteins - antagonists & inhibitors | Mitosis - physiology | Microtubules - enzymology | Drosophila melanogaster - enzymology | Drosophila Proteins - genetics | Enzyme Activation - genetics | Spindle Apparatus - enzymology | Evaluation | Cell research | Physiological aspects | Properties
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4. Full Text PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
by Jiang, Yuhui and Li, Xinjian and Yang, Weiwei and Hawke, David H and Zheng, Yanhua and Xia, Yan and Aldape, Kenneth and Wei, Chongyang and Guo, Fang and Chen, Yan and Lu, Zhimin
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 1, pp. 75 - 87
Tumor-specific pyruvate kinase M2 (PKM2) is instrumental in both aerobic glycolysis and gene transcription. PKM2 regulates G1-S phase transition by controlling... 
INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PYRUVATE-KINASE M2 | CANCER METABOLISM | MITOTIC CHECKPOINT | MAMMALIAN-CELLS | TUMORIGENESIS | BUB1 | PROMOTES | SPINDLE-ASSEMBLY CHECKPOINT | GENE-TRANSCRIPTION | CELL BIOLOGY | Glioblastoma - enzymology | Mitosis | Humans | Neoplasm Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Glioblastoma - genetics | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Kinetochores - enzymology | Brain Neoplasms - enzymology | Chromosome Segregation | Membrane Proteins - genetics | Chromosomes, Human - genetics | Cell Cycle Proteins - metabolism | Brain Neoplasms - genetics | Chromosomes, Human - metabolism | Thyroid Hormones - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mice, Nude | Thyroid Hormones - metabolism | Mice | HeLa Cells | Spindle Apparatus - enzymology | Genetic research | Glucose metabolism | Epidermal growth factor | Genetic transcription | Gliomas | Protein binding | Brain tumors | Chromosomes | Protein kinases | spindle-assembly checkpoint | PKM2 | kinetochore | Bub3 | tumorigenesis | phosphorylation | EGFR
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5. Full Text Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells
by Ertych, Norman and Stolz, Ailine and Stenzinger, Albrecht and Weichert, Wilko and Kaulfuß, Silke and Burfeind, Peter and Aigner, Achim and Wordeman, Linda and Bastians, Holger
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 8, pp. 779 - 791
Chromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer.... 
ANEUPLOIDY | CENTROSOME AMPLIFICATION | MAMMALIAN TISSUE-CELLS | DYNAMICS | TUMOR-SUPPRESSOR | HUMAN SOMATIC-CELLS | AURORA KINASE | MEROTELIC KINETOCHORE ORIENTATION | SMALL-MOLECULE INHIBITOR | MITOTIC SPINDLES | CELL BIOLOGY | Caco-2 Cells | Colorectal Neoplasms - enzymology | Gene Expression | Colorectal Neoplasms - genetics | HCT116 Cells | Humans | Spindle Apparatus - pathology | Microtubules - pathology | HT29 Cells | BRCA1 Protein - genetics | Checkpoint Kinase 2 - genetics | Microtubules - genetics | Models, Biological | Microtubules - enzymology | Spindle Apparatus - genetics | Cell Line, Tumor | Colorectal Neoplasms - pathology | Chromosomal Instability | Genes, Tumor Suppressor | Aurora Kinase A - genetics | Oncogenes | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Development and progression | Genetic aspects | Properties | Chromosomes | Microtubules | Colorectal cancer | Index Medicus
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6. Full Text Antibodies to mitotic apparatus: New association with cholestatic liver disease
by Pascual, Virginia and Perez, Irene and Sánchez-Ramón, Silvia and Sánchez-Pobre, Pilar
American Journal of Gastroenterology, ISSN 0002-9270, 12/2015, Volume 110, Issue 12, pp. 1736 - 1737
GASTROENTEROLOGY & HEPATOLOGY | Autoimmunity | Cholestasis - immunology | Liver Diseases - immunology | Liver Diseases - genetics | Cholestasis - enzymology | Autoantibodies - blood | Humans | Liver Diseases - enzymology | Medical Records | Transaminases - blood | Retrospective Studies | Spindle Apparatus - immunology
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7. Full Text MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway
by Gruber, Ralph and Zhou, Zhongwei and Sukchev, Mikhail and Joerss, Tjard and Frappart, Pierre-Olivier and Wang, Zhao-Qi
Nature Cell Biology, ISSN 1465-7392, 11/2011, Volume 13, Issue 11, pp. 1325 - 1334
Primary microcephaly 1 is a neurodevelopmental disorder caused by mutations in the MCPH1 gene, whose product MCPH1 (also known as microcephalin and BRIT1)... 
MISREGULATED CHROMOSOME CONDENSATION | DNA-DAMAGE RESPONSE | NEURAL STEM | MICROCEPHALIN | NEUROEPITHELIAL CELLS | SPINDLE ORIENTATION | CENTRAL-NERVOUS-SYSTEM | MUTATIONS | ASYMMETRIC CELL-DIVISION | HUMAN BRAIN SIZE | CELL BIOLOGY | Neocortex - pathology | Protein Kinases - metabolism | Protein Kinases - genetics | Cell Proliferation | Microcephaly - genetics | Mitosis | Neocortex - enzymology | Microcephaly - enzymology | Transfection | RNA Interference | Microcephaly - pathology | Cell Differentiation | cdc25 Phosphatases - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cells, Cultured | Organ Size | cdc25 Phosphatases - genetics | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Chromosomal Proteins, Non-Histone - deficiency | Chromosomal Proteins, Non-Histone - genetics | Mice, Knockout | Animals | Centrosome - enzymology | Checkpoint Kinase 1 | Mice | Spindle Apparatus - enzymology | DNA damage | Centrosomes | Physiological aspects | Genetic aspects | Research | Microcephaly | Risk factors
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8. Full Text Cardiomyocyte binucleation is associated with aberrant mitotic microtubule distribution, mislocalization of RhoA and IQGAP3, as well as defective actomyosin ring anchorage and cleavage furrow ingression
by Leone, Marina and Musa, Gentian and Engel, Felix Benedikt
Cardiovascular Research, ISSN 0008-6363, 07/2018, Volume 114, Issue 8, pp. 1115 - 1131
Abstract Aims After birth mammalian cardiomyocytes initiate a last cell cycle which results in binucleation due to cytokinesis failure. Despite its importance... 
Actomyosin ring | Cardiomyocytes | IQGAP3 | Microtubules | RhoA | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIAC MYOCYTES | PROLIFERATION | MYOSIN-II | CONTRACTILE RING | CYTOKINESIS | CELL CORTEX | ANILLIN | RAT-HEART | PROTEINS | ECT2 | ras GTPase-Activating Proteins - metabolism | Cell Proliferation | Signal Transduction | Mitosis | Cells, Cultured | Rats | Spindle Apparatus - pathology | Microscopy, Video | Cytokinesis | Microtubules - pathology | Actomyosin - metabolism | Time-Lapse Imaging | Cell Nucleus - enzymology | Protein Transport | Myocytes, Cardiac - enzymology | Myocytes, Cardiac - pathology | Animals | Time Factors | Cell Nucleus - pathology | Cell Nucleus Division | Microtubules - enzymology | rho GTP-Binding Proteins - metabolism | Spindle Apparatus - enzymology
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9. Full Text Increased Aurora B activity causes continuous disruption of kinetochore–microtubule attachments and spindle instability
by Marta Muñoz-Barrera and Fernando Monje-Casas
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 38, pp. E3996 - E4005
Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct... 
ANAPHASE | COMPLEX | BUDDING YEAST | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | MITOTIC PHOSPHORYLATION | Ipl1 | Sli15 | MITOSIS | CYTOKINESIS | SAC | INCENP | HISTONE H3 | CPC | CHECKPOINT | CHROMOSOME SEGREGATION | Aurora Kinase B - genetics | Aurora Kinase B - metabolism | Chromatids - genetics | Saccharomyces cerevisiae - genetics | Chromatids - enzymology | Saccharomyces cerevisiae Proteins - genetics | Chromosomes, Fungal - genetics | Chromosomes, Fungal - metabolism | Microtubules - genetics | Microtubules - enzymology | Spindle Apparatus - genetics | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Kinetochores - enzymology | Spindle Apparatus - enzymology | Biological Sciences | PNAS Plus
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10. Full Text The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis
by Vazquez-Martin, Alejandro and Oliveras-Ferraros, Cristina and Menendez, Javier A
Cell Cycle, ISSN 1538-4101, 08/2009, Volume 8, Issue 15, pp. 2385 - 2398
The metabolic rheostat AMP-activated protein kinase (AMPK) is unexpectedly required for proper cell division and faithful chromosomal segregation during... 
Genome instability | AMPK | Cytokinesis | Mitosis | Tumor suppressor | MAMMALIAN TARGET | POLARITY | PHOSPHORYLATION | cytokinesis | tumor suppressor | mitosis | TUMOR SUPPRESSORS | CHROMOSOMAL PASSENGERS | DIVISION | CELL BIOLOGY | BREAST-CANCER CELLS | genome instability | ENERGETIC STRESS | GROWTH | ANTIDIABETIC DRUG METFORMIN | AMP-Activated Protein Kinases - metabolism | Chromosome Segregation | Humans | Anaphase - physiology | Aurora Kinases | Aurora Kinase A | Aurora Kinase B | Tubulin - metabolism | Animals | Centrosome - enzymology | Cell Line, Tumor | Mice | Telophase - physiology | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Spindle Apparatus - enzymology
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11. Full Text The multifaceted allosteric regulation of Aurora kinase A
by Levinson, Nicholas Mark
Biochemical Journal, ISSN 0264-6021, 06/2018, Volume 475, Issue 12, pp. 2025 - 2042
The protein kinase Aurora A (AurA) is essential for the formation of bipolar mitotic spindles in all eukaryotic organisms. During spindle assembly, AurA is... 
XENOPUS EGG EXTRACTS | AURORA/IP11-RELATED PROTEIN-KINASE | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROPHOBIC MOTIF PHOSPHORYLATION | MITOTIC SPINDLE | N-MYC | CAENORHABDITIS-ELEGANS EMBRYOS | Humans | Neuroblastoma - enzymology | Melanoma - enzymology | Male | Neoplasm Proteins - antagonists & inhibitors | Aurora Kinase A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Aurora Kinase A - metabolism | Phosphorylation - genetics | Prostatic Neoplasms - genetics | Melanoma - genetics | Spindle Apparatus - genetics | Protein Domains | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Aurora Kinase A - genetics | Prostatic Neoplasms - drug therapy | Allosteric Regulation - drug effects | Allosteric Regulation - genetics | Centromere - enzymology | Neuroblastoma - genetics | Enzyme Activation - drug effects | Animals | Centromere - genetics | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Neuroblastoma - drug therapy | Prostatic Neoplasms - enzymology | Enzyme Activation - genetics | Spindle Apparatus - enzymology | Review | allosteric regulation | aurora kinases | protein dynamics
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12. Full Text The cellular geography of Aurora kinases
by Carmena, Mar and Earnshaw, William C
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 11/2003, Volume 4, Issue 11, pp. 842 - 854
Aurora is the name given to a family of highly conserved protein kinases with essential roles in many aspects of cell division. Yeasts have a single Aurora... 
INNER CENTROMERE PROTEIN | MITOTIC CHROMOSOME CONDENSATION | DROSOPHILA-AURORA | BUDDING YEAST | MATURATION-PROMOTING FACTOR | B KINASE | SPINDLE ASSEMBLY CHECKPOINT | A KINASE | CAENORHABDITIS-ELEGANS EMBRYOS | HISTONE H3 PHOSPHORYLATION | CELL BIOLOGY | Chromosomes - enzymology | Protein Kinases - metabolism | Meiosis - physiology | Animals | Centrosome - enzymology | Humans | Neoplasms - enzymology | Aurora Kinases | Xenopus Proteins | Cell Cycle Proteins | Protein-Serine-Threonine Kinases - metabolism | Spindle Apparatus - enzymology
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