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Clinical Infectious Diseases, ISSN 1058-4838, 11/2017, Volume 65, Issue 10, pp. 1711 - 1720
Background. Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose and... 
dispersible tablet | arterolane maleate | P. falciparum | pediatric | INFECTIOUS DISEASES | ADULTS | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | ANTIMALARIAL | CHILDREN | PHARMACOKINETICS | DIHYDROARTEMISININ-PIPERAQUINE | ARTESUNATE PLUS AMODIAQUINE | Quinolines - blood | Ethanolamines - adverse effects | Artemisinins - pharmacokinetics | Tablets | Humans | Fluorenes - therapeutic use | Antimalarials - blood | Child, Preschool | Infant | Male | Spiro Compounds - therapeutic use | Peroxides - therapeutic use | Spiro Compounds - adverse effects | Peroxides - pharmacokinetics | Peroxides - adverse effects | Quinolines - pharmacokinetics | Ethanolamines - pharmacokinetics | Malaria, Falciparum - mortality | Artemisinins - blood | Female | Fluorenes - adverse effects | Fluorenes - blood | Child | Antimalarials - adverse effects | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Africa | Antimalarials - therapeutic use | Spiro Compounds - pharmacokinetics | India | Ethanolamines - blood | Peroxides - blood | Artemisinins - therapeutic use | Spiro Compounds - blood | Heterocyclic Compounds, 1-Ring - adverse effects | Survival Analysis | Heterocyclic Compounds, 1-Ring - therapeutic use | Ethanolamines - therapeutic use | Quinolines - therapeutic use | Heterocyclic Compounds, 1-Ring - blood | Artemisinins - adverse effects | Drug Combinations | Quinolines - adverse effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2008, Volume 105, Issue 10, pp. 3933 - 3938
We have designed MI-219 as a potent, highly selective and orally active small-molecule inhibitor of the MDM2-p53 interaction. MI-219 binds to human MDM2 with a... 
Up regulation | Laboratory staining techniques | Cell growth | Drug interactions | Cell cycle | Cell lines | Heterologous transplantation | Tumors | Apoptosis | Cancer | Selective toxicity to tumors | Small-molecule inhibitor | Cancer therapy | MDM2-p53 protein-protein interaction | TARGET | APOPTOSIS | CELLS | MULTIDISCIPLINARY SCIENCES | small-molecule inhibitor | RESTORATION | CANCER | cancer therapy | PATHWAY | P53-MDM2 | selective toxicity to tumors | SMALL-MOLECULE ANTAGONISTS | EXPRESSION | STRUCTURE-BASED DESIGN | Apoptosis - drug effects | Humans | Spiro Compounds - administration & dosage | Antineoplastic Agents - administration & dosage | Indoles - administration & dosage | Time Factors | Protein Binding - drug effects | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Spiro Compounds - chemistry | Administration, Oral | Indoles - blood | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Animals | Spiro Compounds - blood | Antineoplastic Agents - blood | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Neoplasms - pathology | Indoles - chemistry | Spiro Compounds - pharmacology | Care and treatment | Influence | Tumor suppressor genes | Research | DNA binding proteins | Properties | Protein-protein interactions | Index Medicus | Biological Sciences | MDM2–p53 protein–protein interaction
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2019, Volume 63, Issue 1
Artesunate (AS), a semisynthetic artemisinin approved for malaria therapy, inhibits human cytomegalovirus (HCMV) replication in vitro, but therapeutic success... 
Half-life | Artemisinins | Pharmacokinetics | Mouse cytomegalovirus | Ozonides | Human cytomegalovirus | INTRAVENOUS GANCICLOVIR | artemisinins | MICROBIOLOGY | mouse cytomegalovirus | TRANSPLANT RECIPIENTS | CELL-CYCLE PROGRESSION | human cytomegalovirus | half-life | ozonides | RESISTANT | IN-VITRO | PLASMODIUM-FALCIPARUM | DISEASE | pharmacokinetics | PHARMACOLOGY & PHARMACY | INFECTION | VALGANCICLOVIR | ARTESUNATE | Antiviral Agents - pharmacokinetics | Humans | Male | Host-Pathogen Interactions - drug effects | CDC2 Protein Kinase - metabolism | Microbial Sensitivity Tests | Heterocyclic Compounds, 1-Ring - chemistry | Antiviral Agents - chemistry | Heterocyclic Compounds, 1-Ring - pharmacology | Isoenzymes - metabolism | Cytomegalovirus Infections - virology | Female | Ganciclovir - pharmacology | Drug Evaluation, Preclinical | Spiro Compounds - chemistry | Fibroblasts - virology | Cell Line | Cytomegalovirus - genetics | Virus Replication - drug effects | Antiviral Agents - pharmacology | CDC2 Protein Kinase - genetics | Drug Administration Schedule | Signal Transduction | Antiviral Agents - blood | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Isoenzymes - genetics | Cytomegalovirus - metabolism | Retinoblastoma Protein - metabolism | Gene Expression Regulation | E2F1 Transcription Factor - metabolism | Fibroblasts - pathology | Spiro Compounds - pharmacokinetics | Drug Resistance, Viral - genetics | Animals | Cytomegalovirus Infections - drug therapy | Retinoblastoma Protein - genetics | Fibroblasts - drug effects | Spiro Compounds - blood | Drug Resistance, Viral - drug effects | Mice | Mice, Inbred BALB C | Heterocyclic Compounds, 1-Ring - blood | E2F1 Transcription Factor - genetics | Spiro Compounds - pharmacology | Cytomegalovirus - drug effects
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2012, Volume 77, Issue 17, pp. 7187 - 7211
Journal Article
Journal Article
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 11/2011, Volume 51, Issue 11, pp. 1519 - 1528
Arterolane (RBx 11160) maleate is a novel, rapidly acting synthetic trioxolane antimalarial compound being developed by Ranbaxy Research Laboratories (Haryana,... 
pharmacodynamics | P. falciparum | patients | pharmacokinetics | recrudescence | malaria | Arterolane | DRUG | EFFICACY | recrudescence, P. falciparum | REGIMENS | SYNTHETIC TRIOXOLANE | PLASMODIUM-FALCIPARUM | PHARMACOLOGY & PHARMACY | ARTEMISININ | ARTESUNATE | Peroxides - administration & dosage | Humans | Middle Aged | Antimalarials - blood | Spiro Compounds - administration & dosage | Male | Spiro Compounds - adverse effects | Peroxides - pharmacokinetics | Peroxides - adverse effects | Dose-Response Relationship, Drug | Heterocyclic Compounds, 1-Ring - administration & dosage | Young Adult | Malaria, Falciparum - blood | Plasmodium falciparum | Malaria, Falciparum - metabolism | Adult | Female | Antimalarials - adverse effects | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Double-Blind Method | Administration, Oral | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Spiro Compounds - pharmacokinetics | Malaria, Falciparum - parasitology | Maleates | Peroxides - blood | Antimalarials - administration & dosage | Spiro Compounds - blood | Adolescent | Heterocyclic Compounds, 1-Ring - adverse effects | Aged | Heterocyclic Compounds, 1-Ring - blood | Drugs | Control | Malaria | Drug utilization | Antimalarials | Dosage and administration | Product/Service Evaluations | Drug therapy | Health aspects | Parasites
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2010, Volume 333, Issue 1, pp. 152 - 160
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2012, Volume 22, Issue 12, pp. 3941 - 3945
Journal Article
Journal Article