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Cancer Letters, ISSN 0304-3835, 2010, Volume 332, Issue 2, pp. 295 - 303
Journal Article
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5996, pp. 1175 - 1180
Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted class of antimalarials— have prompted a need for new treatments. The... 
Malaria | Artemisinins | RESEARCH ARTICLES | Genomics | Adenosine triphosphatases | Antimalarials | Parasites | Inhibitory concentration 50 | Drug resistance | Dosage | Genetic mutation | VIVAX | MULTIDISCIPLINARY SCIENCES | PARASITE PLASMODIUM-FALCIPARUM | ERADICATION | CALCIUM-PUMP | DRUG-RESISTANCE | SARCOPLASMIC-RETICULUM | ANTIMALARIALS | IDENTIFICATION | CHLOROQUINE | ARTEMISININ | Parasitic Sensitivity Tests | Humans | Male | Plasmodium falciparum - drug effects | Indoles - administration & dosage | Plasmodium falciparum - genetics | Protein Synthesis Inhibitors - pharmacology | Mutant Proteins - antagonists & inhibitors | Antimalarials - pharmacokinetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Rats | Spiro Compounds - pharmacokinetics | Adenosine Triphosphatases - antagonists & inhibitors | Antimalarials - administration & dosage | Malaria - parasitology | Adenosine Triphosphatases - genetics | Mice | Mutation | Erythrocytes - parasitology | Plasmodium berghei - drug effects | Plasmodium vivax - growth & development | Protein Synthesis Inhibitors - chemistry | Rats, Wistar | Spiro Compounds - administration & dosage | Genes, Protozoan | Protozoan Proteins - genetics | Protein Synthesis Inhibitors - administration & dosage | Protozoan Proteins - metabolism | Female | Indoles - pharmacology | Protozoan Proteins - chemistry | Drug Resistance | Spiro Compounds - chemistry | Cell Line | Plasmodium vivax - drug effects | Mutant Proteins - metabolism | Drug Discovery | Protozoan Proteins - biosynthesis | Antimalarials - pharmacology | Protein Synthesis Inhibitors - pharmacokinetics | Animals | Mutant Proteins - chemistry | Antimalarials - chemistry | Adenosine Triphosphatases - chemistry | Indoles - pharmacokinetics | Malaria - drug therapy | Plasmodium falciparum - growth & development | Indoles - chemistry | Spiro Compounds - pharmacology | Research | Pharmacology | Inhibitor drugs | Drug therapy | Protein synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2013, Volume 56, Issue 6, pp. 2547 - 2555
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 22, pp. 10147 - 10162
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 801 - 804
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new... 
Enzymes | Antibacterials | Tuberculosis | Mycobacterium tuberculosis | Cell walls | Antituberculars | Bacteria | Reports | Biochemistry | Enantiomers | Codons | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CELL-WALL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Thiazines - therapeutic use | Ethambutol - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Polysaccharides - biosynthesis | Microbial Sensitivity Tests | Racemases and Epimerases - metabolism | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Tuberculosis - drug therapy | Arabinose - metabolism | Thiazines - pharmacology | Molecular Structure | Mycobacterium tuberculosis - metabolism | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Genes, Bacterial | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Racemases and Epimerases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Thiazines - chemistry | Mycobacterium - genetics | Mycobacterium - drug effects | Gene Expression Regulation, Bacterial - drug effects | Animals | Cell Wall - metabolism | Enzyme Inhibitors - cerebrospinal fluid | Mice | Mice, Inbred BALB C | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - genetics | Antitubercular agents | Dosage and administration | Drug therapy | Genetics | Pharmacology | Chemical synthesis
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2008, Volume 73, Issue 3, pp. 789 - 800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A... 
AMINO-TERMINAL DOMAIN | PROTEIN | ENTRY | CORECEPTOR | RECEPTOR ANTAGONISTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTI-HIV-1 ACTIVITY | PHARMACOLOGY & PHARMACY | HIGHLY POTENT | INHIBITOR | BINDING | Anti-HIV Agents - pharmacology | Benzoates - metabolism | Humans | Receptors, CCR5 - genetics | Piperazines - chemistry | Pyrimidines - metabolism | Receptors, CCR5 - metabolism | Piperidines - pharmacology | Amides - metabolism | Anti-HIV Agents - metabolism | Radioligand Assay | Binding Sites | Amides - pharmacology | Anti-HIV Agents - classification | Amino Acid Sequence | Piperidines - metabolism | Models, Molecular | Pyrimidines - pharmacology | HIV Fusion Inhibitors - pharmacology | Piperazines - pharmacology | Triazoles - metabolism | Anti-HIV Agents - chemistry | Amides - chemistry | Benzoates - pharmacology | Hydrophobic and Hydrophilic Interactions | Receptors, CCR5 - chemistry | Quaternary Ammonium Compounds - pharmacology | Cricetulus | Triazoles - chemistry | Benzoates - chemistry | Cyclohexanes - pharmacology | Molecular Sequence Data | Piperazines - metabolism | Quaternary Ammonium Compounds - chemistry | Pyrimidines - chemistry | Cyclohexanes - metabolism | Transfection | Inhibitory Concentration 50 | Cyclohexanes - chemistry | Molecular Structure | Membrane Fusion - drug effects | Spiro Compounds - chemistry | CCR5 Receptor Antagonists | CHO Cells | Protein Structure, Tertiary | Cricetinae | Piperidines - chemistry | Mutagenesis, Site-Directed | Protein Structure, Secondary | HIV-1 - drug effects | Static Electricity | Sequence Homology, Amino Acid | Triazoles - pharmacology | Animals | Quaternary Ammonium Compounds - metabolism | Spiro Compounds - pharmacology | Spiro Compounds - metabolism
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2015, Volume 25, Issue 17, pp. 3585 - 3591
Journal Article