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chemistry, multidisciplinary (15) 15
derivatives (13) 13
spiro[indoline-3 (11) 11
chemistry, organic (10) 10
isatin (10) 10
index medicus (8) 8
organic chemistry (8) 8
multicomponent reaction (7) 7
multicomponent reactions (7) 7
chemical synthesis (6) 6
chemistry, medicinal (6) 6
drug discovery (6) 6
efficient synthesis (6) 6
facile synthesis (6) 6
spiro compounds - chemistry (6) 6
catalysis (5) 5
design (5) 5
spirooxindoles (5) 5
agents (4) 4
aqueous media (4) 4
azomethine ylides (4) 4
cancer (4) 4
chemistry (4) 4
diastereoselective synthesis (4) 4
indoles - chemistry (4) 4
isatins (4) 4
molecular structure (4) 4
one-pot synthesis (4) 4
solvent-free conditions (4) 4
spiro compounds (4) 4
spiro compounds - chemical synthesis (4) 4
1,3-dipolar cycloaddition (3) 3
3-component reaction (3) 3
biochemistry, general (3) 3
catalysts (3) 3
chemical reactions (3) 3
chemistry, applied (3) 3
creatine monohydrate (3) 3
domino reaction (3) 3
efficient (3) 3
green chemistry (3) 3
heterogeneous nanocatalyst (3) 3
indoles - chemical synthesis (3) 3
inhibitors (3) 3
ionic liquids (3) 3
ketones (3) 3
life sciences (3) 3
microwave irradiation (3) 3
molecular docking (3) 3
pharmacy (3) 3
polymer sciences (3) 3
spiro (3) 3
spiro-compounds (3) 3
spirooxindole (3) 3
stereoisomerism (3) 3
synthesis (3) 3
water (3) 3
3-component synthesis (2) 2
4-component reactions (2) 2
acetone (2) 2
acid (2) 2
amines (2) 2
aminopyridine (2) 2
aqueous-medium (2) 2
aromatic-aldehydes (2) 2
azomethine ylide (2) 2
biochemistry & molecular biology (2) 2
biological evaluation (2) 2
combinatorial chemistry techniques (2) 2
condensation (2) 2
crystallography (2) 2
cycloaddition (2) 2
cycloaddition reaction (2) 2
diels–alder reaction (2) 2
facile (2) 2
green synthesis (2) 2
heterocycles (2) 2
heterocyclic compounds (2) 2
humans (2) 2
inhibitory concentration 50 (2) 2
isatin - chemical synthesis (2) 2
isatin - chemistry (2) 2
isoquinolinuclidine (2) 2
mcr (2) 2
molecular biology (2) 2
molecular chemistry (2) 2
nanoparticles (2) 2
nitriles (2) 2
organic-synthesis (2) 2
oxindoles (2) 2
potent (2) 2
products (2) 2
pyrrolidines - chemistry (2) 2
quinoline (2) 2
reagents (2) 2
regioselective synthesis (2) 2
regioselectivity (2) 2
scanning electron microscopy (2) 2
spiro compound (2) 2
spiro[indoline-3, 9′-xanthene]trione derivatives (2) 2
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Journal of the Chinese Chemical Society, ISSN 0009-4536, 10/2013, Volume 60, Issue 10, pp. 1197 - 1201
A facile and environmentally benign procedure for the synthesis of 3‐aryl‐1H‐spiro[indoline‐3′,2‐quin‐azoline]2′,4(3H)‐dione from isatoic anhydride, aromatic... 
Isatoic anhydrid | 1‐Methylimidazolium hydrogen sulfate | Multi component reaction | Isatin | Spiro[indoline‐quinazoline]one | Spiro[indoline-quinazoline]one | 1-Methylimidazolium hydrogen sulfate | SOLVENT-FREE CONDITIONS | ONE-POT SYNTHESIS | MICROWAVE IRRADIATION | CHEMISTRY, MULTIDISCIPLINARY | ISATINS | AGENTS | IONIC LIQUIDS | DERIVATIVES | EFFICIENT
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2012, Volume 53, Issue 28, pp. 3647 - 3649
An efficient synthetic method for 1′-aryl-2′-(2-oxoindolin-3-yl)spiro[indoline-3,5′-pyrroline]-2,3′-diones was successfully developed via the one-pot domino... 
Michael addition | Isatin | One-pot reaction | Spiro compound | Domino reaction | 3-COMPONENT REACTION | 4-COMPONENT REACTIONS | EFFICIENT SYNTHESIS | AZOMETHINE YLIDES | CHEMISTRY, ORGANIC | AROMATIC-ALDEHYDES | 3+2 CYCLOADDITION | ZWITTERIONIC SALTS | MULTICOMPONENT REACTIONS | FACILE SYNTHESIS | DIASTEREOSELECTIVE SYNTHESIS | Acetone
Journal Article
Scientia Iranica, ISSN 1026-3098, 2013, Volume 20, Issue 3, pp. 580 - 586
A simple and efficient method for the synthesis of spiro[indoline-3,9- Œ-xanthene]trione derivatives has been achieved through the condensation reaction of... 
Spiro[indoline-3,9′- xanthene]trione | Nano-reactor | Solvent-free | Isatin | SOLVENT-FREE CONDITIONS | XANTHENE DYES | ONE-POT SYNTHESIS | SIO2-PR-SO3H | Spiro[indoline-3,9 '-xanthene]trione | SBA-15-Pr-SO3H | ENGINEERING, MULTIDISCIPLINARY | PRODUCTS | THIOXANTHENE | AGENTS | MESOPOROUS SILICA | TRIBLOCK | COPOLYMER
Journal Article
Synthetic Communications, ISSN 0039-7911, 09/2017, Volume 47, Issue 18, pp. 1702 - 1707
Synthesis of new thiopyran fused spirooxindoles (spiro[indoline-3,4′-thiopyran]-2-ones) were achieved by a multicomponent reaction of N-methyl isatin,... 
base catalysis | β | multicomponent reaction | oxodithioester | spiro[indoline-3,4′-thiopyran]-2-ones | spiro[indoline-3 | FACILE SYNTHESIS | beta -oxodithioester | CHEMISTRY, ORGANIC | AGENTS | CATALYST | 4-thiopyran]-2-ones | DERIVATIVES | SPIROOXINDOLES
Journal Article
ChemistrySelect, ISSN 2365-6549, 02/2018, Volume 3, Issue 5, pp. 1512 - 1516
A quick, simple and cost‐effective, micelle catalyzed one‐pot strategy for the synthesis of spiro[indoline‐3, 4′‐pyrano[2, 3‐c]pyrazoles] by reacting isatins,... 
Sodium dodecy sulfate | Green chemistry | Aqueous media | Surfactant | Spiro-compounds | MICHAEL REACTION | ORGANIC-SYNTHESIS | IN-WATER | ANTICANCER AGENTS | AQUEOUS-MEDIUM | CHEMISTRY, MULTIDISCIPLINARY | MULTICOMPONENT REACTIONS | SPIROOXINDOLE DERIVATIVES | EXPEDITIOUS SYNTHESIS | ANTIINFLAMMATORY AGENTS | EFFICIENT
Journal Article
Letters in Organic Chemistry, ISSN 1570-1786, 2015, Volume 12, Issue 1, pp. 62 - 66
A facile and efficient synthesis of spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] derivatives by one-pot reactions of isatins, 2,6-diaminopyrimidin-4-one or... 
Microwave | spiro[indoline-3 | Multicomponent reactions | 5′-pyrido | 3-d]pyrimidine | multicomponent reactions | DESIGN | HETEROCYCLES | ONE-POT SYNTHESIS | ISATINS | CHEMISTRY, ORGANIC | spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] | microwave | SPIROOXINDOLES | MOLECULES | WATER
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2013, Volume 4, Issue 8, pp. 806 - 810
Journal Article
Synthetic Communications, ISSN 0039-7911, 03/2009, Volume 39, Issue 8, pp. 1355 - 1366
A simple and efficient synthesis of spiro[indoline-3,4′-quinoline] derivatives by a one-pot reaction of isatin, malononitrile, and enaminone under microwave... 
Microwave irradiation | multicomponent reactions | spiro[indoline-3,4′-quinoline] | Spiro[indoline-3,4'- quinoline] | Multicomponent reactions | ORGANIC-SYNTHESIS | KETONES | spiro[indoline-3 | 4'-quinoline | CHEMISTRY | CHEMISTRY, ORGANIC | AGENTS | FACILE
Journal Article
ChemistrySelect, ISSN 2365-6549, 11/2017, Volume 2, Issue 32, pp. 10496 - 10500
The triethylamine promoted reaction of ethyl glycinate hydrochloride with but‐2‐ynedioate in ethanol at room temperature afforded a new kind of 1,3‐dipolar... 
spiro[indoline-3, 3′-pyrrolidine] | glycinate | azomethine ylide | spiro[indoline-3, 2′-pyrrolizine] | but-2-ynedioate | [3+2] cycloaddition | spiro[indoline-3, 2′-pyrrolizine] | spiro[indoline-3, 3′-pyrrolidine] | spiro[indoline-3,2'-pyrrolizine] | spiro[indoline-3,3'-pyrrolidine] | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Letters in Organic Chemistry, ISSN 1570-1786, 2015, Volume 12, Issue 1, pp. 2 - 12
A library of hitherto unknown functionalized and annulated spiro[indoline-3,1'-indolizin]-2-one derivatives incorporating thiophene moiety has been synthesized... 
regioselectivity | microwave irradiation | spiro[indoline-3 | 1'-indolizin]-2-one derivatives | 2d NMR | DESIGN | FACILE SYNTHESIS | ISATINS | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | spiro[indoline-3,1'-indolizin]-2-one derivatives | 1,3-DIPOLAR CYCLOADDITION REACTIONS | DERIVATIVES | SALTS
Journal Article
ChemistrySelect, ISSN 2365-6549, 10/2017, Volume 2, Issue 31, pp. 10071 - 10075
We have synthesized a set of multi‐substituted spiro[indoline‐3, 4’‐pyrano[2, 3‐c]pyrazole] from 5‐chloroisatin, substituted phenyl hydrazines,... 
Multicomponent synthesis | Spiro-indole | Green synthesis | Atom-economy | Lewis acid catalyst | CONVENIENT SYNTHESIS | SPIRO-OXINDOLES | MDM2-P53 INTERACTION | EFFICIENT SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | 1,3-DIPOLAR CYCLOADDITION REACTION | SMALL-MOLECULE INHIBITORS | AMINO-ACIDS | REGIOSELECTIVE SYNTHESIS | DERIVATIVES | STRUCTURE-BASED DESIGN
Journal Article
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