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Journal Article
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 09/2017, Volume 12, Issue 9, pp. 1409 - 1417
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16074 - 16079
Glucocorticoids are a family of hormones that coordinate diverse physiological processes in responding to stress. Prolonged glucocorticoid exposure over weeks... 
Dendritic spines | Receptors | Corticosteroids | Glucocorticoids | Corticosterone | Neurons | Motor cortex | Dosage | Behavioral neuroscience | Renovations | CORTICOTROPIN-RELEASING HORMONE | LIFE-SPAN | GLUTAMATERGIC TRANSMISSION | DIVERSE REGIONS | CA3 PYRAMIDAL NEURONS | MDR1A P-GLYCOPROTEIN | BASOLATERAL AMYGDALA | MULTIDISCIPLINARY SCIENCES | MEDIAL PREFRONTAL CORTEX | CEREBRAL-CORTEX | WORKING-MEMORY | Corticosterone - pharmacology | Age Factors | Neuronal Plasticity - drug effects | Dendritic Spines - metabolism | Motor Cortex - drug effects | Receptors, Steroid - antagonists & inhibitors | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Motor Cortex - metabolism | Neuronal Plasticity - physiology | Spironolactone - pharmacology | Time Factors | Dendritic Spines - drug effects | Glucocorticoids - metabolism | Mineralocorticoid Receptor Antagonists - pharmacology | Motor Cortex - physiology | Somatosensory Cortex - drug effects | Dendritic Spines - physiology | Mice, Transgenic | Hormone Antagonists - pharmacology | Somatosensory Cortex - physiology | Animals | Glucocorticoids - pharmacology | Luminescent Proteins - genetics | Microscopy, Fluorescence, Multiphoton - methods | Corticosterone - metabolism | Mice | Mifepristone - pharmacology | Somatosensory Cortex - metabolism | Luminescent Proteins - metabolism | Spine | Physiological aspects | Research | Diagnosis | Stress (Psychology) | Drug therapy | Health aspects | Spinal cord | Physiology | Rodents | Stress | Steroids | Index Medicus | Biological Sciences
Journal Article
Brazilian Journal of Medical and Biological Research, ISSN 0100-879X, 2017, Volume 50, Issue 4, pp. e5520 - e5520
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2015, Volume 761, pp. 226 - 234
The present study was designed to characterize the pharmacological profile of CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist. In the... 
CS-3150 | Aldosterone | Urinary Na+/K+ ratio | Mineralocorticoid receptor antagonist | Urinary Na | ratio | TARGET | OXIDATIVE STRESS | DIABETIC-NEPHROPATHY | MESSENGER-RNA | PHARMACOKINETICS | SPIRONOLACTONE | INFLAMMATION | ALDOSTERONE BLOCKER | PHARMACOLOGY & PHARMACY | HYPERTENSION | EPLERENONE | Receptors, Mineralocorticoid - genetics | Urological Agents - pharmacology | Antihypertensive Agents - pharmacology | Pyrroles - pharmacokinetics | Receptors, Mineralocorticoid - metabolism | Humans | Transcriptional Activation - drug effects | Rats, Inbred WKY | Desoxycorticosterone Acetate | Male | Water-Electrolyte Balance - drug effects | Spironolactone - metabolism | Sulfones - pharmacology | Dose-Response Relationship, Drug | Receptors, Mineralocorticoid - drug effects | Aldosterone - metabolism | Spironolactone - pharmacology | Transfection | Sodium - urine | Pyrroles - administration & dosage | Hypertension - chemically induced | HEK293 Cells | Mineralocorticoid Receptor Antagonists - pharmacology | Hypertension - prevention & control | Female | Blood Pressure - drug effects | Radioligand Assay | Spironolactone - analogs & derivatives | Disease Models, Animal | Binding, Competitive | Mineralocorticoid Receptor Antagonists - administration & dosage | Rabbits | Administration, Oral | Aldosterone - pharmacology | Sulfones - pharmacokinetics | Rats, Sprague-Dawley | Hypertension - physiopathology | Adrenalectomy | Pyrroles - pharmacology | Animals | Potassium - urine | Protein Binding | Mineralocorticoid Receptor Antagonists - pharmacokinetics | Sulfones - administration & dosage | Hypertension | Hormones, Sex | Corticosteroids | Drug discovery | Spironolactone | Index Medicus
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 02/2012, Volume 91, Issue 2, pp. 289 - 297
Hypertension is associated with endothelial dysfunction and activated Rho‐associated kinases (ROCKs). The purpose of this study was to evaluate the effects of... 
SMOOTH-MUSCLE | ROCK ACTIVITY | CONVERTING ENZYME-INHIBITION | RENIN-ANGIOTENSIN SYSTEM | POSSIBLE INVOLVEMENT | PROTEIN-KINASE | HEART-FAILURE | DEPENDENT VASCULAR RELAXATION | NITRIC-OXIDE | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Leukocytes - enzymology | Nitroglycerin - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Endothelium, Vascular - physiology | Spironolactone - pharmacology | Vascular Endothelial Growth Factor A - agonists | Nifedipine - therapeutic use | Mineralocorticoid Receptor Antagonists - pharmacology | Female | Hypertension - enzymology | Spironolactone - analogs & derivatives | Vasodilation - physiology | Spironolactone - therapeutic use | Nifedipine - pharmacology | Losartan - pharmacology | Calcium Channel Blockers - pharmacology | Hypertension - physiopathology | Mineralocorticoid Receptor Antagonists - therapeutic use | Cell Movement - drug effects | Eplerenone | Losartan - therapeutic use | Stem Cells - drug effects | Vasodilation - drug effects | Drugs | Hypertension | Dose-response relationship (Biochemistry) | Physiological aspects | Product/Service Evaluations | Drug therapy | Endothelium | Index Medicus | Abridged Index Medicus
Journal Article
Hypertension, ISSN 0194-911X, 02/2007, Volume 49, Issue 2, pp. 355 - 364
Accumulating evidence suggests that mineralocorticoid receptor blockade effectively reduces proteinuria in hypertensive patients. However, the mechanism of the... 
Podocytes | Oxidative stress | Aldosterone | Mineralocorticoid receptor | Sgk1 | NADPH OXIDASE | ACTIVATED PROTEIN-KINASE | aldosterone | mineralocorticoid receptor | BLOOD-PRESSURE | EPITHELIAL-CELLS | podocytes | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | MESANGIAL CELLS | PERIPHERAL VASCULAR DISEASE | KIDNEY | HYPERTENSIVE-RATS | RENAL INJURY | oxidative stress | Up-Regulation | Antihypertensive Agents - pharmacology | Kidney - pathology | Oxidative Stress | Hydralazine - pharmacology | Receptors, Mineralocorticoid - metabolism | Kidney - enzymology | NADPH Oxidases - metabolism | Spin Labels | Nephrectomy - methods | Aldosterone - administration & dosage | Proteinuria - prevention & control | Immediate-Early Proteins - metabolism | Proteinuria - chemically induced | Spironolactone - pharmacology | Time Factors | Cyclic N-Oxides - pharmacology | Mineralocorticoid Receptor Antagonists - pharmacology | Blood Pressure - drug effects | Spironolactone - analogs & derivatives | Protein-Serine-Threonine Kinases - metabolism | Kidney - drug effects | Podocytes - metabolism | Immediate-Early Proteins - physiology | Infusion Pumps | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Rats | Aldosterone - pharmacology | Antioxidants - pharmacology | Podocytes - pathology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Proteinuria - physiopathology | Animals | Podocytes - drug effects | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2015, Volume 309, Issue 1, pp. H127 - H136
Proper perfusion is vital for maintenance of neuronal homeostasis and brain function. Changes in the function and structure of cerebral parenchymal arterioles... 
Hypertension | Inward remodeling | Cerebral parenchymal arterioles | Mineralocorticoid receptor | Myogenic tone | CEREBRAL BLOOD-VESSELS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | myogenic tone | MESENTERIC-ARTERIES | RESISTANCE ARTERIES | inward remodeling | RATS | cerebral parenchymal arterioles | mineralocorticoid receptor | VASCULAR SMOOTH-MUSCLE | STROKE | PRESSURE | CALCIUM-CHANNELS | PERIPHERAL VASCULAR DISEASE | ION CHANNELS | hypertension | BRAIN | Antihypertensive Agents - pharmacology | Cerebrovascular Circulation - physiology | Compliance | Calcium - metabolism | Hydralazine - pharmacology | Receptors, Mineralocorticoid - metabolism | Cerebrum - blood supply | Rats, Inbred WKY | Muscle, Smooth, Vascular - physiopathology | Spironolactone - pharmacology | Hydrochlorothiazide - pharmacology | Arterioles - physiopathology | Middle Cerebral Artery - physiopathology | Mineralocorticoid Receptor Antagonists - pharmacology | Reserpine - pharmacology | Vascular Remodeling - physiology | Spironolactone - analogs & derivatives | Vascular Remodeling - drug effects | Vascular Stiffness | Muscle, Smooth, Vascular - drug effects | Rats, Inbred SHR | Muscle Tonus - physiology | Nifedipine - pharmacology | Middle Cerebral Artery - drug effects | Organ Size | Rats | Middle Cerebral Artery - pathology | Calcium Channel Blockers - pharmacology | Arterioles - drug effects | Hypertension - pathology | Hypertension - physiopathology | Arterioles - pathology | Muscle, Smooth, Vascular - pathology | Animals | Calcium Channels, L-Type - metabolism | Physiological aspects | Development and progression | Mineralocorticoids | Cell receptors | Properties | Arteries | Steroids | Homeostasis | Brain | Cardiovascular disease | Drug therapy | Beta blockers | Index Medicus | Vascular Biology and Microcirculation
Journal Article
Endocrinology, ISSN 0013-7227, 03/2005, Volume 146, Issue 3, pp. 973 - 980
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 12/2003, Volume 93, Issue 12, pp. 1258 - 1266
ABSTRACT—Aldosterone has been suggested to elicit vessel contraction via a nongenomic mechanism. We tested this proposal in microdissected, perfused rabbit... 
Steroid | Smooth muscle | Kidney | Endothelium | endothelium | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | smooth muscle | INJURY | ENDOTHELIAL NITRIC-OXIDE | MINERALOCORTICOID RECEPTOR | SYNTHASE | kidney | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CORTICOSTEROIDS | HYPERTENSION | HEMATOLOGY | DEPENDENT CA2+ CHANNEL | steroid | Arterioles - physiology | Endothelium, Vascular - cytology | Receptors, Mineralocorticoid - genetics | Kidney - blood supply | Calcium - metabolism | Humans | Protein-Serine-Threonine Kinases | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Chromones - pharmacology | Rabbits | Enzyme Inhibitors - pharmacology | Rats | Potassium - pharmacology | Arterioles - drug effects | Benzoquinones | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Arterioles - metabolism | Endothelium, Vascular - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Heart Ventricles - metabolism | Nitric Oxide Synthase - metabolism | Heart Ventricles - drug effects | Receptors, Mineralocorticoid - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Dose-Response Relationship, Drug | Lactams, Macrocyclic | Spironolactone - pharmacology | Nitric Oxide Donors - pharmacology | Quinones - pharmacology | RNA, Messenger - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Aorta - drug effects | RNA, Messenger - genetics | Cells, Cultured | Morpholines - pharmacology | Aldosterone - pharmacology | Gene Expression Regulation - drug effects | Proto-Oncogene Proteins c-akt | Animals | In Vitro Techniques | Dactinomycin - pharmacology | Index Medicus
Journal Article