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spirooxindoles (660) 660
chemistry, organic (593) 593
chemistry, multidisciplinary (380) 380
derivatives (345) 345
spirooxindole (260) 260
construction (245) 245
catalysis (241) 241
index medicus (207) 207
one-pot synthesis (197) 197
synthesis (177) 177
isatin (168) 168
enantioselective synthesis (160) 160
efficient synthesis (144) 144
multicomponent reactions (142) 142
chemistry (137) 137
oxindoles (137) 137
spirooxindole derivatives (134) 134
cycloaddition (131) 131
asymmetric-synthesis (125) 125
inhibitors (108) 108
molecular structure (107) 107
indoles - chemistry (106) 106
cyclization (105) 105
chemistry, applied (102) 102
stereoselective-synthesis (98) 98
natural-products (97) 97
organic chemistry (97) 97
chemical synthesis (94) 94
highly efficient (94) 94
isatins (94) 94
spiro compounds - chemistry (91) 91
1,3-dipolar cycloaddition (89) 89
organocatalysis (88) 88
efficient (87) 87
catalysts (83) 83
3-component synthesis (81) 81
chemistry, medicinal (80) 80
heterocycles (76) 76
spirocyclic oxindoles (76) 76
indoles - chemical synthesis (75) 75
alkaloids (74) 74
spiro compounds - chemical synthesis (74) 74
azomethine ylides (72) 72
cascade reaction (72) 72
enantioselective construction (71) 71
multicomponent reaction (70) 70
water (68) 68
facile (67) 67
michael addition (63) 63
discovery (62) 62
stereocenters (62) 62
enantiomers (60) 60
stereoisomerism (59) 59
3-isothiocyanato oxindoles (54) 54
agents (54) 54
malononitrile (54) 54
facile synthesis (52) 52
design (51) 51
one-pot (51) 51
aldehydes (50) 50
asymmetric catalysis (49) 49
diels-alder reaction (49) 49
tetrahedrons (49) 49
structure-based design (47) 47
domino reactions (46) 46
scaffolds (46) 46
organic-synthesis (45) 45
potent (45) 45
chemical reactions (44) 44
nanoparticles (44) 44
spiro compounds (44) 44
chemical properties (43) 43
diastereoselective synthesis (43) 43
asymmetric synthesis (42) 42
humans (42) 42
indole (42) 42
analysis (41) 41
catalyst (41) 41
organic compounds (41) 41
regioselective synthesis (41) 41
catalytic asymmetric-synthesis (39) 39
oxindole (39) 39
cascade reactions (38) 38
3+2 annulation (36) 36
domino reaction (36) 36
acid (35) 35
inorganic chemistry (35) 35
isothiocyanato oxindoles (35) 35
access (34) 34
aqueous-medium (34) 34
multicomponent synthesis (34) 34
palladium (34) 34
diels-alder reactions (33) 33
esters (33) 33
asymmetry (32) 32
azomethine ylide (32) 32
drug discovery (32) 32
physical chemistry (32) 32
schiff bases (32) 32
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Tetrahedron Letters, ISSN 0040-4039, 10/2014, Volume 55, Issue 40, pp. 5434 - 5438
An efficient synthesis of novel endo′-selective spiro[pyrrolidin-2,3′-oxindoles] has been achieved via a three component regioselective 1,3-dipolar... 
1,3-Dipolar cycloaddition | Pyrrolidine–spirooxindole | 3-Amino oxindole | Regioselectivity | Nitroalkene | Pyrrolidine-spirooxindole | ISATIN | CHEMISTRY, ORGANIC | DERIVATIVES | Schiff bases
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2019, Volume 60, Issue 30, pp. 1952 - 1955
[Display omitted] •Design of a novel domino self-catalytic Michael/aza-Wittig reaction for oxindole-derived phosphazenes and acrolein.•Dual role of the... 
Michael addition | Spirooxindole | Azepane | aza-Wittig reaction | ASYMMETRIC-SYNTHESIS | CHEMISTRY, ORGANIC | Azepane Michael addition | DERIVATIVES | SPIROOXINDOLES
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2014, Volume 70, Issue 2, pp. 484 - 489
An efficient and clean reaction process was developed for the convenient and cheap synthesis of spirooxindole derivatives. One-pot reactions of isatins,... 
One-pot synthesis | Spirooxindole | 4-Dimethylaminopyridine | Multi-component reaction | 3-COMPONENT SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | SPIROOXINDOLE DERIVATIVES | ISATINS | MALONONITRILE | CHEMISTRY | LEADS | INDOLE ALKALOIDS | FACILE | Hydrazine | Nitriles | Hydrazines | Synthesis | Catalysts | Tetrahedrons | Malononitrile | Cleaning | Derivatives | Hydrates
Journal Article
Organic Letters, ISSN 1523-7060, 08/2014, Volume 16, Issue 15, pp. 3884 - 3887
A novel access to spiro[indoline-3,2′-pyrrole]-2,5′-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a... 
ISATIN | CATALYSIS | 1,3-DIPOLAR CYCLOADDITIONS | SPIROOXINDOLE DERIVATIVES | CASCADE REACTIONS | INTRAMOLECULAR HYDROARYLATION | ONE-POT | OXINDOLES | CHEMISTRY, ORGANIC | ENANTIOSELECTIVE CONSTRUCTION | CYCLIZATION
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2017, Volume 23, Issue 62, pp. 15805 - 15819
A highly enantio‐ and diastereoselective strategy to access any member of the sarpagine/macroline family of oxindole alkaloids via internal asymmetric... 
sarpagine | spirooxindoles | total synthesis | enantiospecific | macroline | alkaloids | Sarpagine and Macroline | Alstonisine and Chitosenine | Spirooxindole Alkaloids | Enantiospecific total synthesis
Journal Article
Chemical Society (Great Britain). Chemical Society Reviews, ISSN 0306-0012, 01/2018, Volume 47, Issue 5, pp. 1773 - 1782
Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the... 
Chemical reactions | Catalysis | Nucleophiles | Heterocyclic compounds | Carbonyls | Lactones
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 3/2018, Volume 47, Issue 5, pp. 1773 - 1782
Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the... 
FORMAL 3+2 ANNULATION | BETA-FUNCTIONALIZATION | COOPERATIVE CATALYSIS | ENANTIOSELECTIVE SYNTHESIS | CONJUGATE UMPOLUNG | ALPHA,BETA-UNSATURATED ALDEHYDES | SPIROOXINDOLE LACTONES | STEREOSELECTIVE-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | IMIDAZOLIUM SALTS | SATURATED CARBOXYLIC ESTERS
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 04/2016, Volume 22, Issue 18, pp. 6243 - 6247
A catalytic asymmetric [3+2] cycloaddition reaction of chiral palladium‐containing N1‐1,3‐dipoles with methyleneindolinones has been successfully developed.... 
aziridines | spirooxindole | palladium | asymmetric catalysis | organic chemistry | Enantiomers | Palladium | Catalysis
Journal Article
Tetrahedron, ISSN 0040-4020, 04/2015, Volume 71, Issue 16, pp. 2458 - 2462
A fast and convenient protocol for the synthesis of novel spirooxindole derivatives in excellent yields was developed by the three-component reactions of... 
Malononitrile | Spirooxindole | Pyranothiazolopyrimidine | Three-component reactions | ISATIN | ONE-POT SYNTHESIS | ANALOGS | OXINDOLES | CHEMISTRY, ORGANIC | SPIROOXINDOLES | MULTICOMPONENT REACTIONS | CONSTRUCTION | PYRIMIDINE | THIAZOLOPYRIMIDINES | C-H | Nitriles | Pyrimidines
Journal Article
Tetrahedron, ISSN 0040-4020, 12/2018, Volume 74, Issue 50, pp. 7148 - 7155
A highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles has been developed. With 5 mol% of bifunctional... 
Spirooxindole | Tandem reaction | Asymmetric catalysis | Organocatalysis | 4H-pyran | ASYMMETRIC-SYNTHESIS | ONE-POT | OXINDOLES | CHEMISTRY, ORGANIC | MICHAEL ADDITION | CASCADE REACTION | SPIROOXINDOLES | DIELS-ALDER REACTION | CONSTRUCTION | DERIVATIVES | CONJUGATE ADDITION | Enantiomers | Fine chemicals | Catalysis
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 3, pp. 499 - 502
A one-pot, pseudo four-component, and simple synthesis of spiro[diindenopyridine-indoline]triones and spiro[acenaphthylene-diindenopyridine]triones via the... 
Grindstone | Spiro[diindenopyridine-indoline]trione | Spirooxindole | Isatin | Acenaphthylen-1,2-dione | 3-COMPONENT SYNTHESIS | ISATINS | Spiro[diindenopyridine-indoline]trione, Acenaphthylen-1,2-dione | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | INHIBITORS | FACILE | DERIVATIVES | SPIROOXINDOLES
Journal Article
Organic Letters, ISSN 1523-7060, 05/2018, Volume 20, Issue 10, pp. 2888 - 2891
The highly enantioselective preparation of spirooxindoles bearing α,α-disubstituted α-amino-β-keto esters was achieved through [4 + 1] annulation of oxindoles... 
CYCLOADDITION | CATALYSIS | SPIROOXINDOLE DERIVATIVES | CASCADE REACTIONS | SPIROPYRAZOLONES | MALEIMIDES | CHEMISTRY, ORGANIC | 4 CONSECUTIVE STEREOCENTERS | SPIROCYCLIC OXINDOLES | BIOXINDOLES | ALKYNES
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 55, pp. 8541 - 8544
Magnesium triflate was found to effectively catalyze the tert-amino effect reaction (T-reaction) involving ethyl 3-(2-(dialkylamino)phenyl)-2-nitroacrylates... 
1,5-HYDRIDE TRANSFER/CYCLIZATION | AGENT | SPIROOXINDOLE TETRAHYDROQUINOLINES | SPIROHYDANTOINS | CLOSURE | C-H FUNCTIONALIZATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Organic Letters, ISSN 1523-7060, 07/2017, Volume 19, Issue 13, pp. 3418 - 3421
A simple and efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom-... 
TRANSFORMATION | GAMMA-BUTYROLACTONE | ISATINS | ANTICANCER AGENTS | CYCLIC DIARYLIODONIUM SALTS | CONSTRUCTION | CHEMISTRY, ORGANIC | SPIROOXINDOLE LACTONES | DERIVATIVES | ACCESS | CARBOXYLIC-ACIDS
Journal Article
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