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Journal Article
RNA, ISSN 1355-8382, 2012, Volume 18, Issue 7, pp. 1373 - 1384
The recruitment of ribosomes to eukaryotic cellular mRNAs requires the activity of two prototypic RNA helicases, eukaryotic initiation factor (eIF) 4AI and... 
Translation | eIF4AI | eIF4AII | DEAD-box RNA helicase | Hippuristanol | Translational control | RNA helicase | MAMMALIAN TRANSLATION | FACTOR EIF-4A | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | CROSS-LINKING | translational control | 5' END | EUKARYOTIC TRANSLATION INITIATION | MESSENGER-RNA | translation | hippuristanol | DEGRADATION | INHIBITS TRANSLATION | RNA HELICASE EIF4A | Transcription, Genetic - drug effects | Testis - metabolism | Humans | Fetus - metabolism | Male | Muscle, Skeletal - metabolism | Spleen - drug effects | Prostate - metabolism | Testis - drug effects | Brain - metabolism | Kidney - metabolism | Protein Isoforms - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Prostate - drug effects | Adult | Female | Ovary - drug effects | Lung - metabolism | Thymus Gland - metabolism | Ovary - metabolism | Sterols - pharmacology | Cell Line | Kidney - drug effects | Liver - metabolism | Pancreas - drug effects | Pancreas - metabolism | Thymus Gland - drug effects | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Brain - drug effects | Fetus - drug effects | Placenta - drug effects | Placenta - metabolism | Pregnancy | Transcription, Genetic - physiology | Spleen - metabolism | Lung - drug effects | Eukaryotic Initiation Factor-4A - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 5, p. e36831
.... We focused on the in vitro effects of MJ-29 on ER stress and mitochondria-dependent apoptotic death in WEHI-3 cells, and to hypothesize that MJ-29 might fully impair the orthotopic leukemic mice... 
PERMEABILITY TRANSITION PORE | IMMUNE-RESPONSE | ACUTE LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | BIOLOGY | TUBULIN POLYMERIZATION | DEATH | ANTITUMOR-ACTIVITY | BINDING AGENTS | CANCER | BALB/C MICE | Leukocytes, Mononuclear - metabolism | Reactive Oxygen Species | Apoptosis - drug effects | Calcium - metabolism | Body Weight - drug effects | Male | Leukemia - metabolism | Antineoplastic Agents - administration & dosage | Antigens, CD - metabolism | Antineoplastic Agents - toxicity | Lymphocytes - immunology | Antineoplastic Agents - pharmacology | Macrophages - immunology | Quinazolinones - pharmacology | Cell Survival - drug effects | Unfolded Protein Response - drug effects | Phagocytosis - drug effects | Leukocytes, Mononuclear - drug effects | Endoplasmic Reticulum Stress - drug effects | Leukemia - drug therapy | Mitochondria - drug effects | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Leukemia - mortality | Chemotherapy | Immunotherapy | Leukemia | Calpain | B cells | Cancer | Apoptosis | Flow cytometry | Liver | Body weight | Red pulp | Intracellular signalling | Cytotoxicity | Macrophages | Drug resistance | Cancer therapies | Pulp | Proteins | Mitochondria | Animal tissues | Cell cycle | Life sciences | Quinazolinone | Deoxyribonucleic acid--DNA | Spleen | Stresses | Myelomonocytic leukemia | Immune response | Calcium (intracellular) | Permeability | Stress | Cytometry | Monocytes | Lymphocytes B | Infiltration | Annexin V | Endoplasmic reticulum | Pharmaceuticals | Deoxyribonucleic acid | DNA
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 84, pp. 24 - 35
Abstract Unresolved inflammation is a major contributor to the development of heart failure following myocardial infarction (MI). Pro-resolving lipid... 
Cardiovascular | Myocardial infarction | Splenic remodeling | Resolution of inflammation | Metabololipidomics | Resolvin D1 | Neutrophils | SURVIVAL | CHRONIC HEART-FAILURE | PROTECTIVE ACTIONS | CARDIAC & CARDIOVASCULAR SYSTEMS | RESOLUTION | TISSUE | RECEPTOR | LIPID MEDIATORS | CELL BIOLOGY | THERAPY | PATHWAY | DISEASE | Cell Count | Male | Myocardial Infarction - diagnostic imaging | Spleen - drug effects | Extracellular Matrix - genetics | Inflammation - complications | Pulmonary Edema - physiopathology | Inflammation - drug therapy | Pulmonary Edema - complications | Receptors, Formyl Peptide - metabolism | Ultrasonography | Myocardial Infarction - physiopathology | Cell Polarity - drug effects | Spleen - pathology | Neutrophil Infiltration - drug effects | Ventricular Function - drug effects | Docosahexaenoic Acids - therapeutic use | Arachidonate 5-Lipoxygenase - metabolism | Docosahexaenoic Acids - chemistry | Extracellular Matrix - drug effects | Mice, Inbred C57BL | Cardiomegaly - diagnostic imaging | Cardiomegaly - drug therapy | Cardiomegaly - physiopathology | Pulmonary Edema - drug therapy | Cardiomegaly - complications | Collagen - metabolism | Docosahexaenoic Acids - pharmacology | Myocardial Infarction - complications | Macrophages - metabolism | Animals | Myocardial Infarction - drug therapy | Heart Ventricles - physiopathology | Prostaglandin-Endoperoxide Synthases - metabolism | Macrophages - drug effects | Ventricular Remodeling - drug effects | Heart Ventricles - drug effects | Inflammation | Heart attack | metabololipidomics | liposomes | myocardial infarction | splenic remodeling | neutrophils | resolution of inflammation
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 1, p. e0170814
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment... 
MACROPHAGE INFILTRATION | PAIN | INDUCED MECHANICAL ALLODYNIA | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | DORSAL-ROOT GANGLIA | SPINAL-CORD | NERVE INJURY | SENSORY NEURONS | SATELLITE GLIAL-CELLS | PACLITAXEL | Hyperalgesia - chemically induced | Neuralgia - genetics | Spleen - immunology | Chemokine CCL2 - immunology | Male | Spleen - drug effects | Activating Transcription Factor 3 - immunology | T-Lymphocytes, Regulatory - pathology | Hyperalgesia - pathology | T-Lymphocytes, Regulatory - immunology | Neurofilament Proteins - genetics | Neuralgia - immunology | Chemokine CCL3 - genetics | Microglia - pathology | Lymph Nodes - drug effects | Activating Transcription Factor 3 - genetics | Receptors, Purinergic P2Y12 - genetics | Gene Expression | Receptors, Purinergic P2Y12 - immunology | Mice, Transgenic | Lymph Nodes - immunology | Spinal Cord - immunology | Hyperalgesia - immunology | T-Lymphocytes, Regulatory - drug effects | Hyperalgesia - genetics | Ganglia, Spinal - pathology | Mice | CD8-Positive T-Lymphocytes - immunology | Ganglia, Spinal - drug effects | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Spinal Cord - drug effects | Chemokine CCL3 - immunology | Sensory Receptor Cells - immunology | Neuralgia - pathology | Microglia - immunology | Antineoplastic Agents - adverse effects | Spinal Cord - pathology | Neuralgia - chemically induced | Neurofilament Proteins - immunology | Spleen - pathology | Ganglia, Spinal - immunology | Sensory Receptor Cells - pathology | Microglia - drug effects | Mice, Inbred C57BL | Paclitaxel - adverse effects | Chemokine CCL2 - genetics | Animals | Sensory Receptor Cells - drug effects | CD8-Positive T-Lymphocytes - drug effects | Organoplatinum Compounds - adverse effects | Usage | Chemotherapy | Care and treatment | Oxalic acid | Polyneuropathies | Research | Diagnosis | T cells | Cancer | Spinal cord | Neurosciences | CD8 antigen | Carbon tetrachloride | Interleukin | Central nervous system | Transgenic | Nervous system | Diabetic neuropathy | Lymphocytes T | Cerebrospinal fluid | Peripheral neuropathy | Macrophages | Lymph nodes | Proteins | Neurotoxicity | Interleukin 4 | Pain | Dorsal root ganglia | Lymphocytes | Rodents | Sensory neurons | Tumor necrosis factor-TNF | Horns | Dorsal horn | Peripheral nervous system | Pain sensitivity | Spleen | Pain perception | Immune response | Cytokines | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | CCL3 protein | Interleukin 12 | Inflammation | CCL4 protein | Microglia | CD4 antigen | Studies | White blood cells | TNF inhibitors | Infiltration | Chemokines | Monocyte chemoattractant protein 1
Journal Article
Journal of Radiation Research, ISSN 0449-3060, 11/2019, Volume 60, Issue 6, pp. 747 - 758
ABSTRACT This study examines the ability of arabinoxylan rice bran (MGN-3/Biobran) to enhance the anti-cancer effects of fractionated X-ray irradiation of Ehrlich solid tumor-bearing mice... 
MGN-3 | apoptosis | CANCER | PACLITAXEL | GAMMA-IRRADIATION | IN-VITRO | ONCOLOGY | INDUCED OXIDATIVE STRESS | Biobran | BIOLOGY | radiotherapy | in vivo | MICE | KILLER-CELL ACTIVITY | IONIZING-RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Liver - pathology | Liver - enzymology | Xylans - pharmacology | Apoptosis - drug effects | Apoptosis - radiation effects | Tumor Burden - radiation effects | Body Weight - drug effects | Liver - radiation effects | Spleen - drug effects | DNA Fragmentation - radiation effects | Tumor Suppressor Protein p53 - genetics | Organ Size - radiation effects | Liver - drug effects | Female | DNA Fragmentation - drug effects | Spleen - pathology | bcl-2-Associated X Protein - genetics | Cell Cycle - radiation effects | Carcinoma, Ehrlich Tumor - radiotherapy | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Carcinoma, Ehrlich Tumor - drug therapy | Combined Modality Therapy | Organ Size - drug effects | Animals | Tumor Burden - drug effects | Body Weight - radiation effects | X-Rays | Xylans - therapeutic use | Carcinoma, Ehrlich Tumor - genetics | Spleen - radiation effects | Cell Proliferation - drug effects | Mice | DNA Damage | Cell Cycle - drug effects | Cell Proliferation - radiation effects | Regular Paper
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 4, pp. 776 - 788.e5
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent... 
SIV | animal models | HIV | latent viral reservoir | regulatory T cells | co-inhibitory receptors | CTLA-4 | T follicular helper cells | PD-1 | regulatory T cells | TGF-BETA | REPLICATION | RESERVOIR | REGULATORY CELLS | IMMUNE ACTIVATION | GENE-EXPRESSION | IMMUNODEFICIENCY VIRUS-INFECTION | IMMUNOLOGY | CHRONIC HIV-INFECTION | FOLLICULAR HELPER-CELLS | Humans | Host-Pathogen Interactions - drug effects | Macaca mulatta | Immunologic Memory - drug effects | Host-Pathogen Interactions - immunology | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV-1 - physiology | In Situ Hybridization | T-Lymphocytes, Helper-Inducer - immunology | Lymph Nodes - drug effects | CD4-Positive T-Lymphocytes - virology | Immunologic Memory - immunology | Simian Immunodeficiency Virus - immunology | Anti-Retroviral Agents - therapeutic use | HIV-1 - drug effects | HIV Infections - virology | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Lymph Nodes - virology | Lymph Nodes - immunology | CTLA-4 Antigen - immunology | Simian Immunodeficiency Virus - physiology | Microscopy, Confocal | HIV-1 - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor - immunology | Simian Immunodeficiency Virus - drug effects | CD4-Positive T-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - virology | Therapy | PD-1 protein | Memory | Viruses | Infections | Lymphocytes T | Lymph nodes | CTLA-4 protein | Lymphocytes | Antiretroviral agents | Immunotherapy | Human immunodeficiency virus--HIV | Drug therapy | Deoxyribonucleic acid--DNA | Spleen | Antiretroviral drugs | Immunological memory | Memory cells | Immunoregulation | Latent infection | Monkeys & apes | Antiretroviral therapy | CD4 antigen | Lymphocytes B | Replication
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172684
The massive meat production of broiler chickens make them continuously exposed to potential stressors that stimulate releasing of stress-related hormones like... 
GALLUS-GALLUS-DOMESTICUS | FAT ACCUMULATION | DEOXYRIBONUCLEIC-ACID DEGRADATION | MEAT QUALITY | BLOOD PARAMETERS | SHOWING LONG | MULTIDISCIPLINARY SCIENCES | PHYSIOLOGICAL STRESS | SHORT TONIC IMMOBILITY | ENDOGENOUS GLUCOCORTICOIDS | PROTEIN-SYNTHESIS | Aspartate Aminotransferases - genetics | Caspase 9 - genetics | Corticosterone - pharmacology | Spleen - immunology | Insulin-Like Growth Factor I - genetics | Spleen - drug effects | Meat | Insulin-Like Growth Factor I - immunology | Liver - immunology | Alanine Transaminase - genetics | Liver - drug effects | Triiodothyronine - genetics | T-Lymphocytes - drug effects | Weight Gain - drug effects | Cell Death - drug effects | Alanine Transaminase - immunology | Avian Proteins - immunology | Bursa of Fabricius - drug effects | B-Lymphocytes - cytology | Chickens - growth & development | Immunity, Innate - drug effects | Aspartate Aminotransferases - immunology | Injections, Intramuscular | Thymus Gland - drug effects | Chickens - immunology | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Caspase 9 - immunology | Eating - drug effects | Bursa of Fabricius - immunology | Animals | B-Lymphocytes - immunology | T-Lymphocytes - cytology | Animal Husbandry | T-Lymphocytes - immunology | Thymus Gland - immunology | Cell Proliferation - drug effects | Triiodothyronine - immunology | Avian Proteins - genetics | Usage | Immunology | Cell death | Corticosterone | Physiological aspects | Broilers (Poultry) | Genetic aspects | Research | Gene expression | Bursa of Fabricius | Plasma | Poultry | Insulin-like growth factor I | Liver | Body weight | Cytology | Biochemistry | Lymphocytes T | Insulin-like growth factors | Hormones | Juveniles | Thymus | Proteins | Lymphocytes | Rodents | Gangrene | Physiology | Spleen | Alanine | Immune response | Parameters | Ethanol | Hematology | Mortality | Caspase | Birds | Injection | Insulin | Stress | Beta cells | Immunosuppression | Hepatocytes | Protein synthesis | Chickens | Morphology | Caspase-9 | Chicks | Meat production | Apoptosis | Conversion ratio
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135256
.... Rapamycin, an inhibitor of mTOR, has been widely used as an immunosuppressant and anti-cancer drug... 
MAMMALIAN TARGET | LIFE-SPAN | SEIZURES | TUBEROUS SCLEROSIS COMPLEX | TEMPORAL-LOBE EPILEPSY | EVEROLIMUS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | MICE | TRANSPLANT RECIPIENTS | Neocortex - immunology | Phosphorylation | Spleen - immunology | Age Factors | Microtubule-Associated Proteins - genetics | Tumor Necrosis Factor-alpha - genetics | Body Weight - drug effects | Male | Spleen - drug effects | Hippocampus - drug effects | Dose-Response Relationship, Drug | Ribosomal Protein S6 Kinases - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Interleukins - genetics | Neocortex - drug effects | TOR Serine-Threonine Kinases - genetics | Interleukins - immunology | Exploratory Behavior - drug effects | Tumor Necrosis Factor-alpha - immunology | Female | Thymus Gland - growth & development | Neuropeptides - genetics | Hippocampus - growth & development | Sirolimus - adverse effects | Spleen - growth & development | Hippocampus - immunology | Gene Expression Regulation, Developmental - drug effects | Neocortex - growth & development | Rats | Thymus Gland - drug effects | Maze Learning - drug effects | Rats, Sprague-Dawley | Anxiety - pathology | Microtubule-Associated Proteins - immunology | TOR Serine-Threonine Kinases - immunology | Anxiety - genetics | Organ Size - drug effects | Animals | Immunosuppressive Agents - adverse effects | Thymus Gland - immunology | Anxiety - chemically induced | Neuropeptides - immunology | Ribosomal Protein S6 Kinases - genetics | Complications and side effects | Epilepsy | Patient outcomes | Rapamycin | Dosage and administration | Research | Diagnosis | Drug therapy | Cell differentiation | TOR protein | Brain | Cerebral cortex | Change detection | Memory | Differentiation (biology) | Cognitive ability | Kinases | Immunity | Experiments | Thymus | Proteins | Signal transduction | Interleukin 2 | Rodents | Field tests | Aging | Doublecortin protein | Anxiety | Inhibition | Drug dosages | Spleen | Medical research | Internal medicine | Protein biosynthesis | Tumor necrosis factor-α | Medicine | Side effects | Protein synthesis | γ-Interferon | Pharmacy | Laboratory animals | Cancer | Animal cognition
Journal Article