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Clinical Immunology, ISSN 1521-6616, 2016, Volume 163, pp. 60 - 65
Abstract Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic autoimmune disease characterized by early-onset... 
Allergy and Immunology | Autoimmunity | IPEX | Mutation | FOXP3 | Primary immunodeficiency | X-LINKED SYNDROME | ENTEROPATHY | STABILITY | IMMUNOLOGY | IMMUNE DYSREGULATION | DIMER | SEQUENCE | DISEASE | REGULATORY T-CELLS | POLYENDOCRINOPATHY | IMMUNODYSREGULATION | Eczema - genetics | Eczema - immunology | Immune System Diseases - genetics | Humans | Diabetes Mellitus, Type 1 - congenital | Infant | Male | Meningoencephalitis - immunology | Thrombocytopenia - genetics | Immunoglobulin E - immunology | Diarrhea - immunology | Eosinophilia - genetics | Fatal Outcome | Hepatomegaly - immunology | Genetic Diseases, X-Linked - genetics | Diabetes Mellitus, Type 1 - immunology | Dimerization | Hemorrhage - genetics | Sepsis - immunology | Splenomegaly - genetics | Growth Disorders - immunology | Hemorrhage - immunology | Splenomegaly - immunology | Thrombocytopenia - immunology | Immune System Diseases - immunology | Leukocytosis - immunology | Meningoencephalitis - genetics | Diabetes Mellitus, Type 1 - genetics | Models, Molecular | Klebsiella Infections - genetics | Hepatomegaly - genetics | Forkhead Transcription Factors - genetics | Sepsis - genetics | Lung Diseases - immunology | Genetic Diseases, X-Linked - immunology | Immune System Diseases - congenital | Thymus Gland - abnormalities | Lung Diseases - genetics | Eosinophilia - immunology | Diarrhea - genetics | Klebsiella Infections - immunology | Phenylalanine - genetics | Hydrophobic and Hydrophilic Interactions | Growth Disorders - genetics | Leukocytosis - genetics
Journal Article
Blood, ISSN 0006-4971, 01/2017, Volume 129, Issue 4, pp. 460 - 472
Epithelial-to-mesenchymal-transition (EMT) is critical for normal embryogenesis and effective postnatal wound healing, but is also associated with cancer... 
EPITHELIAL-MESENCHYMAL TRANSITION | IN-VITRO | POSTMITOTIC NEURONS | TGF-BETA | SMAD-INTERACTING PROTEIN-1 | SELF-RENEWAL | HEMATOLOGY | STEM-CELL HOMEOSTASIS | MIR-200 FAMILY | REPRESSORS ZEB1 | LYMPHOBLASTIC-LEUKEMIA | Humans | STAT Transcription Factors - metabolism | Hematopoiesis, Extramedullary - genetics | Janus Kinases - metabolism | Primary Myelofibrosis - pathology | Splenomegaly - pathology | Epithelial-Mesenchymal Transition - genetics | Stem Cells - metabolism | Zinc Finger E-box Binding Homeobox 2 | Repressor Proteins - deficiency | Base Sequence | Bone Marrow - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Adult | Transcription, Genetic | Cell Differentiation | Spleen - pathology | Cytokines - genetics | Cell Lineage - genetics | Primary Myelofibrosis - metabolism | Cytokines - metabolism | Janus Kinases - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Splenomegaly - genetics | Gene Expression Regulation | Repressor Proteins - genetics | Splenomegaly - metabolism | Homeodomain Proteins - genetics | Mice, Knockout | Primary Myelofibrosis - genetics | STAT Transcription Factors - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Spleen - metabolism | Bone Marrow - pathology | Stem Cells - pathology | Mice | Mutation | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2016, Volume 311, Issue 6, pp. H1392 - H1408
The HDL receptor SR-BI mediates the transfer of cholesteryl esters from HDL to cells and controls HDL abundance and structure. Depending on the genetic... 
Myocardial infarction | PDZ domains | SR-BI | Steroidogenic organs | Atherosclerosis | atherosclerosis | DIET-INDUCED ATHEROSCLEROSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | B TYPE-I | myocardial infarction | HIGH-DENSITY-LIPOPROTEIN | ADAPTER PROTEIN PDZK1 | steroidogenic organs | CHOLESTERYL ESTER UPTAKE | HEPATIC SCAVENGER RECEPTOR | PERIPHERAL VASCULAR DISEASE | AUTOSOMAL RECESSIVE HYPERCHOLESTEROLEMIA | E-DEFICIENT MICE | APOLIPOPROTEIN-A-I | Lipoproteins, HDL - genetics | Coronary Occlusion - genetics | Adrenal Cortex - metabolism | Transcriptome | Hematopoiesis, Extramedullary - genetics | Immunoblotting | Male | Coronary Disease - mortality | Reticulocytosis - genetics | Thrombocytopenia - genetics | Leydig Cells - metabolism | Polymerase Chain Reaction | Female | Ovary - metabolism | Splenomegaly - genetics | Liver - metabolism | Receptors, Lipoprotein - genetics | Scavenger Receptors, Class B - genetics | Coronary Artery Disease - mortality | Gene Knock-In Techniques | Animals | Coronary Occlusion - mortality | Coronary Disease - genetics | Apolipoproteins E - genetics | Coronary Artery Disease - genetics | Mice | Hypercholesterolemia - genetics | Mutation | Anemia, Macrocytic - genetics | Genetic aspects | Hypercholesterolemia | High density lipoproteins | Gene expression | Health aspects | Coronary heart disease | Signaling and Stress Response
Journal Article
PLOS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0143216
Chromosomal translocations are driver mutations of human cancers, particularly leukemias. They define disease subtypes and are used as prognostic markers, for... 
CHROMOSOMAL TRANSLOCATIONS | LEUCINE-ZIPPER | GENE | ACUTE-LYMPHOBLASTIC-LEUKEMIA | E2A | MULTIDISCIPLINARY SCIENCES | CHIMERIC TRANSCRIPTION FACTOR | ANTIAPOPTOTIC ACTIVITY | TRANSACTIVATION DOMAINS | LINEAGE LEUKEMIA | TRANSGENIC MICE | Hepatomegaly - pathology | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Antigens, CD19 - genetics | Splenomegaly - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cell Death - genetics | Precursor Cells, B-Lymphoid - pathology | Cell Transformation, Neoplastic - genetics | Integrases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Disease Models, Animal | Promoter Regions, Genetic | Gene Expression | Splenomegaly - genetics | Mice, Transgenic | Basic-Leucine Zipper Transcription Factors - genetics | Hepatomegaly - genetics | Splenomegaly - metabolism | Cell Transformation, Neoplastic - metabolism | Gene Knock-In Techniques | CD79 Antigens - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Genetic Engineering | Oncogene Proteins, Fusion - genetics | Antigens, CD19 - metabolism | Hepatomegaly - metabolism | Mice | CD79 Antigens - genetics | Cell Transformation, Neoplastic - pathology | Myxovirus Resistance Proteins - genetics | Integrases - genetics | Myxovirus Resistance Proteins - metabolism | Genetic aspects | B cells | Health aspects | Leukemia | Hematopoietic stem cells | Flow cytometry | Transformation | Transcription factors | Laboratories | Genomics | Genes | Proteins | Precursors | Transgenic animals | Rodents | Bone marrow | Translocation | Immunoglobulins | CD19 antigen | Anemia | Mortality | Minimal residual disease | Myelocytes | Progenitor cells | Hemopoiesis | Pathology | Chromosome translocations | Leukocytosis | Lymphocytes B | Lymphopenia | Cell death | Medical prognosis | Cells (biology) | Stem cells | Comparative studies | Infiltration | Mutation | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85362
Systemic mastocytosis with associated hematologic clonal non-mast cell disease (SM-AHNMD) is a rare and heterogeneous subtype of SM and few studies on this... 
CRITERIA | KITD816V | POLYCYTHEMIA-VERA | LINEAGE DISEASES | MULTIDISCIPLINARY SCIENCES | Prognosis | Cell Count | Hematologic Neoplasms - mortality | Humans | Middle Aged | Male | Mastocytosis, Systemic - diagnosis | Mastocytosis, Systemic - genetics | Neutropenia - complications | Neutropenia - diagnosis | Monocytes - pathology | Neutropenia - mortality | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Hematologic Neoplasms - complications | Neutropenia - genetics | Proto-Oncogene Proteins c-cbl - genetics | Hematologic Neoplasms - diagnosis | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Mastocytosis, Systemic - mortality | Adolescent | Survival Analysis | Aged | Hematologic Neoplasms - genetics | Mutation | Mastocytosis, Systemic - complications | Medical research | Mast cell disease | Analysis | Patient outcomes | Medicine, Experimental | Hemoglobin | Bones | Genetic aspects | Density | Splenomegaly | Mastocytosis | Disease | Laboratories | Liver | Leukemia | Multivariate analysis | Defects | Variables | Chronic myelomonocytic leukemia | Lesions | Neutropenia | Enlargement | Cell survival | Hematology | Patients | Survival | Studies | Monocytes | Medical prognosis | Tryptase | Bone mineral density | Blood diseases | Ascites | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 9, pp. 3422 - 3427
The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune... 
Spleen | Pathogens | Virulence | Alleles | Viruses | Evolution | Infections | Coevolution | Biological adaptation | Genotypes | Host-pathogen | Endangered species | Antibiotic resistance | Pathogen escape of adaptive immunity | PARASITES | VIRUS | pathogen escape of adaptive immunity | MULTIDISCIPLINARY SCIENCES | host-pathogen | MAJOR HISTOCOMPATIBILITY COMPLEX | POLYMORPHISM | ANTAGONISTIC COEVOLUTION | GENETIC DIVERSITY | antibiotic resistance | ADAPTATION | DISEASE | endangered species | LEUKEMIA | SELECTION | Adaptation, Physiological | Tumor Virus Infections - genetics | Retroviridae Infections - virology | Tumor Virus Infections - virology | Friend murine leukemia virus - pathogenicity | Mice, Inbred BALB C - immunology | Viral Load | Host-Pathogen Interactions - immunology | Genetic Variation | Proviruses - genetics | Virulence - genetics | Splenomegaly - etiology | Tumor Virus Infections - immunology | Female | Retroviridae Infections - genetics | Splenomegaly - virology | Animals, Congenic | Mice, Inbred BALB C - genetics | Friend murine leukemia virus - genetics | Major Histocompatibility Complex - genetics | Selection, Genetic | Virus Integration | Animals | Genetic Fitness - genetics | Retroviridae Infections - immunology | Virus Replication | Friend murine leukemia virus - immunology | Friend murine leukemia virus - physiology | Mice | Evolution, Molecular | Virus diseases | Allelomorphism | Major histocompatibility complex | Genetic aspects | Adaptation (Biology) | Research | Health aspects | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4488 - 4497
The NLRP3 inflammasome is a protein complex responsible for caspase-1-dependent maturation of the proinflammatory cytokines IL-1 beta and IL-18.... 
MEDICINE, RESEARCH & EXPERIMENTAL | INTERLEUKIN-1 | ACTIVATION | PROTEIN | DISEASE | ALPHA | COLD AUTOINFLAMMATORY SYNDROME | PYROPTOSIS | ETANERCEPT | ARTHRITIS | MAST-CELL | Tumor Necrosis Factor-alpha - metabolism | Cryopyrin-Associated Periodic Syndromes - genetics | Caspases - genetics | Tumor Necrosis Factor-alpha - genetics | Cryopyrin-Associated Periodic Syndromes - therapy | Caspase 1 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - biosynthesis | Interleukin-1beta - genetics | Inflammasomes - biosynthesis | Inflammasomes - genetics | Mice, Knockout | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | Caspases - metabolism | Caspase 1 - genetics | Interleukin-1beta - metabolism | Transcription, Genetic | Cryopyrin-Associated Periodic Syndromes - pathology | Mice | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cryopyrin-Associated Periodic Syndromes - metabolism | Comparative analysis | Tumor necrosis factor | Genetic transcription | Splenomegaly | Transcription | Caspase-11 | Pathogenesis | Body weight | Nervous system | Arthritis | Inflammatory diseases | Caspase-1 | Lipopolysaccharides | Proteins | Missense mutation | Etanercept | Rodents | Interleukin 1 | Tumor necrosis factor-TNF | Spleen | Cold | Cytokines | Dendritic cells | Cryopyrin | Caspase | Inflammation | Roles | Gene expression | Interleukin 18 | Survival analysis | TNF inhibitors | Skin | Mutation | Alzheimers disease | Apoptosis
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6279, pp. 1324 - 1329
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1757 - 1773
Autoimmunity is traditionally attributed to altered lymphoid cell selection and/or tolerance, whereas the contribution of innate immune cells is less well... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TYROSINE KINASE | MURINE LUPUS | ANTIGEN-PRESENTING CELLS | MONOCLONAL-ANTIBODY | BAFF/APRIL SYSTEM | T-CELL | IMMUNOLOGY | SRC-FAMILY KINASES | ACTIVATING FACTOR | Myeloid Cells - cytology | Gene Expression - genetics | Autoantibodies - blood | Dendritic Cells - immunology | Interferon-gamma - metabolism | T-Lymphocytes - transplantation | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Autoimmunity - immunology | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Gene Expression - immunology | Myeloid Cells - drug effects | B-Cell Activation Factor Receptor - genetics | Antibodies, Monoclonal - immunology | B-Lymphocytes - metabolism | B-Lymphocytes - cytology | Splenomegaly - genetics | Antibodies, Monoclonal - pharmacology | Splenomegaly - immunology | Spleen - cytology | Mice, Knockout | Macrophages - metabolism | Models, Immunological | B-Cell Activating Factor - metabolism | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Mice | src-Family Kinases - genetics | Nephritis - genetics | Autoimmunity - genetics | Adoptive Transfer | Nephritis - immunology | B-Cell Activating Factor - immunology | Interferon-gamma - genetics | Spleen - pathology | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Macrophages - cytology | B-Lymphocytes - drug effects | Autoantibodies - immunology | Animals | Spleen - metabolism | T-Lymphocytes - cytology | B-Cell Activating Factor - genetics | Lymphocyte Activation - drug effects | Myeloid Cells - metabolism | Nephritis - metabolism | Proto-Oncogene Proteins c-hck - genetics | Cell Proliferation - drug effects | Dendritic Cells - cytology | B-Cell Activating Factor - blood | Interferon-gamma - blood | Interferon-gamma - pharmacology
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 5, pp. 445 - 455
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3500 - 10
Inflammation, although responsible for controlling infection, is often associated with the pathogenesis of chronic diseases. Leishmania donovani, the causative... 
MIGRATION | RESPONSES | CCR7 EXPRESSION | INFLAMMATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MICE | HYPOXIA | IL-12 | DONOVANI INFECTION | CD8(+) T-CELLS | Inflammation - pathology | Spleen - immunology | Interleukin-12 - genetics | Humans | Leishmaniasis, Visceral - immunology | Splenomegaly - pathology | Th1 Cells - immunology | CD11 Antigens - genetics | CD4-Positive T-Lymphocytes - immunology | Splenomegaly - parasitology | CD11 Antigens - immunology | Leishmaniasis, Visceral - parasitology | Interferon-gamma - genetics | Dendritic Cells - metabolism | Dendritic Cells - parasitology | Leishmania donovani - immunology | Splenomegaly - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Splenomegaly - immunology | Leishmania donovani - pathogenicity | Cellular Microenvironment - immunology | Leishmaniasis, Visceral - pathology | Spleen - parasitology | Animals | Interferon-gamma - immunology | Interleukin-10 - genetics | Interleukin-12 - immunology | Leishmaniasis, Visceral - genetics | Inflammation - genetics | Leishmania donovani - genetics | Mice | Cellular Microenvironment - genetics | Interleukin-10 - immunology | Spleen | Splenomegaly | CD11c antigen | Dendritic cells | Therapeutic applications | Chronic infection | Interleukin 12 | Lymphocytes T | Inflammation | Leishmaniasis | CD4 antigen | Visceral leishmaniasis | Parasitic diseases | γ-Interferon | Interleukin 10 | Bone marrow | Hypoxia | Life Sciences
Journal Article
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