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Clinical Immunology, ISSN 1521-6616, 2016, Volume 163, pp. 60 - 65
Abstract Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic autoimmune disease characterized by early-onset... 
Allergy and Immunology | Autoimmunity | IPEX | Mutation | FOXP3 | Primary immunodeficiency | X-LINKED SYNDROME | ENTEROPATHY | STABILITY | IMMUNOLOGY | IMMUNE DYSREGULATION | DIMER | SEQUENCE | DISEASE | REGULATORY T-CELLS | POLYENDOCRINOPATHY | IMMUNODYSREGULATION | Eczema - genetics | Eczema - immunology | Immune System Diseases - genetics | Humans | Diabetes Mellitus, Type 1 - congenital | Infant | Male | Meningoencephalitis - immunology | Thrombocytopenia - genetics | Immunoglobulin E - immunology | Diarrhea - immunology | Eosinophilia - genetics | Fatal Outcome | Hepatomegaly - immunology | Genetic Diseases, X-Linked - genetics | Diabetes Mellitus, Type 1 - immunology | Dimerization | Hemorrhage - genetics | Sepsis - immunology | Splenomegaly - genetics | Growth Disorders - immunology | Hemorrhage - immunology | Splenomegaly - immunology | Thrombocytopenia - immunology | Immune System Diseases - immunology | Leukocytosis - immunology | Meningoencephalitis - genetics | Diabetes Mellitus, Type 1 - genetics | Models, Molecular | Klebsiella Infections - genetics | Hepatomegaly - genetics | Forkhead Transcription Factors - genetics | Sepsis - genetics | Lung Diseases - immunology | Genetic Diseases, X-Linked - immunology | Immune System Diseases - congenital | Thymus Gland - abnormalities | Lung Diseases - genetics | Eosinophilia - immunology | Diarrhea - genetics | Klebsiella Infections - immunology | Phenylalanine - genetics | Hydrophobic and Hydrophilic Interactions | Growth Disorders - genetics | Leukocytosis - genetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 6, pp. 2612 - 2623
Cellular FLIP (c-FLIP) specifically inhibits caspase-8 and suppresses death receptor-induced apoptosis. c-FLIP has also been reported to transmit activation... 
IMMUNE-SYSTEM | DENDRITIC CELLS | PROTEIN-KINASE | PROMOTES ACTIVATION | STEADY-STATE | MEDIATED APOPTOSIS | IMMUNOLOGY | C-FLIPL | NF-KAPPA-B | EXPRESSION | T-LYMPHOCYTES | Myeloid Cells - cytology | Neutrophils - cytology | Anti-Inflammatory Agents | Dendritic Cells - immunology | Lectins, C-Type - immunology | Enzyme Activation - immunology | Caspase 8 - genetics | Signal Transduction - immunology | RNA Interference | Myeloid Cells - immunology | Bone Marrow Cells - immunology | Leukocyte Count | p38 Mitogen-Activated Protein Kinases - metabolism | B7-1 Antigen - biosynthesis | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Splenomegaly - immunology | Neutrophils - immunology | Histocompatibility Antigens Class II - biosynthesis | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Antigen Presentation - immunology | Mice, Knockout | Caspase 8 - immunology | Animals | Apoptosis - immunology | B7-2 Antigen - biosynthesis | Granulocyte Colony-Stimulating Factor - biosynthesis | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Toll-Like Receptor 2 - immunology | T-Lymphocytes - immunology | Mice | RNA, Small Interfering | CASP8 and FADD-Like Apoptosis Regulating Protein - immunology | Enzyme Activation - genetics | Interleukin-2 - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1757 - 1773
Autoimmunity is traditionally attributed to altered lymphoid cell selection and/or tolerance, whereas the contribution of innate immune cells is less well... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TYROSINE KINASE | MURINE LUPUS | ANTIGEN-PRESENTING CELLS | MONOCLONAL-ANTIBODY | BAFF/APRIL SYSTEM | T-CELL | IMMUNOLOGY | SRC-FAMILY KINASES | ACTIVATING FACTOR | Myeloid Cells - cytology | Gene Expression - genetics | Autoantibodies - blood | Dendritic Cells - immunology | Interferon-gamma - metabolism | T-Lymphocytes - transplantation | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Autoimmunity - immunology | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Gene Expression - immunology | Myeloid Cells - drug effects | B-Cell Activation Factor Receptor - genetics | Antibodies, Monoclonal - immunology | B-Lymphocytes - metabolism | B-Lymphocytes - cytology | Splenomegaly - genetics | Antibodies, Monoclonal - pharmacology | Splenomegaly - immunology | Spleen - cytology | Mice, Knockout | Macrophages - metabolism | Models, Immunological | B-Cell Activating Factor - metabolism | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Mice | src-Family Kinases - genetics | Nephritis - genetics | Autoimmunity - genetics | Adoptive Transfer | Nephritis - immunology | B-Cell Activating Factor - immunology | Interferon-gamma - genetics | Spleen - pathology | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Macrophages - cytology | B-Lymphocytes - drug effects | Autoantibodies - immunology | Animals | Spleen - metabolism | T-Lymphocytes - cytology | B-Cell Activating Factor - genetics | Lymphocyte Activation - drug effects | Myeloid Cells - metabolism | Nephritis - metabolism | Proto-Oncogene Proteins c-hck - genetics | Cell Proliferation - drug effects | Dendritic Cells - cytology | B-Cell Activating Factor - blood | Interferon-gamma - blood | Interferon-gamma - pharmacology
Journal Article
Immunity, ISSN 1074-7613, 02/2008, Volume 28, Issue 2, pp. 206 - 217
Alterations in the stoichiometric balance between members of Bcl-2 and Fas apoptotic pathway could lead to the pathogenesis of systemic lupus erythematosus... 
MOLIMMUNO | APOPTOSIS | PROTEIN | B-CELL | DISEASE | NEGATIVE SELECTION | MURINE LUPUS | LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | THYMOCYTES | T-CELLS | LPR | Autoimmunity | Kidney - pathology | Autoantibodies - blood | Humans | fas Receptor - deficiency | Kidney - immunology | Lupus Erythematosus, Systemic - metabolism | fas Receptor - metabolism | Membrane Proteins - deficiency | fas Receptor - immunology | Mice, Inbred MRL lpr | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Lupus Erythematosus, Systemic - immunology | Proto-Oncogene Proteins - immunology | fas Receptor - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Macrophages - immunology | Proto-Oncogene Proteins - metabolism | Apoptosis Regulatory Proteins - immunology | Membrane Proteins - genetics | Lymphatic Diseases - immunology | Splenomegaly - immunology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - deficiency | Antigen-Presenting Cells - immunology | Apoptosis Regulatory Proteins - metabolism | Macrophage Activation | Animals | B-Lymphocytes - immunology | Lupus Erythematosus, Systemic - genetics | T-Lymphocytes - immunology | Mice | Lupus Erythematosus, Systemic - pathology | Apoptosis | Lupus | Development and progression | Systemic lupus erythematosus | Statistical analysis | Disease | Pathogenesis | Lymphocytes | Mortality | Arthritis | Autoimmune diseases | Gene expression
Journal Article
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 02/2012, Volume 188, Issue 4, pp. 1656 - 1667
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2004, Volume 173, Issue 7, pp. 4744 - 4754
Inflammation in the kidney and other tissues (lung, and salivary and lacrimal glands) is characteristic of MRL-Fas(lpr) mice with features of lupus.... 
MRL-LPR MICE | OP OP MOUSE | M-CSF | IFN-GAMMA | MRL/LPR MICE | OSTEOPETROTIC OP/OP MICE | MESANGIAL CELLS | ACUTE-RENAL-FAILURE | TNF-ALPHA | IMMUNOLOGY | SYSTEMIC AUTOIMMUNITY | Salivary Glands - immunology | Leukocytes - pathology | Salivary Glands - pathology | Spleen - immunology | Apoptosis - genetics | Cell Migration Inhibition | Cytokines - physiology | Lymphatic Diseases - genetics | Mice, Inbred MRL lpr | Chemokines - antagonists & inhibitors | B-Lymphocytes - pathology | Kidney Tubules - pathology | Growth Inhibitors - genetics | Macrophage Colony-Stimulating Factor - genetics | Lupus Nephritis - pathology | Epithelium - pathology | Macrophages - pathology | Splenomegaly - genetics | Complement C3 - metabolism | Macrophage Activation - immunology | Lymphatic Diseases - immunology | Splenomegaly - immunology | Chemokines - physiology | Lacrimal Apparatus - immunology | Splenomegaly - prevention & control | Mice, Transgenic | Lupus Nephritis - immunology | Kidney Glomerulus - pathology | Down-Regulation - genetics | Mice, Knockout | Immunoglobulin Isotypes - biosynthesis | B-Lymphocytes - immunology | Growth Inhibitors - physiology | Lymphatic Diseases - pathology | T-Lymphocytes - immunology | Mice | Kidney Glomerulus - immunology | Immunoglobulin G - metabolism | Lupus Nephritis - prevention & control | Bone Marrow - immunology | Leukopenia - immunology | Macrophage Activation - genetics | Leukopenia - genetics | Macrophage Colony-Stimulating Factor - deficiency | Epithelium - immunology | Kidney Glomerulus - metabolism | T-Lymphocytes - pathology | Lacrimal Apparatus - pathology | Spleen - pathology | Macrophages - immunology | Skin - pathology | Skin - immunology | Kidney Tubules - immunology | Severity of Illness Index | Lung - pathology | Lupus Nephritis - genetics | Growth Inhibitors - deficiency | Mice, Inbred C57BL | Lymphatic Diseases - prevention & control | Leukopenia - pathology | Mice, Inbred C3H | Animals | Apoptosis - immunology | Down-Regulation - immunology | Bone Marrow - pathology | Cytokines - antagonists & inhibitors | Macrophage Colony-Stimulating Factor - physiology | Lung - immunology
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 1955 - 1963
Tight control of B cell differentiation into plasma cells (PCs) is critical for proper immune responses and the prevention of autoimmunity. The Ets1... 
B-CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BRUTONS TYROSINE KINASE | AUTOIMMUNE-DISEASE DEVELOPMENT | CHINESE HAN POPULATION | DEFICIENT MICE | IMMUNOLOGY | LYN(-/-) MICE | PLASMA-CELL DIFFERENTIATION | TRANSCRIPTION FACTOR | GENOME-WIDE ASSOCIATION | Spleen - immunology | Antibodies - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Protein-Tyrosine Kinases - metabolism | Autoantibodies - blood | Immunoglobulin M - immunology | Protein-Tyrosine Kinases - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Gene Expression - immunology | src-Family Kinases - metabolism | Antibodies - immunology | Plasma Cells - metabolism | B-Lymphocytes - metabolism | Enzyme-Linked Immunosorbent Assay | Splenomegaly - genetics | Mice, Inbred C57BL | Splenomegaly - immunology | Signal Transduction - genetics | Splenomegaly - metabolism | Reverse Transcriptase Polymerase Chain Reaction | src-Family Kinases - immunology | Blotting, Western | Mice, Knockout | Cell Differentiation - immunology | Proto-Oncogene Protein c-ets-1 - immunology | Autoantibodies - immunology | Animals | B-Lymphocytes - immunology | Immunoglobulin M - blood | Spleen - metabolism | Epistasis, Genetic | Proto-Oncogene Protein c-ets-1 - genetics | src-Family Kinases - genetics | Plasma Cells - immunology
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6279, pp. 1324 - 1329
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2014, Volume 57, pp. 66 - 76
Abstract Each year, up to one fifth of the United States population is infected with influenza virus. Although mortality rates are low, hundreds of thousands... 
Allergy and Immunology | Pulmonary inflammation | Lupus | MRL-Faslpr | SLE | Influenza | MRL-Fas | BACTERIAL LIPOPOLYSACCHARIDE | MESSENGER-RNA EXPRESSION | MRL-Fas(lpr) | RENAL-DISEASE | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | TUMOR-NECROSIS-FACTOR | IMMUNE-RESPONSES | MRL/LPR MICE | TNF-ALPHA | T-CELLS | SYSTEMIC AUTOIMMUNITY | Influenza A Virus, H1N1 Subtype - immunology | Lupus Erythematosus, Systemic - complications | Viral Matrix Proteins - genetics | Humans | Orthomyxoviridae Infections - complications | Influenza A Virus, H1N1 Subtype - physiology | Splenomegaly - pathology | Immunoglobulin M - immunology | Host-Pathogen Interactions - immunology | Lung - virology | Mice, Inbred MRL lpr | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Lupus Erythematosus, Systemic - immunology | Pneumonia - immunology | Influenza A Virus, H1N1 Subtype - genetics | Lung - pathology | Kidney Diseases - pathology | Mice, Inbred C57BL | Splenomegaly - immunology | Reverse Transcriptase Polymerase Chain Reaction | Pneumonia - virology | Kidney Diseases - immunology | Animals | Apoptosis - immunology | Gene Expression Regulation, Viral | Antibodies, Viral - immunology | T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Autoimmunity | Complications and side effects | Systemic lupus erythematosus | Immunoglobulin G | Arthritis | Inflammation | T cells | Pulmonary Inflammation
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3500 - 10
Inflammation, although responsible for controlling infection, is often associated with the pathogenesis of chronic diseases. Leishmania donovani, the causative... 
MIGRATION | RESPONSES | CCR7 EXPRESSION | INFLAMMATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MICE | HYPOXIA | IL-12 | DONOVANI INFECTION | CD8(+) T-CELLS | Inflammation - pathology | Spleen - immunology | Interleukin-12 - genetics | Humans | Leishmaniasis, Visceral - immunology | Splenomegaly - pathology | Th1 Cells - immunology | CD11 Antigens - genetics | CD4-Positive T-Lymphocytes - immunology | Splenomegaly - parasitology | CD11 Antigens - immunology | Leishmaniasis, Visceral - parasitology | Interferon-gamma - genetics | Dendritic Cells - metabolism | Dendritic Cells - parasitology | Leishmania donovani - immunology | Splenomegaly - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Splenomegaly - immunology | Leishmania donovani - pathogenicity | Cellular Microenvironment - immunology | Leishmaniasis, Visceral - pathology | Spleen - parasitology | Animals | Interferon-gamma - immunology | Interleukin-10 - genetics | Interleukin-12 - immunology | Leishmaniasis, Visceral - genetics | Inflammation - genetics | Leishmania donovani - genetics | Mice | Cellular Microenvironment - genetics | Interleukin-10 - immunology | Spleen | Splenomegaly | CD11c antigen | Dendritic cells | Therapeutic applications | Chronic infection | Interleukin 12 | Lymphocytes T | Inflammation | Leishmaniasis | CD4 antigen | Visceral leishmaniasis | Parasitic diseases | γ-Interferon | Interleukin 10 | Bone marrow | Hypoxia | Life Sciences
Journal Article