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Nature (London), ISSN 1476-4687, 2016, Volume 537, Issue 7619, pp. 197 - 201
Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat-intron intermediate. Here we present the 3.8 angstrom... 
U4/U6.U5 TRI-SNRNP | IN-VITRO | ELECTRON CRYOMICROSCOPY | ACTIVE-SITE | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | PRE-MESSENGER-RNA | CATALYTIC ACTIVATION | RNA Precursors - chemistry | RNA Helicases - metabolism | Spliceosomes - chemistry | RNA, Fungal - ultrastructure | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA Precursors - metabolism | RNA, Fungal - genetics | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Introns - genetics | RNA Splice Sites - genetics | RNA, Fungal - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Exons - genetics | Magnesium - metabolism | Nuclear Proteins - metabolism | Spliceosomes - ultrastructure | Esterification | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Base Pairing | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Structure | Brewer's yeast | Methods | RNA splicing | Proteins | Enzymes | Molecular structure | Microscopy | Catalysis | Ribonucleic acid--RNA | Binding sites
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7660, pp. 617 - 621
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome's catalytic centre. Here we... 
U4/U6.U5 TRI-SNRNP | COMPLEX | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | U2 SNRNP | CRYO-EM STRUCTURE | REQUIRES ATP | RNA Helicases - metabolism | Ribonucleoprotein, U2 Small Nuclear - chemistry | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoprotein, U2 Small Nuclear - metabolism | Base Sequence | Protein Domains | RNA Precursors - metabolism | Ribonucleoproteins, Small Nuclear - chemistry | Protein Stability | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | Introns - genetics | RNA Splice Sites - genetics | Models, Molecular | Nuclear Proteins - metabolism | RNA Precursors - genetics | Spliceosomes - ultrastructure | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Baking yeast | Ribonucleoproteins (small nuclear) | Molecular structure | mRNA | Ribonucleoproteins (U2 small nuclear) | Electron microscopy | Ribonucleic acid--RNA | snRNA | Proteins | DNA helicase | Transmission electron microscopy | Catalysis | Atomic structure
Journal Article
PloS one, ISSN 1932-6203, 2007, Volume 2, Issue 9, p. e921
.... Here we analyzed the consequence of SMN deficiency on snRNP metabolism in the spinal cord of mouse models of SMA with differing phenotypic severities... 
MULTIDISCIPLINARY SCIENCES | RNA-Binding Proteins - genetics | Immunoprecipitation | Spinal Cord - metabolism | Humans | Ribonucleoproteins, Small Nuclear - genetics | Brain - metabolism | Muscular Atrophy, Spinal - genetics | Spliceosomes - metabolism | Kidney - metabolism | Mice, Mutant Strains | Spinal Cord - pathology | Ribonucleoproteins - genetics | DEAD Box Protein 20 | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | Fibroblasts - metabolism | Cell Line | Muscular Atrophy, Spinal - metabolism | Electrophoresis, Polyacrylamide Gel | Genotype | Nuclear Proteins - metabolism | Ribonucleoproteins - metabolism | SMN Complex Proteins | Muscular Atrophy, Spinal - pathology | Nerve Tissue Proteins - genetics | Blotting, Western | Nerve Tissue Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | DEAD-box RNA Helicases - genetics | Blotting, Northern | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Fibroblasts - cytology | Mice | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Proteins | Physiological aspects | Analysis | Spinal muscular atrophy | Spinal cord | Animal models | Ribonucleoproteins (small nuclear) | Syngeneic grafts | Pathogenesis | SMN protein | Impairment | Biochemistry | Biosynthesis | Biology | Machinery | Machinery and equipment | Atrophy | Genotype & phenotype | Motor neuron diseases | Rodents | Animal tissues | Assembly | Age | Neurological disorders | Cell survival | Kidneys | Splicing | Introns | Macromolecules | Ribonucleoproteins | Metabolism | Pathology | Comparative analysis
Journal Article
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2017, Volume 75, Issue 6, pp. 1071 - 1098
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear messenger RNAs, with exons arranged colinearly to their genomic order.... 
Biomedicine, general | Biochemistry, general | Chromatin | Cardiovascular disease | Exosomes | Cell Biology | Life Sciences | Spliceosome | Life Sciences, general | Alu elements | microRNA | RNA polymerase II | Cancer | GROUP-II INTRON | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRE-MESSENGER-RNAS | BINDING PROTEIN | CELL BIOLOGY | NONCODING RNA | INTERVENING SEQUENCE | EXTRACELLULAR VESICLES | GENE-EXPRESSION | POLYMERASE-II | GENOME-WIDE ASSOCIATION | Neoplasms - metabolism | Chromatin - metabolism | Alternative Splicing | Spliceosomes - genetics | Exons | Humans | Eukaryotic Cells - metabolism | MicroRNAs - metabolism | RNA Polymerase II - metabolism | Trans-Splicing | Cardiovascular Diseases - pathology | RNA, Messenger - metabolism | Cardiovascular Diseases - genetics | RNA - genetics | Spliceosomes - metabolism | Neoplasms - genetics | Chromatin - chemistry | RNA - metabolism | Cardiovascular Diseases - metabolism | Introns | RNA, Messenger - genetics | RNA Stability | RNA Polymerase II - genetics | Eukaryotic Cells - cytology | MicroRNAs - genetics | Neoplasms - pathology | Alu Elements | Anopheles | MicroRNA | Genes | Genomics | Genetic transcription | Biomedical engineering | Post-transcription | Transcription elongation | Splicing | Genomes | Gene expression | Ribonucleic acid--RNA | Cells | Gene sequencing | Proteins | Eukaryotes | Biomedical materials | miRNA | Gene mapping | Molecular biology | Transcription initiation | Elongation | Review
Journal Article
Molecular & cellular proteomics, ISSN 1535-9484, 2014, Volume 13, Issue 12, pp. 3558 - 3571
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 542, Issue 7641, pp. 377 - 380
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications-branching and exon ligation(1)-catalysed at a single catalytic metal site... 
2ND STEP | ANGSTROM RESOLUTION | ELECTRON CRYOMICROSCOPY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL INTERACTIONS | CATALYTIC CENTER | CRYO-EM STRUCTURE | SPLICING FACTOR | SITE CHOICE | PRE-MESSENGER-RNA | RNA Helicases - metabolism | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Cell Cycle Proteins - ultrastructure | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - ultrastructure | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | RNA, Small Nuclear - genetics | Protein Domains | Ribonucleoprotein, U5 Small Nuclear - ultrastructure | Adenosine Triphosphatases - ultrastructure | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | RNA Splice Sites - genetics | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | Exons - genetics | Spliceosomes - ultrastructure | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | DNA-Binding Proteins - ultrastructure | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Protein Binding | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | RNA sequencing | Methods | Mutation | Catalysis | Ribonucleic acid--RNA | Binding sites | Crystal structure
Journal Article