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Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 3, pp. 1246 - 1257
Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito. Sporozoites invade hepatocytes... 
LIVER-STAGE | IMMUNIZATION | RODENT MALARIA PARASITES | PROTECTIVE IMMUNITY | CD8+ T-CELLS | CIRCUMSPOROZOITE PROTEIN | HOST-CELL TRAVERSAL | MOSQUITO | DRAINING LYMPH-NODE | IMMUNOLOGY | STERILE PROTECTION | Inflammation - pathology | Plasmodium berghei - immunology | Skin - cytology | Humans | CD8-Positive T-Lymphocytes - parasitology | Inflammation - parasitology | Sporozoites - immunology | Female | Injections, Intradermal | Skin - immunology | Plasmodium berghei - parasitology | Cell Line | Sporozoites - transplantation | Anopheles - parasitology | Malaria - immunology | Mice, Inbred C57BL | Skin - parasitology | Sporozoites - radiation effects | Mice, Transgenic | Host-Parasite Interactions - immunology | Inflammation - immunology | Lymph Nodes - immunology | Antigen Presentation - immunology | Hep G2 Cells | Animals | Lymph Nodes - parasitology | Ear | Malaria - parasitology | Mice | Anopheles - immunology | CD8-Positive T-Lymphocytes - immunology | Malaria/immunology | Antigen Presentation/immunology | Lymph Nodes/immunology | Sporozoites/transplantation | Inflammation/immunology | Life Sciences | Lymph Nodes/parasitology | CD8-Positive T-Lymphocytes/immunology | Immunology | Skin/cytology | Sporozoites/radiation effects | Anopheles/immunology | Inflammation/pathology | Plasmodium berghei/parasitology | Plasmodium berghei/immunology | Inflammation/parasitology | Skin/parasitology | CD8-Positive T-Lymphocytes/parasitology | Sporozoites/immunology | Host-Parasite Interactions/immunology | Skin/immunology | Anopheles/parasitology | Malaria/parasitology
Journal Article
Plos Pathogens, ISSN 1553-7366, 2010, Volume 6, Issue 5, pp. e1000877 - 13
Journal Article
Immunity, ISSN 1074-7613, 10/2016, Volume 45, Issue 4, pp. 889 - 902
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106241
Background: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane... 
APICAL MEMBRANE ANTIGEN-1 | RESPONSES | IMMUNOGENICITY | PROTEIN | PROTECTION | LIVER STAGES | SAFETY | MULTIDISCIPLINARY SCIENCES | VACCINE | CANDIDATE | CD8(+) T-CELLS | Antigens, Protozoan - immunology | DNA - immunology | Humans | Malaria, Falciparum - pathology | DNA - administration & dosage | Membrane Proteins - immunology | Plasmodium falciparum - immunology | Epitopes - immunology | Membrane Proteins - administration & dosage | Malaria, Falciparum - parasitology | Interleukin-2 - immunology | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Tumor Necrosis Factor-alpha - immunology | Plasmodium falciparum - pathogenicity | Adult | Immunologic Memory | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | Infection | Plasmodium falciparum | Immunization | Malaria | Adenoviruses | DNA | Interferon | T cells | Health aspects | Antigenic determinants | CD8 antigen | Liver | Effector cells | Lymphocytes T | Infections | Vaccines | Immunity | Proteins | Immunology | Interleukin 2 | Lymphocytes | Plasmid DNA | Volunteers | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Antigens | Medical research | Immunological memory | Memory cells | Priming | Epitopes | Tumor necrosis factor-α | Vectors (Biology) | Membrane proteins | Plasmids | γ-Interferon | Comparative analysis | Deoxyribonucleic acid
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 614 - 623
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2528 - 2538
Malaria results in >1,000,000 deaths per year worldwide. Although no licensed vaccine exists, much effort is currently focused on subunit vaccines that elicit... 
X-IRRADIATED SPOROZOITES | LISTERIA-MONOCYTOGENES | PROTECTIVE IMMUNITY | INTERFERON-GAMMA | LIVER STAGES | NITRIC-OXIDE SYNTHASE | IFN-GAMMA | INFLUENZA-VIRUS | IMMUNOLOGY | MALARIA HEPATIC STAGES | STERILE PROTECTION | Tumor Necrosis Factor-alpha - metabolism | Plasmodium berghei - immunology | Fas Ligand Protein - metabolism | Perforin - genetics | Dendritic Cells - immunology | Liver Diseases, Parasitic - immunology | Listeria monocytogenes - immunology | Sporozoites - immunology | Fas Ligand Protein - immunology | Signal Transduction - immunology | Malaria Vaccines - immunology | TNF-Related Apoptosis-Inducing Ligand - deficiency | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Perforin - immunology | Interferon-gamma - genetics | Interferon-gamma - deficiency | Dendritic Cells - metabolism | Immunologic Memory - immunology | Malaria - immunology | Plasmodium yoelii - immunology | TNF-Related Apoptosis-Inducing Ligand - immunology | Liver Diseases, Parasitic - parasitology | Mice, Knockout | Malaria - prevention & control | Perforin - deficiency | Animals | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Malaria - parasitology | Culicidae - parasitology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | TNF-Related Apoptosis-Inducing Ligand - genetics
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1197 - 1209.e10
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of ( ) sporozoites, can protect from malaria in animal models... 
circumsporozoite protein | Plasmodium falciparum | natural infection | affinity maturation | protective antibodies | malaria | memory B cells | epitope specificity | human | X-ray structures | SYSTEM | RESPONSES | IMMUNITY | TRANSMISSION | MEMORY B-CELLS | HUMAN MALARIA | STAGE | PLASMODIUM-FALCIPARUM SPOROZOITES | CIRCUMSPOROZOITE PROTEIN | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | Plasmodium berghei - immunology | Immunoglobulin Heavy Chains - biosynthesis | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | B-Lymphocytes - parasitology | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Epitopes - immunology | Sporozoites - chemistry | Immunity, Humoral | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protein Interaction Domains and Motifs | Immunoglobulin Heavy Chains - immunology | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Antigens, Protozoan - chemistry | Antibodies, Protozoan - immunology | Malaria - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antibodies, Protozoan - chemistry | Antibodies, Protozoan - biosynthesis | Malaria - prevention & control | Malaria, Falciparum - parasitology | Animals | B-Lymphocytes - immunology | Protein Conformation, beta-Strand | Malaria - parasitology | Malaria, Falciparum - immunology | Protein Binding | Immunologic Memory | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Viral antibodies | Wildlife conservation | Malaria | Analysis | Children's hospitals | Malaria vaccine | Antibodies | Development and progression | B cells | Health aspects | Antigenic determinants | Vector-borne diseases | Animal models | Immunological memory | Immunoglobulins | Complementarity | Molecular structure | Vaccines | Epitopes | Parasites | Aquatic insects | Immunity | Disease transmission | Lymphocytes B | Coding | Sporozoites | Monoclonal antibodies | Affinity | Immunity (humoral) | Human behavior | Complementarity-determining region 3 | Binding sites | Circumsporozoite protein
Journal Article
Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6055, pp. 475 - 480
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2011, Volume 187, Issue 3, pp. 1347 - 1357
Identification of correlates of protection for infectious diseases including malaria is a major challenge and has become one of the main obstacles in... 
LINEAGE RELATIONSHIP | IMMUNITY | IMMUNOGENICITY | VACCINIA VIRUS ANKARA | EFFICACY | FALCIPARUM | IN-VIVO | SPOROZOITES | ADENOVIRAL VECTORS | IMMUNOLOGY | PLASMODIUM-BERGHEI | Plasmodium berghei - immunology | CD8-Positive T-Lymphocytes - pathology | Genetic Vectors - administration & dosage | Humans | Plasmodium berghei - genetics | CD8-Positive T-Lymphocytes - parasitology | Liver Diseases, Parasitic - immunology | Epitopes, T-Lymphocyte - administration & dosage | Epitopes, T-Lymphocyte - genetics | Genetic Vectors - therapeutic use | Protozoan Proteins - genetics | Liver Diseases, Parasitic - prevention & control | Liver Diseases, Parasitic - pathology | H-2 Antigens - genetics | Malaria Vaccines - immunology | Adenoviridae - genetics | Female | Epitopes, T-Lymphocyte - immunology | H-2 Antigens - administration & dosage | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | Immunologic Memory - genetics | Genetic Vectors - immunology | Malaria - immunology | Vaccinia - genetics | Malaria - prevention & control | H-2 Antigens - immunology | Animals | Malaria Vaccines - administration & dosage | Malaria - pathology | Vaccinia - immunology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Transgenes - immunology | Protozoan Proteins - immunology | Malaria Vaccines - genetics
Journal Article