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Cancer Science, ISSN 1347-9032, 05/2019, Volume 110, Issue 5, pp. 1525 - 1535
The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in various cancers. In some such cancers, Ras and Raf are hotspots for... 
Ras/Raf/ERK | tumor suppressor | cancer | Sprouty/Spred | oncogene | Development and progression | Tumors | Medical research | Epidermal growth factor | MicroRNAs | Extracellular signal-regulated kinase | Raf protein | Mutation | Kinases | Spred | Ras | Raf | Review | Sprouty | ERK
Journal Article
Experimental Eye Research, ISSN 0014-4835, 01/2019, Volume 178, pp. 160 - 175
Spred, like Sprouty (Spry) and also Sef proteins, have been identified as important regulators of receptor tyrosine kinase (RTK)-mediated MAPK/ERK-signaling in... 
Spred | ERK1/2 | Fiber differentiation | Lens epithelial cell proliferation | FGF | Development | Sprouty | OCULAR MEDIA | RAS | MOUSE | SUBCELLULAR-LOCALIZATION | MESENCHYMAL TRANSITION | SPROUTY PROTEINS | OPHTHALMOLOGY | NEURAL RETINA | KINASE ACTIVATION | EXPRESSION | Proteins | Tyrosine | Growth | Stem cells | Genetic engineering | Transplantation | Cell differentiation
Journal Article
TRENDS IN CELL BIOLOGY, ISSN 0962-8924, 01/2006, Volume 16, Issue 1, pp. 45 - 54
Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and... 
TRANSLOCATION DOMAIN | FGF | PROSTATE-CANCER | GROWTH | LUNG MORPHOGENESIS | DROSOPHILA-SPROUTY | KIDNEY DEVELOPMENT | INHIBITOR | ERK ACTIVATION | EXPRESSION | CELL BIOLOGY
Journal Article
Development, ISSN 0950-1991, 06/2004, Volume 131, Issue 12, pp. 2853 - 2864
Journal Article
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5
Myofibroblasts play critical roles in the development of idiopathic pulmonary fibrosis by depositing components of extracellular matrix. One source of lung... 
SPROUTY | GROWTH-FACTOR-BETA | SIGNALING PATHWAYS | TGF-BETA | MULTIDISCIPLINARY SCIENCES | KINASE | MECHANISMS | INDUCTION | IDIOPATHIC PULMONARY-FIBROSIS | PROTEINS | PLASTICITY
Journal Article
by Zhang, Y and Yuan, FK and Liu, L and Chen, ZF and Ma, XY and Lin, Z and Zou, J
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 09/2019, Volume 60, Issue 12, pp. 3854 - 3862
PURPOSE. Subconjunctival injection of antagomir-21 attenuates the progression of corneal neovascularization. We examined the underlying mechanism by... 
MIGRATION | proangiogenic | DOWN-REGULATION | SPROUTY GENES | PROLIFERATION | HYPOXIA | corneal epithelial cell | corneal wound healing | MOUSE MODEL | OPHTHALMOLOGY | SPRY2 | miR-21 | NEOVASCULARIZATION | HIF-1-ALPHA | epithelial markers | EXPRESSION
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 02/2002, Volume 4, Issue 2, pp. 170 - 174
Fibroblast growth factors (FGFs) are pleiotrophic growth factors that control cell proliferation, migration, differentiation and embryonic patterning(1).... 
SPROUTY | ACTIVATION | ZEBRAFISH | PATTERN | PATHWAY | MAP KINASE | RECEPTOR | MESODERM INDUCTION | XENOPUS EMBRYO | REQUIREMENT | CELL BIOLOGY
Journal Article
DEVELOPMENT, ISSN 0950-1991, 05/2019, Volume 146, Issue 9, p. dev173575
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal signaling. Nodal asymmetry is... 
FGF | FLUID-FLOW | Left-right asymmetry | LRO | Leftward flow | CONVERGENT EXTENSION | DEVELOPMENTAL BIOLOGY | SPECIFICATION | Pkd2 | MOUSE EMBRYO | CELL-DEATH | CILIA LENGTH | MESODERM FORMATION | NODAL FLOW | GENE-EXPRESSION | Sprouty
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2015, Volume 137, Issue 3, pp. 560 - 570
Sprouty proteins are evolutionary‐conserved modulators of receptor tyrosine kinase signaling, deregulation of which has been implicated in the pathophysiology... 
prognostic biomarker | Sprouty 2 | epithelial ovarian cancer | downregulation | Sprouty 4 | MIGRATION | TYROSINE KINASE | BREAST-CANCER | HUMAN PROSTATE-CANCER | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | TUMOR-CELL PROLIFERATION | EPIGENETIC INACTIVATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Prognosis | Humans | Middle Aged | Neoplasms, Glandular and Epithelial - metabolism | Ki-67 Antigen - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Ovarian Neoplasms - mortality | Neoplasm Metastasis | Neoplasm Grading | Neoplasms, Glandular and Epithelial - mortality | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Retrospective Studies | Neoplasms, Glandular and Epithelial - diagnosis | Interleukin-6 - metabolism | Ovarian Neoplasms - drug therapy | Ovarian Neoplasms - diagnosis | Down-Regulation | Risk Factors | Nerve Tissue Proteins - metabolism | Neoplasms, Glandular and Epithelial - drug therapy | Biomarkers | Carcinoma, Ovarian Epithelial | Aged | Neoplasm Staging | Deregulation | Fibroblast growth factors | Endothelial growth factors | Analysis | Ovarian cancer | Proteins | Multivariate analysis | Growth factors | Medical prognosis
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, 12/2018, Volume 293, Issue 49, pp. 18841 - 18853
The Gag protein of avian sarcoma virus (ASV) lacks an N-myristoyl (myr) group, but contains structural domains similar to those of HIV-1 Gag. Similarly to... 
PLECKSTRIN HOMOLOGY DOMAINS | TYPE-1 GAG | UBIQUITINATION | MEMBRANE-BINDING | ESCRT-II | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | PLASMA-MEMBRANE | SPROUTY PROTEINS | PHOSPHOINOSITIDES
Journal Article
Virology, ISSN 0042-6822, 03/2019, Volume 529, pp. 169 - 176
Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including... 
Coxsackievirus | Vesicles | MicroRNA | Apoptosis | VIRUS | SUDDEN-DEATH | HEART-FAILURE | MITOCHONDRIA | MYOCARDITIS | DILATED CARDIOMYOPATHY | SUBVERSION | SPROUTY | REPLICATION | YOUNG | VIROLOGY
Journal Article
by Sun, M and Huang, F and Yu, D and Zhang, Y and Xu, H and Zhang, L and Li, L and Dong, L and Guo, L and Wang, S
CELL DEATH & DISEASE, ISSN 2041-4889, 08/2015, Volume 6
The origin of rhabdomyosarcoma (RMS) remains controversial. However, specific microRNAs (miRNAs) are downregulated in RMS and it is possible that re-expression... 
SKELETAL-MUSCLE | CELLS | ACTIVATION | GENE | QUANTIFICATION | KINASE | GROWTH | IDENTIFICATION | EXPRESSION | SPROUTY PROTEINS | CELL BIOLOGY
Journal Article