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International Journal of Cancer, ISSN 0020-7136, 07/2019, Volume 145, Issue 1, pp. 164 - 178
Cancer cell repopulation through cell cycle re-entry by quiescent (G ) cell is thought to be an important mechanism behind treatment failure and cancer... 
SPT16 | SSRP1 | SKP2 | MYC
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2019, Volume 508, Issue 3, pp. 864 - 870
FACT (Facilitates Chromatin Transactions) is a heterodimeric protein complex involved in RNA polymerase II transcription elongation, playing essential roles in... 
Histone chaperone | Histone (H3-H4)2 | Spt16 | FACT | Aminopeptidase-like domain | Histone (H3-H4)
Journal Article
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 03/2012, Volume 1819, Issue 3-4, pp. 247 - 255
FACT is a roughly 180 kDa heterodimeric protein complex important for managing the properties of chromatin in eukaryotic cells. Chromatin is a repressive... 
Histone chaperone | Spt16 | Pob3 | Nucleosome reorganization | DNA-POLYMERASE ALPHA | COMPLEX | YFACT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION ELONGATION | YEAST FACT | REPLICATION | BIOPHYSICS | HISTONE CHAPERONE FACT | N-TERMINAL DOMAIN | CHROMATIN TRANSCRIPTION | BINDING | Histones | Genetic transcription | RNA | RNA polymerases
Journal Article
by Bi, L and Xie, CL and Yao, M and Hnit, SST and Vignarajan, S and Wang, YL and Wang, Q and Xi, ZC and Xu, HX and Li, Z and de Souza, P and Tee, A and Wong, M and Liu, T and Zhao, XD and Zhou, J and Xu, L and Dong, QH
INTERNATIONAL JOURNAL OF CANCER, ISSN 0020-7136, 07/2019, Volume 145, Issue 1, pp. 164 - 178
Cancer cell repopulation through cell cycle re-entry by quiescent (G(0)) cell is thought to be an important mechanism behind treatment failure and cancer... 
UBIQUITIN LIGASE | PIRH2 | MECHANISMS | SUBUNITS | SPT16 | SSRP1 | QUIESCENCE DECISION | P27(KIP1) | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | MYC | PROSTATE-CANCER | SKP2 | EXPRESSION | CYCLE REENTRY
Journal Article
by Jiang, H and Xu, SD and Chen, YP and Li, HY and Tian, L and Zhou, HY and Zhao, ZW and Yang, C and Zhong, ZH and Cai, GC and Su, D
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 01/2019, Volume 508, Issue 3, pp. 864 - 870
FACT (Facilitates Chromatin Transactions) is a heterodimeric protein complex involved in RNA poly-merase H transcription elongation, playing essential roles in... 
Histone chaperone | COMPLEX | PROTEIN | NUCLEOSOME-BINDING | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | Histone (H3-H4) | SSRP1 | FACT | BIOPHYSICS | Aminopeptidase-like domain | Spt16 | H2A-H2B
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2019, Volume 145, Issue 1, pp. 164 - 178
Cancer cell repopulation through cell cycle re‐entry by quiescent (G0) cell is thought to be an important mechanism behind treatment failure and cancer... 
SPT16 | SSRP1 | SKP2 | MYC | Analysis | Cancer cells | Chromatin | Transcription | Repopulation | Therapeutic applications | Lung cancer | Myc protein | Gene expression | DNA repair | DNA biosynthesis | Degradation | Proteins | Loosening | Cell cycle | Histones | Prostate | Prostate cancer | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 564 - 568
Journal Article
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2018, Volume 1861, Issue 9, pp. 892 - 904
FAcilitates Chromatin Transcription (FACT) has been considered essential for transcription through chromatin mostly based on cell-free experiments. However,... 
Chromatin | SSRP1 | SPT16 | Transcription | Histone | Cancer | RNA-POLYMERASE-II | MOBILITY-GROUP BOX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACILITATES CHROMATIN TRANSCRIPTION | CELL-CYCLE PROGRESSION | MIDDLE DOMAIN REVEALS | NUCLEOSOME CORE PARTICLE | DNA-REPLICATION | BIOPHYSICS | MESSENGER-RNA | CK2 PHOSPHORYLATES
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 294 - 306
FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in... 
crystal structure | histone chaperone | histone binding | Spt16-Pob3 | nucleosome reorganization | Histone chaperone | Histone binding | Nucleosome reorganization | Crystal structure | SYSTEM | DOMAIN | CHROMATIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HISTONE CHAPERONE | SPT16 | CORE PARTICLE | DNA-REPLICATION | FEATURES | CELL BIOLOGY | Transcription Factors - chemistry | Histones - chemistry | Nucleosomes - chemistry | Saccharomyces cerevisiae - genetics | Protein Multimerization | Transcriptional Elongation Factors - chemistry | Molecular Sequence Data | Crystallography, X-Ray | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Conserved Sequence | Transcriptional Elongation Factors - genetics | Gene Expression Regulation, Fungal | High Mobility Group Proteins - metabolism | High Mobility Group Proteins - chemistry | Models, Molecular | Nucleosomes - metabolism | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Amino Acid Motifs | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Sequence Alignment | Histones - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Histones - metabolism | High Mobility Group Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Peptides | Analysis | Chemical properties | Medical colleges | Structure | Crystals
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2018, Volume 71, Issue 2, pp. 284 - 293.e4
Journal Article