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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79194
The global population remains vulnerable in the face of the next pandemic influenza virus outbreak, and reformulated vaccinations are administered annually to... 
RESPONSES | IMMUNITY | IGA | MECHANISM | MULTIDISCIPLINARY SCIENCES | VACCINE | VIRAL-INFECTION | Orthomyxoviridae Infections - prevention & control | Recombinant Fusion Proteins - immunology | Influenza Vaccines - administration & dosage | Adjuvants, Immunologic - administration & dosage | Poly I-C - administration & dosage | Humans | Squalene - immunology | RNA, Viral - administration & dosage | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Viral - blood | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Emulsions - administration & dosage | HEK293 Cells | Madin Darby Canine Kidney Cells | Polysorbates - administration & dosage | Female | Influenza A virus - immunology | Poly I-C - immunology | Nucleic Acid Conformation | Recombinant Fusion Proteins - administration & dosage | Orthomyxoviridae Infections - blood | Enzyme-Linked Immunosorbent Assay | Immunization - methods | Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage | Sendai virus - immunology | Squalene - administration & dosage | Injections, Intramuscular | Administration, Intranasal | Sendai virus - genetics | Animals | Influenza Vaccines - immunology | RNA, Viral - chemistry | Dogs | Antibodies, Viral - immunology | RNA, Viral - immunology | Mice | Mice, Inbred BALB C | Orthomyxoviridae Infections - immunology | Influenza viruses | Influenza vaccines | Epidemics | RNA | Influenza | Vaccination | Lectins | Immunization | Pandemics | Emulsions | Mucosa | Antibodies | Adjuvants | Viruses | Outbreaks | Nanoemulsions | Poly (I:C) | Vaccines | Immunoglobulin A | Ribonucleic acid--RNA | Disease control | Immunity | Proteins | Hemagglutinins | Influenza A | Viral infections | Ribonucleic acid
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 6, pp. 916 - 922
Highlights • Nanoliposome adjuvant induced a robust mucosal and systemic response towards an amebiasis antigen. • Vaccine induced mucosal IgA inhibited... 
Allergy and Immunology | Liposome | Vaccine | Amebiasis | Immune response | Entamoeba | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | PROTECTION | INTESTINAL AMEBIASIS | T-CELL | IMMUNOLOGY | SUBUNIT VACCINE | B-CELLS | IMMUNIZATION | RESPONSES | RETINOIC ACID | LECTIN | Entamoeba histolytica - immunology | Oligodeoxyribonucleotides - administration & dosage | Adjuvants, Immunologic - administration & dosage | Antigens, Protozoan - immunology | Liposomes - administration & dosage | Lipopolysaccharides - administration & dosage | Interleukin-17 - immunology | Protozoan Vaccines - chemistry | Entamoebiasis - immunology | Immunity, Mucosal - drug effects | Toll-Like Receptor 8 - immunology | Entamoebiasis - parasitology | Adjuvants, Immunologic - chemistry | Toll-Like Receptor 7 - immunology | Mice, Inbred CBA | Polysorbates - administration & dosage | Toll-Like Receptor 3 - genetics | Lectins - chemistry | Membrane Glycoproteins - immunology | Entamoeba histolytica - growth & development | Liposomes - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Immunization | Tretinoin - administration & dosage | Vaccines, Subunit | Antigens, Protozoan - chemistry | Lectins - immunology | Protozoan Vaccines - immunology | Membrane Glycoproteins - agonists | Squalene - administration & dosage | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 3 - agonists | Interleukin-17 - biosynthesis | Protozoan Vaccines - administration & dosage | Entamoeba histolytica - drug effects | Antibodies, Protozoan - biosynthesis | Membrane Glycoproteins - genetics | Liposomes - chemistry | Animals | Interferon-gamma - immunology | Entamoebiasis - prevention & control | Toll-Like Receptor 8 - genetics | Mice | RNA - administration & dosage | Alum Compounds - administration & dosage | Interferon-gamma - biosynthesis | Vaccination | Drugs | Evaluation | Antigens | Drug delivery systems | Communicable diseases | Mortality | Lectins | Drug therapy, Combination | Cells | Vehicles | Tretinoin | Studies | Aqueous solutions | Cytokines | Ligands | Vaccines | Experiments | Tropical diseases
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 34, Issue 3, pp. 313 - 319
Highlights • CMV seronegative girls between 12 and 17 years of age received CMV glycoprotein B (gB) vaccine with MF59 or saline placebo at 0, 1 and 6 months. •... 
Allergy and Immunology | Cytomegalovirus | Vaccine | CMV gB | Adolescent | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | PREVENTION | TRANSPLANT RECIPIENTS | IMMUNOLOGY | ADJUVANT | PLASMA | DNA | DISEASE | CMV INFECTION | Cytomegalovirus Vaccines - adverse effects | Adjuvants, Immunologic - administration & dosage | Vaccines, Subunit - genetics | Humans | DNA, Viral - analysis | Cytomegalovirus Infections - immunology | Vaccines, Synthetic - immunology | Cytomegalovirus Vaccines - administration & dosage | Antibodies, Viral - blood | Drug-Related Side Effects and Adverse Reactions - pathology | Adjuvants, Immunologic - adverse effects | Cytomegalovirus Infections - prevention & control | Vaccines, Synthetic - adverse effects | Blood - virology | Polymerase Chain Reaction | Polysorbates - administration & dosage | Female | Immunization Schedule | Vaccines, Subunit - adverse effects | Child | Cytomegalovirus Vaccines - genetics | Placebos - administration & dosage | Antigens, Viral - analysis | Polysorbates - adverse effects | Viral Envelope Proteins - genetics | Double-Blind Method | Vaccines, Synthetic - genetics | Squalene - administration & dosage | Urine - virology | Vaccines, Subunit - immunology | Squalene - adverse effects | Drug-Related Side Effects and Adverse Reactions - epidemiology | Vaccines, Subunit - administration & dosage | Viral Envelope Proteins - immunology | Vaccines, Synthetic - administration & dosage | DNA, Viral - genetics | Cytomegalovirus Vaccines - immunology | Clinical trials | Medical colleges | Vaccines | Teenage girls | Antigens | Cytomegalovirus infections | Vaccination | Urine | Confidence intervals | Substance abuse treatment | Consent | Hispanic Americans | Population | Infections | adolescent | vaccine | cytomegalovirus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 27, pp. 11169 - 11174
Oil-in-water emulsions have been successfully used to increase the efficacy, immunogenicity, and cross-protection of human vaccines; however, their mechanism... 
Antigens | Monocytes | Emulsions | Cytokines | Aluminum | Vaccination | Vaccine components | Neutrophils | Antibodies | Agonists | MF59-ADJUVANTED VACCINE | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | SEROGROUP-B MENINGOCOCCUS | IL-1-BETA | ALUMINUM-HYDROXIDE | DIFFERENTIATION | ANTIBODY-RESPONSES | NALP3 INFLAMMASOME | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Neisseria meningitidis, Serogroup B - immunology | Male | Polysorbates - pharmacology | Antibodies, Bacterial - biosynthesis | Polysorbates - administration & dosage | Female | Toll-Like Receptors - metabolism | Signal Transduction | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Myeloid Differentiation Factor 88 - genetics | Squalene - administration & dosage | Mice, Knockout | Carrier Proteins - genetics | Freund's Adjuvant - administration & dosage | Animals | Carrier Proteins - metabolism | Myeloid Differentiation Factor 88 - deficiency | Bacterial Vaccines - administration & dosage | Squalene - pharmacology | Mice | Vaccines, Synthetic - administration & dosage | Alum Compounds - administration & dosage | Myeloid Differentiation Factor 88 - metabolism | Proteins | Physiological aspects | Inflammation | Genetic aspects | Health aspects | Biological Sciences
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2009, Volume 361, Issue 25, pp. 2424 - 2435
Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 377, Issue 9773, pp. 1256 - 1263
Summary Background Cytomegalovirus end-organ disease can be prevented by giving ganciclovir when viraemia is detected in allograft recipients. Values of viral... 
Internal Medicine | PROPHYLAXIS | MEDICINE, GENERAL & INTERNAL | LIVER-TRANSPLANTATION | VIRUS | LOAD | DISEASE | PREVENTION | PREEMPTIVE THERAPY | RENAL-TRANSPLANTATION | INFECTION | VALGANCICLOVIR | Liver Transplantation | Adjuvants, Immunologic - administration & dosage | Viral Envelope Proteins - pharmacology | Humans | Middle Aged | DNA, Viral - isolation & purification | Male | Organ Transplantation | Cytomegalovirus Vaccines - administration & dosage | Cytomegalovirus Infections - prevention & control | Time Factors | Polymerase Chain Reaction | Polysorbates - administration & dosage | Adult | Female | Immunosuppressive Agents - administration & dosage | Cytomegalovirus - genetics | Cytomegalovirus - isolation & purification | Viremia - diagnosis | Enzyme-Linked Immunosorbent Assay | Squalene - administration & dosage | Treatment Outcome | Kidney Transplantation | Viral Envelope Proteins - administration & dosage | Cytomegalovirus Infections - diagnosis | Antibodies, Viral - isolation & purification | Cytomegalovirus - immunology | Cytomegalovirus Vaccines - pharmacology | Viremia - prevention & control | Immunosuppressive Agents - adverse effects | Aged | Organ transplant recipients | Usage | Viral vaccines | Cytomegaloviruses | Health aspects | Design | Clinical trials | Genomes | Disease | Blood products
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 2010, Volume 74, Issue 3, pp. 474 - 482
Nanostructured lipid carriers (NLCs) made from mixtures of Precirol and squalene were prepared to investigate whether the bioavailability of lovastatin can be... 
Nanostructured lipid carriers | Lovastatin | Emulsifier | Pharmacokinetics | Lipid nanoparticles | Oral administration | NLC | EMULSION | DRUG-DELIVERY SYSTEM | NANOPARTICLES SLN | RATS | BIOAVAILABILITY | INTESTINAL METABOLISM | SPECTROSCOPY | FORMULATIONS | <