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Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2013, Volume 4, Issue 10, pp. 932 - 936
We report the development of a new trifluoromethyltriazolobenzoxazepine series of squalene synthase inhibitors. Structure–activity studies and pharmacokinetics... 
inhibitor | dyslipidemia | Squalene synthase | triazolobenzoxazepine | FARNESOL | CHEMISTRY, MEDICINAL | ACIDS | MYOPATHY | DERIVATIVES
Journal Article
Asian Journal of Pharmaceutical and Clinical Research, ISSN 0974-2441, 10/2018, Volume 11, Issue 10, pp. 200 - 206
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 21, pp. 7402 - 7412
Antihyperlipidemic morpholine derivatives ( – ), combining several pharmacophore moieties, were evaluated in vitro and in vivo and optimized towards more... 
Autodock | Lipid peroxidation | Triglycerides | Squalene synthase | Aromatic tetrahydro-1,4-oxazines | Squalene synthase inhibitors | LDL-cholesterol | Synthesis | Total cholesterol | Molecular modeling | Docking | Drug design | Lipoxygenase | SYSTEM | EP2306 | ANTIOXIDANT | DRUGS | HEALTH | CHOLESTEROL-BIOSYNTHESIS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | CHEMISTRY, ORGANIC | DISEASE | MORPHOLINE DERIVATIVES | Antioxidants - chemistry | Humans | Hypolipidemic Agents - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Computer Simulation | Enzyme Inhibitors - chemistry | Drug Design | Hypolipidemic Agents - chemistry | Binding Sites | Morpholines - chemical synthesis | Anti-Inflammatory Agents - pharmacology | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Hypolipidemic Agents - pharmacology | Lipoxygenase - chemistry | Morpholines - chemistry | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Phosphates | Purines | Niacinamide | Blood cholesterol | Analysis | Low density lipoproteins | Albumin
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2012, Volume 20, Issue 9, pp. 3072 - 3093
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2011, Volume 18, Issue 29, pp. 4418 - 4439
Atherosclerosis and related heart disease is strongly associated with elevated blood levels of total (and LDL) cholesterol. Due to the widespread incidence as... 
Hyperlipidemia | Cholesterol biosynthesis | Triglycerides | Morpholines | In vitro | In vivo | Benzoxazepines | Lapaquistat | Antibiotics | LDL | Atherosclerosis | Squalestatins | Anti-dyslipidemic | Quinuclidines | hyperlipidemia | LOW-DENSITY-LIPOPROTEIN | IN-VITRO | squalestatins | BIOLOGICAL EVALUATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | in vivo | PRESQUALENE DIPHOSPHATE | quinuclidines | atherosclerosis | CHEMISTRY, MEDICINAL | lapaquistat | 4,1-BENZOXAZEPINE DERIVATIVES | BIOCHEMISTRY & MOLECULAR BIOLOGY | triglycerides | POTENT INHIBITOR | morpholines | cholesterol biosynthesis | in vitro | benzoxazepines | CORONARY-HEART-DISEASE | QUINUCLIDINE DERIVATIVES | antibiotics | LAPAQUISTAT ACETATE | Atherosclerosis - drug therapy | Humans | Hyperlipidemias - drug therapy | Enzyme Inhibitors - pharmacology | Hypolipidemic Agents - pharmacology | Drug Discovery | Enzyme Inhibitors - therapeutic use | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Hypolipidemic Agents - therapeutic use | Hypolipidemic Agents - chemistry | Drugs | Enzymes | Lipoproteins (low density) | HMG-CoA reductase inhibitors | Clinical trials | Squalene | Lipids | Structure-activity relationships | Nuclei | Cholesterol | Blood levels | Side effects | Reviews | Acids | Arteriosclerosis | statins | Hydroxymethylglutaryl-CoA reductase | Drug discovery | Heart diseases
Journal Article
Journal Article
International Food Research Journal, ISSN 1985-4668, 2018, Volume 25, Issue 3, pp. 1189 - 1196
Mentha piperita has been well known for its hypolipidemic activity. This prompted the present study to be carried out on a selected 12 phyto-constituents of... 
HMGR | Menthoside | Squalene synthase | Piperitoside | Eriodictyol | HMG CoA reductase | HMG CoA reductase (HMGR) | PROFILE | CHOLESTEROL | FRUIT | Menthoside piperitoside | FOOD SCIENCE & TECHNOLOGY | RATS | PIPERITA | STATINS | PEPPERMINT
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2011, Volume 19, Issue 17, pp. 5207 - 5224
Journal Article
Journal Article
Current Bioactive Compounds, ISSN 1573-4072, 08/2019, Volume 15, Issue 4, p. 415
Background: Squalene Synthase is one of the cholesterol biosynthetic pathway enzymes, inhibition of which produces potent lipid lowering action. A variety of... 
Enzymes | Toxicity | Liver | Squalene | Cytotoxicity | Lipids | Pharmacology | Biosynthesis | Carboxylic acids | Derivatives | Nitrogen | Cholesterol | Substitutes | Lysates | Organic chemistry | Inhibitors | Enzyme inhibitors | Aromatic compounds | Inhibition | Chemical synthesis | Hepatotoxicity | Statins | Enzyme-linked immunosorbent assay | Hydroxyl groups
Journal Article
Journal Article
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