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PloS one, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136023
.... First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors... 
CELL LUNG-CANCER | TUMOR-INFILTRATING LYMPHOCYTES | INTERLEUKIN-2 | GEFITINIB | IMPACT | MULTIDISCIPLINARY SCIENCES | ANTIBODY | B7-H1 | T-CELLS | CHEMOTHERAPY | LIGAND 1 EXPRESSION | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Carcinoma, Large Cell - mortality | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - mortality | Neoplasm Grading | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Squamous Cell - therapy | Programmed Cell Death 1 Receptor - metabolism | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | B7-H1 Antigen - metabolism | Carcinoma, Non-Small-Cell Lung - therapy | Adenocarcinoma - therapy | Aged | Neoplasm Staging | Carcinoma, Large Cell - therapy | Adenocarcinoma - mortality | Care and treatment | Physiological aspects | Genetic aspects | Research | Lung cancer, Non-small cell | Apoptosis | Immunohistochemistry | Thoracic surgery | PD-1 protein | Lung cancer | Clinical trials | Oncology | Cancer therapies | Lymph nodes | Subgroups | Proteins | Rank tests | Regression models | Bcl-x protein | Lymphocytes | Immunotherapy | Medical research | Immunoglobulins | Squamous cell carcinoma | Cell survival | Cytokines | Hematology | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Regression analysis | Patients | Medicine | Pathology | Chemotherapy | Hospitals | Cell death | Medical prognosis | PD-L1 protein | Ligands | Diagnostic systems | Solid tumors | Cancer | Tumors
Journal Article
by Campbell, Joshua D and Yau, Christina and Bowlby, Reanne and Liu, Yuexin and Brennan, Kevin and Fan, Huihui and Taylor, Alison M and Wang, Chen and Walter, Vonn and Akbani, Rehan and Byers, Lauren Averett and Creighton, Chad J and Coarfa, Cristian and Cherniack, Andrew D and Gevaert, Olivier and Prunello, Marcos and Shen, Hui and Chen, Jianhong and Cheng, Hui and Hayes, D. Neil and Bullman, Susan and Pedamallu, Chandra Sekhar and Ojesina, Akinyemi I and Mungall, Karen L and Hegde, Apurva and Diao, Lixia and Ma, Wencai and Sumazin, Pavel and Chen, Ting-Wen and Zuna, Rosemary and Al-Ahmadie, Hikmat and Zhou, Jane H and Drill, Esther and Wong, Christopher K and Stuart, Joshua M and Laird, Peter W and Hoadley, Katherine A and Weinstein, John N and Peto, Myron and Pickering, Curtis R and Chen, Zhong and Van Waes, Carter and Caesar-Johnson, Samantha J and Ferguson, Martin L and Tarnuzzer, Roy and Wang, Zhining and Zenklusen, Jean C and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Kim, Jaegil and Lawrence, Michael S and Lin, Pei and Noble, Michael S and Saksena, Gordon and Voet, Doug and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Reynolds, Sheila and Hegde, Apurva M and Ju, Zhenlin and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Abeshouse, Adam and Armenia, Joshua and Chakravarty, Debyani and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Luna, Augustin and Nissan, Moriah G and Ochoa, Angelica and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sumer, S. Onur and Sun, Yichao and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Cell reports (Cambridge), ISSN 2211-1247, 2018, Volume 23, Issue 1, pp. 194 - 212.e6
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Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 3, p. e57020
...), large cell carcinoma (LCC), squamous cell carcinoma (SCC) and adenocarcinoma (AC). We identified a small... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSFORMATION | THERAPY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | GROWTH | HMGA2 | MICE | CARCINOMA | PROGRESSION | TUMOR-INITIATING CELLS | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Antigens, CD - genetics | Antigens, CD - metabolism | Octamer Transcription Factor-3 - genetics | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Vimentin - genetics | Thy-1 Antigens - genetics | Hyaluronan Receptors - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Cadherins - genetics | Lung Neoplasms - genetics | Carcinoma, Large Cell - metabolism | Nanog Homeobox Protein | Immunophenotyping | Small Cell Lung Carcinoma - genetics | Mice, SCID | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Thy-1 Antigens - metabolism | Small Cell Lung Carcinoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Primary Cell Culture | Care and treatment | Analysis | Stem cells | Cancer cells | Physiological aspects | Research | Cancer | Adenocarcinoma | Vimentin | Cell culture | Therapy | Biotechnology | Thoracic surgery | Mesenchyme | Oct-4 protein | Lung cancer | Radiation | Population studies | Identification | Biology | mRNA | Metastasis | Cancer therapies | CD90 antigen | N-Cadherin | Immunology | CD44 antigen | Population | Medical research | Squamous cell carcinoma | Hematology | Small cell lung carcinoma | Cell division | Tumor cell lines | Gene expression | Cadherin | Spheroids | Morbidity | Medicine | Pathology | Lungs | Medical prognosis | Pancreatic cancer | Irradiation | Prostate | Tumors
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2017, Volume 77, Issue 13, pp. 3540 - 3550
.... In this study, we evaluated tumor specimens from 65 patients with melanoma, lung nonsquamous, squamous cell lung or head and neck cancers who were treated with the approved PD1-targeting antibodies... 
BREAST-CANCER | BIOMARKERS | ANTI-PD-1 THERAPY | PEMBROLIZUMAB | ONCOLOGY | CLINICAL ONCOLOGY/COLLEGE | RECOMMENDATIONS | SENSITIVITY | MECHANISMS | TUMORS | AMERICAN SOCIETY | Gene Expression - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Squamous Cell Carcinoma of Head and Neck | Melanoma - genetics | Gene Expression - immunology | Aged, 80 and over | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Head and Neck Neoplasms - drug therapy | Gene Expression Profiling - methods | Melanoma - pathology | Head and Neck Neoplasms - pathology | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Carcinoma, Squamous Cell - drug therapy | Melanoma - immunology | Melanoma - drug therapy | Nivolumab | Head and Neck Neoplasms - genetics | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | PD-1 protein | CD8 antigen | Antibodies | Activation | Lymphocytes T | Killer cells | Cell activation | Lymphocytes | Natural killer cells | Signatures | Immune system | Squamous cell carcinoma | Head | Immune response | Small cell lung carcinoma | Tumor-infiltrating lymphocytes | Melanoma | Lung carcinoma | Gene expression | Ribonucleic acid--RNA | Patients | CD4 antigen | Immune checkpoint | Reproducibility | PD-L1 protein | Biomarkers | Head and neck cancer | Interferon | Solid tumors | Cancer | Tumors
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 2012, Volume 84, Issue 1, pp. 189 - 195
Purpose To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center... 
Radiology | Hematology, Oncology and Palliative Medicine | Head-and-neck cancer | Parotid carcinoma | Radiotherapy | Toxicity | Quality of life | HEAD | PROGNOSTIC-FACTORS | ONCOLOGY | NECK | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | SALIVARY-GLAND CARCINOMA | Adenocarcinoma - pathology | Parotid Gland - surgery | Carcinoma, Acinar Cell - drug therapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Acinar Cell - pathology | Carcinoma, Acinar Cell - radiotherapy | Carcinoma, Squamous Cell - surgery | Male | Carcinoma, Squamous Cell - radiotherapy | Young Adult | Carcinoma, Mucoepidermoid - radiotherapy | Netherlands | Carcinoma, Acinar Cell - secondary | Parotid Neoplasms - radiotherapy | Aged, 80 and over | Adult | Carcinoma, Adenoid Cystic - secondary | Female | Parotid Neoplasms - surgery | Carcinoma - pathology | Adenocarcinoma - radiotherapy | Carcinoma - secondary | Carcinoma, Adenoid Cystic - surgery | Carcinoma - drug therapy | Radiotherapy Dosage | Carcinoma, Mucoepidermoid - secondary | Carcinoma, Adenoid Cystic - pathology | Neoplasm Invasiveness | Treatment Outcome | Carcinoma, Mucoepidermoid - surgery | Carcinoma - radiotherapy | Cancer Care Facilities | Lymphatic Irradiation | Adenocarcinoma - secondary | Carcinoma, Mucoepidermoid - pathology | Disease-Free Survival | Regression Analysis | Adolescent | Parotid Neoplasms - pathology | Quality of Life | Carcinoma, Squamous Cell - secondary | Aged | Carcinoma, Adenoid Cystic - radiotherapy | Neoplasm Staging | Adenocarcinoma - surgery | Neck Dissection | Care and treatment | Carcinoma | Nuclear radiation | Patient outcomes | Surgery | Cancer | Index Medicus | Adenocarcinoma | Adenoid | Cell survival | Preservation | Risk groups | Radiation | Clinical trials | Adjuvants | Multivariate analysis | Survival | Risk factors | Side effects | Neck | Bell's palsy | squamous cell carcinoma | SURGERY | PATIENTS | FAILURES | METASTASES | TOXICITY | STANDARD OF LIVING | IRRADIATION | MULTIVARIATE ANALYSIS | HEALTH HAZARDS | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | SIDE EFFECTS
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