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animals (2) 2
cell line (2) 2
drug discovery (2) 2
humans (2) 2
phosphorylation (2) 2
17a-hydroxyprogesterone (1) 1
192142-39-5 (1) 1
58186-27-9 (1) 1
9004-10-8 (1) 1
acarbose (1) 1
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brsk, brain-specific kinase (1) 1
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dyrk, dual-specificity tyrosine-phosphorylated and -regulated kinase (1) 1
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erk, extracellular-signal-regulated kinase (1) 1
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glucose tolerance tests (1) 1
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high-throughput screening assays (1) 1
hipk, homeodomain-interacting protein kinase (1) 1
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hypoglycemic agents - pharmacology (1) 1
idebenone (1) 1
igf-1, insulin-like growth factor-1 (1) 1
ikk, inhibitory κb kinase (1) 1
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mapkap-k, mapk-activated protein kinase (1) 1
mark, microtubule-affinity-regulating kinase (1) 1
mbp, myelin basic protein (1) 1
melk, maternal embryonic leucine-zipper kinase (1) 1
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mitogen-activated protein kinases - antagonists & inhibitors (1) 1
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mms, methyl methanesulfonate (1) 1
mnk, mapk-integrating protein kinase (1) 1
molecular docking simulation (1) 1
msk, mitogen- and stress-activated protein kinase (1) 1
mst, mammalian homologue ste20-like kinase (1) 1
ndrg, n-myc downstream-regulated gene (1) 1
nek, nima-related kinase (1) 1
nfat, nuclear factor for activated t-cells (1) 1
nonalcoholic steatohepatitis (1) 1
p38 map kinase (1) 1
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Pharmacological research, ISSN 1043-6618, 2018, Volume 137, pp. 89 - 103
.... Given the multiple benefits of Shc reduction in vivo, we investigated whether any of 1680 drugs used in humans may function as Shc inhibitors, and thus potentially serve as novel anti-diabetics... 
metabolic syndrome | insulin sensitivity | type 2 diabetes | Drug discovery | Shc | idebenone | acarbose (PubChem CID: 41774) | 17a-Hydroxyprogesterone (PubChem CID: 6238) | FPA 124 (PubChem CID: 16034833) | Src I1 (PubChem CID: 1474853) | candesartan cilexetil (PubChem CID: 2540) | BI78D3 (PubChem CID: 2747117) | Idebenone (PubChem CID: 3686) | PQ401 (PubChem CID: 9549305) | LIFE-SPAN | LIPID-PEROXIDATION | PHOSPHORYLATION | HEART-FAILURE | P66SHC | NONALCOHOLIC STEATOHEPATITIS | PHARMACOKINETICS | DISEASE | LIVER | PHARMACOLOGY & PHARMACY | P66(SHC) | Cell Line | Insulin - pharmacology | Diabetes Mellitus, Experimental - drug therapy | Humans | Mice, Inbred C57BL | Src Homology 2 Domain-Containing, Transforming Protein 1 - antagonists & inhibitors | Ubiquinone - analogs & derivatives | Insulin Resistance | Male | Drug Repositioning | Hypoglycemic Agents - pharmacology | Mice, Knockout | Ubiquinone - pharmacology | Animals | High-Throughput Screening Assays | Female | Receptor, Insulin - metabolism | Molecular Docking Simulation | Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism | Cytoprotection | Type 2 diabetes | Enzymes | Hyperglycemia | Analysis | Liver | Insulin resistance | Glucose tolerance tests | Drug approval | Insulin | Prediabetic state | Protein binding
Journal Article
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