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Nature, ISSN 0028-0836, 01/2015, Volume 517, Issue 7535, pp. 455 - 459
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were... 
IN-VITRO | STREPTOCOCCUS-PNEUMONIAE | PEPTIDOGLYCAN PRECURSOR | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | PRECURSOR LIPID II | ENTEROCOCCUS-FAECIUM | STAPHYLOCOCCUS-AUREUS | VANCOMYCIN-RESISTANCE | CELL-WALL BIOSYNTHESIS | DISCOVERY | Molecular Sequence Data | Biological Products - pharmacology | Depsipeptides - pharmacology | Drug Resistance, Microbial - genetics | Betaproteobacteria - chemistry | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Teichoic Acids - biosynthesis | Cell Wall - drug effects | Mycobacterium tuberculosis - cytology | Time Factors | Anti-Bacterial Agents - chemistry | Female | Staphylococcal Infections - microbiology | Depsipeptides - chemistry | Disease Models, Animal | Multigene Family - genetics | Staphylococcus aureus - genetics | Staphylococcal Infections - drug therapy | Microbial Viability - drug effects | Depsipeptides - isolation & purification | Depsipeptides - biosynthesis | Anti-Bacterial Agents - isolation & purification | Cell Wall - chemistry | Biological Products - isolation & purification | Betaproteobacteria - genetics | Staphylococcus aureus - chemistry | Peptidoglycan - biosynthesis | Biological Products - chemistry | Animals | Cell Wall - metabolism | Staphylococcus aureus - cytology | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Mice | Staphylococcus aureus - drug effects | Mycobacterium tuberculosis - genetics | Drug resistance in microorganisms | Antibiotics | Health aspects | Analysis | Soil microbiology | Proteins | Enzymes | Microorganisms | Bacteria | Antimicrobial agents | Lipids | Biosynthesis | Drug resistance | Drug dosages | Bacteriology | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2012, Volume 109, Issue 33, pp. 13182 - 13187
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 153 - 158
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and... 
LISTERIA-MONOCYTOGENES | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | MIXED LINEAGE KINASE | PERFORIN | NLRP3 INFLAMMASOME | INTRACELLULAR BACTERIA | GRANZYMES | CASPASE-1 ACTIVATION | GRANULYSIN | CELL-DEATH | Conserved Sequence - genetics | Inflammasomes - metabolism | Phosphatidylinositol Phosphates - metabolism | Pyroptosis - drug effects | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Neoplasm Proteins - pharmacology | Escherichia coli - cytology | Neoplasm Proteins - metabolism | Escherichia coli - metabolism | Protein Multimerization - genetics | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - cytology | Porosity - drug effects | Neoplasm Proteins - genetics | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Amino Acid Sequence | Cell Line | Microbial Viability - drug effects | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Neoplasm Proteins - chemistry | Cardiolipins - metabolism | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Microscopy, Electron | Pyroptosis - genetics | Protein Transport | Liposomes - chemistry | Animals | Membrane Proteins - chemistry | Cell Membrane Permeability - drug effects | Staphylococcus aureus - cytology | Liposomes - metabolism | Mice | Mutation | Staphylococcus aureus - drug effects | Listeria monocytogenes - drug effects | Observations | Apoptosis | Proteins | Membranes | Bacterial infections | Immunology | Plasmids | Bacteria | Infections | Cells
Journal Article
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 03/2012, Volume 4, Issue 126, p. 126ra35
Despite the need for new antibiotics to treat drug-resistant bacteria, current clinical combinations are largely restricted to beta-lactam antibiotics paired... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELL-WALL SYNTHESIS | LOCALIZATION | EVOLUTION | BACILLUS-SUBTILIS | FTSI PBP3 | DIVISION SITE | Z RING | INHIBITORS | IDENTIFICATION | TRANSPEPTIDASE | CELL BIOLOGY | Virulence - drug effects | Cytoskeletal Proteins - antagonists & inhibitors | Pyridines - chemistry | Bacterial Proteins - chemistry | Crystallography, X-Ray | Protein Transport - drug effects | Methicillin-Resistant Staphylococcus aureus - cytology | Guanosine Diphosphate | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Methicillin-Resistant Staphylococcus aureus - pathogenicity | Cytoskeletal Proteins - metabolism | Staphylococcal Infections - microbiology | Drug Resistance, Bacterial - drug effects | Disease Models, Animal | Bacterial Proteins - antagonists & inhibitors | Staphylococcal Infections - drug therapy | Gene Regulatory Networks - genetics | Protein Structure, Secondary | Methicillin-Resistant Staphylococcus aureus - drug effects | Cytoskeletal Proteins - chemistry | Mutation - genetics | Cell Division - drug effects | Imipenem - pharmacology | Drug Synergism | beta-Lactams - pharmacology | Animals | Bacterial Proteins - metabolism | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Mice | Pyridines - pharmacology | Thiazoles - pharmacology | beta-Lactams - therapeutic use
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 118 - 121
Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle... 
BACTERIAL PATHOGENS | BLOOD-PLATELETS | COMPLEMENT | POLYMERIC NANOPARTICLES | PROTEIN | MULTIDISCIPLINARY SCIENCES | SURFACE | TOXINS | EXPRESSION | BINDING | DELIVERY | Platelet Adhesiveness | Nanoparticles - chemistry | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Collagen - chemistry | Male | Unilamellar Liposomes - chemistry | Complement Activation - immunology | Blood Platelets - cytology | Cell Membrane - metabolism | Staphylococcal Infections - microbiology | Macrophages - immunology | Staphylococcal Infections - blood | Disease Models, Animal | Staphylococcal Infections - metabolism | Staphylococcus aureus - metabolism | Staphylococcal Infections - drug therapy | Vancomycin - administration & dosage | Collagen - immunology | Rats | Coronary Restenosis - drug therapy | Coronary Restenosis - metabolism | Rats, Sprague-Dawley | Blood Vessels - cytology | Taxoids - pharmacokinetics | Taxoids - administration & dosage | Animals | Vancomycin - pharmacokinetics | Anti-Bacterial Agents - pharmacokinetics | Staphylococcus aureus - cytology | Polymers - chemistry | Coronary Restenosis - blood | Mice | Nanoparticles - administration & dosage | Anti-Bacterial Agents - administration & dosage | Drug Delivery Systems - methods | Nanoparticles | Blood platelets | Properties | Proteins | Spleen | Immunoglobulins | Microorganisms | Membranes | Liver | Collagen | Staphylococcus infections | Blood | Veins & arteries
Journal Article