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Molecular Cell, ISSN 1097-2765, 12/2012, Volume 48, Issue 5, pp. 667 - 680
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2012, Volume 447, Issue 1, pp. 125 - 136
Phosphorylation of STAT3 (signal transducer and activator of transcription 3) is critical for its nuclear import and transcriptional activity. Although a... 
Signal transducer and activator of transcription 3 (STAT3) | Transcriptome analysis | Interleukin-6 (IL-6) | Nucleocytoplasmic trafficking | Transcription factor | Cytokine | cytokine | transcription factor | nucleocytoplasmic trafficking | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-CELLS | interleukin-6 (IL-6) | UNPHOSPHORYLATED STAT3 | STAT3 ISOFORMS | ACTIVATED STAT3 | PATHWAY | signal transducer and activator of transcription 3 (STAT3) | EPIDERMAL-GROWTH-FACTOR | transcriptome analysis | PROTEIN-TYROSINE-PHOSPHATASE | SIGNAL TRANSDUCER | Mutagenesis, Site-Directed | Alternative Splicing | Gene Expression - drug effects | Humans | Cells, Cultured | DNA Primers - genetics | STAT3 Transcription Factor - chemistry | Gene Knockout Techniques | src Homology Domains | Animals | Cell Nucleus - metabolism | Base Sequence | HEK293 Cells | STAT3 Transcription Factor - deficiency | Mice | Kinetics | Phosphorylation - drug effects | Cell Nucleus - drug effects | Cytokines - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine - chemistry | Amino Acid Substitution | ERt, substrate-binding portion of the oestrogen receptor | WT, wild-type | HEK, human embryonic kidney | VP16, viral protein 16 | Fc, cytoplasmic fluorescence | gp130, glycoprotein 130 | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | MEF, murine embryonic fibroblast | iSTAT3, inducible specific STAT3 spliceform | Fn, nuclear fluorescence | GO, gene ontology | FBS, fetal bovine serum | STAT3, signal transducer and activator of transcription 3 | OSM, oncostatin M | CLSM, confocal laser-scanning microscopy | DAPI, 4′,6-diamidino-2-phenylindole | SHP, SH2 domain-containing protein tyrosine phosphatase | JAK, Janus kinase | IL, interleukin | Fc, ratio of nuclear to cytoplasmic fluorescence | SH2, Src homology 2 | Hsp90, heat-shock protein of 90 kDa | MAPK, mitogen-activated protein kinase
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 2018, Volume 18, Issue 11, pp. 664 - 665
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 729 - 739
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of... 
ATF4, activating transcription factor 4 | HIF1A, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor) | HDAC3, histone deacetylase 3 | XPO1, exportin 1 | EGF, epidermal growth factor | MAP1LC3A, microtubule-associated protein 1 light chain 3 α | LMP, lysosomal membrane permeabilization | COX8, cytochrome c oxidase subunit VIII | MMP14, matrix metallopeptidase 14 (membrane-inserted) | MLS, mitochondrial localization sequence | EIF2AK2, eukaryotic translation initiation factor 2-α kinase 2 | CuB, cucurbitacin B | autophagy | IMM, inner mitochondrial membrane | CTSL, cathepsin L | IL6, interleukin 6 | miRNA, microRNA | CTSB, cathepsin B | PDGFRB, platelet-derived growth factor receptor, β polypeptide | receptor tyrosine kinases | RTK, receptor tyrosine kinases | PTPN2, protein tyrosine phosphatase, non-receptor type 2 | CNTF, ciliary neurotrophic factor | MAPK1, mitogen-activated protein kinase 1 | ALK, anaplastic lymphoma receptor tyrosine kinase | NES, nuclear export signal | EIF2A, eukaryotic initiation factor 2A, 65kDa | NDUFA13, NADH dehydrogenase (ubiquinone) 1 α subcomplex, 13 | VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | PTPN6, protein tyrosine phosphatase, non-receptor type 6 | ROS, reactive oxygen species | ETC, electron transport chain | SH2, src homology 2 | targeted therapy | PRKAA2, protein kinase, AMP-activated, α 2 catalytic subunit | STAT3 | BNIP3, BCL2/adenovirus E1B 19kDa interacting protein 3 | NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | STAT3, signal transducer and activator of transcription 3 (acute-phase response factor) | NLS, nuclear localization signal | FOXO1/3, forkhead box O1/3 | mitoSTAT3, mitochondrial STAT3 | mitophagy | PTPN11, protein tyrosine phosphatase, non-receptor type 11 | KDR, kinase insert domain receptor | cancer | ConA, concanavalin A | CYCS, cytochrome c, somatic | ER, endoplasmic reticulum | Mitophagy | Targeted therapy | Autophagy | Receptor tyrosine kinases | Cancer | CANCER-CELLS | TRANSCRIPTION FACTORS | HEPATOCELLULAR-CARCINOMA CELLS | TYROSINE PHOSPHORYLATION | SERINE PHOSPHORYLATION | CELL BIOLOGY | ELECTRON-TRANSPORT CHAIN | JAK/STAT PATHWAY | MITOCHONDRIAL STAT3 | IN-VIVO | SIGNAL TRANSDUCER | Neoplasms - metabolism | Neoplasms - therapy | Animals | Models, Biological | Humans | Mitochondria - metabolism | STAT3 Transcription Factor - chemistry | Subcellular Fractions - metabolism | STAT3 Transcription Factor - metabolism
Journal Article
International Immunology, ISSN 0953-8178, 11/2011, Volume 23, Issue 11, pp. 701 - 712
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental... 
Joint destruction | Chronic inflammation | Collagen-induced arthritis | Rheumatoid arthritis | IL-6 | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | STAT3 | MONOCLONAL-ANTIBODY | IMMUNOLOGY | rheumatoid arthritis | OSTEOCLASTOGENESIS | RODENT MODELS | TUMOR-NECROSIS-FACTOR | collagen-induced arthritis | REGULATORY T-CELLS | DOUBLE-BLIND | joint destruction | NF-KAPPA-B | chronic inflammation | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Arthritis, Experimental - drug therapy | RANK Ligand - metabolism | Humans | Arthritis, Rheumatoid - complications | Interleukin-1beta - adverse effects | Arthritis, Experimental - pathology | RANK Ligand - immunology | Inflammation - complications | Signal Transduction - immunology | Osteoclasts - immunology | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-1beta - metabolism | Piperidines | Gene Expression - immunology | STAT3 Transcription Factor - deficiency | Tumor Necrosis Factor-alpha - immunology | Mice, Inbred DBA | Pyrroles - therapeutic use | Interleukin-6 - metabolism | Joints - metabolism | STAT3 Transcription Factor - genetics | Joints - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Interleukin-1beta - immunology | Joints - pathology | Arthritis, Experimental - immunology | Inflammation - immunology | Pyrimidines - pharmacology | Arthritis, Rheumatoid - pathology | Pyrroles - pharmacology | Animals | Tumor Necrosis Factor-alpha - adverse effects | Interleukin-6 - pharmacology | RANK Ligand - antagonists & inhibitors | Pyrimidines - therapeutic use | Fibroblasts - drug effects | Interleukin-6 - immunology | Fibroblasts - immunology | Mice | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Chronic Disease | Osteoclasts - drug effects | Animal models | Transcription | Leukemia inhibitory factor | Stat3 protein | Data processing | Inflammation | Joint diseases | Osteoblasts | Inflammatory diseases | Interleukin 6 | Osteoclastogenesis | Collagen | Interleukin 1 | TRANCE protein | Tumor necrosis factor- alpha
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 05/2019, Volume 110, pp. 130 - 139
Journal Article
Cancer Letters, ISSN 0304-3835, 02/2018, Volume 415, pp. 117 - 128
Journal Article