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Publication DateAnnals of the New York Academy of Sciences, ISSN 0077-8923, 2006, Volume 1091, pp. 151 - 169
Recent evidence indicates a convergence of molecular targets for both prevention and therapy of cancer. Signal-transducer-and-activator-of-transcription-3...
Chemoresistance | STAT3 | Cancer | Interleukin-6 | MULTIDISCIPLINARY SCIENCES | LEUKEMIA INHIBITORY FACTOR | PROTEIN-TYROSINE KINASE | MULTIPLE-MYELOMA CELLS | interleukin-6 | DNA-BINDING ACTIVITY | SIGNALING INDUCES APOPTOSIS | chemoresistance | TRANSCRIPTION 3 STAT3 | EPIDERMAL-GROWTH-FACTOR | EMBRYONIC STEM-CELLS | SQUAMOUS-CELL CARCINOMA | cancer | STAT3 SERINE PHOSPHORYLATION | Neoplasms - metabolism | Gene Targeting - methods | Animals | STAT3 Transcription Factor - physiology | Humans | STAT3 Transcription Factor - deficiency | Neoplasms - prevention & control | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasms - drug therapy
Chemoresistance | STAT3 | Cancer | Interleukin-6 | MULTIDISCIPLINARY SCIENCES | LEUKEMIA INHIBITORY FACTOR | PROTEIN-TYROSINE KINASE | MULTIPLE-MYELOMA CELLS | interleukin-6 | DNA-BINDING ACTIVITY | SIGNALING INDUCES APOPTOSIS | chemoresistance | TRANSCRIPTION 3 STAT3 | EPIDERMAL-GROWTH-FACTOR | EMBRYONIC STEM-CELLS | SQUAMOUS-CELL CARCINOMA | cancer | STAT3 SERINE PHOSPHORYLATION | Neoplasms - metabolism | Gene Targeting - methods | Animals | STAT3 Transcription Factor - physiology | Humans | STAT3 Transcription Factor - deficiency | Neoplasms - prevention & control | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasms - drug therapy
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Loading RightsMolecular Cell, ISSN 1097-2765, 12/2012, Volume 48, Issue 5, pp. 667 - 680
In a screen designed to identify novel inducers of autophagy, we discovered that STAT3 inhibitors potently stimulate the autophagic flux. Accordingly, genetic...
CELLS | ACTIVATION | MITOCHONDRIAL STAT3 | PROTEIN | SIGNALING PATHWAY | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIMERIZATION | KAPPA-B | INTEGRATED STRESS-RESPONSE | UNPHOSPHORYLATED STAT3 | CELL BIOLOGY | Palmitic Acid - pharmacology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | STAT3 Transcription Factor - chemistry | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Eukaryotic Initiation Factor-2 - deficiency | Transfection | RNA Interference | Time Factors | STAT3 Transcription Factor - deficiency | Eukaryotic Initiation Factor-2 - metabolism | Protein Interaction Domains and Motifs | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | eIF-2 Kinase - genetics | Cytoplasm - enzymology | Catalytic Domain | Signal Transduction | Mice, Inbred C57BL | eIF-2 Kinase - chemistry | Mice, Knockout | Protein Interaction Mapping | src Homology Domains | Animals | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Protein Conformation | Mice | Molecular Docking Simulation | Enzyme Activation | STAT3 Transcription Factor - antagonists & inhibitors | Fatty acids | Universities and colleges
CELLS | ACTIVATION | MITOCHONDRIAL STAT3 | PROTEIN | SIGNALING PATHWAY | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIMERIZATION | KAPPA-B | INTEGRATED STRESS-RESPONSE | UNPHOSPHORYLATED STAT3 | CELL BIOLOGY | Palmitic Acid - pharmacology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | STAT3 Transcription Factor - chemistry | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Eukaryotic Initiation Factor-2 - deficiency | Transfection | RNA Interference | Time Factors | STAT3 Transcription Factor - deficiency | Eukaryotic Initiation Factor-2 - metabolism | Protein Interaction Domains and Motifs | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | eIF-2 Kinase - genetics | Cytoplasm - enzymology | Catalytic Domain | Signal Transduction | Mice, Inbred C57BL | eIF-2 Kinase - chemistry | Mice, Knockout | Protein Interaction Mapping | src Homology Domains | Animals | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Protein Conformation | Mice | Molecular Docking Simulation | Enzyme Activation | STAT3 Transcription Factor - antagonists & inhibitors | Fatty acids | Universities and colleges
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Loading RightsBiochemical Journal, ISSN 0264-6021, 10/2012, Volume 447, Issue 1, pp. 125 - 136
Phosphorylation of STAT3 (signal transducer and activator of transcription 3) is critical for its nuclear import and transcriptional activity. Although a...
Signal transducer and activator of transcription 3 (STAT3) | Transcriptome analysis | Interleukin-6 (IL-6) | Nucleocytoplasmic trafficking | Transcription factor | Cytokine | cytokine | transcription factor | nucleocytoplasmic trafficking | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-CELLS | interleukin-6 (IL-6) | UNPHOSPHORYLATED STAT3 | STAT3 ISOFORMS | ACTIVATED STAT3 | PATHWAY | signal transducer and activator of transcription 3 (STAT3) | EPIDERMAL-GROWTH-FACTOR | transcriptome analysis | PROTEIN-TYROSINE-PHOSPHATASE | SIGNAL TRANSDUCER | Mutagenesis, Site-Directed | Alternative Splicing | Gene Expression - drug effects | Humans | Cells, Cultured | DNA Primers - genetics | STAT3 Transcription Factor - chemistry | Gene Knockout Techniques | src Homology Domains | Animals | Cell Nucleus - metabolism | Base Sequence | HEK293 Cells | STAT3 Transcription Factor - deficiency | Mice | Kinetics | Phosphorylation - drug effects | Cell Nucleus - drug effects | Cytokines - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine - chemistry | Amino Acid Substitution | ERt, substrate-binding portion of the oestrogen receptor | WT, wild-type | HEK, human embryonic kidney | VP16, viral protein 16 | Fc, cytoplasmic fluorescence | gp130, glycoprotein 130 | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | MEF, murine embryonic fibroblast | iSTAT3, inducible specific STAT3 spliceform | Fn, nuclear fluorescence | GO, gene ontology | FBS, fetal bovine serum | STAT3, signal transducer and activator of transcription 3 | OSM, oncostatin M | CLSM, confocal laser-scanning microscopy | DAPI, 4′,6-diamidino-2-phenylindole | SHP, SH2 domain-containing protein tyrosine phosphatase | JAK, Janus kinase | IL, interleukin | Fc, ratio of nuclear to cytoplasmic fluorescence | SH2, Src homology 2 | Hsp90, heat-shock protein of 90 kDa | MAPK, mitogen-activated protein kinase
Signal transducer and activator of transcription 3 (STAT3) | Transcriptome analysis | Interleukin-6 (IL-6) | Nucleocytoplasmic trafficking | Transcription factor | Cytokine | cytokine | transcription factor | nucleocytoplasmic trafficking | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-CELLS | interleukin-6 (IL-6) | UNPHOSPHORYLATED STAT3 | STAT3 ISOFORMS | ACTIVATED STAT3 | PATHWAY | signal transducer and activator of transcription 3 (STAT3) | EPIDERMAL-GROWTH-FACTOR | transcriptome analysis | PROTEIN-TYROSINE-PHOSPHATASE | SIGNAL TRANSDUCER | Mutagenesis, Site-Directed | Alternative Splicing | Gene Expression - drug effects | Humans | Cells, Cultured | DNA Primers - genetics | STAT3 Transcription Factor - chemistry | Gene Knockout Techniques | src Homology Domains | Animals | Cell Nucleus - metabolism | Base Sequence | HEK293 Cells | STAT3 Transcription Factor - deficiency | Mice | Kinetics | Phosphorylation - drug effects | Cell Nucleus - drug effects | Cytokines - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine - chemistry | Amino Acid Substitution | ERt, substrate-binding portion of the oestrogen receptor | WT, wild-type | HEK, human embryonic kidney | VP16, viral protein 16 | Fc, cytoplasmic fluorescence | gp130, glycoprotein 130 | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | MEF, murine embryonic fibroblast | iSTAT3, inducible specific STAT3 spliceform | Fn, nuclear fluorescence | GO, gene ontology | FBS, fetal bovine serum | STAT3, signal transducer and activator of transcription 3 | OSM, oncostatin M | CLSM, confocal laser-scanning microscopy | DAPI, 4′,6-diamidino-2-phenylindole | SHP, SH2 domain-containing protein tyrosine phosphatase | JAK, Janus kinase | IL, interleukin | Fc, ratio of nuclear to cytoplasmic fluorescence | SH2, Src homology 2 | Hsp90, heat-shock protein of 90 kDa | MAPK, mitogen-activated protein kinase
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Loading RightsNature Reviews Cancer, ISSN 1474-175X, 2018, Volume 18, Issue 11, pp. 664 - 665
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Loading RightsACS Chemical Biology, ISSN 1554-8929, 02/2016, Volume 11, Issue 2, pp. 308 - 318
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates the expression of genes related to cell cycle, cell...
JAK INHIBITORS | DNA-BINDING DOMAIN | ACTIVATION | CONSTITUTIVE STAT3 | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | TRANSCRIPTION FACTOR STAT3 | GROWTH-SUPPRESSIVE ACTIVITY | SMALL-MOLECULE INHIBITOR | SIGNAL TRANSDUCER | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Humans | Models, Molecular | STAT3 Transcription Factor - chemistry | DNA - metabolism | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Drug Discovery | src Homology Domains - drug effects | Neoplasms - drug therapy | Small Molecule Libraries - chemistry | Animals | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | STAT3 Transcription Factor - metabolism
JAK INHIBITORS | DNA-BINDING DOMAIN | ACTIVATION | CONSTITUTIVE STAT3 | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | TRANSCRIPTION FACTOR STAT3 | GROWTH-SUPPRESSIVE ACTIVITY | SMALL-MOLECULE INHIBITOR | SIGNAL TRANSDUCER | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Humans | Models, Molecular | STAT3 Transcription Factor - chemistry | DNA - metabolism | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Drug Discovery | src Homology Domains - drug effects | Neoplasms - drug therapy | Small Molecule Libraries - chemistry | Animals | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | STAT3 Transcription Factor - metabolism
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Loading RightsFEBS Journal, ISSN 1742-464X, 07/2015, Volume 282, Issue 14, pp. 2600 - 2611
The STAT family of transcription factors (signal transducers and activators of transcription) transduce signals from cytokine receptors to the nucleus, where...
cancer therapeutics | inhibitors | STAT | cancer | tumourigenesis | signalling | STAT3 | DNA-BINDING DOMAIN | CONSTITUTIVE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | SMALL-MOLECULE INHIBITOR | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | IN-VITRO | JAK/STAT PATHWAY | REGULATORY T-CELLS | SIGNAL TRANSDUCER | Neoplasms - metabolism | Protein Structure, Tertiary | STAT3 Transcription Factor - physiology | Humans | Gene Expression Regulation, Neoplastic | Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Molecular Targeted Therapy - methods | Oncogenes | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasms - drug therapy | Oncology | Transcription factors | Tumorigenesis | Cancer therapies | Rodents | Apoptosis
cancer therapeutics | inhibitors | STAT | cancer | tumourigenesis | signalling | STAT3 | DNA-BINDING DOMAIN | CONSTITUTIVE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | SMALL-MOLECULE INHIBITOR | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | IN-VITRO | JAK/STAT PATHWAY | REGULATORY T-CELLS | SIGNAL TRANSDUCER | Neoplasms - metabolism | Protein Structure, Tertiary | STAT3 Transcription Factor - physiology | Humans | Gene Expression Regulation, Neoplastic | Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Molecular Targeted Therapy - methods | Oncogenes | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasms - drug therapy | Oncology | Transcription factors | Tumorigenesis | Cancer therapies | Rodents | Apoptosis
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Loading RightsAutophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 729 - 739
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of...
ATF4, activating transcription factor 4 | HIF1A, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor) | HDAC3, histone deacetylase 3 | XPO1, exportin 1 | EGF, epidermal growth factor | MAP1LC3A, microtubule-associated protein 1 light chain 3 α | LMP, lysosomal membrane permeabilization | COX8, cytochrome c oxidase subunit VIII | MMP14, matrix metallopeptidase 14 (membrane-inserted) | MLS, mitochondrial localization sequence | EIF2AK2, eukaryotic translation initiation factor 2-α kinase 2 | CuB, cucurbitacin B | autophagy | IMM, inner mitochondrial membrane | CTSL, cathepsin L | IL6, interleukin 6 | miRNA, microRNA | CTSB, cathepsin B | PDGFRB, platelet-derived growth factor receptor, β polypeptide | receptor tyrosine kinases | RTK, receptor tyrosine kinases | PTPN2, protein tyrosine phosphatase, non-receptor type 2 | CNTF, ciliary neurotrophic factor | MAPK1, mitogen-activated protein kinase 1 | ALK, anaplastic lymphoma receptor tyrosine kinase | NES, nuclear export signal | EIF2A, eukaryotic initiation factor 2A, 65kDa | NDUFA13, NADH dehydrogenase (ubiquinone) 1 α subcomplex, 13 | VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | PTPN6, protein tyrosine phosphatase, non-receptor type 6 | ROS, reactive oxygen species | ETC, electron transport chain | SH2, src homology 2 | targeted therapy | PRKAA2, protein kinase, AMP-activated, α 2 catalytic subunit | STAT3 | BNIP3, BCL2/adenovirus E1B 19kDa interacting protein 3 | NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | STAT3, signal transducer and activator of transcription 3 (acute-phase response factor) | NLS, nuclear localization signal | FOXO1/3, forkhead box O1/3 | mitoSTAT3, mitochondrial STAT3 | mitophagy | PTPN11, protein tyrosine phosphatase, non-receptor type 11 | KDR, kinase insert domain receptor | cancer | ConA, concanavalin A | CYCS, cytochrome c, somatic | ER, endoplasmic reticulum | Mitophagy | Targeted therapy | Autophagy | Receptor tyrosine kinases | Cancer | CANCER-CELLS | TRANSCRIPTION FACTORS | HEPATOCELLULAR-CARCINOMA CELLS | TYROSINE PHOSPHORYLATION | SERINE PHOSPHORYLATION | CELL BIOLOGY | ELECTRON-TRANSPORT CHAIN | JAK/STAT PATHWAY | MITOCHONDRIAL STAT3 | IN-VIVO | SIGNAL TRANSDUCER | Neoplasms - metabolism | Neoplasms - therapy | Animals | Models, Biological | Humans | Mitochondria - metabolism | STAT3 Transcription Factor - chemistry | Subcellular Fractions - metabolism | STAT3 Transcription Factor - metabolism
ATF4, activating transcription factor 4 | HIF1A, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor) | HDAC3, histone deacetylase 3 | XPO1, exportin 1 | EGF, epidermal growth factor | MAP1LC3A, microtubule-associated protein 1 light chain 3 α | LMP, lysosomal membrane permeabilization | COX8, cytochrome c oxidase subunit VIII | MMP14, matrix metallopeptidase 14 (membrane-inserted) | MLS, mitochondrial localization sequence | EIF2AK2, eukaryotic translation initiation factor 2-α kinase 2 | CuB, cucurbitacin B | autophagy | IMM, inner mitochondrial membrane | CTSL, cathepsin L | IL6, interleukin 6 | miRNA, microRNA | CTSB, cathepsin B | PDGFRB, platelet-derived growth factor receptor, β polypeptide | receptor tyrosine kinases | RTK, receptor tyrosine kinases | PTPN2, protein tyrosine phosphatase, non-receptor type 2 | CNTF, ciliary neurotrophic factor | MAPK1, mitogen-activated protein kinase 1 | ALK, anaplastic lymphoma receptor tyrosine kinase | NES, nuclear export signal | EIF2A, eukaryotic initiation factor 2A, 65kDa | NDUFA13, NADH dehydrogenase (ubiquinone) 1 α subcomplex, 13 | VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | PTPN6, protein tyrosine phosphatase, non-receptor type 6 | ROS, reactive oxygen species | ETC, electron transport chain | SH2, src homology 2 | targeted therapy | PRKAA2, protein kinase, AMP-activated, α 2 catalytic subunit | STAT3 | BNIP3, BCL2/adenovirus E1B 19kDa interacting protein 3 | NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | STAT3, signal transducer and activator of transcription 3 (acute-phase response factor) | NLS, nuclear localization signal | FOXO1/3, forkhead box O1/3 | mitoSTAT3, mitochondrial STAT3 | mitophagy | PTPN11, protein tyrosine phosphatase, non-receptor type 11 | KDR, kinase insert domain receptor | cancer | ConA, concanavalin A | CYCS, cytochrome c, somatic | ER, endoplasmic reticulum | Mitophagy | Targeted therapy | Autophagy | Receptor tyrosine kinases | Cancer | CANCER-CELLS | TRANSCRIPTION FACTORS | HEPATOCELLULAR-CARCINOMA CELLS | TYROSINE PHOSPHORYLATION | SERINE PHOSPHORYLATION | CELL BIOLOGY | ELECTRON-TRANSPORT CHAIN | JAK/STAT PATHWAY | MITOCHONDRIAL STAT3 | IN-VIVO | SIGNAL TRANSDUCER | Neoplasms - metabolism | Neoplasms - therapy | Animals | Models, Biological | Humans | Mitochondria - metabolism | STAT3 Transcription Factor - chemistry | Subcellular Fractions - metabolism | STAT3 Transcription Factor - metabolism
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Loading RightsScientific Reports, ISSN 2045-2322, 12/2015, Volume 5, Issue 1, p. 17663
STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates...
EPITHELIAL-MESENCHYMAL TRANSITION | CELL LUNG-CANCER | HEPATOCELLULAR-CARCINOMA CELLS | STEM-CELLS | TRANSCRIPTION 3 STAT3 | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR GENE | G-QUARTET OLIGONUCLEOTIDES | NF-KAPPA-B | UNPHOSPHORYLATED STAT3 | SIGNAL TRANSDUCER | Animals | Neoplasms - genetics | Epigenesis, Genetic | Humans | Epithelial-Mesenchymal Transition | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Neoplasms - pathology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell proliferation | G protein-coupled receptors | Leukocyte migration | Mesenchyme | Transcription | Cytokines | MiRNA | Stat3 protein | Gene expression | Cadherin | Stem cells | Toll-like receptors | Antitumor activity | Growth factors | Cell migration | Cancer
EPITHELIAL-MESENCHYMAL TRANSITION | CELL LUNG-CANCER | HEPATOCELLULAR-CARCINOMA CELLS | STEM-CELLS | TRANSCRIPTION 3 STAT3 | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR GENE | G-QUARTET OLIGONUCLEOTIDES | NF-KAPPA-B | UNPHOSPHORYLATED STAT3 | SIGNAL TRANSDUCER | Animals | Neoplasms - genetics | Epigenesis, Genetic | Humans | Epithelial-Mesenchymal Transition | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Neoplasms - pathology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell proliferation | G protein-coupled receptors | Leukocyte migration | Mesenchyme | Transcription | Cytokines | MiRNA | Stat3 protein | Gene expression | Cadherin | Stem cells | Toll-like receptors | Antitumor activity | Growth factors | Cell migration | Cancer
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Loading RightsInternational Immunology, ISSN 0953-8178, 11/2011, Volume 23, Issue 11, pp. 701 - 712
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental...
Joint destruction | Chronic inflammation | Collagen-induced arthritis | Rheumatoid arthritis | IL-6 | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | STAT3 | MONOCLONAL-ANTIBODY | IMMUNOLOGY | rheumatoid arthritis | OSTEOCLASTOGENESIS | RODENT MODELS | TUMOR-NECROSIS-FACTOR | collagen-induced arthritis | REGULATORY T-CELLS | DOUBLE-BLIND | joint destruction | NF-KAPPA-B | chronic inflammation | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Arthritis, Experimental - drug therapy | RANK Ligand - metabolism | Humans | Arthritis, Rheumatoid - complications | Interleukin-1beta - adverse effects | Arthritis, Experimental - pathology | RANK Ligand - immunology | Inflammation - complications | Signal Transduction - immunology | Osteoclasts - immunology | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-1beta - metabolism | Piperidines | Gene Expression - immunology | STAT3 Transcription Factor - deficiency | Tumor Necrosis Factor-alpha - immunology | Mice, Inbred DBA | Pyrroles - therapeutic use | Interleukin-6 - metabolism | Joints - metabolism | STAT3 Transcription Factor - genetics | Joints - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Interleukin-1beta - immunology | Joints - pathology | Arthritis, Experimental - immunology | Inflammation - immunology | Pyrimidines - pharmacology | Arthritis, Rheumatoid - pathology | Pyrroles - pharmacology | Animals | Tumor Necrosis Factor-alpha - adverse effects | Interleukin-6 - pharmacology | RANK Ligand - antagonists & inhibitors | Pyrimidines - therapeutic use | Fibroblasts - drug effects | Interleukin-6 - immunology | Fibroblasts - immunology | Mice | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Chronic Disease | Osteoclasts - drug effects | Animal models | Transcription | Leukemia inhibitory factor | Stat3 protein | Data processing | Inflammation | Joint diseases | Osteoblasts | Inflammatory diseases | Interleukin 6 | Osteoclastogenesis | Collagen | Interleukin 1 | TRANCE protein | Tumor necrosis factor- alpha
Joint destruction | Chronic inflammation | Collagen-induced arthritis | Rheumatoid arthritis | IL-6 | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | STAT3 | MONOCLONAL-ANTIBODY | IMMUNOLOGY | rheumatoid arthritis | OSTEOCLASTOGENESIS | RODENT MODELS | TUMOR-NECROSIS-FACTOR | collagen-induced arthritis | REGULATORY T-CELLS | DOUBLE-BLIND | joint destruction | NF-KAPPA-B | chronic inflammation | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Arthritis, Experimental - drug therapy | RANK Ligand - metabolism | Humans | Arthritis, Rheumatoid - complications | Interleukin-1beta - adverse effects | Arthritis, Experimental - pathology | RANK Ligand - immunology | Inflammation - complications | Signal Transduction - immunology | Osteoclasts - immunology | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-1beta - metabolism | Piperidines | Gene Expression - immunology | STAT3 Transcription Factor - deficiency | Tumor Necrosis Factor-alpha - immunology | Mice, Inbred DBA | Pyrroles - therapeutic use | Interleukin-6 - metabolism | Joints - metabolism | STAT3 Transcription Factor - genetics | Joints - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Interleukin-1beta - immunology | Joints - pathology | Arthritis, Experimental - immunology | Inflammation - immunology | Pyrimidines - pharmacology | Arthritis, Rheumatoid - pathology | Pyrroles - pharmacology | Animals | Tumor Necrosis Factor-alpha - adverse effects | Interleukin-6 - pharmacology | RANK Ligand - antagonists & inhibitors | Pyrimidines - therapeutic use | Fibroblasts - drug effects | Interleukin-6 - immunology | Fibroblasts - immunology | Mice | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Chronic Disease | Osteoclasts - drug effects | Animal models | Transcription | Leukemia inhibitory factor | Stat3 protein | Data processing | Inflammation | Joint diseases | Osteoblasts | Inflammatory diseases | Interleukin 6 | Osteoclastogenesis | Collagen | Interleukin 1 | TRANCE protein | Tumor necrosis factor- alpha
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Loading RightsInternational Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 05/2019, Volume 110, pp. 130 - 139
STAT3β is an isoform of STAT3 (signal transducer and activator of transcription 3) that differs from the STAT3α isoform by the replacement of the C-terminal 55...
JAK/STAT3 pathway | Prognostic factor | Cancer suppressor | STAT3β | STAT3 | COLONY-STIMULATING FACTOR | STAT3 beta | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | UNPHOSPHORYLATED STAT3 | DNA-BINDING ACTIVITY | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | ACUTE-PHASE RESPONSE | MITOCHONDRIAL STAT3 | EPIDERMAL-GROWTH-FACTOR | TRANSCRIPTION FACTOR | SIGNAL TRANSDUCER | Tyrosine | Squamous cell carcinoma | Phosphatases | Leukemia | Mitochondrial DNA | B cells | T cells | Chemotherapy | Lymphomas | Interferon | Tumor proteins | Mitogens | Growth factors | Adenosine triphosphate | Cancer | Protein binding
JAK/STAT3 pathway | Prognostic factor | Cancer suppressor | STAT3β | STAT3 | COLONY-STIMULATING FACTOR | STAT3 beta | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | UNPHOSPHORYLATED STAT3 | DNA-BINDING ACTIVITY | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | ACUTE-PHASE RESPONSE | MITOCHONDRIAL STAT3 | EPIDERMAL-GROWTH-FACTOR | TRANSCRIPTION FACTOR | SIGNAL TRANSDUCER | Tyrosine | Squamous cell carcinoma | Phosphatases | Leukemia | Mitochondrial DNA | B cells | T cells | Chemotherapy | Lymphomas | Interferon | Tumor proteins | Mitogens | Growth factors | Adenosine triphosphate | Cancer | Protein binding
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Loading RightsInternational Journal of Molecular Sciences, ISSN 1661-6596, 06/2018, Volume 19, Issue 6, p. 1656
Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies...
Mitochondria | Calcium | Stat3 | B cells | CD8 cells | T cells | ATP | Mitochondrial Stat3 | CD4 cells | INTERLEUKIN-6 RECEPTOR | SUPERCOMPLEX I1III2IV1 | calcium | mitochondria | TARGETING STAT3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial Stat3 | CD4(+) T-CELLS | TRANSCRIPTION FACTOR STAT3 | CHEMISTRY, MULTIDISCIPLINARY | HYPER-IGE SYNDROME | ELECTRON-TRANSPORT CHAIN | B-CELLS | FOLLICULAR-HELPER-CELLS | SIGNAL TRANSDUCER | Lymphocytes - metabolism | Lymphocytes - physiology | Animals | STAT3 Transcription Factor - physiology | Signal Transduction | Mitochondrial Proteins - metabolism | Humans | Gene Expression Regulation | Mitochondrial Proteins - physiology | Mitochondria - metabolism | STAT3 Transcription Factor - metabolism | Transcription factors | Immune response | Lymphocytes | Stat3 protein | Pharmacology | Gene expression | Metabolism | Inflammatory diseases | Immune system
Mitochondria | Calcium | Stat3 | B cells | CD8 cells | T cells | ATP | Mitochondrial Stat3 | CD4 cells | INTERLEUKIN-6 RECEPTOR | SUPERCOMPLEX I1III2IV1 | calcium | mitochondria | TARGETING STAT3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial Stat3 | CD4(+) T-CELLS | TRANSCRIPTION FACTOR STAT3 | CHEMISTRY, MULTIDISCIPLINARY | HYPER-IGE SYNDROME | ELECTRON-TRANSPORT CHAIN | B-CELLS | FOLLICULAR-HELPER-CELLS | SIGNAL TRANSDUCER | Lymphocytes - metabolism | Lymphocytes - physiology | Animals | STAT3 Transcription Factor - physiology | Signal Transduction | Mitochondrial Proteins - metabolism | Humans | Gene Expression Regulation | Mitochondrial Proteins - physiology | Mitochondria - metabolism | STAT3 Transcription Factor - metabolism | Transcription factors | Immune response | Lymphocytes | Stat3 protein | Pharmacology | Gene expression | Metabolism | Inflammatory diseases | Immune system
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12.
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The role of STAT3 in leading the crosstalk between human cancers and the immune system
Cancer Letters, ISSN 0304-3835, 02/2018, Volume 415, pp. 117 - 128
The development and progression of human cancers are continuously and dynamically regulated by intrinsic and extrinsic factors. As a converging point of...
Immunosuppression | Immunity | STAT3 | Treg | Cancer | DNA-BINDING DOMAIN | TARGETING STAT3 | IMMATURE MYELOID CELLS | SMALL-MOLECULE INHIBITOR | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOLOGY | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | TRANSCRIPTION FACTOR | GROWTH-SUPPRESSIVE ACTIVITY | SIGNAL TRANSDUCER | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Immunity - immunology | Gene Expression Regulation, Neoplastic - immunology | Macrophages - metabolism | Models, Immunological | Neoplasms - genetics | Immune System - metabolism | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Immune System - immunology | STAT3 Transcription Factor - immunology | Immunity - genetics | Dendritic Cells - metabolism | Macrophages - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Phosphorylation | Transcription | Crosstalk | Multiple myeloma | Metastasis | Kinases | Cancer therapies | Proteins | Angiogenesis | Cell growth | Immunotherapy | Cell cycle | DNA methylation | Vascular endothelial growth factor | Deoxyribonucleic acid--DNA | Immune system | Immune response | Cytokines | Tumor cells | Stat3 protein | Gene expression | Tumors | Apoptosis | immunosuppression | cancer | immunity
Immunosuppression | Immunity | STAT3 | Treg | Cancer | DNA-BINDING DOMAIN | TARGETING STAT3 | IMMATURE MYELOID CELLS | SMALL-MOLECULE INHIBITOR | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOLOGY | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | TRANSCRIPTION FACTOR | GROWTH-SUPPRESSIVE ACTIVITY | SIGNAL TRANSDUCER | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Immunity - immunology | Gene Expression Regulation, Neoplastic - immunology | Macrophages - metabolism | Models, Immunological | Neoplasms - genetics | Immune System - metabolism | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Immune System - immunology | STAT3 Transcription Factor - immunology | Immunity - genetics | Dendritic Cells - metabolism | Macrophages - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Phosphorylation | Transcription | Crosstalk | Multiple myeloma | Metastasis | Kinases | Cancer therapies | Proteins | Angiogenesis | Cell growth | Immunotherapy | Cell cycle | DNA methylation | Vascular endothelial growth factor | Deoxyribonucleic acid--DNA | Immune system | Immune response | Cytokines | Tumor cells | Stat3 protein | Gene expression | Tumors | Apoptosis | immunosuppression | cancer | immunity
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