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Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2140 - 2148
Purpose: EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase) was recently identified as a transforming fusion gene in... 
NPM-ALK | GEFITINIB | ONCOLOGY | EML4-ALK FUSION GENE | STAT3 | CYCLE ARREST | KINASE INHIBITORS | EGFR MUTATIONS | LARGE-CELL LYMPHOMA | IDENTIFICATION | MEDIATED LYMPHOMAGENESIS | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Neoplasms, Experimental - pathology | Protein-Tyrosine Kinases - genetics | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Cell Transformation, Neoplastic - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasms, Experimental - genetics | Apoptosis Regulatory Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 07/2007, Volume 116, Issue 5, pp. 535 - 544
Background - The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning ( PC) and cardioprotection is poorly understood. We addressed... 
Myocardial infarction | Occlusion | Ischemia | Stress | MYOCARDIUM | stress | CARDIAC & CARDIOVASCULAR SYSTEMS | CYCLOOXYGENASE-2 | MECHANISM | MEDIATOR | myocardial infarction | STAT3 | CONSCIOUS RABBITS | ischemia | EPSILON | INFARCTION | GENE | occlusion | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | Nitric Oxide Synthase Type II - physiology | Cyclooxygenase 2 - biosynthesis | STAT3 Transcription Factor - physiology | MAP Kinase Kinase Kinase 2 - physiology | Protein Processing, Post-Translational - drug effects | Time Factors | Cyclooxygenase 2 - genetics | Mice, Mutant Strains | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Triazenes - pharmacology | Nitric Oxide Donors - therapeutic use | Hypertension - genetics | Nitric Oxide Donors - pharmacology | Phosphorylation - drug effects | Triazenes - therapeutic use | MAP Kinase Kinase Kinase 1 - physiology | STAT1 Transcription Factor - physiology | Specific Pathogen-Free Organisms | Mitogen-Activated Protein Kinase 1 - physiology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide Synthase Type III | Adaptation, Physiological - physiology | Nitric Oxide - physiology | Stress, Physiological - physiopathology | DNA - metabolism | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | DNA - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Ischemic Preconditioning, Myocardial | Hypertension - complications | Signal Transduction - physiology | Mice | Protein Kinase C-epsilon - physiology | Myocardial Reperfusion Injury - prevention & control | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 36, pp. 30436 - 30443
An important feature of the adaptive immune response is its remarkable capacity to regulate the duration of inflammatory responses, and effector T cells have... 
SURVIVAL | SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-2 | INTERLEUKIN-10 | NF-KAPPA-B | BINDING | P27(KIP1) | Cell Nucleus - immunology | Forkhead Transcription Factors - immunology | 14-3-3 Proteins - immunology | Humans | Cytoplasm - metabolism | CD4-Positive T-Lymphocytes - immunology | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Forkhead Transcription Factors - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Receptors, Antigen, T-Cell - immunology | Cytoplasm - genetics | Cytokines - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | 14-3-3 Proteins - genetics | Cytokines - immunology | Cyclin-Dependent Kinase Inhibitor p27 - immunology | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Gene Expression Regulation - immunology | Jurkat Cells | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Forkhead Transcription Factors - genetics | Mice, Knockout | 14-3-3 Proteins - metabolism | Animals | Cell Nucleus - genetics | Cyclin-Dependent Kinase Inhibitor p21 - immunology | Cytoplasm - immunology | Active Transport, Cell Nucleus - immunology | Forkhead Box Protein O1 | Mice | Receptors, Antigen, T-Cell - genetics | STAT3 Transcription Factor - immunology | Forkhead Box Protein O3 | Lymphocyte Activation - physiology | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus | FoxO | Immunology | T Cell | Interleukin | Cytokine | STAT3 | Cellular Immune Response
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, pp. e10290 - e10290
Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na3VO4 desensitized keratinocytes to UVB-induced... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | TRANSCRIPTION 3 | PROMOTION STAGES | EPITHELIAL CARCINOGENESIS | SUBSTRATE | BIOLOGY | SKIN CARCINOGENESIS | PROLIFERATION | SIGNAL TRANSDUCER | NEGATIVE REGULATOR | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2015, Volume 308, Issue 11, pp. C869 - C878
Abnormally elevated bone morphogenetic protein 4 (BMP4) expression and mediated signaling play a critical role in the pathogenesis of chronic hypoxia-induced... 
Noggin | Store-operated calcium entry | TRPC | Pulmonary hypertension | PHYSIOLOGY | MATRIX GLA PROTEIN | pulmonary hypertension | BONE-MORPHOGENETIC PROTEIN | noggin | store-operated calcium entry | CELL-PROLIFERATION | PRIMARY PULMONARY-HYPERTENSION | CELL BIOLOGY | SIGNAL-TRANSDUCTION | INTRACELLULAR CA2 | JAK-STAT PATHWAY | ANTAGONIST GREMLIN | ENDOTHELIAL-CELLS | ARTERIAL SMOOTH-MUSCLE | Phosphorylation | Bone Morphogenetic Protein 4 - genetics | Follistatin - genetics | Follistatin - metabolism | Male | Bone Morphogenetic Protein 4 - metabolism | Hypoxia - metabolism | Pulmonary Artery - metabolism | Carrier Proteins - pharmacology | Janus Kinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Myocytes, Smooth Muscle - drug effects | TRPC Cation Channels - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Extracellular Matrix Proteins - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Calcium-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Extracellular Matrix Proteins - genetics | Gene Expression Regulation | Janus Kinase 2 - genetics | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Hypoxia - complications | Pulmonary Artery - drug effects | Pulmonary Artery - cytology | Proteins - genetics | Carrier Proteins - genetics | Hypoxia - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Hypoxia - pathology | TRPC Cation Channels - metabolism | Primary Cell Culture | Calcium Signaling - genetics | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Calcium-Binding Proteins - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Physiological aspects | Bone morphogenetic proteins | Cellular signal transduction | Ion channels | Gene expression | Identification and classification | Proteins | Calcium | Rodents | Atoms & subatomic particles | Hypoxia | Index Medicus
Journal Article
European Journal of Nutrition, ISSN 1436-6207, 4/2018, Volume 57, Issue 3, pp. 1157 - 1168
This study examined the effect of soy proteins with depletion of different subunits of the two major storage proteins, β-conglycinin and glycinin, on hepatic... 
Soy protein | Metabolic disease | Chemistry | Nutrition | Liver | Rats | Glycinin | β-Conglycinin | Lipid metabolism | PROTEIN | beta-Conglycinin | ABNORMALITIES | DOWN-REGULATION | INDUCTION | DIETARY SOY | ISOFLAVONES | NUTRITION & DIETETICS | PLASMA-LIPIDS | INFLAMMATION | FATTY LIVER | MICE | Liver - pathology | Vegetable Proteins - chemistry | Caseins - adverse effects | Male | Antigens, Plant - chemistry | Soybean Proteins - chemistry | Vacuoles - pathology | Lipid Droplets - metabolism | Protein Subunits - genetics | Vegetable Proteins - metabolism | Hyperlipidemias - metabolism | Soybean Proteins - genetics | Liver - metabolism | Lipid Droplets - pathology | Globulins - chemistry | Lipid Metabolism | Sex Characteristics | Hyperlipidemias - prevention & control | Rats, Sprague-Dawley | Vegetable Proteins - therapeutic use | Seed Storage Proteins - chemistry | Plants, Genetically Modified - metabolism | Seed Storage Proteins - genetics | Globulins - therapeutic use | Hyperlipidemias - pathology | Protein Processing, Post-Translational | Seed Storage Proteins - metabolism | Phosphorylation | Liver - enzymology | Weaning | Globulins - metabolism | Diet, High-Fat - adverse effects | Protein Subunits - metabolism | Female | Food, Genetically Modified | STAT3 Transcription Factor - metabolism | Seed Storage Proteins - therapeutic use | Globulins - genetics | Soybean Proteins - metabolism | Plants, Genetically Modified - genetics | Antigens, Plant - genetics | Antigens, Plant - therapeutic use | Animals | Vegetable Proteins - genetics | Hyperlipidemias - etiology | Protein Subunits - therapeutic use | Antigens, Plant - metabolism | Soybean Proteins - therapeutic use | Protein Subunits - chemistry | Soybeans | Stat3 protein | Lipids | Metabolism | Storage proteins | Proteins | Casein | Diet | Soy products | Rodents | Sterol regulatory element-binding protein | Isoflavones | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 42, pp. 35556 - 35564
IL-32 alpha is known as a proinflammatory cytokine. However, several evidences implying its action in cells have been recently reported. In this study, we... 
PROINFLAMMATORY CYTOKINE | RHEUMATOID-ARTHRITIS | CANCER-CELLS | ACTIVATION | SYNOVIAL FIBROBLASTS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | ANXIETY-LIKE BEHAVIOR | MACROPHAGE DIFFERENTIATION | EXPRESSION | Enzyme Activators - pharmacology | Phosphorylation - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Tetradecanoylphorbol Acetate - pharmacology | Monocytes - cytology | Humans | Monocytes - metabolism | NF-kappa B - metabolism | Interleukins - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Carcinogens - pharmacology | Protein Kinase C-epsilon - antagonists & inhibitors | Interleukins - biosynthesis | Phosphorylation - drug effects | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Interleukin-6 - genetics | Protein Kinase C-epsilon - genetics | Gene Expression Regulation - physiology | Gene Expression Regulation - drug effects | Promoter Regions, Genetic - physiology | NF-kappa B - genetics | Signal Transduction - drug effects | Protein Kinase C-epsilon - metabolism | Cell Line, Tumor | Interleukin-6 - biosynthesis | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Index Medicus | Gene Regulation | THP-1 | Interleukin | STAT3 | PKCϵ | Immunochemistry | Chromatin Immunoprecipitation (ChIP) | Interleukin-32α | Interleukin-6
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2019, Volume 25, Issue 1, pp. 130 - 140
In T lymphocytes, the Wiskott-Aldrich Syndrome protein (WASP) and WASP-interacting-protein (WIP) regulate T cell antigen receptor (TCR) signaling, but their... 
ALK | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | ACTIN POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RHOA | DEFICIENCY | CELL BIOLOGY | CDC42 | MUTATIONS | RAC1 | WIP | Wiskott-Aldrich Syndrome Protein - deficiency | Cell Proliferation | Humans | cdc42 GTP-Binding Protein - metabolism | Guanosine Triphosphate - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Lymphoma, T-Cell - metabolism | MAP Kinase Signaling System | Lymphoma, T-Cell - enzymology | Wiskott-Aldrich Syndrome Protein - metabolism | Anaplastic Lymphoma Kinase - metabolism | Cytoskeletal Proteins - metabolism | STAT3 Transcription Factor - metabolism | Tumor Suppressor Proteins - metabolism | Cell Survival | Down-Regulation | Kaplan-Meier Estimate | CCAAT-Enhancer-Binding Protein-beta - metabolism | Animals | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Protein Binding | T-Lymphocytes - immunology | Mice | Enzyme Activation | Research | B cells | T cells | Protein kinases | Cdc42 protein | GTP | Stat3 protein | MAP kinase | Lymphocytes T | CCAAT/enhancer-binding protein | Kinases | Lymphoma | Suppressors | Proteins | T-cell receptor | Inhibitors | Clonal deletion | Protein kinase | Lymphocytes | Deletion | Tumor suppressor genes | Lymphomas | Anaplastic large-cell lymphoma | Protein-tyrosine kinase | T-cell lymphoma | Tumors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 27, pp. 24113 - 24124
In LPS-treated macrophages, activation of STAT3 is considered to be crucial for terminating the production of inflammatory cytokines. By analyzing the role of... 
TUMOR-NECROSIS-FACTOR | SOCS3 MESSENGER-RNA | CYTOKINE SIGNALING-3 | HUMAN MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TNF-ALPHA | NF-KAPPA-B | IL-10 | CUTTING EDGE | BETA | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Interferon Regulatory Factor-3 - genetics | Transcription Factor RelA - genetics | Cell Nucleus - metabolism | Interferon-beta - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation - physiology | Interferon-beta - biosynthesis | Macrophages - cytology | Mice, Knockout | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Cell Nucleus - genetics | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Interleukin-10 - biosynthesis | Signal Transduction - physiology | Mice | Index Medicus | NF-κB | STAT Transcription Factor | Signal Transduction | Interleukin | Interferon | Lipopolysaccharide (LPS) | Macrophage
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127942 - e0127942
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although... 
SURVIVAL PATHWAYS | REGULATED KINASE | INFARCT SIZE | HEART | ISCHEMIA/REPERFUSION INJURY | JAK-STAT PATHWAY | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | INDUCIBLE GENE | AKT | CONFERS RESISTANCE | Mitogen-Activated Protein Kinase 3 - genetics | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Suppressor of Cytokine Signaling Proteins - genetics | Myocardium - pathology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | Mice, Knockout | Muscle Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Suppressor of Cytokine Signaling 3 Protein | Phosphorylation - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Deletion | Myocardium - metabolism | Muscle Proteins - metabolism | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Myocardial Reperfusion Injury - genetics | Myocardial Reperfusion Injury - prevention & control | Prevention | Physiological aspects | Cellular signal transduction | Research | Cytokines | Reperfusion injury | Heart | Myocardial infarction | Phosphorylation | Bcl-2 protein | Transcription | Physicians | Leukemia | Myocardial ischemia | AKT protein | Activation | Kinases | Proteins | Signal transduction | Mitochondria | Negative feedback | Reperfusion | Ischemia | Clonal deletion | Rodents | Deletion | Janus kinase | Heart diseases | Internal medicine | Coronary artery | Stat3 protein | Extracellular signal-regulated kinase | Cardiomyocytes | Mcl-1 protein | Medicine | Signaling | Injury prevention | Coronary vessels | Infarction | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article