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Neuropharmacology, ISSN 0028-3908, 2004, Volume 47, Issue 6, pp. 904 - 915
Oxidative stress and apoptosis play pivotal roles in the pathogenesis of neurodegenerative diseases. We investigated the effects of vitamin E analogs on... 
Neuroprotection | Oxidative stress | Tocotrienol | Non-antioxidant function | Apoptosis | PROTEIN-KINASE-C | LIPID-PEROXIDATION | TOCOPHEROL | apoptosis | DOPAMINERGIC-NEURONS | NEUROSCIENCES | tocotrienol | ANTIOXIDANT PROPERTIES | BREAST-CANCER CELLS | PALM OIL | neuroprotection | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | non-antioxidant function | MUSCLE-CELL-PROLIFERATION | oxidative stress | Immunohistochemistry | L-Lactate Dehydrogenase - metabolism | Rats, Wistar | Apoptosis - drug effects | Bisbenzimidazole | Vitamin E - analogs & derivatives | Chromatography, High Pressure Liquid | Carcinogens - toxicity | Tetrazolium Salts | Staurosporine - toxicity | Neuroprotective Agents - pharmacology | Carcinogens - antagonists & inhibitors | Neostriatum - drug effects | Thiazoles | Neurons - drug effects | Hydrogen Peroxide - toxicity | In Situ Nick-End Labeling | Cell Survival - drug effects | Neostriatum - cytology | Antimetabolites - antagonists & inhibitors | Cells, Cultured | Rats | Antioxidants - pharmacology | Tocotrienols | Antimetabolites - toxicity | Buthionine Sulfoximine - antagonists & inhibitors | Staurosporine - antagonists & inhibitors | Animals | Oxidative Stress - drug effects | Hydrogen Peroxide - antagonists & inhibitors | Fluorescent Dyes | Buthionine Sulfoximine - toxicity | Vitamin E - pharmacology | Index Medicus
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2015, Volume 71, Issue 42, pp. 7990 - 7997
The first synthesis of fradcarbazole A ( ) has been accomplished by using a biomimetic intramolecular cyclization/dehydration to construct the... 
Cytotoxicity | PKC-Beta | Fradcarbazole A | Staurosporine | Biomimetic synthesis | THIOUREAS | POTENT | ASSAY | BIOLOGY | CHEMISTRY | CHEMISTRY, ORGANIC | DERIVATIVES | Oxazoles
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, pp. 586 - 601
The chalcone motif can be found in many molecules that contribute to essential biological processes, and many chalcone-containing compounds exhibit potent... 
Quinazolin-4(3H)-one | Chalcone analogue | Cytotoxicity | Mitochondrial death pathway | Apoptosis | TARGET | CELLS | CHEMISTRY, MEDICINAL | STAUROSPORINE-INDUCED APOPTOSIS | MECHANISM | ANTIOPPORTUNISTIC INFECTION AGENTS | PHASE-II | HEPATOCELLULAR-CARCINOMA | BIOLOGICAL EVALUATION | DERIVATIVES | Index Medicus
Journal Article
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 2018, Volume 22, Issue 5, pp. 505 - 517
Background: We report a novel MCR4 useful for generating chiral analogs of staurosporine a promiscuous and potent protein kinases inhibitor. Method: Our... 
Meldrum’s acid | Multicomponent reaction | Staurosporine | Ugi | Isocyanide | Hexa-substituted benzene | Tetramic acid | HETEROBICYCLIC ALIPHATIC RINGS | ISOCYANIDES | CHEMISTRY, ORGANIC | 2-AMINOFURANS | isocyanide | tetramic acid | hexa-substituted benzene | CYCLOADDITION | GENERATION | multicomponent reaction | Meldrum's acid
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 2, pp. 702 - 713
Journal Article
Tetrahedron, ISSN 0040-4020, 2005, Volume 61, Issue 30, pp. 7304 - 7316
Journal Article
Neuropeptides, ISSN 0143-4179, 2010, Volume 44, Issue 6, pp. 495 - 508
Abstract TRH (thyroliberin) and its analogues were reported to possess neuroprotective effects in cellular and animal experimental models of acute and chronic... 
Endocrinology & Metabolism | Advanced Basic Science | Bcl-2 | PI3-K | Hydrogen peroxide | Staurosporine | RGH-2202 | Beta-amyloid | Montirelin | MPP | Homocysteine | 3-Nitropropionate | Beta amyloid | STAUROSPORINE-INDUCED APOPTOSIS | ENDOGENOUS DOPAMINERGIC NEUROTOXIN | 3 Nitropropionate | PI3 K | Bcl 2 | NEUROSCIENCES | GLUTAMATE-INDUCED TOXICITY | IN-VITRO | CASPASE-3 ACTIVATION | THYROTROPIN-RELEASING-HORMONE | ENDOCRINOLOGY & METABOLISM | BCL-2 OVEREXPRESSION | CENTRAL-NERVOUS-SYSTEM | 1,25-DIHYDROXYVITAMIN D-3 | RGH 2202 | PARKINSONS-DISEASE | Propionates - pharmacology | MAP Kinase Signaling System - physiology | Oxidants - pharmacology | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Thyrotropin-Releasing Hormone - pharmacology | Caspase 3 - metabolism | Cell Line, Tumor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neuroprotective Agents - pharmacology | Homocysteine - pharmacology | Cytotoxins - metabolism | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Thyrotropin-Releasing Hormone - analogs & derivatives | Proto-Oncogene Proteins c-akt - metabolism | Tretinoin - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacology | Hydrogen Peroxide - pharmacology | Animals | Cell Differentiation - drug effects | Convulsants - pharmacology | Neuroblastoma - metabolism | Staurosporine - pharmacology | Evaluation | Nervous system diseases | Parkinson's disease | Neuropeptides | Neuroblastoma | Heterocyclic compounds | Analysis | Neurohormones | Mitogens | Protein kinases | Tretinoin | Index Medicus
Journal Article