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Nature (London), ISSN 1476-4687, 08/2017, Volume 549, Issue 7672, pp. 389 - 393
...), suggests a possible role of somatic mutations in myeloid cells in neurodegeneration. Yet the expression of BRAF(V600E... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells | Index Medicus
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2015, Volume 17, Issue 8, pp. 994 - 1003
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2001, Volume 21, Issue 19, pp. 7691 - 7704
Journal Article
Journal of inherited metabolic disease, ISSN 0141-8955, 3/2018, Volume 41, Issue 2, pp. 221 - 229
.... Human induced pluripotent stem cells (iPSC) represent an alternative system that complements the available MPSII murine model... 
Human Genetics | Biochemistry, general | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | Endocrinology & Metabolism | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neurons - pathology | Iduronate Sulfatase - metabolism | Oligodendrocyte Precursor Cells - enzymology | Neuroglia - pathology | Humans | Astrocytes - pathology | Lysosomes - enzymology | Male | Astrocytes - enzymology | Neurogenesis | Mucopolysaccharidosis II - pathology | Mucopolysaccharidosis II - genetics | Female | Lysosomes - pathology | Induced Pluripotent Stem Cells - pathology | Induced Pluripotent Stem Cells - enzymology | Mucopolysaccharidosis II - enzymology | Glycosaminoglycans - metabolism | Neuroglia - enzymology | Cells, Cultured | Oligodendrocyte Precursor Cells - pathology | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Oligodendroglia - pathology | Cell Lineage | Phenotype | Neurons - enzymology | Iduronate Sulfatase - genetics | Oligodendroglia - enzymology | Medical research | Enzymes | Genetic vectors | Neurons | Analysis | Stem cells | Medicine, Experimental | Mucopolysaccharidosis | Sulfates | Tubulins | Cell culture | Animal models | Glycosaminoglycans | Central nervous system | Stem cell transplantation | Leukocytes | Neuronal-glial interactions | Respiratory tract | Airway management | Tubulin | Allografts | Gag protein | Oligodendrocytes | Rheumatic heart disease | Heart diseases | Astrocytes | Blood cells | Glial fibrillary acidic protein | Coronary artery disease | Hearing loss | Neurological complications | Culture media | Pluripotency | Index Medicus
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 10/2014, Volume 147, Issue 4, pp. 822 - 834.e13
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1159 - 1167
...+ chronic myeloid leukaemia (CML) stem/progenitor cells. Here, to enhance the BMS-214662 apoptotic effect, we further targeted the extracellular signal-regulated kinase (ERK... 
BMS-214662 | HSC | MEK inhibitor | CML | TKI | PD184352 | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Antigens, CD34 - analysis | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Chronic-Phase - pathology | Neoplasm Proteins - antagonists & inhibitors | K562 Cells - drug effects | Blast Crisis - enzymology | MAP Kinase Kinase 1 - genetics | Tumor Cells, Cultured - enzymology | Genes, Dominant | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Benzamides - pharmacology | Farnesyltranstransferase - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Hematopoietic Stem Cells - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Benzodiazepines - pharmacology | Blast Crisis - pathology | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Leukemia, Myeloid, Chronic-Phase - enzymology | K562 Cells - enzymology | Drug Synergism | Recombinant Fusion Proteins - genetics | Genes, ras | Hematopoietic Stem Cells - enzymology | Neoplastic Stem Cells - enzymology | Drug Screening Assays, Antitumor | Oncogene Protein p21(ras) - genetics | Antimitotic agents | Physiological aspects | Chronic myeloid leukemia | Research | Drug therapy | Antineoplastic agents | Protein kinases | Health aspects | Apoptosis | Index Medicus | FTI | CD34
Journal Article