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steroid 16-alpha-hydroxylase (357) 357
aryl hydrocarbon hydroxylases (337) 337
cytochrome p-450 enzyme system - genetics (320) 320
steroid hydroxylases - genetics (275) 275
animals (253) 253
humans (252) 252
male (234) 234
cytochrome p-450 enzyme system - metabolism (191) 191
rats (176) 176
cytochrome p-450 cyp2c9 (164) 164
pharmacology & pharmacy (154) 154
steroid hydroxylases - metabolism (151) 151
female (143) 143
cytochrome p450 family 2 (127) 127
liver - enzymology (95) 95
biochemistry & molecular biology (93) 93
metabolism (89) 89
microsomes, liver - enzymology (82) 82
hydroxylation (78) 78
molecular sequence data (74) 74
rats, sprague-dawley (73) 73
base sequence (68) 68
alleles (67) 67
genotype (67) 67
aryl hydrocarbon hydroxylases - metabolism (65) 65
steroid 16-alpha-hydroxylase - metabolism (64) 64
steroid 16-alpha-hydroxylase - genetics (63) 63
kinetics (62) 62
aryl hydrocarbon hydroxylases - genetics (61) 61
expression (61) 61
polymorphism, genetic (58) 58
mixed function oxygenases - genetics (56) 56
cytochrome p450 (54) 54
mice (54) 54
cyp2c9 (52) 52
cytochrome p-450 cyp3a (52) 52
rna, messenger - metabolism (51) 51
adult (49) 49
cytochrome p-450 enzyme system - biosynthesis (46) 46
liver - metabolism (46) 46
cytochrome p-450 cyp2c19 (45) 45
enzymes (45) 45
mixed function oxygenases - metabolism (45) 45
cytochrome p-450 (44) 44
liver - drug effects (42) 42
substrate specificity (40) 40
amino acid sequence (39) 39
cells, cultured (39) 39
liver (39) 39
middle aged (38) 38
index medicus (37) 37
isoenzymes - metabolism (37) 37
rna, messenger - genetics (37) 37
polymorphism (36) 36
warfarin (36) 36
steroid hydroxylases - biosynthesis (35) 35
toxicology (35) 35
isoenzymes - genetics (34) 34
rats, wistar (34) 34
recombinant proteins - metabolism (34) 34
cytochrome p-450 cyp2c8 (33) 33
tolbutamide (33) 33
pharmacokinetics (32) 32
gene expression (31) 31
microsomes, liver - metabolism (31) 31
cytochrome p-450 enzyme inhibitors (30) 30
phenytoin (30) 30
sex factors (30) 30
cloning, molecular (29) 29
drug-metabolism (29) 29
messenger-rna (28) 28
mutation (28) 28
sex characteristics (28) 28
aged (27) 27
genetic-polymorphism (27) 27
microsomes, liver - drug effects (27) 27
polymerase chain reaction (27) 27
rabbits (27) 27
testosterone - metabolism (27) 27
cytochrome p-450 enzyme system - chemistry (26) 26
gene expression regulation, enzymologic (26) 26
rat-liver (26) 26
allelic variant (25) 25
enzyme inhibitors - pharmacology (25) 25
gene expression regulation, enzymologic - drug effects (25) 25
genetics & heredity (25) 25
rat (25) 25
biophysics (24) 24
endocrinology & metabolism (24) 24
gene-expression (24) 24
rna, messenger - analysis (24) 24
dna - genetics (23) 23
identification (23) 23
mutagenesis, site-directed (23) 23
purification (23) 23
steroid hydroxylases - antagonists & inhibitors (23) 23
subfamily (23) 23
transfection (23) 23
cell line (22) 22
genetic variation (22) 22
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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 12/2014, Volume 307, Issue 11, pp. C989 - C998
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2016, Volume 163, pp. 183 - 192
16-dehydropregnenolone (DHP) is a promising novel antihyperlipidemic agent developed and patented by Central Drug Research Institute (CDRI), India. The purpose... 
16-dehydropregnenolone | Cocktail | Pharmacokinetics | CYP450 | Real time RT-PCR | Microsomes | COCKTAIL PROBE DRUGS | IN-VITRO COCKTAIL | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | TANDEM MASS-SPECTROMETRY | INHIBITION | METABOLISM | ENDOCRINOLOGY & METABOLISM | SCHISANDRA-CHINENSIS | DRUG-DRUG INTERACTIONS | Tolbutamide - pharmacology | Liver - enzymology | Chlorzoxazone - metabolism | Pregnenolone - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - genetics | Dextromethorphan - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Microsomes, Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Caffeine - pharmacology | Cytochrome P450 Family 2 - genetics | Microsomes, Liver - enzymology | Tolbutamide - metabolism | Caffeine - metabolism | Dextromethorphan - pharmacology | Administration, Oral | Gene Expression Regulation | Rats | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Dapsone - metabolism | Animals | Pregnenolone - analogs & derivatives | Cytochrome P450 Family 2 - metabolism | Cytochrome P-450 CYP3A - metabolism | Chlorzoxazone - pharmacology | Hypolipidemic Agents - administration & dosage | Steroid 16-alpha-Hydroxylase - genetics | Dapsone - pharmacology | Hypolipidemic Agents - pharmacokinetics | Pregnenolone - administration & dosage | Physiological aspects | Enzymes | Liquid chromatography | Gastrointestinal agents | RNA | Mass spectrometry | Cytochrome P-450
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1174 - 1179
Journal Article
Journal Article
Clinical Nutrition, ISSN 0261-5614, 2014, Volume 34, Issue 4, pp. 685 - 693
Summary Background & aims It has recently been reported that anti-inflammatory lipid mediators are increased in the late phase of acute inflammation, whereas... 
Gastroenterology and Hepatology | Lipopolysaccharide | Lipidomics | Sepsis | Lard | Lipid mediator | High-fat diet | MORTALITY | ACTIVATION | ACID | RESOLUTION | TISSUE | PATHOPHYSIOLOGY | OBESITY | NUTRITION & DIETETICS | LIVER | MICE | INFLAMMATORY RESPONSE | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Rats, Wistar | Lipopolysaccharides - administration & dosage | Tumor Necrosis Factor-alpha - genetics | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Alanine Transaminase - blood | Endotoxemia - pathology | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | Lipopolysaccharides - adverse effects | Cytochrome P450 Family 2 | Tandem Mass Spectrometry | Liver - drug effects | Cyclooxygenase 2 - genetics | Diet, High-Fat | Cytochrome P450 Family 4 | Interleukin-6 - metabolism | Interleukin-6 - genetics | Down-Regulation | Endotoxemia - drug therapy | Liver - metabolism | RNA, Messenger - genetics | Rats | Fatty Acids, Unsaturated - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Epoxide Hydrolases - genetics | Organ Size - drug effects | Animals | Aspartate Aminotransferases - blood | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Lipid Metabolism - drug effects | Cytochrome P-450 Enzyme System - genetics | Steroid 16-alpha-Hydroxylase - genetics | Epoxide Hydrolases - metabolism | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Medical colleges
Journal Article
Experimental Physiology, ISSN 0958-0670, 12/2017, Volume 102, Issue 12, pp. 1596 - 1606
New FindingsWhat is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation... 
diabetes mellitus | brain ischemia | hyperbaric oxygenation | stroke | THERAPEUTIC WINDOW | 20-HETE | PHYSIOLOGY | MODEL | DAMAGE | INFARCT VOLUME | CEREBRAL-ARTERY OCCLUSION | ISCHEMIC-STROKE | BRAIN | Infarction, Middle Cerebral Artery - physiopathology | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Diabetes Mellitus, Type 1 - metabolism | Infarction, Middle Cerebral Artery - therapy | Steroid 16-alpha-Hydroxylase - metabolism | Infarction, Middle Cerebral Artery - metabolism | RNA, Messenger - metabolism | Diabetes Mellitus, Type 1 - therapy | Diabetes Mellitus, Experimental - therapy | Brain - metabolism | Neuroprotective Agents - pharmacology | Time Factors | Cytochrome P450 Family 2 - genetics | Female | Nitric Oxide Synthase Type III - metabolism | Diabetes Mellitus, Experimental - metabolism | Reperfusion Injury - metabolism | Diabetes Mellitus, Experimental - physiopathology | Reperfusion Injury - pathology | Diabetes Mellitus, Type 1 - physiopathology | RNA, Messenger - genetics | Combined Modality Therapy | Infarction, Middle Cerebral Artery - pathology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Epoxide Hydrolases - genetics | Brain - drug effects | Gene Expression Regulation, Enzymologic | Cytochrome P450 Family 4 - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Reperfusion Injury - prevention & control | Cytochrome P450 Family 2 - metabolism | Reperfusion Injury - physiopathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Steroid 16-alpha-Hydroxylase - genetics | Amidines - pharmacology | Epoxide Hydrolases - metabolism | Hyperbaric Oxygenation | Cytochrome P450 Family 4 - genetics | Stroke (Disease) | Metabolites | RNA | Type 1 diabetes | Nitric oxide | Cytochrome P-450 | Cytochrome | Stroke | Streptozocin | Cytochrome P450 | Diabetes mellitus | Cortex | Acid production | Gene expression | Epoxide hydrolase | Nitric-oxide synthase | Reperfusion | Acids | Ischemia | Cerebral blood flow | Rodents | Diabetes | Oxygenation
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2013, Volume 367, Issue 1-2, pp. 74 - 84
► Expression of , , and MB-COMT levels were higher in endometriosis. ► Expression of , , , , and was decreased. ► Three NQO1 isoforms were detected; NQO1c... 
Glutathione S-transferase pi 1 (GSTP1) | (NRH):quinone oxidoreductase 2 (NQO2) | Sulfotransferases (SULTs) | NAD(P)H:quinone oxidoreductase 1 (NQO1) | Cytochrome P450 (CYP) | Catechol-O-methyltransferase (COMT) | ORTHO-QUINONES | CELLS | OXIDATIVE STRESS | HUMAN-BREAST-CANCER | RECEPTOR | CYTOCHROME-P450 ISOFORMS | ESTRONE | 17-BETA-ESTRADIOL | CELL BIOLOGY | CATECHOL-O-METHYLTRANSFERASE | ENDOCRINOLOGY & METABOLISM | EXPRESSION | Immunohistochemistry | Cytochrome P-450 CYP1A1 - genetics | Steroid Hydroxylases - metabolism | Reactive Oxygen Species - metabolism | Endometriosis - genetics | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Gene Expression Profiling | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | Catechol O-Methyltransferase - genetics | Case-Control Studies | Young Adult | Catechol O-Methyltransferase - metabolism | Endometriosis - enzymology | Estrogens - chemistry | Isoenzymes - metabolism | Metabolic Detoxication, Phase II - genetics | Adult | Female | Metabolic Detoxication, Phase I - genetics | Estrogens - metabolism | Steroid Hydroxylases - genetics | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Ovary - pathology | Up-Regulation - genetics | Cytochrome P-450 CYP1A1 - metabolism | Blotting, Western | Aryl Hydrocarbon Hydroxylases - metabolism | Gene Expression Regulation, Enzymologic | Ovary - enzymology | Cytochrome P-450 CYP1B1 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Endometriosis | Thiols | Glutathione transferase | Quinone | Cytochrome P-450
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 09/2014, Volume 28, Issue 9, pp. 4111 - 4122
Journal Article
American Journal of Physiology : Endocrinology and Metabolism, ISSN 0193-1849, 07/2012, Volume 303, Issue 1, pp. E40 - E54
Daskalopoulos EP, Malliou F, Rentesi G, Marselos M, Lang MA, Konstandi M. Stress is a critical player in CYP3A, CYP2C, and CYP2D regulation: role of adrenergic... 
Epinephrine | Drug metabolism | Glucocorticoids | Rat | Cytochrome P-450s | cytochrome P-450s | PHYSIOLOGY | NEUROTRANSMITTER REGULATION | rat | CYTOCHROMES P450 | THYROID-HORMONE | epinephrine | DRUG-METABOLIZING-ENZYMES | CULTURED-HEPATOCYTES | ACTIVATED RECEPTOR | GROWTH-HORMONE | HEPATIC CYTOCHROME-P450 | drug metabolism | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | glucocorticoids | MALE-RAT LIVER | Rats, Wistar | Aryl Hydrocarbon Hydroxylases - genetics | Stress, Physiological | Adrenergic Agonists - pharmacology | Male | Hepatocytes - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | Cytochrome P450 Family 2 | Hepatocytes - cytology | Cytochrome P-450 CYP3A - genetics | Isoenzymes - metabolism | Stress, Psychological - metabolism | Enzyme Induction - drug effects | Restraint, Physical - adverse effects | Hepatocytes - drug effects | Cytochrome P-450 CYP2D6 - genetics | Isoenzymes - genetics | Receptors, Adrenergic - metabolism | Cells, Cultured | Rats | Aryl Hydrocarbon Hydroxylases - metabolism | Receptors, Adrenergic - chemistry | Stress, Psychological - pathology | Maternal Deprivation | Animals | Signal Transduction - drug effects | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Corticosterone - metabolism | Protein Kinase Inhibitors - pharmacology | Epinephrine - metabolism | Cytochrome P-450 | Physiological aspects | Stress (Physiology) | Genetic aspects | Research | Genetic regulation | Health aspects
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 04/2015, Volume 284, Issue 1, pp. 79 - 91
Perinatal exposure of rats and mice to the typically reported 4 mg/g bd wt dose of monosodium glutamate (MSG) results in a complete block in GH secretion as... 
MSG | SOCS2 | STAT5b | Sexual dimorphism | CYP2C11 | Growth hormone | SOMATOSTATIN ANALOG OCTREOTIDE | SEXUALLY DIMORPHIC EXPRESSION | PHENOBARBITAL INDUCTION | CHROMOSOMAL LOCALIZATION | CIRCULATING GROWTH-HORMONE | HEPATIC CYTOCHROME-P450 | SEX-DEPENDENT FORMS | PHARMACOLOGY & PHARMACY | HUMAN LIVER | TOXICOLOGY | GH-DEFICIENT ADULTS | GENDER-DIFFERENCES | Transcription, Genetic - drug effects | Aryl Hydrocarbon Hydroxylases - biosynthesis | Age Factors | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Steroid 21-Hydroxylase - metabolism | Male | MicroRNAs - metabolism | Cytochrome P450 Family 2 | RNA, Messenger - biosynthesis | STAT5 Transcription Factor - metabolism | Ubiquitination | Sodium Glutamate - toxicity | Time Factors | Steroid 21-Hydroxylase - genetics | Female | Active Transport, Cell Nucleus | Binding Sites | Flavoring Agents - toxicity | Hepatocytes - drug effects | Animals, Newborn | Promoter Regions, Genetic | Growth Hormone - blood | Albumins - metabolism | Cells, Cultured | Enzyme Induction | Sex Characteristics | Rats, Sprague-Dawley | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Sex Factors | Cytochrome P-450 Enzyme System - genetics | Steroid 16-alpha-Hydroxylase - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | Hepatocytes - enzymology | Steroid 16-alpha-Hydroxylase - biosynthesis | Genetic transcription | Monosodium glutamate | RNA | Glutamate | Cytochrome P-450 | Index Medicus | CHROMATIN | STH | TRANSCRIPTION | ALBUMINS | RATS | 60 APPLIED LIFE SCIENCES | PULSES | INHIBITION | MESSENGER-RNA | TRANSDUCERS | DOSES | PROMOTERS | LIVER CELLS | FOOD ADDITIVES | MICE | METABOLIC DISEASES | SECRETION | RECEPTORS | MALES | PLANT GROWTH | GHR | growth hormone | sexual dimorphism
Journal Article