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1. New drug treatment possibilities in castration resistant prostate carcinoma
by Meisel, A and Stenner, F
Praxis (Bern. 1994), ISSN 1661-8157, 09/2012, Volume 101, Issue 18, p. 1143
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Immunotherapy - methods | Androgen Receptor Antagonists - therapeutic use | Prognosis | Humans | Bone Neoplasms - secondary | Drug Resistance, Neoplasm | Male | Palliative Care | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Androgen Receptor Antagonists - adverse effects | Orchiectomy | Taxoids - therapeutic use | Lung Neoplasms - secondary | Antineoplastic Agents - adverse effects | Aged | Bone Neoplasms - drug therapy | Lung Neoplasms - diagnosis | Prostatic Neoplasms - drug therapy | Taxoids - adverse effects
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2. Full Text Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
by James, Nicholas D and de Bono, Johann S and Spears, Melissa R and Clarke, Noel W and Mason, Malcolm D and Dearnaley, David P and Ritchie, Alastair W.S and Amos, Claire L and Gilson, Clare and Jones, Rob J and Matheson, David and Millman, Robin and Attard, Gerhardt and Chowdhury, Simon and Cross, William R and Gillessen, Silke and Parker, Christopher C and Russell, J. Martin and Berthold, Dominik R and Brawley, Chris and Adab, Fawzi and Aung, San and Birtle, Alison J and Bowen, Jo and Brock, Susannah and Chakraborti, Prabir and Ferguson, Catherine and Gale, Joanna and Gray, Emma and Hingorani, Mohan and Hoskin, Peter J and Lester, Jason F and Malik, Zafar I and McKinna, Fiona and McPhail, Neil and Money-Kyrle, Julian and O’Sullivan, Joe and Parikh, Omi and Protheroe, Andrew and Robinson, Angus and Srihari, Narayanan N and Thomas, Carys and Wagstaff, John and Wylie, James and Zarkar, Anjali and Parmar, Mahesh K.B and Sydes, Matthew R and STAMPEDE Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 338 - 351
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Care and treatment | Prostate cancer | Prednisolone | Medical research | Prostate-specific antigen | Clinical trials | Endocrine therapy | Oncology | Metastasis | Radiation therapy | Cancer therapies | Metastases | Mens health | Androgens | Medical prognosis | Death | Prostate | Index Medicus | Abridged Index Medicus
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3. Full Text Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
by Fizazi, Karim and Tran, NamPhuong and Fein, Luis and Matsubara, Nobuaki and Rodriguez-Antolin, Alfredo and Alekseev, Boris Y and Özgüroğlu, Mustafa and Ye, Dingwei and Feyerabend, Susan and Protheroe, Andrew and De Porre, Peter and Kheoh, Thian and Park, Youn C and Todd, Mary B and Chi, Kim N and LATITUDE Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 352 - 360
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Androgen Antagonists - therapeutic use | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Prednisone | Research | Prostate cancer | Medical research | Prostate-specific antigen | Clinical trials | Metastasis | Patients | Cancer therapies | Metastases | Androgens | Chemotherapy | Pain | Castration | Medical prognosis | Hypokalemia | Death | Prostate | Index Medicus | Abridged Index Medicus | Abiraterone Acetate/administration & dosage | Prednisolone/administration & dosage | Androgen Antagonists/administration & dosage | Medical and Health Sciences | Medicin och hälsovetenskap | Neoplasm Metastasis/drug therapy | Steroid 17-alpha-Hydroxylase/antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols/adverse effects | Klinisk medicin | Clinical Medicine | Prostatic Neoplasms/drug therapy | Cancer and Oncology | Cancer och onkologi
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4. Full Text Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
by Devore, Natasha M and Scott, Emily E
Nature (London), ISSN 0028-0836, 02/2012, Volume 482, Issue 7383, pp. 116 - 119
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Structure in molecular biology | Molecular biophysics | Crystalline structure | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | United States | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Benzimidazoles - chemistry | Antineoplastic Agents - metabolism | Biocatalysis - drug effects | Receptors, Androgen - chemistry | Androstadienes - metabolism | Prostatic Neoplasms - drug therapy | United States Food and Drug Administration | Catalytic Domain | Androstenes | Models, Molecular | Antineoplastic Agents - chemistry | Androstadienes - chemistry | Androstenols - metabolism | Hydrogen Bonding | Androstenols - chemistry | Benzimidazoles - metabolism | Ligands | Protein Conformation | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Chemical properties | Structure | Drug therapy | Health aspects | Prostate cancer | Cytochrome P-450 | Enzymes | Mutation | E coli | Nitrogen | Index Medicus
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5. Full Text Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
by Gonzalez, Eric and Guengerich, F. Peter
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13168 - 13185
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | NADPH-Ferrihemoprotein Reductase - genetics | Stereoisomerism | Humans | Imidazoles - chemistry | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Androstenedione - metabolism | Cytochromes b5 - genetics | Pregnenolone - metabolism | Progesterone - chemistry | Biocatalysis - drug effects | Dehydroepiandrosterone - chemistry | Cytochrome P-450 Enzyme Inhibitors - chemistry | Dehydroepiandrosterone - metabolism | Naphthalenes - metabolism | Binding Sites | 17-alpha-Hydroxypregnenolone - metabolism | Imidazoles - metabolism | Naphthalenes - chemistry | Recombinant Proteins - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Models, Molecular | Rats | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Naphthalenes - pharmacology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Progesterone - metabolism | Androstenedione - chemistry | Ligands | Pregnenolone - chemistry | Protein Conformation | Steroid 17-alpha-Hydroxylase - genetics | 17-alpha-Hydroxypregnenolone - chemistry | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | Index Medicus | pre-steady-state kinetics | steroid metabolism | oxidation-reduction (redox) | steroidogenesis | cytochrome P450 | Enzymology | steady-state kinetics | enzyme kinetics
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6. Full Text Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer
by Li, Zhenfei and Bishop, Andrew C and Alyamani, Mohammad and Garcia, Jorge A and Dreicer, Robert and Bunch, Dustin and Liu, Jiayan and Upadhyay, Sunil K and Auchus, Richard J and Sharifi, Nima
Nature (London), ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
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7. Full Text Human cytochrome P450 17A1 conformational selection: Modulation by ligand and cytochrome b5
by Estrada, D. Fernando and Skinner, Andria L and Laurence, Jennifer S and Scott, Emily E
The Journal of biological chemistry, ISSN 0021-9258, 05/2014, Volume 289, Issue 20, pp. 14310 - 14320
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androstenols - pharmacology | Humans | Protein Conformation - drug effects | Androstenes | Models, Molecular | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Androstenols - metabolism | Nuclear Magnetic Resonance, Biomolecular | Cytochromes b5 - pharmacology | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Index Medicus
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8. Full Text Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2
by Fehl, Charlie and Vogt, Caleb D and Yadav, Rahul and Li, Kelin and Scott, Emily E and Aubé, Jeffrey
Journal of medicinal chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 11, pp. 4946 - 4960
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Catalytic Domain | Humans | Steroid 21-Hydroxylase - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Androstenes - pharmacology | Androstenes - chemistry | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Drug Design | Steroid 21-Hydroxylase - antagonists & inhibitors | Androstenes - metabolism | Cytochrome P-450 Enzyme Inhibitors - chemistry | Molecular Docking Simulation | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Steroid 21-Hydroxylase - chemistry | Index Medicus | X-ray crystallography | steroidogenesis | inhibition | cytochrome P450
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9. Full Text Structural and kinetic basis of steroid 17α,20-lyase activity in Teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2
by Pallan, Pradeep S and Nagy, Leslie D and Lei, Li and Gonzalez, Eric and Kramlinger, Valerie M and Azumaya, Caleigh M and Wawrzak, Zdzislaw and Waterman, Michael R and Guengerich, F. Peter and Egli, Martin
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 6, pp. 3248 - 3268
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Catalytic Domain | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Molecular Sequence Data | Zebrafish | Androstenes - pharmacology | Animals | Protein Binding | Molecular Docking Simulation | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | Progesterone - pharmacology | Index Medicus | Steroidogenesis | Enzyme Kinetics | Enzymology | Pre-steady-state Kinetics | X-ray Crystallography | Cytochrome P450
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10. Full Text CYP17 inhibitors for prostate cancer therapy
by Vasaitis, Tadas S and Bruno, Robert D and Njar, Vincent C.O
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 2011, Volume 125, Issue 1, pp. 23 - 31
Inhibitors of CYP17 | Ketoconazole | TAK-700 | Abiraterone acetate | Inhibition of androgen synthesis | CYP17 | VN/124-1 (TOK-001) | Prostate cancer (PC) | PC treatment | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Humans | Receptors, Androgen - metabolism | Androgens - biosynthesis | Male | Clinical Trials as Topic | Structure-Activity Relationship | Enzyme Inhibitors - therapeutic use | Disease Progression | Prostatic Neoplasms - enzymology | Androgens - chemistry | Molecular Structure | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Prostatic Neoplasms - drug therapy | Medical colleges | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Research | Antineoplastic agents | Antimitotic agents | Prevention | Antiandrogens | Health aspects | Prostate cancer | Cancer | Index Medicus
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