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Praxis (Bern. 1994), ISSN 1661-8157, 09/2012, Volume 101, Issue 18, p. 1143
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Immunotherapy - methods | Androgen Receptor Antagonists - therapeutic use | Prognosis | Humans | Bone Neoplasms - secondary | Drug Resistance, Neoplasm | Male | Palliative Care | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Androgen Receptor Antagonists - adverse effects | Orchiectomy | Taxoids - therapeutic use | Lung Neoplasms - secondary | Antineoplastic Agents - adverse effects | Aged | Bone Neoplasms - drug therapy | Lung Neoplasms - diagnosis | Prostatic Neoplasms - drug therapy | Taxoids - adverse effects
Journal Article
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 338 - 351
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Care and treatment | Prostate cancer | Prednisolone | Medical research | Prostate-specific antigen | Clinical trials | Endocrine therapy | Oncology | Metastasis | Radiation therapy | Cancer therapies | Metastases | Mens health | Androgens | Medical prognosis | Death | Prostate | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 352 - 360
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Androgen Antagonists - therapeutic use | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Prednisone | Research | Prostate cancer | Medical research | Prostate-specific antigen | Clinical trials | Metastasis | Patients | Cancer therapies | Metastases | Androgens | Chemotherapy | Pain | Castration | Medical prognosis | Hypokalemia | Death | Prostate | Index Medicus | Abridged Index Medicus | Abiraterone Acetate/administration & dosage | Prednisolone/administration & dosage | Androgen Antagonists/administration & dosage | Medical and Health Sciences | Medicin och hälsovetenskap | Neoplasm Metastasis/drug therapy | Steroid 17-alpha-Hydroxylase/antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols/adverse effects | Klinisk medicin | Clinical Medicine | Prostatic Neoplasms/drug therapy | Cancer and Oncology | Cancer och onkologi
Journal Article
Nature (London), ISSN 0028-0836, 02/2012, Volume 482, Issue 7383, pp. 116 - 119
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Structure in molecular biology | Molecular biophysics | Crystalline structure | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | United States | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Benzimidazoles - chemistry | Antineoplastic Agents - metabolism | Biocatalysis - drug effects | Receptors, Androgen - chemistry | Androstadienes - metabolism | Prostatic Neoplasms - drug therapy | United States Food and Drug Administration | Catalytic Domain | Androstenes | Models, Molecular | Antineoplastic Agents - chemistry | Androstadienes - chemistry | Androstenols - metabolism | Hydrogen Bonding | Androstenols - chemistry | Benzimidazoles - metabolism | Ligands | Protein Conformation | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Chemical properties | Structure | Drug therapy | Health aspects | Prostate cancer | Cytochrome P-450 | Enzymes | Mutation | E coli | Nitrogen | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13168 - 13185
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | NADPH-Ferrihemoprotein Reductase - genetics | Stereoisomerism | Humans | Imidazoles - chemistry | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Androstenedione - metabolism | Cytochromes b5 - genetics | Pregnenolone - metabolism | Progesterone - chemistry | Biocatalysis - drug effects | Dehydroepiandrosterone - chemistry | Cytochrome P-450 Enzyme Inhibitors - chemistry | Dehydroepiandrosterone - metabolism | Naphthalenes - metabolism | Binding Sites | 17-alpha-Hydroxypregnenolone - metabolism | Imidazoles - metabolism | Naphthalenes - chemistry | Recombinant Proteins - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Models, Molecular | Rats | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Naphthalenes - pharmacology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Progesterone - metabolism | Androstenedione - chemistry | Ligands | Pregnenolone - chemistry | Protein Conformation | Steroid 17-alpha-Hydroxylase - genetics | 17-alpha-Hydroxypregnenolone - chemistry | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | Index Medicus | pre-steady-state kinetics | steroid metabolism | oxidation-reduction (redox) | steroidogenesis | cytochrome P450 | Enzymology | steady-state kinetics | enzyme kinetics
Journal Article
Nature (London), ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2014, Volume 289, Issue 20, pp. 14310 - 14320
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androstenols - pharmacology | Humans | Protein Conformation - drug effects | Androstenes | Models, Molecular | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Androstenols - metabolism | Nuclear Magnetic Resonance, Biomolecular | Cytochromes b5 - pharmacology | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 11, pp. 4946 - 4960
Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Catalytic Domain | Humans | Steroid 21-Hydroxylase - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Androstenes - pharmacology | Androstenes - chemistry | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Drug Design | Steroid 21-Hydroxylase - antagonists & inhibitors | Androstenes - metabolism | Cytochrome P-450 Enzyme Inhibitors - chemistry | Molecular Docking Simulation | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Steroid 21-Hydroxylase - chemistry | Index Medicus | X-ray crystallography | steroidogenesis | inhibition | cytochrome P450
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 6, pp. 3248 - 3268
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Catalytic Domain | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Molecular Sequence Data | Zebrafish | Androstenes - pharmacology | Animals | Protein Binding | Molecular Docking Simulation | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | Progesterone - pharmacology | Index Medicus | Steroidogenesis | Enzyme Kinetics | Enzymology | Pre-steady-state Kinetics | X-ray Crystallography | Cytochrome P450
Journal Article
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 2011, Volume 125, Issue 1, pp. 23 - 31
Inhibitors of CYP17 | Ketoconazole | TAK-700 | Abiraterone acetate | Inhibition of androgen synthesis | CYP17 | VN/124-1 (TOK-001) | Prostate cancer (PC) | PC treatment | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Humans | Receptors, Androgen - metabolism | Androgens - biosynthesis | Male | Clinical Trials as Topic | Structure-Activity Relationship | Enzyme Inhibitors - therapeutic use | Disease Progression | Prostatic Neoplasms - enzymology | Androgens - chemistry | Molecular Structure | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Prostatic Neoplasms - drug therapy | Medical colleges | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Research | Antineoplastic agents | Antimitotic agents | Prevention | Antiandrogens | Health aspects | Prostate cancer | Cancer | Index Medicus
Journal Article