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1. Full Text Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease
by James Brown III and Catherine Theisler and Simone Silberman and Debra Magnuson and Numa Gottardi-Littell and John M. Lee and Debra Yager and Janet Crowley and Kumar Sambamurti and Mohammad M. Rahman and Allison B. Reiss and Christopher B. Eckman and Benjamin Wolozin
The Journal of biological chemistry, ISSN 0021-9258, 08/2004, Volume 279, Issue 33, pp. 34674 - 34681
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Immunohistochemistry | Oligodendroglia - metabolism | Receptors, Steroid - metabolism | Humans | Immunoblotting | Cerebral Cortex - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Time Factors | Protein Kinase C - metabolism | Liver X Receptors | Amyloid beta-Protein Precursor - metabolism | Adenoviridae - genetics | Inhibitory Concentration 50 | Neurons - metabolism | Orphan Nuclear Receptors | DNA-Binding Proteins | Cholesterol 24-Hydroxylase | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Cells, Cultured | Rats | Rats, Sprague-Dawley | Polymorphism, Genetic | Animals | Alzheimer Disease - metabolism | Hydroxycholesterols - metabolism | Cholestanetriol 26-Monooxygenase | Thiazoles - pharmacology | Steroid Hydroxylases - biosynthesis | Astrocytes - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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2. Full Text Functional characterization of 3-ketosteroid 9α-hydroxylases in Rhodococcus ruber strain chol-4
by Guevara, Govinda and Heras, Laura Fernández de las and Perera, Julián and Llorens, Juana María Navarro
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 176 - 187
ADD | Rhodococcus | AD | 3-Ketosteroid-9α-Hydroxylase | Steroids | MYCOBACTERIUM-TUBERCULOSIS | DELTA-DEHYDROGENASE ISOENZYME | MOLECULAR CHARACTERIZATION | PHTHALATE DIOXYGENASE | REDUCTASE COMPONENT | RHODOCHROUS DSM43269 | STRUCTURAL FEATURES | TARGETED DISRUPTION | BRIDGING ASPARTATE-178 | 3-Ketosteroid-9 alpha-Hydroxylase | EXTRACELLULAR CHOLESTEROL OXIDASE | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Rhodococcus - classification | Open Reading Frames | Mixed Function Oxygenases - metabolism | Phylogeny | Protein Subunits - metabolism | Rhodococcus - isolation & purification | Isoenzymes - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Rhodococcus - enzymology | Protein Subunits - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Isoenzymes - genetics | Bacterial Proteins - genetics | Recombinant Proteins - genetics | Cholesterol - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Escherichia coli - genetics | Rhodococcus - genetics | Androstenes - metabolism | Bacterial Proteins - metabolism | Kinetics | Mutation | Mixed Function Oxygenases - genetics | Sewage - microbiology | Index Medicus
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3. Full Text Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
by Blomberg Jensen, Martin and Nielsen, John E and Jørgensen, Anne and Rajpert-De Meyts, Ewa and Kristensen, David Møbjerg and Jørgensen, Niels and Skakkebaek, Niels E and Juul, Anders and Leffers, Henrik
Human reproduction (Oxford), ISSN 0268-1161, 5/2010, Volume 25, Issue 5, pp. 1303 - 1311
Testis | Reproduction | CYP | Hydroxylase | Vitamin D receptor | Life Sciences & Biomedicine | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Epididymis - metabolism | Immunohistochemistry | Steroid Hydroxylases - metabolism | Testis - metabolism | Seminal Vesicles - metabolism | Spermatogenesis | Humans | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Male | DNA Primers - genetics | Spermatozoa - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Tissue Distribution | Cytochrome P450 Family 2 | Base Sequence | Adult | Steroid Hydroxylases - genetics | Gene Expression | RNA, Messenger - genetics | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Rats | Vitamin D3 24-Hydroxylase | Genitalia, Male - metabolism | Receptors, Calcitriol - metabolism | Animals | Cholestanetriol 26-Monooxygenase - genetics | Cholestanetriol 26-Monooxygenase - metabolism | Vitamin D - metabolism | Mice | Index Medicus
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4. Full Text Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand‐bound and ‐unbound crystal structures
by Dangi, Bikash and Lee, Chang Woo and Kim, Ki‐Hwa and Park, Sun‐Ha and Yu, Eun‐Ji and Jeong, Chang‐Sook and Park, Hyun and Lee, Jun Hyuck and Oh, Tae‐Jin
The FEBS journal, ISSN 1742-464X, 05/2019, Volume 286, Issue 9, pp. 1683 - 1699
crystal structure | Streptomyces | cytochrome P450 | steroid hydroxylase | X‐ray crystallography | X-ray crystallography | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Steroid Hydroxylases - metabolism | Catalytic Domain | Steroid Hydroxylases - chemistry | Bacterial Proteins - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Chromatography, High Pressure Liquid | Androstenedione - metabolism | Sequence Homology, Amino Acid | Testosterone - metabolism | Sequence Alignment | Progesterone - metabolism | Conserved Sequence | Nuclear Magnetic Resonance, Biomolecular | Protein Binding | Bacterial Proteins - metabolism | Ligands | Protein Conformation | Streptomyces - enzymology | Testosterone | Hydroxylation | Structure | Analysis | Cytochrome P-450 | Crystals | Cytochrome | Enzymes | Protein engineering | Regioselectivity | Cytochrome P450 | Biocatalysts | Substrates | Proteins | Organic chemistry | Heme | Hydroxyl groups | Crystal structure | Steroids | Cytochromes P450 | Index Medicus
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5. Full Text Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases
by Neunzig, J and Bernhardt, R
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 05/2018, Volume 179, pp. 3 - 7
Steroid hormone biosynthesis | Sulfonated steroids | Cytochromes P450 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Steroid Hydroxylases - metabolism | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Animals | Hormones - biosynthesis | Humans | Steroids - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Steroids - biosynthesis | Pregnenolone - metabolism | Physiological aspects | Dehydroepiandrosterone | Metabolites | Cytochrome P-450 | Cytochrome | Excretion | Cytochrome P450 | Biochemistry | Steroid hormones | Steroids | Index Medicus
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6. Full Text Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator
by Cui, X and Pertile, R and Liu, P and Eyles, D.W
Neuroscience, ISSN 0306-4522, 2015, Volume 304, pp. 90 - 100
Neurology | developmental vitamin D (DVD)-deficiency | 1,25(OH)2D3 | proliferation | N-cadherin | dopamine | tyrosine hydroxylase | Tyrosine hydroxylase | Dopamine | Proliferation | 1,25(OH) 2 D 3 | Developmental vitamin D (DVD)-deficiency | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Steroids - administration & dosage | Tyrosine 3-Monooxygenase - metabolism | Cadherins - metabolism | Humans | Cell Proliferation - physiology | Vitamin D Deficiency - drug therapy | Receptors, Calcitriol - metabolism | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Receptors, Calcitriol - genetics | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Nerve Tissue Proteins - metabolism | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | Transfection | Cell Line, Tumor | Female | Vitamin D - administration & dosage | Cell Proliferation - drug effects | Vitamin D Deficiency - metabolism | Dopamine - metabolism | Disease Models, Animal | Tyrosine | Phenols | Calcifediol | Alfacalcidol | Hydroxylases | Vitamin D | Index Medicus
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7. Full Text The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha
by Umetani, Michihisa and Ghosh, Pritam and Ishikawa, Tomonori and Umetani, Junko and Ahmed, Mohamed and Mineo, Chieko and Shaul, Philip W
Cell metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 172 - 182
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Steroid Hydroxylases - metabolism | Apolipoproteins E - deficiency | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Apolipoproteins E - metabolism | Cytochrome P450 Family 7 | RNA Interference | Estrogen Receptor alpha - metabolism | Female | Cytokines - genetics | Steroid Hydroxylases - genetics | Macrophages - immunology | Cell Line | Atherosclerosis - pathology | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Endothelial Cells - metabolism | Inflammation | Cell Adhesion - drug effects | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Estrogen Receptor alpha - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Apolipoproteins E - genetics | Steroid Hydroxylases - deficiency | Hydroxycholesterols - metabolism | Macrophages - drug effects | Mice | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Metabolites | Atherosclerosis | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Cholesterol | Prevention | Blood circulation disorders | Liver | Endothelium | Index Medicus
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8. Full Text Age‐related decline in osteoblastogenesis and 1α‐hydroxylase/CYP27B1 in human mesenchymal stem cells: stimulation by parathyroid hormone
by Geng, Shuo and Zhou, Shuanhu and Glowacki, Julie
Aging cell, ISSN 1474-9718, 12/2011, Volume 10, Issue 6, pp. 962 - 971
CYP27B1 | signaling | PTH | mesenchymal stem cells | vitamin D | marrow stromal cells | Signaling | Marrow stromal cells | Vitamin D | Mesenchymal stem cells | Gene Expression Regulation, Enzymologic - drug effects | RNA, Small Interfering - genetics | Steroid Hydroxylases - metabolism | Humans | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Parathyroid Hormone - pharmacology | Insulin-Like Growth Factor I - genetics | Mesenchymal Stromal Cells - cytology | Parathyroid Hormone - metabolism | Polymerase Chain Reaction | Aging | Adult | Osteoblasts - cytology | Steroid Hydroxylases - genetics | Naphthols - pharmacology | Enzyme Inhibitors - pharmacology | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Mesenchymal Stromal Cells - metabolism | Vitamin D - pharmacology | Signal Transduction - genetics | Tyrphostins - pharmacology | Blotting, Western | Calcifediol - pharmacology | Organophosphates - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Cell Differentiation - drug effects | Gene Expression Regulation, Enzymologic - genetics | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Vitamin D - analogs & derivatives | Aged | Osteoblasts - metabolism | Insulin-Like Growth Factor I - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Mesenchymal Stem Cells | Marrow Stromal Cells
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9. Full Text LCI699, a Potent 11β-hydroxylase Inhibitor, Normalizes Urinary Cortisol in Patients With Cushing's Disease: Results From a Multicenter, Proof-of-Concept Study
by Bertagna, Xavier and Pivonello, Rosario and Fleseriu, Maria and Zhang, Yiming and Robinson, Paul and Taylor, Ann and Watson, Catherine E and Maldonado, Mario and Hamrahian, Amir H and Boscaro, Marco and Biller, Beverly M. K
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 04/2014, Volume 99, Issue 4, pp. 1375 - 1383
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Humans | Middle Aged | Pyridines - pharmacokinetics | Hydrocortisone - urine | Male | Reference Values | Steroid 11-beta-Hydroxylase - antagonists & inhibitors | Treatment Outcome | Urinalysis - standards | Imidazoles - pharmacokinetics | Pituitary ACTH Hypersecretion - drug therapy | Feasibility Studies | Dose-Response Relationship, Drug | Pituitary ACTH Hypersecretion - urine | Adult | Female | Imidazoles - therapeutic use | Pyridines - therapeutic use | Index Medicus | Abridged Index Medicus
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