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2012, ISBN 0470874325, xii, 289
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the... 
Ion channels | Metabolism | Cholesterol | Membrane proteins | Life Sciences | Science | Biology | Molecular Biology
Book
European Journal of Endocrinology, ISSN 0804-4643, 10/2014, Volume 171, Issue 4, pp. P1 - P29
Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of... 
OBSTRUCTIVE SLEEP-APNEA | ENDOCRINOLOGY & METABOLISM | SYMPATHETIC-NERVE ACTIVITY | FOLLICLE-STIMULATING-HORMONE | IMPAIRED GLUCOSE-TOLERANCE | QUALITY-OF-LIFE | TANDEM MASS-SPECTROMETRY | ANTI-MULLERIAN-HORMONE | ANDROGEN RECEPTOR GENE | LOW-DOSE FLUTAMIDE | TYPE-2 DIABETES-MELLITUS | Body Composition | Glucose Intolerance - metabolism | Polycystic Ovary Syndrome - etiology | Cardiovascular Diseases - prevention & control | Humans | Polycystic Ovary Syndrome - diagnosis | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Glucose Intolerance - etiology | Ultrasonography | Infertility, Female - etiology | Female | Obesity - etiology | Polycystic Ovary Syndrome - psychology | Concept Formation | Ovary - metabolism | Bariatric Surgery | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Gonadal Steroid Hormones - metabolism | Ovary - pathology | Polycystic Ovary Syndrome - metabolism | Cardiovascular Diseases - metabolism | Risk Reduction Behavior | Obesity - complications | Insulin Resistance | Biomarkers - blood | Infertility, Female - metabolism | Obesity - metabolism | Polycystic Ovary Syndrome - therapy | Phenotype | Obesity - therapy | Ovary - diagnostic imaging | Glucose - metabolism | Quality of Life | Androgens - metabolism | Lipid Peroxidation | Infertility, Female - therapy
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2006, Volume 75, Issue 1, pp. 19 - 37
Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological and metabolic parameters. It is this diversity that enables... 
MEF2 | Calcium-dependent protein kinase | Myofiber | Calcineurin | Exercise adaptation | Hypertrophy | PROTEIN-KINASE-C | myofiber | hypertrophy | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCINEURIN-NFAT PATHWAY | calcium-dependent protein kinase | GLUCOSE-TRANSPORT | calcineurin | INDUCED INSULIN-RESISTANCE | exercise adaptation | TYPE-2 DIABETIC-PATIENTS | FATTY-ACID OXIDATION | FIBER-TYPE | GENE-EXPRESSION | MEF2 TRANSCRIPTION FACTOR | II HISTONE DEACETYLASES | Protein Kinases - metabolism | ras Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Muscle, Skeletal - cytology | Isoenzymes - metabolism | Protein Kinase C - metabolism | Steroids - metabolism | MEF2 Transcription Factors | Somatomedins - metabolism | Muscular Dystrophies - metabolism | NFATC Transcription Factors - metabolism | Myogenic Regulatory Factors - metabolism | Histone Deacetylases - metabolism | Muscle, Skeletal - physiology | Myofibrils - physiology | Obesity - metabolism | Transcription Factors - metabolism | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Muscle, Skeletal - pathology | PPAR delta - metabolism | Atrophy - metabolism | Calcineurin - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Anabolic Agents - metabolism | Mitogen-Activated Protein Kinases - metabolism | Muscles | Physiological aspects | Genetic aspects | Research | Gene expression
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33210
Brassinosteroids (BRs) and polyamines (PAs) are well-established growth regulators playing key roles in stress management among plants. In the present study,... 
OXIDATIVE STRESS | RESPONSIVE 2-COMPONENT SYSTEM | TOLERANCE | MULTIDISCIPLINARY SCIENCES | LIGHT | DROUGHT | TOXICITY | ABSCISIC-ACID | SPERMIDINE | CELL-DEATH | WATER | Trace Elements - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | NADPH Oxidases - metabolism | Spermidine - metabolism | Seedlings - growth & development | Brassinosteroids - metabolism | Chromium - toxicity | Raphanus - genetics | Abscisic Acid - metabolism | Plant Proteins - metabolism | Stress, Physiological - drug effects | Raphanus - metabolism | Superoxide Dismutase - metabolism | Brassinosteroids - pharmacology | Indoleacetic Acids - metabolism | Seedlings - drug effects | Chromium - metabolism | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Photosystem II Protein Complex - metabolism | Polyamines - metabolism | Catalase - metabolism | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Polyamines - pharmacology | Raphanus - drug effects | Spermidine - pharmacology | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Peroxidase - metabolism | Seedlings - metabolism | Trace Elements - toxicity | Antioxidants | Enzymes | Physiological aspects | Superoxide | Photosynthesis | Polyamines | Metallothionein | Steroids | Oxidative stress | Regulators | Reactive oxygen species | Hydrogen peroxide | Ascorbic acid | Seeds | Horticulture | Genomics | Proline | Superoxide dismutase | Physiological responses | Catalase | Glutathione reductase | Betaine | Pigments | Abscisic acid | Physiology | Peroxidase | Glycine betaine | Plant sciences | Sugars | Glutathione | Soil contamination | Plants (botany) | Abiotic stress | Growth regulators | Brassinosteroids | Data processing | Phytochelatins | Metabolism | Photosynthetic pigments | Gene expression | Malondialdehyde | Seedlings | Salinity | Studies | Mitigation | Environmental science | Plant growth | Phenols | Chromium | Methods | Reductase
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 172 - 182
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol... 
ADHESION | SIGNALING PATHWAYS | HEART-DISEASE | DNA-BINDING | LIVER X RECEPTORS | INFLAMMATION | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | INTERLEUKIN-6 GENE-EXPRESSION | STEROL 27-HYDROXYLASE | CELL BIOLOGY | Steroid Hydroxylases - metabolism | Apolipoproteins E - deficiency | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Apolipoproteins E - metabolism | Cytochrome P450 Family 7 | RNA Interference | Estrogen Receptor alpha - metabolism | Female | Cytokines - genetics | Steroid Hydroxylases - genetics | Macrophages - immunology | Cell Line | Atherosclerosis - pathology | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Endothelial Cells - metabolism | Inflammation | Cell Adhesion - drug effects | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Estrogen Receptor alpha - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Apolipoproteins E - genetics | Steroid Hydroxylases - deficiency | Hydroxycholesterols - metabolism | Macrophages - drug effects | Mice | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Metabolites | Atherosclerosis | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Cholesterol | Prevention | Blood circulation disorders | Liver | Endothelium
Journal Article
1970, ISBN 9780127309507, xi, 613
Book
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2010, Volume 118, Issue 3, pp. 177 - 187
Aldo-keto reductase (AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase), may stimulate proliferation via steroid hormone and... 
Estrogen receptor | Peroxisome proliferator activated receptor γ | Prostaglandin F synthase | Prostaglandin D 2 | 17β-Hydroxysteroid dehydrogenase | Prostaglandin D | SIGNALING PATHWAYS | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKR1C3 | PROLIFERATOR-ACTIVATED RECEPTOR | RISK | Prostaglandin D-2 | CELECOXIB | ENDOCRINOLOGY & METABOLISM | PROGNOSTIC MARKER | F SYNTHASE | INHIBITORS | 17 beta-Hydroxysteroid dehydrogenase | AROMATASE | Peroxisome proliferator activated receptor | gamma | Up-Regulation | Prostaglandins - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Dinoprost - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Breast Neoplasms - metabolism | Testosterone - metabolism | Breast Neoplasms - enzymology | Transfection | Prostaglandin D2 - metabolism | Prostaglandin D2 - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | 5-alpha-Dihydroprogesterone - metabolism | Dinoprost - pharmacology | Etiocholanolone - metabolism | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Recombinant Proteins - metabolism | Estradiol - metabolism | Estrone - pharmacology | Gonadal Steroid Hormones - metabolism | Biocatalysis | Etiocholanolone - analogs & derivatives | Gonadal Steroid Hormones - pharmacology | Progesterone - analogs & derivatives | Recombinant Proteins - genetics | 20-alpha-Dihydroprogesterone - metabolism | Androsterone - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Breast Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Progesterone - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Prostaglandin D2 - pharmacology | Ketosteroids - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Prostaglandins - metabolism | Physiological aspects | Testosterone | Breast cancer | Progesterone | Estradiol | Synthetic prostaglandins F | Index Medicus
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 4/2003, Volume 51, Issue 6, pp. 925 - 948
The isoprenoid biosynthetic pathway provides intermediates for the synthesis of a multitude of natural products which serve numerous biochemical functions in... 
Life Sciences | Biochemistry, general | Plant Pathology | methylerythritol | Arabidopsis | chlorophyll | Plant Sciences | mevalonate | deoxyxylulose | isoprenoid | Methylerythritol | Chlorophyll | Mevalonate | Isoprenoid | Deoxyxylulose | CATALYZES 3 STEPS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | FARNESYL-DIPHOSPHATE SYNTHASE | ABSCISIC-ACID BIOSYNTHESIS | SYNECHOCYSTIS SP PCC-6803 | PLANT SCIENCES | RAB GERANYLGERANYL TRANSFERASE | NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE | FUNCTIONAL EXPRESSION | PHYTOCHROME-CHROMOPHORE BIOSYNTHESIS | MOLECULAR-CLONING | Sesquiterpenes - metabolism | Ubiquinone - metabolism | Plastoquinone - metabolism | Vitamin K 1 - metabolism | Protein Prenylation | Terpenes - metabolism | Gibberellins - metabolism | Plastids - metabolism | Abscisic Acid - metabolism | Cholestanols - metabolism | Steroids, Heterocyclic - metabolism | Brassinosteroids | Chromosome Mapping | Mitochondria - metabolism | Chlorophyll - metabolism | Genome, Plant | Tocopherols - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Plastids - enzymology | Genes, Plant - genetics | Carotenoids - metabolism | Monoterpenes - metabolism | Phytosterols - metabolism | Dimethylallyltranstransferase - metabolism | Cytosol - metabolism | Chromosomes, Plant - genetics | Bacteria | Flowers & plants | Metabolism | Natural products
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2005, Volume 433, Issue 2, pp. 397 - 412
Drugs and bile acids are taken up into hepatocytes by specialized transport proteins localized at the basolateral membrane, e.g., organic anion transporting... 
Coactivators and corepressors | Gene regulation | Drug metabolism | Xenobiotics | Nuclear receptors | Bile acids and salts | Hepatocyte nuclear factors | SMALL HETERODIMER PARTNER | xenobiotics | NEGATIVE FEEDBACK-REGULATION | SALT EXPORT PUMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | hepatocyte nuclear factors | coactivators and corepressors | ORPHAN NUCLEAR RECEPTOR | nuclear receptors | BIOPHYSICS | gene regulation | CONSTITUTIVE ANDROSTANE RECEPTOR | drug metabolism | bile acids and salts | FARNESOID-X-RECEPTOR | CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE | STEROL 27-HYDROXYLASE GENE | FAMILIAL INTRAHEPATIC CHOLESTASIS | Steroid 12-alpha-Hydroxylase - metabolism | Steroid Hydroxylases - metabolism | Histone Acetyltransferases | Receptors, Steroid - metabolism | Receptors, Virus - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | Homeostasis | Receptors, Glucocorticoid - metabolism | Coxsackie and Adenovirus Receptor-Like Membrane Protein | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Transcription, Genetic | Heat-Shock Proteins - metabolism | Bile Acids and Salts - metabolism | Receptors, Calcitriol - metabolism | Forecasting | Transcription Factors - metabolism | Feedback, Physiological | Pharmaceutical Preparations - metabolism | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Models, Biological | Nuclear Receptor Coactivator 1 | Ligands | Trans-Activators - metabolism | Cholestanetriol 26-Monooxygenase | Hepatocyte Nuclear Factor 4 | Multidrug Resistance-Associated Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 509 - 536
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the hydrophilic cardenolide ouabain and the... 
Cell proliferation | Arterial hypertension | Endogenous cardiotonic steroids | Rostafuroxin | Sodium/potassium-adenosinetriphosphatase | Cancer therapy | Ouabain | Marinobufagenin | Sodium pump | Oleandrin | Bufalin | Sodium metabolism | ouabain | PROTEIN-KINASE-C | PHYSIOLOGY | BOVINE ADRENOCORTICAL-CELLS | BUFALIN INDUCES APOPTOSIS | PLASMALEMMAL NA/K-ATPASE | cell proliferation | SIGNAL-TRANSDUCING FUNCTION | endogenous cardiotonic steroids | FACTOR-KAPPA-B | oleandrin | sodium/potassium-adenosinetriphosphatase | VASCULAR SMOOTH-MUSCLE | NA+-K+-ATPASE | CELL BIOLOGY | arterial hypertension | cancer therapy | OUABAIN-LIKE COMPOUND | sodium pump | DIGITALIS-LIKE COMPOUNDS | bufalin | rostafuroxin | sodium metabolism | marinobufagenin | Cardiac Glycosides - pharmacology | Neoplasms - metabolism | Antihypertensive Agents - pharmacology | Digoxin - metabolism | Calcium - metabolism | Humans | Myocardial Contraction - drug effects | Hypertension - drug therapy | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antihypertensive Agents - metabolism | Ouabain - metabolism | Antineoplastic Agents - metabolism | Bufanolides - metabolism | Antineoplastic Agents - pharmacology | Blood Pressure - drug effects | Molecular Structure | Cell Death - drug effects | Sodium Chloride - metabolism | Ouabain - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Diabetes Mellitus - metabolism | Cardiovascular System - drug effects | Antihypertensive Agents - therapeutic use | Antineoplastic Agents - chemistry | Digoxin - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Neoplasms - drug therapy | Antihypertensive Agents - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Myocytes, Cardiac - drug effects | Cardiovascular System - metabolism | Diabetes Mellitus - physiopathology | Cardiac Glycosides - chemistry | Myocytes, Cardiac - metabolism | Bufanolides - pharmacology | Cardiac Glycosides - metabolism | Cardiac Glycosides - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article