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Scientific Reports, ISSN 2045-2322, 04/2014, Volume 4, Issue 1, pp. 1 - 11
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31602 - 31615
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7121 - 7127
Journal Article
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 03/2018, Volume 62, Issue 3
Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the... 
lanosterol 14 alpha-demethylase | CYTOCHROME-P450 | SUBSTITUTION | ASPERGILLUS-FUMIGATUS | REDUCED SUSCEPTIBILITY | voriconazole | CROSS-RESISTANCE | MICROBIOLOGY | itraconazole | CYP51A | antifungal resistance | CYP51 | fungal infections | X-ray crystallography | fluconazole | AMINO-ACID | drug resistance mechanisms | AZOLE RESISTANCE | PHARMACOLOGY & PHARMACY | BINDING | Fungal Proteins - chemistry | Fluconazole - pharmacology | Fluconazole - chemistry | Saccharomyces cerevisiae - genetics | Sterol 14-Demethylase - genetics | Aspergillus fumigatus - enzymology | Substrate Specificity | Crystallography, X-Ray | Saccharomyces cerevisiae - drug effects | Antifungal Agents - chemistry | Histidine - metabolism | Recombinant Fusion Proteins - metabolism | Itraconazole - pharmacology | Candida albicans - genetics | Fluconazole - metabolism | Microbial Sensitivity Tests | Antifungal Agents - metabolism | Cloning, Molecular | Protein Interaction Domains and Motifs | Antifungal Agents - pharmacology | Itraconazole - metabolism | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Genetic Vectors - chemistry | Oligopeptides - genetics | Genetic Vectors - metabolism | Histidine - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Itraconazole - chemistry | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Aspergillus fumigatus - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Saccharomyces cerevisiae - enzymology | Sterol 14-Demethylase - metabolism | Kinetics | Mutation | Sterol 14-Demethylase - chemistry | Candida albicans - enzymology | Fungal Proteins - metabolism
Journal Article